1. A modified vasoactive intestinal polypeptide having the amino acid sequence of
Acy-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Val-Ala-Ala-Lys-Lys-Tyr-Leu-Asn-Trp-lle-Lys-Lys-Ala-Lys-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Lys (\u03b5-long acyl)-X(SEQ ID NO:6):
wherein:
Acyl is a C2-C16 acyl chain;
long acyl is a C6-C24 acyl chain;
X is OH or NHR1; and
R1 is H, lower alkyl, haloalkyl, or PEG.
2. The modified polypeptide of claim 1, wherein acyl is a C4-C8 acyl chain; long acyl is a C6-C14 acyl chain; and PEG is a polyethylene glycol chain of C2-C20.
3. A method for producing the modified polypeptide of claim 1, said method comprising synthesizing a polypeptide with the SEQ ID NO:6 by the sequential addition of protected amino acids from a peptide chain, removing the protecting groups, desalting and purifying the polypeptide.
4. A pharmaceutical composition comprising the modified polypeptide of claim 1, or acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient.
5. The pharmaceutical composition of claim 4, further comprising at least one compound selected from the group consisting of insulin, insulin analogs, incretin, incretin analogs, glucagon-like peptide, glucagon-like peptide analogs, exendin, exendin analogs, sulfonylureas, biguanidase, \u03b1-gulocosidase inhibitors, thiazolidinediones, peroxisome proliferator activated receptor (PPAR) agonists, PPAR antagonists and PPAR partial agonists.
6. A modified vasoactive intestinal polypeptide having the amino acid sequence of
Acy-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Val-Ala-Ala-Lys-Lys-Tyr-Leu-Asn-Trp-lle-Lys-Lys-Ala-Lys-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Lys (\u03b5-long acyl)-X(SEQ ID NO:6):
wherein:
Acyl is a C5 acyl chain;
long acyl is a C18 acyl chain;
X is OH or NHR1; and
R1 is H, lower alkyl, haloalkyl, or PEG.
7. A method for producing the modified polypeptide of claim 6, said method comprising synthesizing a polypeptide with the SEQ ID NO:6 by the sequential addition of protected amino acids from a peptide chain, removing the protecting groups, desalting and purifying the polypeptide.
8. A pharmaceutical composition comprising the modified polypeptide of claim 6, or acceptable salt thereof, and at least one pharmaceutically acceptable carrier or excipient.
9. The pharmaceutical composition of claim 8, further comprising at least one compound selected from the group consisting of insulin, insulin analogs, incretin, incretin analogs, glucagon-like peptide, glucagon-like peptide analogs, exendin, exendin analogs, sulfonylureas, biguanidase, \u03b1-gulocosidase inhibitors, thiazolidinediones, peroxisome proliferator activated receptor (PPAR) agonists, PPAR antagonists and PPAR partial agonists.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A radio network controller comprising;
a plurality of functional modules, wherein the functional modules at least comprising: an ATM interface module, an interface management module, a radio signaling management module and a radio bearer processing module, characterized in that the radio network controller replaces an ATM switch with an IP switching network to achieve data and signaling exchange among the above functional modules in the radio network controller.
2. The radio network controller according to claim 1, wherein the IP switching network supports QoS.
3. The radio network controller according to claim 1, wherein each of the functional modules respectively comprise at least one functional board, and the functions of each of the functional modules are respectively achieved in different functional boards.
4. The radio network controller according to claim 1, wherein each of the functional modules are arranged in a single chassis to form a elementary unit of the radio network controller.
5. The radio network controller according to claim 4, wherein the IP switching network is an IP switching module contained in the chassis, and each of the functional modules achieves data and signaling exchange inside the radio network controller by connecting with the IP switching module.
6. The radio network controller according to claim 1, wherein the ATM interface module and the radio bearer processing module, after being extended, are configured in at least one extended chassis, such that the radio network controller further comprises at least one extended unit of the radio network controller.
7. The radio network controller according to claim 6, wherein the IP switching network comprises a group of IP switching modules and concentrator routing switches, wherein the IP switching module connects each of the functional modules in the elementary unit and extended unit of the radio network controller, and the concentrator routing switch connects the units via the IP switching module in the elementary unit and extended units of the radio network controller.
8. The radio network controller according to claim 6, wherein the number of the interface ATM boards constituting the ATM interface module is configured according to the data flow of the interfaces and the number of the ports required to be provided, and the number of the radio bearer processing boards constituting the radio bearer processing module is configured according to the number of the users to be supported and the data flow.
9. The radio network controller according to claim 4, wherein each of the functional modules comprise information filling means for filling in a DiffServ field of an IP header to be transmitted.
10. The radio network controller according to claim 5, wherein the IP switching module or the concentrator routing switch comprises reading means for reading a DiffServ field of an IP header of a data package.
11. The radio network controller according to claim 1, characterized in that, the interface ATM board constituting the ATM interface module comprises means for achieving IPATM conversion, for providing a standard ATM interface between the radio network controller and an external network element.
12. The radio network controller according to claim 6, wherein each of the functional modules comprise information filling means for filling in a DiffServ field of an IP header to be transmitted.
13. The radio network controller according to claim 7, wherein the IP switching module or the concentrator routing switch comprises reading means for reading a DiffServ field of an IP header of a data package.