1. A method comprising:
receiving an identification of a set of cloud-populated data to be transported from a set of host storage clouds to at least one target data store;
identifying a data transport pathway from the set of host storage clouds to the at least one target data store; and
initiating the transport of the set of cloud-populated data to the at least one target data store via a data distribution service in view of a set of de-population commands, wherein the data transport pathway comprises a dedicated transport connection between the set of host storage clouds and the target data store.
2. The method of claim 1, wherein the at least one target data store comprises at least one data store in a premise network.
3. The method of claim 1, wherein the at least one target data store comprises at least one data store in a virtual network.
4. The method of claim 1, wherein the set of cloud-populated data comprises at least one of a set of selected databases, directories, or files stored in one or more local cloud data stores hosted in the set of host storage clouds.
5. The method of claim 1, wherein the data transport pathway comprises at least a set of dedicated reverse staging connections between the data distribution service and the at least one target data store.
6. The method of claim 5, wherein the set of dedicated reverse staging connections comprises at least one of a wide area network (WAN), a metropolitan area network (MAN), or an optical network connection.
7. The method of claim 6, wherein the data distribution service is located within at least one of geographic proximity or network proximity of the at least one target store.
8. The method of claim 1, wherein the data transport pathway comprises at least
a set of dedicated transport connections between the set of host storage clouds and the data distribution service, and
a set of dedicated reverse staging connections between the data distribution service and the at least one target data store.
9. The method of claim 1, wherein the set of de-population commands comprises at least one of a set of specifications for the data transport pathway, an identification of the set of cloud-populated data, an identification of a set of locations of the set of cloud-populated data, a set of security specifications for the set of cloud-populated data, or a schedule for conducting the transport of the set of cloud-populated data.
10. The method of claim 1, further comprising at least one of
deleting the set of cloud-populated data from the set of host storage clouds after transport of the set of cloud-populated data to the at least one target data store, or
archiving the set of cloud-populated data from the set of host storage clouds after transport of the set of cloud-populated data to the at least one target data store.
11. A method comprising:
receiving an identification of a set of cloud-populated data to be transported from a set of host storage clouds to at least one target data store;
identifying a data transport pathway from the set of host storage clouds to the at least one target data store; and
initiating the transport of the set of cloud-populated data to the at least one target data store via a data distribution service in view of a set of de-population commands, wherein the data transport pathway comprises at least a set of dedicated transport connections between the set of host storage clouds and the data distribution service.
12. The method of claim 11, wherein the set of dedicated transport connections comprises at least one of a wide area network (WAN), a metropolitan area network (MAN), or an optical network connection.
13. The method of claim 12, wherein the data distribution service is located within at least one of geographic proximity or network proximity of the set of host storage clouds.
14. A system comprising:
an interface to at least one target data store coupled to a data distribution service; and
a processor, communicating with the at least one target data store via the interface, the processor to\u2014
receive an identification of the set of cloud-populated data to be transported from a set of host storage clouds to the at least one target data store,
identify a data transport pathway from the set of host storage clouds to the at least one target data store, and
initiate the transport of the set of cloud-populated data to the at least one target data store via a data distribution service in view of a set of de-population commands, wherein the data transport pathway comprises a dedicated transport connection between the set of host storage clouds and the target data store.
15. The system of claim 13, wherein the at least one target data store comprises at least one data store in a premise network.
16. The system of claim 13, wherein the at least one target data store comprises at least one data store in a virtual network.
17. The system of claim 13, wherein the set of cloud-populated data comprises at least one of a set of selected databases, directories, or files stored in one or more local cloud data stores hosted in the set of host storage clouds.
18. The system of claim 13, wherein the data transport pathway comprises at least a set of dedicated transport connections between the set of host storage clouds and the data distribution service.
19. The system of claim 18, wherein the set of dedicated transport connections comprises at least one of a wide area network (WAN), a metropolitan area network (MAN), or an optical network connection.
20. The system of claim 19, wherein the data distribution service is located within at least one of geographic proximity or network proximity of the set of host storage clouds.
21. The system of claim 13, wherein the data transport pathway comprises at least a set of dedicated reverse staging connections between the data distribution service and the at least one target data store.
22. The system of claim 21, wherein the set of dedicated reverse staging connections comprises at least one of a wide area network (WAN), a metropolitan area network (MAN), or an optical network connection.
23. The system of claim 22, wherein the data distribution service is located within at least one of geographic proximity or network proximity of the at least one target store.
24. The system of claim 13, wherein the data transport pathway comprises at least
a set of dedicated transport connections between the set of host storage clouds and the data distribution service, and
a set of dedicated reverse staging connections between the data distribution service and the at least one target data store.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. Substantially pure, biologically active recombinant human thyrotropin (rTSH).
2. The thyrotropin of claim 1 labeled isotopically with I131, I125, chemoluminiscently or fluoroscently.
3. The thyrotropin of claim 1 produced by recombinant genetic process using constructs with gene elements that enhance thyrotropin production.
4. A clone comprising complete nucleotide sequence for the expression of the thyrotropin of claim 1 in a suitable expression vector.
5. The clone of claim 4 further comprising first untranslated exon of TSH-.
6. A method for producing TSH, comprising
(a) allowing expression of TSH by the clone of claim 4 in a suitable expression vector; and
(b) then recovering substantially pure TSH by conventional purification and isolation methodology.
7. A method for producing TSH, comprising
(a) allowing expression of TSH by the clone of claim 5 in a suitable expression vector; and
(b) then recovering substantially pure TSH by conventional purification and isolation methodology.
8. A method for producing TSH, comprising
(a) allowing expression of TSH by the clone of claim 4, wherein TSH is about 3 to 5 times in excess of TSH;
(b) then recovering substantially pure TSH by conventional purification and isolation methodology.
9. A method for producing TSH, comprising
(a) allowing expression of TSH by the clone of claim 5, wherein TSH is about 3 to 5 times in excess of TSH;
(b) then recovering substantially pure TSH by conventional purification and isolation methodology.
10. A TSH antagonist produced by a mutant of the clone of claim 4.
11. A TSH agonist produced by a mutant of the clone of claim 4.
12. A kit comprising containers separately containing
(a) universal standard of substantially pure unlabeled rTSH;
(b) substantially pure, labeled rTSH;
(c) antibodies against purified rTSH; and
(d) instructional material describing the use of reagents (a), (b) and (c).
13. Anti-rTSH antibodies without interfering cross-reactivity with non-TSH hormones.
14. A method for determining the level of TSH in a sample comprising reacting an aliquot of a sample in which the amount of TSH is to be determined with the antibodies of claim 13 and comparing the level of antibody reactivity with a predetermined standard antibody-rTSH reactivity curve to determine the amount of TSH present in said sample.
15. A method of diagnosing the extent of thyroid cancer, comprising administering rTSH of claim 1 to a patient to maximize 131I uptake, and then administering a visualizing dose of 131I to said patient; and then visualizing the cancer by standard visualizing means.
16. A method for treating thyroid cancer, comprising administering therapeutic regimen of a combination of rTSH of claim 1 and 131I or 131I labeled rTSH to a patient afflicted with thyroid cancer.
17. A method of blocking TSH activity, comprising inhibiting TSH activity by competitive amount of the antagonist of claim 10.
18. A method of stimulating TSH activity, comprising inducing TSH production by the agonist of claim 11.