1-31. (canceled)
32. A method for the computer-aided design of vaccines, the method comprising using molecular simulation of a proposed vaccine nanoparticle to predict the proposed vaccine nanoparticle’s overall and molecular scale properties, and applying bioinformatics to the thus-predicted properties to predict the likely immunogenicity of the proposed vaccine nanoparticle.
33. The method of claim 32 wherein the thus-predicted properties include overall size, geometry and thermal stability of the proposed vaccine nanoparticle.
34. The method of claim 32 wherein the thus-predicted properties include epitope conformation, the geometric relation between multiple closely-lying epitopes, and the statistics of the variations of epitope structure over time as predicted by the molecular simulation.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A fiberglass product, comprising:
a plurality of fibers; and
a binder composition, wherein the binder composition, prior to curing, comprises:
a mixture of Maillard reactants; and
one or more modifiers selected from the group consisting of:
a copolymer comprising one or more vinyl aromatic derived units and at least one of maleic anhydride and maleic acid;
an adduct of styrene, at least one of maleic anhydride and maleic acid, and at least one of an acrylic acid and an acrylate;
one or more latexes, and
any combination thereof.
2. The fiberglass product of claim 1, wherein the copolymer is present, and wherein the vinyl aromatic derived units comprise styrene.
3. The fiberglass product of claim 1, wherein the mixture of Maillard reactants comprises at least one polycarboxylic acid, at least one of ammonia and an amine, and at least one carbohydrate source.
4. The fiberglass product of claim 1, wherein the mixture of Maillard reactants comprises ammonia, citric acid, and dextrose.
5. The fiberglass product of claim 1, wherein the mixture of Maillard reactants comprises a polycarboxylic acid ammonium salt and a carbohydrate source, and wherein the one or more modifiers is the copolymer and the copolymer comprises styrene maleic anhydride.
6. The fiberglass product of claim 1, wherein the mixture of Maillard reactants comprises ammonia, citric acid, and dextrose, and wherein the one or more modifiers is the copolymer and the copolymer comprises styrene maleic anhydride.
7. The fiberglass product of claim 1, wherein the copolymer is present and has a molecular weight of about 1,000 to about 500,000.
8. The fiberglass product of claim 1, wherein the mixture of Maillard reactants is present in an amount of about 80 wt % to about 99 wt %, based on a total weight of the mixture of Maillard reactants and the one or more modifiers.
9. The fiberglass product of claim 1, wherein the one or more modifiers is selected from the group consisting of: the copolymer; the adduct; and a combination thereof.
10. The fiberglass product of claim 1, wherein the one or more modifiers is the copolymer.
11. The fiberglass product of claim 1, wherein the one or more modifiers is the adduct.
12. The fiberglass product of claim 1, wherein the copolymer is present and has a molecular weight of about 10,000 to about 500,000.
13. A process for preparing a fiberglass product, comprising:
contacting a plurality of fibers with a binder composition, the binder composition comprising:
a mixture of Maillard reactants; and
one or more modifiers selected from the group consisting of:
a copolymer comprising one or more vinyl aromatic derived units and at least one of maleic anhydride and maleic acid;
an adduct of styrene, at least one of maleic anhydride and maleic acid, and at least one of an acrylic acid and an acrylate;
one or more latexes; and
any combination thereof;
collecting the contacted fibers to form a non-woven mat; and
heating the non-woven mat to at least partially cure the binder composition.
14. The process of claim 13, wherein the copolymer is present, and wherein the vinyl aromatic derived units comprise styrene.
15. The process of claim 13, wherein the mixture of Maillard reactants comprises at least one polycarboxylic acid, at least one of ammonia and an amine, and at least one carbohydrate source.
16. The process of claim 13, wherein the mixture of Maillard reactants comprises ammonia, citric acid, and dextrose.
17. The process of claim 13, wherein the binder composition comprises an aqueous mixture when contacted with the plurality of fibers.
18. The process of claim 13, wherein the binder composition is produced by combining the mixture of Maillard reactants with the one or more modifiers.
19. The process of claim 18, wherein the mixture of Maillard reactants comprises a polycarboxylic acid ammonium salt and a carbohydrate source, and wherein the one or more modifiers is the copolymer and the copolymer comprises styrene maleic anhydride.
20. The process of claim 13, wherein the mixture of Maillard reactants is present in an amount of about 80 wt % to about 99 wt %, based on a total weight of the mixture of Maillard reactants and the one or more modifiers.
21. The process of claim 13, wherein the one or more modifiers is selected from the group consisting of: the copolymer; the adduct; and a combination thereof.
22. The process of claim 13, wherein the one or more modifiers is the copolymer.