1. A solid composition consisting essentially of
a) a carrier which has at least one of the following physical properties:
elasticity module in the range of 5-100 Ncm,
density of 1-10 mgcm3,
chamber diameter of more than 0.75 mm and less than 4 mm andor having a chamber diameter average below 3 mm
and evenly distributed and fixed upon said carrier
b) solid fibrinogen, and
c) solid thrombin.
2. A composition according to claim 1 wherein the carrier is a biodegradable polymer selected from the group consisting of polyhyaluronic acid, polyhydroxy acid, lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine and collagen.
3. A carrier according to claim 2 wherein the carrier is a collagen sponge which comprises collagen type I material from mammalian, transgenic or recombinant sources.
4. A composition according to claim 1 wherein the carrier has one or more active sides wherein fibrinogen is present in an amount of 2-10 mgcm2, and thrombin is present in an amount of 1.5-5.5 IUcm2.
5. A composition according to claim 1 wherein the fibrinogen is human, purified from a natural source, or transgenic or recombinant human fibrinogen.
6. A composition according to claim 1 wherein the fibrinogen is purified from a natural source.
7. A composition according to claim 1 wherein the fibrinogen is transgenic or recombinant.
8. A composition according to claim 1 wherein the thrombin is human, purified from a natural source, or transgenic or recombinant human thrombin.
9. A composition according to claim 1 wherein the thrombin is purified from a natural source.
10. A composition according to claim 1 wherein the thrombin is transgenic or recombinant.
11. A composition for haemostasis, tissue sealing and tissue gluing which contains a flexible carrier which has at least one of the following physical properties:
elasticity module in the range of 5-100 Ncm,
density of 1-10 mgcm3,
chamber diameter of more than 0.75 mm and less than 4 mm andor having a chamber
diameter average below 3 mm
and which further comprises
solid fibrinogen
and solid thrombin
and does not comprise any antifibronolytic agent such as aprotinin, -aminocaproic acid or 2-antiplasmin,
the solid fibrinogen and solid thrombin being fixed to the carrier in a manner so that the abrasion is less than 1.0 mgcm2 when a sample of the coated material is shaken on a Vibrofix shaker at a frequence of about 1000 rpm for 2 minutes and
if the coated carrier material is inserted into an endoscopic equipment and thereafter removed, the material is substantially unchanged and has a cast of coating material less than 20% as an indication of the flexibility of the carrier and the solid adhesion of the solid fibrinogen and solid thrombin,
said material being substantially air tight and liquid tight and having an elasticity factor of at least 1.25 as determined by a test comprising fixation of the coated carrier to a Latex sheet, expansion of the Latex by pressure three times and at the third time measuring the area of the coated carrier at the highest point of Latex sheet expansion and comparing the expanded area of the coated carrier with the starting area of the coated area.
12. A composition according to claim 11 wherein the carrier is a biodegrable polymer selected from the group consisting of a polyhyaluronic acid, polyhydroxy acid, lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine and collagen.
13. A composition according to claim 11 wherein the carrier and has one or more active sides wherein fibrinogen is present in an amount of 2-10 mgcm2, and thrombin is present in an amount of 1.5-2.5 IUcm2.
14. A composition according to claim 11 wherein the fibrinogen is human, purified from a natural source, or transgenic or recombinant human fibrinogen.
15. A composition according to claim 11 wherein the fibrinogen is purified from a natural source.
16. A composition according to claim 11 wherein the fibrinogen is transgenic or recombinant.
17. A composition according to claim 11 wherein the thrombin is human, purified from a natural source, or transgenic or recombinant human thrombin.
18. A composition according to claim 11 wherein the thrombin is purified from a natural source.
19. A composition according to claim 11 wherein the thrombin is transgenic or recombinant.
20. A composition according to claim 1 for surgical interventions in the gastrointestinal system, such as the oesophagus, stomach, small intestine, large intestine, rectum, on parenchymal organs, such as liver, spleen, pancreas, kidneys, lungs, adrenal glands, thyroid and lymph nodes, cardiovascular surgery, thoracic surgery including surgery on the trachea, bronchi and lungs, surgical interventions in the ear, nose and throat (ENT) area including dental surgery, gynaecological, urological, vascular, bone (e.g. spongiosa resection), and emergency surgery, neurological surgery, lymphatic, biliary, and cerebrospinal (CSF) fistulae, and air leakages during thoracic and pulmonal surgery.
21. Use of a carrier having at least one of the following physical properties:
an elasticity module in the range of 5-100 Ncm,
a density of 1-10 mgcm3,
chamber diameter of more than 0.75 mm and less than 4 mm andor having a chamber diameter average below 3 mm
and a sufficient amount of fibrinogen and a sufficient amount of thrombin for the preparation of a product for tissue sealing.
22. Use of a carrier having at least one of the following physical properties:
an elasticity module in the range of 5-100 Ncm,
a density of 1-10 mgcm3,
chamber diameter of more than 0.75 mm and less than 4 mm andor having a chamber diameter average below 3 mm
and a sufficient amount of fibrinogen and a sufficient amount of thrombin for the preparation of a product for haemostasis.
23. Use of a carrier having at least one of the following physical properties:
an elasticity module in the range of 5-100 Ncm,
a density of 1-10 mgcm3,
chamber diameter of more than 0.75 mm and less than 4 mm andor having a chamber diameter average below 3 mm
and a sufficient amount of fibrinogen and a sufficient amount of thrombin for the preparation of a product for tissue sealing.
24. A composition according to claim 11 for surgical interventions in the gastrointestinal system, such as the oesophagus, stomach, small intestine, large intestine, rectum, on parenchymal organs, such as liver, spleen, pancreas, kidneys, lungs, adrenal glands, thyroid and lymph nodes, cardiovascular surgery, thoracic surgery including surgery on the trachea, bronchi and lungs, surgical interventions in the ear, nose and throat (ENT) area including dental surgery, gynaecological, urological, vascular, bone (e.g. spongiosa resection), and emergency surgery, neurological surgery, lymphatic, biliary, and cerebrospinal (CSF) fistulae, and air leakages during thoracic and pulmonal surgery.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for calculating a size of an object in vivo using images acquired by an imager, the method comprising:
determining a distance traveled by said imager during capture of two of said images;
calculating relative spatial coordinates of a set of objects within said images using said distance; and
calculating the size of one of the set of objects from said spatial coordinates;
wherein the above steps are performed by a processor.
2. The method according to claim 1 wherein said distance traveled is non-negligible as compared to a distance between said imager and said objects.
3. The method according to claim 1 wherein the imager is included within an endoscope.
4. The method according to claim 1 wherein the imager is included within a swallowable capsule.
5. The method according to claim 1 comprising determining the position of the imager.
6. The method according to claim 1 comprising determining the velocity of the imager.
7. The method according to claim 1 comprising determining an optical flow of the images.
8. The method according to claim 1 comprising determining the distance traveled by analyzing the images.
9. The method according to claim 1 wherein the object is in a gastrointestinal tract.
10. A swallowable capsule comprising:
an image sensor capable of obtaining images from within the gastrointestinal tract;
a distance-detecting sensor capable of generating data for determining a distance traveled by said capsule during reception of at least two of said images, wherein said data may be used by a processor for generating spatial coordinates of at least one object found within said two images and for converting said spatial coordinates into a size calculation of said at least one object.
11. The capsule according to claim 10 where said distance-detecting sensor includes an induction coil.
12. The capsule according to claim 10 wherein said distance-detecting sensor includes a velocity sensor.
13. The capsule according to claim 10 wherein distance-detecting sensor includes an imager.