1. A battery cell configured to have a structure in which an electrode assembly comprising a separator disposed between a cathode and an anode is mounted in a battery case, wherein
the battery case comprises an upper case and a lower case, the upper case andor the lower case being provided with a receiving part, in which the electrode assembly is mounted,
the electrode assembly comprises a plurality of electrodes or unit cells stacked in a height direction on the basis of a plane, two or more of the electrodes or the unit cells having different planar sizes,
the receiving part of the battery case is provided with stair-like steps corresponding to an external appearance of the electrode assembly, and
the electrode assembly includes two or more electrode groups, the two or more electrode groups being of different types selected from the group consisting of:
a first electrode group having a laminated structure in which a cathode plate, a separator plate, an anode plate, and another separator plate are laminated while being sequentially stacked,
a second electrode group having a laminated structure in which an anode plate, a separator plate, a cathode plate, and another separator plate are laminated while being sequentially stacked,
a third electrode group having a laminated structure in which a cathode plate, an anode plate, and separator plates are laminated while being stacked such that the two of the separator plates are located at the outermost sides of the stacked structure, and
a fourth electrode group having a laminated structure in which a cathode plate, an anode plate, and a separator plate are laminated while being stacked such that the separator plate is disposed between the cathode plate and the anode plate.
2. The battery cell according to claim 1, wherein the two or more electrodes or unit cells having different planar sizes are different from each other in terms of at least one selected from among a thickness, a breadth (horizontal length), and a width (vertical length) of each electrode or each unit cell.
3. The battery cell according to claim 1, wherein each of the unit cells has different kinds of electrodes or the same kind of electrodes located at opposite sides of a structure in which one or more cathodes and one or more anodes are stacked in a state in which a separator is disposed respectively between the cathodes and the anodes.
4. The battery cell according to claim 1, wherein electrode terminals of the unit cells are electrically connected to each other.
5. The battery cell according to claim 1, wherein the unit cells are stacked such that the sizes of the unit cells are decreased from a lower part to an upper part of the electrode assembly.
6. The battery cell according to claim 1, wherein the battery case is formed of a laminate sheet comprising a metal layer and a resin layer.
7. The battery cell according to claim 1, wherein the battery case has a thickness of 50 \u03bcm to 200 \u03bcm.
8. The battery cell according to claim 1, wherein the stair-like steps are formed by applying a vacuum into the battery case to deform the battery case such that the battery case corresponds to the external appearance of the electrode assembly.
9. The battery cell according to claim 8, wherein, before the vacuum is applied, a portion, at which the steps are to be formed, of the receiving part of the battery case is curved in vertical section to correspond to a shape of the steps.
10. The battery cell according to claim 9, wherein the receiving part of the battery case is formed in a hemispherical shape including a planar portion corresponding to a size of an upper end of the electrode assembly.
11. The battery cell according to claim 8, wherein primary stair-like steps are formed at the receiving part of the battery case by molding before the vacuum is applied, and then a vacuum is applied into the battery case to deform the battery case such that the battery case corresponds to the external appearance of the electrode assembly to form secondary stair-like steps.
12. The battery cell according to claim 8, wherein the stair-like steps are formed by pressing the receiving part of the battery case using a stair-like press member having a structure corresponding to the external appearance of the electrode assembly and then applying a vacuum into the battery case to deform the battery case such that the battery case corresponds to the external appearance of the electrode assembly.
13. The battery cell according to claim 1, wherein the battery cell is a lithium ion battery cell or a lithium ion polymer battery cell.
14. A battery pack comprising a battery cell according to claim 1 as a unit battery, wherein the battery cell comprises two or more battery cells.
15. A device comprising the battery pack according to claim 14 as a power source.
16. The device according to claim 15, wherein the device is selected from among a mobile phone, a portable computer, a smartphone, a tablet PC, a smart pad, a netbook computer, an LEV, an electric vehicle, a hybrid electric vehicle, a plug-in hybrid electric vehicle, and a power storage device.
17. The battery pack according to claim 14, wherein the two or more battery cells are connected in series.
18. The battery pack according to claim 14, wherein the two or more battery cells are connected in parallel.
19. The battery pack according to claim 14, wherein the two or more battery cells include two or more battery cells connected in series and two or more battery cells connected in parallel.
20. A device comprising a battery cell according to claim 1 as a power source.
21. The device according to claim 20, wherein the device is selected from among a mobile phone, a portable computer, a smartphone, a tablet personal computer (PC), a smart pad, a netbook computer, a light electric vehicle (LEV), an electric vehicle, a hybrid electric vehicle, a plug-in hybrid electric vehicle, and a power storage device.
22. A kit including:
a battery cell configured to have a structure in which an electrode assembly comprising a separator disposed between a cathode and an anode is mounted in a battery case, wherein
the battery case comprises an upper case and a lower case, the upper case andor the lower case being provided with a receiving part, in which the electrode assembly is mounted,
the electrode assembly comprises a plurality of electrodes or unit cells stacked in a height direction on the basis of a plane, two or more of the electrodes or the unit cells having different planar sizes, and
the receiving part of the battery case is provided with stair-like steps corresponding to an external appearance of the electrode assembly; and
a stair-like press member shaped to correspond to at least two of the stair-like steps.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An isolated human polypeptide selected from the group consisting of:
(a) a polypeptide encoded by a polynucleotide comprising the sequence of SEQ ID NO:1;
(b) a polypeptide comprising a polypeptide sequence comprising at least 95% identity along the entire length of the polypeptide sequence of SEQ ID NO:2 and which is encoded for by a polynucleotide sequence which hybridizes to the comvlement of SEQ ID NO:1 under stringent conditions comprising overnight incubation at 42\xb0 C. in a solution comprising: 50% formamide, 5\xd7SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5\xd7 Denhardt’s solution, 10% dextran sulfate, and 20 microgramml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1\xd7SSC at 65\xb0 C., and which polypeptide binds to survivin;
(c) a polypeptide comprising at least 95% identity along the entire length of the polypeptide sequence of SEQ ID NO:2 and which is encoded for by a polynucleotide sequence which hybridizes to the complement of SEQ ID NO:1 under stringent conditions comprising overnight incubation at 42\xb0 C. in a solution comprising: 50% formamide, 5\xd7SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5\xd7 Denhardt’s solution, 10% dextran sulfate, and 20 microgramml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1\xd7SSC at 65\xb0 C., and which polypeptide binds to survivin; and
(d) the polypeptide sequence of SEQ ID NO:2.
2. An isolated polypeptide comprising the polypeptide sequence of SEQ ID NO:2.
3. The polypeptide of claim 2 which is the polypeptide sequence of SEQ ID NO:2.
4. An isolated human polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising a polynucleotide sequence comprising at least 95% identity along the entire length of the polynucleotide sequence of SEQ ID NO:1 which hybridizes to the complement of SEQ ID NO:1 under stringent conditions comprising overnight incubation at 42\xb0 C. in a solution comprising: 50% formamide, 5\xd7SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5\xd7Denhardt’s solution, 10% dextran sulfate, and 20 microgramml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1\xd7SSC at 65\xb0 C.;
(b) a polynucleotide comprising at least 95% identity along the entire length of the polynucleotide of SEQ ID NO:1 which hybridizes to the complement of SEQ ID NO:1 under stringent conditions comprising overnight incubation at 42\xb0 C. in a solution comprising: 50% formamide, 5\xd7SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5\xd7 Denhardt’s solution, 10% dextran sulfate, and 20 microgramml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1\xd7SSC at 65\xb0 C. and which binds to survivin;
(c) a polynucleotide comprising a polynucleotide sequence encoding a polypeptide sequence comprising at least 95% identity along the entire length of the polypeptide sequence of SEQ ID NO:2 and which hybridizes to the complement of SEQ ID NO:1 under stringent conditions comprising overnight incubation at 42\xb0 C. in a solution comprising: 50% formamide, 5\xd7SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5\xd7 Denhardt’s solution, 10% dextran sulfate, and 20 microgramml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1\xd7SSC at 65\xb0 C., and which polypeptide binds to survivin;
(d) a polynucleotide comprising a polynucleotide sequence encoding a polypeptide sequence comprising at least 95% identity along the entire length of the polypeptide sequence of SEQ ID NO:2 and which hybridizes to the complement of SEQ ID NO:1 under stringent conditions comprising overnight incubation at 42\xb0 C. in a solution comprising: 50% formamide, 5\xd7SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5\xd7 Denhardt’s solution, 10% dextran sulfate, and 20 microgramml denatured, sheared salmon sperm DNA; followed by washing the filters in 0.1\xd7SSC at 65\xb0 C., and which polypeptide binds to survivin;
(e) a polynucleotide which is the RNA equivalent of a polynucleotide of (a) to (d); and
(f) a polynucleotide sequence complementary over its entire length to said polynucleotide of any one of (a) to (e).
5. A polynucleotide of claim 4 selected from the group consisting of:
(a) a polynucleotide comprising the polynucleotide of SEQ ID NO:1;
(b) the polynucleotide of SEQ ID NO:1;
(c) a polynucleotide comprising a polynucleotide sequence encoding the polypeptide of SEQ ID NO:2; and
(d) a polynucleotide encoding the polypeptide of SEQ ID NO:2.
6. An expression vector comprising a polynucleotide capable of producing a polypeptide of claim 1 when said expression vector is present in a compatible host cell.
7. A recombinant host cell comprising the expression vector of claim 6, wherein said cell is expressing a polypeptide of claim 1.
8. A process for producing a polypeptide,
comprising culturing a host cell as defined in claim 7 under conditions sufficient for the production of said polypeptide and recovering the polypeptide from the culture medium.
9. A fusion protein comprising an Immunoglobulin Fc-region and a polypeptide of claim 1.
10. An isolated antibody which is immunospecific for the polypeptide of claim 1.
11. A method for screening to identify compounds that stimulate or inhibit the survivin binding activity of the polypeptide of claim 1, or its expression in cells, comprising a method selected from the group consisting of:
(a) measuring or, detecting, quantitatively or qualitatively, the binding of a candidate compound to the polypeptide, or a fusion protein thereof, by means of a label directly or indirectly associated with the candidate compound;
(b) measuring the competition of binding of a candidate compound to the polypeptide or a fusion protein thereof, in the presence of a labeled competitor;
(c) testing whether a candidate compound results in a signal generated by activation or inhibition of the polypeptide, using detection systems appropriate to the cells or cell membranes expressing the polypeptide;
(d) mixing a candidate compound with a solution containing a polypeptide of claim 1, to form a mixture, measuring activity of the polypeptide in the mixture, and comparing the activity of the mixture to a control mixture which contains no candidate compound; or
(e) detecting the effect of a candidate compound on the production of mRNA encoding said polypeptide or said polypeptide in cells, using an ELISA assay.
12. The polypeptide of claim 1, comprising at least 99% identity.
13. The polynucleotide of claim 4, comprising at least 99% identity.