1. A radiator fin comprising two heat conducting vanes, wherein the two heat conducting vanes are joined end to end and top to top, and multiple strength vanes which are provided in a space between said two heat conducting vanes are next to the inner wall of said two heat conducting vanes.
2. The radiator fin, as recited in claim 1, wherein said two heat conducting vanes further provide allowing ventilation regions
3. The radiator fin, as recited in claim 2, wherein said allowing ventilation regions are breather holes provided in said two heat conducting vanes.
4. The radiator fin, as recited in claim 2, wherein said allowing ventilation regions are breather grooves provided in said two heat conducting vanes.
5. The radiator fin, as recited in claim 4, wherein said breather grooves are lateral or longitudinal grooves which are provided correspondingly at interval in said two heat conducting vanes.
6. The radiator fin, as recited in claim 1, wherein said strength vanes are laterally or longitudinally provided in said space between said two heat conducting vanes.
7. The radiator fin, as recited in claim 2, wherein said two heat conducting vanes are joined end to end and top to top by welding.
8. The radiator fin, as recited in claim 3, wherein said two heat conducting vanes are joined end to end and top to top by welding.
9. The radiator fin, as recited in claim 4, wherein said two heat conducting vanes are joined end to end and top to top by welding.
10. The radiator fin, as recited in claim 1, wherein said two heat conducting vanes are provided into a closed body.
11. The radiator fin, as recited in claim 1, wherein said two heat conducting vanes and said strength vanes are in porous structure.
12. The radiator fin, as recited in claim 10, wherein said two heat conducting vanes and said strength vanes are in porous structure.
13. A radiator fin component comprising a base and at least a radiator fin comprising two heat conducting vanes, wherein the two heat conducting vanes are joined end to end and top to top, and multiple strength vanes which are provided in a space between the two heat conducting vanes are next to the inner wall of the two heat conducting vanes, wherein multiple track grooves are provided on said base correspond to said heat conducting vanes, wherein riveting structures correspond to said track grooves are provided in said riveting regions of said heat conducting vanes and said base; wherein said riveting structures are pushed into said track grooves by a downward pressure to a top of said radiator fin to fix said radiator fins to said base.
14. The radiator fin, as recited in claim 13, wherein said two heat conducting vanes further provide allowing ventilation regions
15. The radiator fin, as recited in claim 14, wherein said allowing ventilation regions are breather holes provided in said two heat conducting vanes.
16. The radiator fin, as recited in claim 14, wherein said allowing ventilation regions are breather grooves provided in said two heat conducting vanes.
17. The radiator fin, as recited in claim 16, wherein said breather grooves are lateral or longitudinal grooves which are provided correspondingly at interval in said two heat conducting vanes.
18. The radiator fin, as recited in claim 13, wherein said strength vanes are laterally or longitudinally provided in said space between said two heat conducting vanes.
19. The radiator fin, as recited in claim 14, wherein said two heat conducting vanes are joined end to end and top to top by welding.
20. The radiator fin, as recited in claim 15, wherein said two heat conducting vanes are joined end to end and top to top by welding.
21. The radiator fin, as recited in claim 16, wherein said two heat conducting vanes are joined end to end and top to top by welding.
22. The radiator fin, as recited in claim 13, wherein said two heat conducting vanes are provided into a closed body.
23. The radiator fin, as recited in claim 13, wherein said two heat conducting vanes and said strength vanes are in porous structure.
24. The radiator fin, as recited in claim 22, wherein said two heat conducting vanes and said strength vanes are in porous structure.
25. The radiator fin component, as recited in claim 23, wherein said track grooves each has a narrow top and a wider base forming a shape, wherein a set of riveting structures corresponding to said track grooves each has a shape which are provided in said riveting regions of said heat conducting vanes and said base.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. Use of a compound of general formula (I)
Where:
W\u2550H, halogen, NO2, NH2, OH, C1-C6 alcoxy, C1-C6 haloalcoxy, C1-C6 haloalkyl; R corresponds to C1-C7 alkyl, 2-phenyl, 3-phenyl, 4-phenyl, 2-benzyl, 3-benzyl, 4-benzyl, 2-ethylbenzyl, 3-ethylbenzyl, 4-ethylbenzyl, benzyl, thiophene, furan, pyrrole, 2-pyridine, 3-pyridine, 4-pyridine, pyrazine, pyrimidine, benzothiophene, benzofuran, indole, quinoline, isoquinoline, naphthalene, CH2-2-thiophene, CH2-3-thiophene, CH2-2-furan, CH2-3-furan, CH3CH2-2-thiophene, CH3CH2-3-thiophene, CH3CH2-2-furan, CH3CH2-3-furan; R\u2032 corresponds to O\u2014NO2\u2212 or SO2NHOH or furoxan or any pharmaceutically-acceptable salt thereof, characterized by being for the preparation of a drug for the treatment of diseases which require reducing the levels of the TNF-\u03b1 factor and an exogenous source of nitric oxide.
2. Use according to claim 1, characterized by the compound being of formula (IA)
3. Use according to claim 1, characterized by the compound being of formula (IB)
4. Use according to claim 1, characterized by the compound being of formula (IC)
5. Use according to claim 1, characterized by the compound being of formula (ID)
6. Use according to claim 1, characterized by the compound being of formula (IE)
7. Use of a compound of general formula (II)
W\u2014R1\u2014SO2NHR2 \u2003\u2003II
wherein W\u2550H, halogen, NO2, NH2, OH, C1-C6 alcoxy, C1-C6 haloalcoxy, C1-C6 haloalkyl , R1 corresponds to 2-phenyl, 3-phenyl, 4-phenyl, 2-benzyl, 3-benzyl, 4-benzyl, 2-ethylbenzyl, 3-ethylbenzyl, 4-ethylbenzyl, benzyl, thiophene, furan, pyrrole, 2-pyridine, 3-pyridine, 4-pyridine, pyrazine, pyrimidine, benzothiophene, benzofuran, indole, quinoline, isoquinoline, naphthalene, CH2-2-thiophene, CH2-3-thiophene, CH2-2-furan, CH2-3-furan, CH3CH2-2-thiophene, CH3CH2-3-thiophene, CH3CH2-2-furan, CH3CH2-3-furan; R2 corresponds to OH, H, C(\u2550O)NHOH, C(\u2550S)NHOH, C(\u2550O)NOH (C6H5); or any pharmaceutically acceptable salt thereof, characterized by being for the preparation of a drug for the treatment of diseases which require reducing the levels of the TNF-\u03b1 factor and an exogenous source of nitric oxide.
8. Use according to claim 7, characterized by the compound being of formula (IIA)
9. Use according to claim 1, characterized by being for the treatment of sickle-cell disease.
10. Pharmaceutical composition for the treatment of diseases which require reducing the levels of the TNF-\u03b1 factor and an exogenous source of nitric oxide characterized by comprising the compound as defined in claim 1 in a pharmaceutically acceptable carrier.
11. Method for obtaining the compound of formula (IIA)
Characterized in that it comprises the following steps:
a) mixing, in a suitable container, hydroxylamine hydrochloride, sodium bicarbonate and water;
b) adding ethanol to the mixture obtained in step a;
c) adding 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl) benzenesulphonyl chloride to the mixture obtained in step b.
12. Method for obtaining according to claim 11, characterized in that the addition of ethanol in step b) occurs only after the elimination of the CO2 released in step a).
13. Method for obtaining according to claim 11, characterized in that after step c), the solvent is evaporated and the obtained product is washed with hot dichloromethane.
14. Compound characterized by being of formula (IC)
15. Compound characterized by being of formula: