1. A method for treating a mammalian host in need of an anticancer treatment, which comprises administering to said host an effective anticancer amount of at least one compound represented by the formula 1:
wherein each R individually is H, an aliphatic acyl group or an aromatic acyl group;
A is selected from the group consisting of
wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro.
2. The method of claim 1 wherein each R is H.
3. The method of claim 1 wherein A is
4. The method of claim 3 wherein X is H.
5. The method of claim 1 wherein X is H.
6. The method of claim 1 wherein said compound is 1-(4-thio-\u03b2-D-arabinofuranosyl) cytosine.
7. The method of claim 1 wherein said host is suffering from a cancer selected from the group consisting of melanoma, prostate cancer, mammary cancer, renal cancer, colon cancer, lung cancer, leukemias and lymphomas.
8. A method of inhibiting replication of DNA which comprises contacting said cell with an effective amount of at least one compound represented by the formula 1:
wherein each R individually is H, an aliphatic acyl group or an aromatic acyl group;
A is selected from the group consisting of
wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro.
9. The method of claim 8 wherein each R is H.
10. The method of claim 8 wherein A is
11. The method of claim 10 wherein X is H.
12. The method of claim 8 wherein X is H.
13. The method of claim 8 wherein said compound is 1-(4-thio-\u03b2-D-arabinofuranosyl) cytosine.
14-19. (Cancelled)
20. The method of claim 1 wherein A is:
21. The method of claim 20 wherein X is H.
22. The method of claim 7 wherein each R is H.
23. The method of claim 7 wherein A is:
24. The method of claim 23 wherein X is H.
25. The method of claim 7 wherein X is H.
26. The method of claim 7 wherein said compound is 1-(4-thio-\u03b2-D-arabinofuranosyl) cytosine.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method to archive log entries created by a data storage system, comprising the steps of:
providing a data storage system comprising first memory and a library log encoded in said first memory;
writing a plurality of log entries to said library log, wherein each log entry comprises a log entry time;
encoding a log archive in a second memory, wherein said second memory is external to said data storage system;
setting a time T0 equal to current time;
at time T0, copying to said log archive said plurality of log entries written to said library log;
determining a time T1 when an earliest log entry was written to said library log;
determining a time T2 when a latest log entry was written to said library log;
calculating a log interval TINT equal to (T2\u2212T1);
setting a retrieval time equal to (T0+TINT);
determining whether to perform an intermediate inspection of the library log;
when performing an intermediate inspection of the library log, determining a number (N) of log entries written to library log retrieved at time T0;
establishing a previous log filling rate equal to (N)TINT;
setting an intermediate sampling interval TS, wherein said intermediate sampling interval is less than said log interval;
setting an intermediate sampling time, wherein said intermediate sampling time equals (T0+TS);
when current time equals said intermediate sampling time, inspecting the library log created after time T0;
determining a number (M) of log entries written to the library log after time T0;
establishing a current log filling rate equal to (M)TS;
determining whether said current log filling rate is greater than said previous log filling rate; and
when said current log filling rate is greater than said previous log filling rate, adjusting said log interval TINT to be less than (T2\u2212T1).
2. The method of claim 1, further comprising the steps of:
setting a minimum log interval;
determining if said adjusted log interval is less than said minimum log interval; and
when said adjusted log interval is less than said minimum log interval, setting said log interval equal to said minimum log interval.
3. The method of claim 1, further comprising the steps of:
when said current log filling rate is not greater than said previous log filling rate, determining if said current log filling rate is less than said previous log filling rate; and
when said current log filling rate is less than said previous log filling rate, adjusting said log interval TINT to be greater than (T2\u2212T1).
4. An article of manufacture comprising a processor and a computer readable storage medium having computer readable program code disposed therein to archive a plurality of log entries stored by a data storage system in a first memory, wherein each log entry comprises a log entry time, the computer readable program code comprising a series of computer readable program steps to effect:
encoding a log archive in a second memory, wherein said second memory is external to said data storage system;
setting a time T0 equal to current time;
at time T0, copying to said log archive said plurality of log entries written to said library log;
determining a time T1 when an earliest log entry was written to said library log;
determining a time T2 when a latest log entry was written to said library log;
calculating a log interval TINT equal to (T2\u2212T1);
setting a retrieval time equal to (T0+TINT);
determining whether to perform an intermediate inspection of the library log;
when performing an intermediate inspection of the library log, determining a number (N) of log entries written to library log retrieved at time T0;
establishing a previous log filling rate equal to (N)TINT;
setting an intermediate sampling interval TS, wherein said intermediate sampling interval is less than said log interval;
setting an intermediate sampling time, wherein said intermediate sampling time equals (T0+TS);
when current time equals said intermediate sampling time, inspecting the library log created after time T0;
determining a number (M) of log entries written to the library log after time T0;
establishing a current log filling rate equal to (M)TS;
determining whether said current log filling rate is greater than said previous log filling rate; and
when said current log filling rate is greater than said previous log filling rate, adjusting said log interval TINT to be less than (T2\u2212T1).
5. The article of manufacture of claim 4, said computer readable program code further comprising a series of computer readable program steps to effect:
setting a minimum log interval;
determining whether said adjusted log interval is less than said minimum log interval; and
when said adjusted log interval is less than said minimum log interval, setting said log interval equal to said minimum log interval.
6. The article of manufacture of claim 4, said computer readable program code further comprising a series of computer readable program steps to effect:
when said current log filling rate is not greater than said previous log filling rate, determining if said current log filling rate is less than said previous log filling rate; and
when said current log filling rate is less than said previous log filling rate, adjusting said log interval TINT to be greater than (T2\u2212T1).