1. A method for identifying an antibody or antigen binding fragment thereof comprising the steps of:
(a) screening a library of antibodies or antigen binding fragments against at least one immunogen;
(b) obtaining a plurality of antibodies or antigen binding fragments that are specific for the immunogen;
(c) dividing the plurality of antibodies or antigen binding fragments into at least a first pool and a second pool, wherein each pool contains at least one antibody or antigen binding fragment;
(d) testing said antibodies or antigen binding fragments from said first pool for function in an vitro assay;
(e) dividing the antibodies or antigen binding fragments from said first pool into two or more sub-pools, to the extent function in an vitro assay is observed in step (d), wherein each sub-pool contains at least one antibody or antigen binding fragment;
(f) testing said antibodies or antigen binding fragments from said first and second sub-pools of said first pool for function in an vitro assay; and
(g) identifying at least one antibody or antigen binding fragment from step (f) that are functional in an vitro assay.
2. A method according to claim 1, further comprising:
(h) testing said antibodies or antigen binding fragments from said second pool for function in an vitro assay;
(i) dividing the antibodies or antigen binding fragments from said second pool into two or more sub-pools, to the extent function in an vitro assay is observed in step (h), wherein each sub-pool contains at least one antibody or antigen binding fragment;
(j) testing said antibodies or antigen binding fragments from said first and second sub-pools of said second pool for function in an vitro assay efficacy against disease; and
(k) identifying at least one antibody or antigen binding fragment from step (j) that is functional in an vitro assay.
3. The method according to claim 1, wherein the library of antibodies or antigen binding fragments used to screen against at least one immunogen comprises a phage display library displaying antibodies or antigen binding fragments thereof.
4. The method according to claim 1, further comprising:
(h) combining the antibodies or antigen binding fragments identified as functional in an vitro assay;
(i) testing the combination of antibodies or antigen binding fragments for function in an vitro assay; and
(j) identifying a synergistic combination of antibodies or antigen binding fragments.
5. The method according to claim 4, further comprising:
(k) combining a subset of the antibodies or antigen binding fragments identified as a synergistic combination, wherein the subset combination comprises at least one less antibody or antigen binding fragment than the synergistic combination;
(l) testing the subset combination of antibodies or antigen binding fragments for function in an vitro assay; and
(m) identifying the subset combination of antibodies or antigen binding fragments that maintains synergistic activity.
6. The method according to claim 1, wherein step (a), the screening of a library of antibodies or antigen binding fragments comprises screening a library of antibodies or antigen binding fragments against a first and a second immunogen.
7. The method according to claim 6, wherein step (b) of claim 1, the obtaining a plurality of antibodies or antigen binding fragments that are specific for the immunogen, further comprises:
(ba) combining the plurality of antibodies or antigen binding fragments specific for the first immunogen with the plurality of antibodies or antigen binding fragments specific for the second immunogen;
(bb) testing the combination of pluralities of antibodies or antigen binding fragments for function in an vitro assay; and
(be) identifying a synergistic combination of pluralities of antibodies or antigen binding fragments functional in an vitro assay.
8. The method according to claim 7, further comprising:
(bd) combining a subset of the pluralities of antibodies or antigen binding fragments identified as a synergistic combination, wherein the subset combination comprises at least one less antibody or antigen binding fragment than the synergistic combination;
(be) testing the subset combination of pluralities of antibodies or antigen binding fragments for function in an vitro assay; and
(bf) identifying the subset combination of pluralities of antibodies or antigen binding fragments that maintains synergistic activity.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An apparatus for expressing an accuracy of a measured location of a terminal, the apparatus comprising:
a storage unit to store accuracy information used for indicating an accuracy of a measured location corresponding to each possible location of the terminal; and
a controller to express an accuracy of a measured location in a particular area, based on the accuracy information.
2. The apparatus of claim 1, wherein the accuracy information comprises at least one of information associated with an accuracy of a measured location of each building present in the particular area, and information associated with an accuracy of a measured location in each of a plurality of sections, when one of the buildings comprises the plurality of sections.
3. The apparatus of claim 1, wherein the controller is configured to express the accuracy of the measured location in the particular area, based on information associated with an accuracy of a measured location of each building present in the particular area.
4. The apparatus of claim 1, wherein when one of buildings present in the particular area comprises a plurality of sections, the controller is configured to express the accuracy of the measured location in the particular area, based on information associated with an accuracy of a measured location in each of the sections.
5. The apparatus of claim 1, wherein:
the controller is configured to express a building list that describes building identifiers of buildings present in the particular area, and an accuracy of a measured location corresponding to each of the building identifiers, or
when one of buildings present in the particular area comprises a plurality of sections, the controller is configured to express a section list that describes section identifiers of the sections and an accuracy of a measured location corresponding to each of the section identifiers.
6. The apparatus of claim 1, wherein the controller is configured to express the accuracy of the measured location so that different accuracies of measured locations are differentiated from each other using at least one of a voice, a number, a character, a vibration, a sound, and a color or a shading on a map.
7. The apparatus of claim 1, further comprising:
a location information obtainment unit to obtain information associated with a location of the terminal,
wherein the controller is configured to express an accuracy of a measured location in the location of the terminal or an accuracy of a measured location in an area comprising the location of the terminal, based on the accuracy information.
8. The apparatus of claim 1, wherein the accuracy of the measured location comprises information regarding whether a location is measurable in the particular area.
9. An apparatus for expressing an accuracy of a measured location of a terminal, the apparatus comprising:
a location information obtainment unit to obtain information associated with a location of the terminal;
a calculator to calculate an accuracy of a measured location in the location of the terminal;
an expression unit to express the calculated accuracy of the measured location; and
a controller to control the expression unit to express the calculated accuracy of the measured location in real time.
10. The apparatus of claim 9, wherein when the terminal comprises an execution icon associated with a location based service, the controller is configured to control the execution icon based on the accuracy of the measured location.
11. The apparatus of claim 9, further comprising:
a selector to select a scheme from a plurality of schemes for expressing the accuracy of the measured location,
wherein the controller is configured to express the accuracy of the measured location according to the selected scheme.
12. The apparatus of claim 11, wherein the plurality of schemes comprises at least one of a scheme of expressing the accuracy of the measured location using a number, a scheme of expressing the accuracy of the measured location using a character, a scheme of expressing the accuracy of the measured location using a vibration, a scheme of expressing the accuracy of the measured location using a sound, a scheme of expressing the accuracy of the measured location using a voice, a scheme of expressing the accuracy of the measured location using a distance, and a scheme of expressing the accuracy of the measured location using a map.
13. A method of expressing an accuracy of a measured location of a terminal, the method comprising:
accessing a storage unit where accuracy information used for indicating an accuracy of a measured location corresponding to each possible location of the terminal is stored; and
expressing an accuracy of a measured location in a particular area, based on the accuracy information.
14. The method of claim 13, wherein the accuracy information comprises at least one of information associated with an accuracy of a measured location of each building present in the particular area, and information associated with an accuracy of a measured location in each of a plurality of sections, when one of the buildings comprises the plurality of sections.
15. The method of claim 13, wherein the expressing comprises expressing the accuracy of the measured location in the particular area, based on information associated with an accuracy of a measured location in each building present in the particular area.
16. The method of claim 13, wherein the expressing comprises expressing the accuracy of the measured location in the particular area, based on information associated with an accuracy of a measured location in each of a plurality of sections when one of buildings present in the particular area comprises the plurality of sections.
17. The method of claim 13, wherein:
the expressing comprises expressing a building list that describes building identifiers of buildings present in the particular area, and an accuracy of a measured location corresponding to each of the building identifiers, or expressing a section list that describes section identifiers of a plurality of sections and an accuracy of a measured location corresponding to each of the section identifiers when one of buildings present in the particular area comprises the plurality of sections.
18. The method of claim 13, wherein the expressing comprises expressing the accuracy of the measured location so that different accuracies of measured locations are differentiated from each other, using at least one of a voice, a number, a character, a vibration, a sound, and a color or a shading on a map.
19. The method of claim 13, further comprising:
obtaining information associated with a location of the terminal,
wherein the expressing comprises expressing an accuracy of a measured location in the location of the terminal or an accuracy of a measured location in an area comprising the location of the terminal, based on the accuracy information.
20. The apparatus of claim 13, wherein the accuracy of the measured location comprises information regarding whether a location is measurable in the particular area.
21. A method of expressing an accuracy of a measured location of a terminal, the method comprising:
obtaining information associated with a location of the terminal;
calculating an accuracy of a measured location in the location of the terminal;
expressing the calculated accuracy of the measured location; and
expressing the calculated accuracy of the measured location in real time.
22. The method of claim 21, wherein the expressing comprises controlling, based on the accuracy of the measured location, an execution icon associated with a location based service, when the terminal comprises the execution icon.
23. The method of claim 21, further comprising:
selecting a scheme from a plurality of schemes for expressing the accuracy of the measured location,
wherein the expressing comprises expressing the accuracy of the measured location according to the selected scheme.
24. The method of claim 23, wherein the plurality of schemes comprises at least one of a scheme of expressing the accuracy of the measured location using a number, a scheme of expressing the accuracy of the measured location using a character, a scheme of expressing the accuracy of the measured location using a vibration, a scheme of expressing the accuracy of the measured location using a sound, a scheme of expressing the accuracy of the measured location using a voice, a scheme of expressing the accuracy of the measured location using a distance, and a scheme of expressing the accuracy of the measured location using a map.
25. A computer-readable storage medium comprising program instructions for causing a processor to implement a method of expressing an accuracy of a measured location of a terminal, the method comprising:
accessing a storage unit where accuracy information used for indicating an accuracy of a measured location corresponding to each possible location of the terminal is stored; and
expressing an accuracy of a measured location in a particular area, based on the accuracy information.
26. A terminal for expressing the accuracy of a measured location of the terminal, the terminal comprising:
a location information obtainment unit configured to measure location information about the location of the terminal;
a calculator configured to calculate an accuracy of the measured location information about the location of the terminal; and
a controller configured to express the accuracy of the measured location that includes the terminal, based on the calculated accuracy of the measured location information.
27. The terminal of claim 26, further comprising a display, wherein the controller is configured to express the accuracy of the measured location that includes the terminal on the display by displaying a map including a plurality of structures located around the terminal that are differentiated based on the calculated accuracy of the measured location of each respective structure.
28. The terminal of claim 27, wherein the accuracy of each measured location of each respective structure is differentiated on the map by at least one of a shape, a color, a size, and a shade.
29. The terminal of claim 27, wherein the map includes a building that the terminal is located in and also a plurality of buildings located around the terminal.
30. The terminal of claim 29, wherein at least one building includes a plurality of sections, the location information obtainment unit is configured to measure location information of each section, the calculator is configured to calculate the accuracy of each measured location of each section, and the map expresses the accuracy of each measured location of each section.
31. The terminal of claim 26, further comprising a speaker, wherein the speaker is configured to express the accuracy of the measured location using sound.