1-12. (canceled)
13. A method of treating erectile dysfunction which comprises administering to a patient in need thereof a combination composition comprising as active ingredients propionyl L-carnitine or a pharmaceutically acceptable salt thereof and a drug useful for the treatment of erectile dysfunction selected from the group consisting of sildenafil, apomorphine prostaglandin E1, pentolamine and papaverine.
14. The method of claim 13, wherein the pharmaceutically acceptable salt of propionyl L-carnitine is selected from the group consisting of chloride, bromide, orotate, acid aspartate, acid citrate, magnesium citrate, acid phosphate, fumarate, acid fumarate, magnesium fumarate, lactate, maleate, acid maleate, mucate, acid oxalate, pamoate, acid pamoate, acid sulphate, glucose phosphate, tartrate, acid tartrate, magnesium tartrate, 2-amino ethansulphonate, magnesium 2-amino etansulphonate, choline tartrate and trichloroacetate.
15. The method of claim 13 or 14, in which the erectile dysfunction patient is affected by diabetes mellitus.
16. The method of claims 13 or 14 in which the erectile dysfunction patient does not respond to treatment with drugs useful for the treatment of erectile dysfunction.
17. The method of claim 16, in which the drug useful for the treatment of erectile dysfunction is selected from the group consisting of sildenafil, apomorphine prostaglandin E1, pentolamine and papaverine.
18. A pharmaceutical composition comprising, as active ingredients, propionyl L-carnitine or a pharmaceutically acceptable salt thereof and a drug selected from the group consisting of sildenafil, apomorphine prostaglandin, pentolamine and papaverine and at least one excipient andor pharmaceutically acceptable diluent.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
We claim:
1. A solvent-free silicone composition for forming a cured release coating comprising (A) 100 parts by weight of a diorganopolysiloxane having in each molecule at least two alkenyl groups and a viscosity of 50 to 5,000 mPa-s at 25 C.;
(B) 3 to 50 parts by weight of an organohydrogenpolysiloxane mixture comprising constituent (b-1) and constituent (b-2) in a weight ratio of 1:0.01 to 1:1, where (b- 1) is a diorganopolysiloxane having a viscosity of 1 to 1,000 mPa-s at 25 C. and having both molecular terminals capped with silicon-bonded hydrogen atoms and (b-2) is an organohydrogenpolysiloxane having a viscosity of 1 to 1,000 mPa-s at 25 C. and having at least three pendant silicon-bonded hydrogen atoms in each molecular chain; and
(C) a catalytic amount of a platinum-type catalyst.
2. The silicone composition of claim 1, where the alkenyl group in component (A) is 5-hexenyl.
3. The silicone composition of claim 1, where the alkenyl group in component (A) is vinyl.
4. The silicone composition of claim 1, where constituent (b-1) is a dimethylpolysiloxane having both terminals of the molecular chain capped with dimethylhydrogensiloxy groups.
5. The silicone composition of claim 1, where constituent (b-2) is selected from the group consisting of trimethylsiloxy-capped methylhydrogenpolysiloxane and trimethylsiloxy-capped copolymer of dimethylpolysiloxane and methylhydrogensiloxane.
6. The silicone composition of claim 1 further comprising 1 to 20 parts by weight of component (D) a dimethylpolysiloxane having a viscosity of 100 to 1,000,000 mPa-s at 25 C.
7. The silicone composition of claim 1, where component (A) has a viscosity of 100 to 2,000 mPa-s at 25 C.
8. The silicone composition of claim 1, where component (b-1) has a viscosity of 2 to 500 mPa-s at 25 C.
9. The silicone composition of claim 1, where component (b-2) has a viscosity of 2 to 500 mPa-s at 25 C.
10. The silicone composition of claim 1, where component (A) has a viscosity of 100 to 2,000 mPa-s at 25 C., component (b-1) has a viscosity of 2 to 500 mPa-s at 25 C., and component (b-2) has a viscosity of 2 to 500 mPa-s at 25 C.
11. The silicone composition of claim 1, where the weight ratio of constituent (b-1) to constituent (b-2) is 1:0.01 to 1:0.5.
12. The silicone composition of claim 1, where the weight ratio of constituent (b-1) to constituent (b-2) is 1:0.05 to 1:0.4.
13. A cured silicone release coating formed by curing a solvent-free silicone composition comprising
(A) 100 parts by weight of a diorganopolysiloxane having in each molecule at least two alkenyl groups and a viscosity of 50 to 5,000 mPa-s at 25 C.;
(B) 3 to 50 parts by weight of an organohydrogenpolysiloxane mixture comprising constituent (b-1) and constituent (b-2) in a weight ratio of 1:0.01 to 1: 1, where (b-1) is a diorganopolysiloxane having a viscosity of 1 to 1,000 mPa-s at 25 C. and having both molecular terminals capped with silicon-bonded hydrogen atoms and (b-2) is an organohydrogenpolysiloxane having a viscosity of 1 to 1,000 mPa-s at 25 C. and having at least three pendant silicon-bonded hydrogen atoms in each molecular chain; and
(C) a catalytic amount of a platinum-type catalyst.
14. The cured silicone release coating according to claim 13, where the alkenyl group in component (A) is selected from the group consisting of 5-hexenyl and vinyl.
15. The cured silicone release coating according to claim 13, where constituent (b-1) is a dimethylpolysiloxane having both terminals of the molecular chain capped with dimethylhydrogensiloxy groups and constituent (b-2) is selected from the group consisting of trimethylsiloxy-capped methylhydrogenpolysiloxane and trimethylsiloxy-capped copolymer of dimethylpolysiloxane and methylhydrogensiloxane.