1. A compound of the formula (I) or a salt thereof:
wherein
R1 represents \u2014O-lower alkyl, -lower alkylene-phenyl, or -lower alkylene-pyridyl, in which phenyl or pyridyl may be substituted with carboxy or protected carboxy,
R2 and R3 are the same as or different from each other and represent H, lower alkyl, cycloalkyl, aryl, heteroaryl, nitrogen-containing saturated hetero ring, -lower alkylene-aryl, or -lower alkylene-heteroaryl, in which lower alkyl, cycloalkyl, aryl, heteroaryl, and nitrogen-containing saturated hetero ring may be substituted, or
R2 and R3 may be combined with a nitrogen atom to which they bind to form 5- to 7-membered saturated cyclic amino, in which the 5- to 7-membered saturated cyclic amino may be substituted,
R4’s are the same as or different from each other and represent halogen, lower alkyl, \u2014OH, \u2014O-lower alkyl, \u2014NO2, or a group represented by the formula (II):
wherein R41 and R42 are the same as or different from each other and represent H or lower alkyl which may be substituted, or R41 and R42 may be combined with a nitrogen atom to which they bind to form 5- to 7-membered saturated cyclic amino, and
n represents 0 to 2,
provided that N-(4-methoxyphenyl)-2-({3-(4-methylpiperazin-1-yl)sulfonylbenzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide is excluded.
2. The compound or a salt thereof according to claim 1, wherein n is 0.
3. The compound or a salt thereof according to claim 2, wherein R1 is -lower alkylene-(phenyl substituted with carboxy or protected carboxy).
4. The compound or a salt thereof according to claim 3, wherein R1 is -lower alkylene-(phenyl substituted with carboxy).
5. The compound or a salt thereof according to claim 4, wherein R2 is lower alkyl, cycloalkyl, or phenyl, each of which is substituted with carboxy.
6. The compound or a salt thereof according to claim 5, wherein R3 is lower alkyl or cycloalkyl.
7. The compound or a salt thereof according to claim 6, wherein R2 and R3 are combined with a nitrogen atom to which they bind to form pyrrolidin-1-yl, piperidin-1-yl, piperazin-1-yl, morpholin-4-yl, or azepan-1-yl, each of which may be substituted.
8. The compound or a salt thereof according to claim 7, wherein R2 and R3 are combined with a nitrogen atom to which they bind to form piperazin-1-yl which may be substituted.
9. (canceled)
10. A pharmaceutical composition, comprising a compound or a salt thereof according to claim 1, and a pharmaceutically acceptable excipient.
11. A method for preventing or treating hyperphosphatemia, comprising administering to a subject in need thereof an effective amount of a compound or a salt thereof according to claim 1.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
We claim:
1. An impeller arrangement comprising:
a plurality of substantially identical integrally molded angular segments, each segment including a rim portion, a vane portion and a hub portion, the rim portions and hub portions having end surfaces on opposite angular ends of the segments and the segments being assembled with the end surfaces of the rim and hub portions bonded to corresponding surfaces of adjacent segments.
2. An impeller arrangement according to claim 1 wherein the end surfaces of the rim and hub portions of adjacent segments are bonded using an adhesive.
3. An impeller arrangement according to claim 1 wherein each segment comprises a fiber-reinforced polymer composite resin material.
4. An impeller arrangement according to claim 3 wherein the composite material contains fibers chosen from glass, aramid, carbon, polyester and quartz materials.
5. An impeller arrangement according to claim 3 wherein the segments are bonded using the same resin material from which the segments are formed.
6. An impeller arrangement according to claim 1 including a radially outer layer surrounding the rim portions of the segments and comprising a resin impregnated veil cloth.
7. An impeller arrangement according to claim 1 wherein the rim portion of each segment is angularly offset from the hub portion of the segment.
8. A method for manufacturing an impeller arrangement comprising:
providing a mold for molding an integral impeller segment containing a rim portion and a hub portion and a vane joining the rim portion and the hub portion, the rim and hub portions each having angularly opposite end surfaces;
molding a plurality of substantially identical segments using fiber-reinforced resin material; and
assembling the plurality of segments into an impeller by bonding the end surfaces of the rim and hub portions of each segment to corresponding end surfaces of rim and hub portions of adjacent segments.
9. A method according to claim 8 including injection molding a fiber-reinforced polymer composite material into the same mold to form each segment.
10. A method according to claim 8 including bonding the end surfaces of the rim and hub portions of each segment to corresponding end surfaces of adjacent segments using an adhesive.
11. A method according to claim 10 including bonding the end surfaces of the rim and hub portions of each segment to corresponding end surfaces of adjacent segments using the same resin material used in forming the segments.
12. A method according to claim 8 including machining the outer surface of the rim portion a n d applying a resin-impregnated veil cloth around the outer surface.
13. A method according to claim 8 including inserting a hub piece into an opening provided in the assembled hub portions of the segments.