1. A method for processing a media sheet by advancing the media sheet through a nip in a media processing device, the nip capable of being configured by abuttingly coupling a heater device to a pressure roller, the method comprising:
determining a first value of the heater device temperature of the heater device and a pressure roller temperature value of the pressure roller;
generating a signal for configuring the nip, wherein the signal is generated upon determining the first value of the heater device temperature and the pressure roller temperature value;
determining a second value of the heater device temperature of the heater device on generating the signal; and
verifying a closure of the nip for advancing the media sheet through the nip based on the first value of the heater device temperature, the second value of the heater device temperature and the pressure roller temperature value.
2. The method of claim 1 further comprising advancing the media sheet through the nip for processing the media sheet upon verifying the nip as closed.
3. The method of claim 1 further comprising generating an error message upon the verifying indicating the nip as failing to close.
4. The method of claim 1 further comprising switching the media processing device to an operational mode prior to determining the first value of the heater device temperature.
5. The method of claim 1 wherein the second value of the heater device temperature is determined on occurrence of a predefined time interval after determining the first value of the heater device temperature.
6. A method of claim 1 wherein the closure of the nip is verified based on
a temperature difference between the first value of the heater device temperature and the second value of the heater device temperature, and,
the pressure roller temperature value.
7. The method of claim 6 wherein the nip is verified as closed based on one of whether the pressure roller temperature value is less than or equal to a first threshold value and the temperature difference is greater than a second threshold value, and, whether the pressure roller temperature value is greater than the first threshold value and the temperature difference is greater than a third threshold value, is satisfied.
8. The method of claim 7 wherein the nip is verified as open based on one of whether the pressure roller temperature value is less than or equal to the first threshold value and the temperature difference is less than the second threshold value and whether the pressure roller temperature value is greater than the first threshold value and the temperature difference is less than the third threshold value, is satisfied.
9. A method for fusing toner particles onto a media sheet by advancing the media sheet through a fuser nip in a media processing device, the fuser nip capable of being configured by abuttingly coupling a heater device to a pressure roller, the method comprising:
determining a first value of the heater device temperature of the heater device and a pressure roller temperature value of the pressure roller;
generating a signal for configuring the fuser nip, wherein the signal is generated upon determining the first value of the heater device temperature and the pressure roller temperature value;
determining a second value of the heater device temperature of the heater device on generating the signal; and
verifying a closure of the fuser nip for advancing the media sheet through the fuser nip based on the first value of the heater device temperature, the second value of the heater device temperature and the pressure roller temperature value.
10. The method of claim 9 further comprising advancing the media sheet through the fuser nip for fusing the toner particles onto the media sheet upon verifying the fuser nip as closed.
11. The method of claim 9 further comprising generating an error message upon the verifying indicating the fuser nip as failing to close.
12. A method of claim 9 wherein the closure of the fuser nip is verified based on
a temperature difference between the first value of the heater device temperature and the second value of the heater device temperature, and,
the pressure roller temperature value.
13. The method of claim 12 wherein the fuser nip is verified as closed based on one of whether the pressure roller temperature value is less than or equal to a first threshold value and the temperature difference is greater than a second threshold value and whether the pressure roller temperature value is greater than the first threshold value and the temperature difference is greater than a third threshold value, is satisfied.
14. The method of claim 13 wherein the fuser nip is verified as open based on one of whether the pressure roller temperature value is less than or equal to the first threshold value and the temperature difference is less than the second threshold value, and, whether the pressure roller temperature value is greater than the first threshold value and the temperature difference is less than the third threshold value, is satisfied.
15. A computer program product embodied on a non-transitory computer readable medium for processing a media sheet by advancing the media sheet through a nip in a media processing device, the nip capable of being configured by abuttingly coupling a heater device to a pressure roller, the computer program product comprising a program module having instructions for:
determining a first value of the heater device temperature of the heater device and a pressure roller temperature value of the pressure roller;
generating a signal for configuring the nip, wherein the signal is generated based upon determining the first value of the heater device temperature and the pressure roller temperature value;
determining a second value of the heater device temperature of the heater device on generating the signal; and
verifying a closure of the nip for advancing the media sheet through the nip based on the first value of the heater device temperature, the second value of the heater device temperature and the pressure roller temperature value.
16. The computer program product according to claim 15 wherein the program module further comprises instructions for advancing the media sheet through the nip for processing the media sheet upon verifying the nip as closed.
17. The computer program product according to claim 15 wherein the program module further comprises instructions for generating an error message upon the verifying indicating the nip as failing to close.
18. The computer program product according to claim 15 wherein the instructions for verifying the closure of the nip comprises instructions for verifying the closure of the nip based on
a temperature difference between the first value of the heater device temperature and the second value of the heater device temperature, and,
the pressure roller temperature value.
19. The computer program product according to claim 18 wherein the instructions for verifying the closure of the nip comprises instructions for verifying the nip as closed based on one of whether the pressure roller temperature value is less than or equal to a first threshold value and the temperature difference is greater than a second threshold value, and, whether the pressure roller temperature value is greater than the first threshold value and the temperature difference is greater than a third threshold value, is satisfied.
20. The computer program product according to claim 19 wherein the instructions for verifying the closure of the nip comprises instructions for verifying the nip as open based on one of whether the pressure roller temperature value is less than or equal to the first threshold value and the temperature difference is less than the second threshold value, and, whether the pressure roller temperature value is greater than the first threshold value and the temperature difference is less than the third threshold value, is satisfied.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for treating elevated intraocular pressure, the method comprising the step of intracameral or anterior vitreal administration, to a patient with elevated intraocular pressure (IOP), of a sustained release implant comprising an anti-hypertensive agent and a biodegradable polymer, wherein the implant comprises from about 10 to about 50 weight percent the anti-hypertensive agent and from about 50 to about 90 weight percent the biodegradable polymer, and wherein the implant releases therapeutically effective amounts of the anti-hypertensive for a period of time between about 10 days and about 120 days.
2. The method of claim 1, wherein the implant can reduce IOP from about 20% to about 70% of baseline IOP.
3. A method for treating elevated intraocular pressure, the method comprising the step of intracameral administration against the trabecular meshwork, to a patient with elevated intraocular pressure, of a sustained release rod shaped implant comprising latanoprost or bimatoprost and a biodegradable polymer, wherein the implant comprises from about 10 to about 50 weight percent the latanoprost or bimatoprost and from about 50 to about 90 weight percent the biodegradable polymer, wherein the implant releases therapeutically effective amounts of the latanoprost or bimatoprost for a period of time between about 10 days and about 120 days.
4. A method for treating elevated intraocular pressure, the method comprising the step of intracameral or anterior vitreal administration to a patient with elevated intraocular pressure a plurality of sustained release biodegradable microspheres having an average diameter between 30 and 60 microns, the microspheres comprising from about 10 to about 30 weight percent an anti-hypertensive agent and from about 70 to about 90 weight percent a biodegradable polymer, wherein the microspheres release therapeutically effective amounts of the anti-hypertensive agent for a period of time between about 10 days and about 120 days.
5. The method of claim 4, wherein the biodegradable polymer comprises a polylactic polyglycolic copolymer (PLGA) andor a poly lactic acid polymer (PLA).
6. The method of claim 4, wherein the antihypertensive agent is selected from the group consisting of latanoprost, bimatoprost and travoprost and their salts, esters and prodrugs.
7. The method of claim 4, wherein the antihypertensive agent is selected from the group consisting of Compounds A to O, and their salts, esters and prodrugs:
8. The method of claim 4, wherein the drug delivery system comprises a high viscosity hyaluronic acid.
9. A method for treating elevated intraocular pressure, the method comprising the step of intracameral administration to a patient with elevated intraocular pressure a plurality of sustained release biodegradable microspheres having an average diameter between 30 and 60 microns, the microspheres comprising from about 10 to about 30 weight percent latanoprost and from about 70 to about 90 weight percent a biodegradable polymer, wherein the microspheres release therapeutically effective amounts of the latanoprost for a period of time between about 10 day and about 120 days.
10. A method for treating elevated intraocular pressure, the method comprising the step of intracameral administration against the trabecular meshwork, to a patient with elevated intraocular pressure, a sustained release rod shaped implant comprising latanoprost and a biodegradable polymer, wherein the implant comprises from about 10 to about 50 weight percent an anti-hypertensive agent and from about 50 to about 90 weight percent a biodegradable polymer, wherein the implant releases therapeutically effective amounts of the latanoprost for a period of time between about 10 day and about 120 days.
11. A pharmaceutical composition for intraocular use to treat an ocular condition, the composition comprising a plurality of sustained release biodegradable microspheres having an average diameter between 30 and 60 microns, the microspheres comprising from about 10 to about 30 weight percent an anti-hypertensive agent and from about 70 to about 90 weight percent a biodegradable polymer, wherein the microspheres release therapeutically effective amounts of the anti-hypertensive agent for a period of time between about 10 day and about 120 days.
12. The composition of claim 11 wherein the microspheres comprise from about 1% to about 99% by weight of the polymer.
13. The composition of claim 11, wherein the polymer is a PLGA.
14. The composition of claim method of claim 11, wherein the antihypertensive agent is selected from the group consisting of latanoprost, bimatoprost and travoprost and their salts, esters and prodrugs.
15. The composition of claim 11, wherein the antihypertensive agent is selected from the group consisting of Compounds A to O, and their salts, esters and prodrugs:
16. The composition of claim 11 further comprising a high viscosity hyaluronic acid.
17. The composition of claim 11 wherein the ocular condition is glaucoma.
18. The method of claim 1, wherein the antihypertensive agent is selected from the group consisting of Compounds A to O, and their salts, esters and prodrugs: