1460766257-cf63ce81-3429-45d7-a626-95f5b855140d

1. A seed of the corn variety LH326, wherein a representative sample of seed of the variety has been deposited under ATCC Accession No. PTA-8860.
2. A plant produced by growing the seed of claim 1.
3. A plant part of the plant of claim 2.
4. The plant part of claim 3, further defined as pollen, a protoplast, an ovule or a cell.
5. A tissue culture of cells obtained from the plant of claim 2.
6. The tissue culture of claim 5, wherein the cells are from a tissue selected from the group consisting of leaf, pollen, embryo, root, root tip, anther, silk, flower, kernel, ear, cob, husk, stalk and meristem.
7. A method for producing corn seed comprising growing the plant of claim 2 until seed is produced and collecting the seed.
8. The method of claim 7, wherein the corn seed is hybrid and wherein the method comprises crossing the plant of claim 2 with a second, different corn plant.
9. The method of claim 7, wherein the seed is inbred seed.
10. A seed produced by the method of claim 7.
11. A method of introducing a heritable trait selected from the group consisting of male sterility, herbicide tolerance, insect resistance, disease resistance, waxy starch, modified fatty acid metabolism, modified phytic acid metabolism, modified carbohydrate metabolism and modified protein metabolism into corn variety LH326 comprising the steps of:
(a) crossing a plant of variety LH326, with another corn plant that heritably carries the trait to produce F1 progeny plants, at least some of which heritably carry the trait, wherein a representative sample of seed of variety LH326 have been deposited under ATCC Accession No. PTA-8860;
(b) selecting F1 progeny plants that heritably carry the trait;
(c) crossing the selected progeny plants with another plant of variety LH326 to produce next-generation progeny plants at least some of which heritably carry the trait;
(d) selecting next-generation progeny plants that heritably carry the trait and exhibit the morphological and physiological characteristics of variety LH326; and
(e) repeating steps (c) and (d) three or more times to produce selected progeny plants that comprise the trait and all of the morphological and physical characteristics of corn variety LH326 set forth in Table 1 as determined at the 5% significance level when grown under the same environmental conditions.
12. A plant produced by the method of claim 11, wherein the plant comprises the heritable trait and all of the physiological and morphological characteristics of corn variety LH326 listed in Table 1 as determined at the 5% significance level when grown under the same environmental conditions.
13. The plant of claim 12, wherein the heritable trait is herbicide tolerance and the tolerance is conferred to a herbicide selected from the group consisting of: imidazolinone, sulfonylurea, glyphosate, glufosinate, L-phosphinothricin, triazine and benzonitrile.
14. The plant of claim 12, wherein the heritable trait is insect resistance and the insect resistance is conferred by a transgene encoding a Bacillus thuringiensis endotoxin.
15. The plant of claim 12, wherein the heritable trait is male sterility and the trait is conferred by a cytoplasmic nucleic acid molecule that confers male sterility.
16. The plant of claim 12, wherein the heritable trait is modified fatty acid metabolism and the trait is conferred by a transgene encoding a fatty acid desaturase.
17. The plant of claim 12, wherein the heritable trait is modified carbohydrate metabolism and the trait is conferred by a transgene encoding a fructosyltransferase, levansucrase, alpha-amylase, invertase or starch branching enzyme.
18. A method of introducing a heritable trait selected from the group consisting of male sterility, herbicide tolerance, insect resistance, disease resistance, waxy starch, modified fatty acid metabolism, modified phytic acid metabolism, modified carbohydrate metabolism and modified protein metabolism into a plant of corn variety LH326 comprising introducing a transgene conferring the trait into the plant, wherein a representative sample of seed of variety LH326 has been deposited under ATCC Accession No. PTA-8860.
19. A plant produced by the method of claim 18, wherein the plant comprises the transgene and has all of the physiological and morphological characteristics of corn variety LH326 listed in Table 1 as determined at the 5% significance level when grown under the same environmental conditions.
20. The plant of claim 19, wherein the heritable trait is herbicide tolerance and the resistance is conferred to an herbicide selected from the group consisting of:
imidazolinone, sulfonylurea, glyphosate, glufosinate, L-phosphinothricin, triazine and benzonitrile.
21. The plant of claim 19, wherein the heritable trait is insect resistance and the insect resistance is conferred by a transgene encoding a Bacillus thuringiensis endotoxin.
22. The plant of claim 19, wherein the heritable trait is modified fatty acid metabolism and the trait is conferred by a transgene encoding a fatty acid desaturase.
23. The plant of claim 19, wherein the heritable trait is modified carbohydrate metabolism and the trait is conferred by a transgene encoding a fructosyltransferase, levansucrase, alpha-amylase, invertase or starch branching enzyme.
24. A method of producing an inbred corn plant derived from the corn variety LH326, the method comprising the steps of:
(a) preparing a progeny plant derived from corn variety LH326 by crossing a plant of the corn variety LH326 with a second corn plant, wherein a sample of the seed of the corn variety LH326 was deposited under ATCC Accession No. PTA-8860;
(b) crossing the progeny plant with itself or a second plant to produce a seed of a progeny plant of a subsequent generation;
(c) growing a progeny plant of a subsequent generation from said seed and crossing the progeny plant of a subsequent generation with itself or a second plant; and
(d) repeating steps (b) and (c) for an addition 3-10 generations to produce an inbred corn plant derived from the corn variety LH326.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1-90. (canceled)
91. A pharmaceutical composition comprising a pharmaceutically inert carrier and a pharmaceutically effective amount of a compound of formula IC:
wherein R1 is selected from the group consisting of:
A) alkyl of from 1 to 10 carbon atoms;
B) alkenyl of from 2 to 10 carbon atoms and 1-2 sites of alkenyl unsaturation;
C) alkynyl of from 2 to 10 carbon atoms and from 1-2 sites of alkynyl unsaturation;
D) cycloalkyl of from 3 to 12 carbon atoms;
E) cycloalkenyl of from 4 to 8 carbon atoms;
F) substituted alkyl of from 1 to 10 carbon atoms, having from 1 to 3 substituents selected from:
1) alkoxy of from 1 to 10 carbon atoms;
2) substituted alkoxy of the formula substituted alkyl-O\u2014 where substituted alkyl is as defined in F herein;
3) cycloalkyl which is as defined in D herein;
4) substituted cycloalkyl is defined in I herein;
5) cycloalkenyl which is defined in E herein;
6) substituted cycloalkenyl which is defined in J herein;
7) acyl selected from alkyl-C(O)\u2014, substituted alkyl-C(O)\u2014, cycloalkyl-C(O)\u2014, substituted cycloalkyl-C(O)\u2014, aryl-C(O)\u2014, heteroaryl-C(O)\u2014 and heterocyclic-C(O)\u2014 wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein;

wherein cycloalkyl is defined in D herein; wherein substituted cycloalkyl is defined in I herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
8) acylamino having the formula \u2014C(O)NRR where each R is independently hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, or heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
9) acyloxy selected from alkyl-C(O)O\u2014, substituted alkyl-C(O)O\u2014, cycloalkyl-C(O)O\u2014, aryl-C(O)O\u2014, heteroaryl-C(O)O\u2014, and heterocyclic-C(O)O\u2014 wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein cycloalkyl is defined in D herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
10) amino;
11) aminoacyl having the formula \u2014NRC(O)R wherein each R is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, and heterocyclic; wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
12) aminoacyloxy having the formula \u2014NRC(O)OR wherein each R is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, and heterocyclic; wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
13) cyano;
14) halogen;
15) hydroxyl;
16) carboxyl;
17) carboxylalkyl having the formula \u201c\u2014C(O)Oalkyl\u201d wherein alkyl is defined in A herein;
18) thiol;
19) thioalkoxy having the formula \u2014S-alkyl, wherein alkyl is defined in A herein;
20) substituted thioalkoxy having the formula \u2014S-substituted alkyl, wherein substituted alkyl is defined in F herein;
21) aryl having from 6 to 14 ring carbon atoms, optionally substituted with from 1 to 5 substituents selected from the group consisting of:
a) hydroxy;
b) acyl as defined in F7 herein;
c) acyloxy as defined in F9 herein;
d) alkyl as defined in A herein;
e) substituted alkyl as defined in F herein;
f) alkoxy as defined in F1 herein;
g) substituted alkoxy as defined in F2 herein;
h) alkenyl as defined in B herein;
i) substituted alkenyl as defined in G herein;
j) alkynyl as defined in C herein;
k) substituted alkynyl as defined in H herein;
l) amino;
m) aminoacyl as defined in F11 herein;
n) acylamino as defined in F8 herein;
o) alkaryl of the formula -alkylene-aryl having 8 carbon atoms in the alkylene moiety and aryl is defined in F21 herein;
p) aryl as defined in F21 herein;
q) aryloxy having the formula \u2014O-aryl wherein aryl is defined in F21 herein;
r) azido;
s) carboxyl;
t) carboxylalkyl having the formula \u201c\u2014C(O)Oalkyl\u201d wherein alkyl is defined in A herein;
u) cyano;
v) halo selected from fluoro, chloro, bromo and iodo;
w) nitro;
x) heteroaryl as defined in F22 herein;
y) heterocyclic as defined in F23 herein;
z) aminoacyloxy as defined in F12 herein;
aa) oxyacylamino having the formula \u2014OC(O)NRR where each R is independently hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, or heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
bb) thioalkoxy having the formula \u2014S-alkyl, wherein alkyl is defined in A herein;
cc) substituted thioalkoxy having the formula \u2014S-substituted alkyl, wherein substituted alkyl is defined in F herein;
dd) thioaryloxy having the formula \u2014S-aryl wherein aryl is defined in F21 herein;
ee) thioheteroaryloxy having the formula \u2014S-heteroaryl wherein heteroaryl is defined F22 herein;
ff) \u2014SO-alkyl wherein alkyl is defined in A herein;
gg) \u2014SO-substituted alkyl wherein substituted alkyl is defined in F herein;
hh) \u2014SO-aryl wherein aryl is defined in F21 herein;
ii) \u2014SO-heteroaryl wherein heteroaryl is defined in F22 herein;
jj) \u2014SO2-alkyl wherein alkyl is defined in A herein;
kk) \u2014SO2-substituted alkyl wherein substituted alkyl is defined in F herein;
ll) \u2014SO2-aryl wherein aryl is defined in F21 herein;
mm) \u2014SO2-heteroaryl wherein heteroaryl is defined in F22 herein;
nn) trihalomethyl wherein halo is defined in 120 herein;
oo) mono- and dialkylamino wherein alkyl is defined in A herein;
pp) mono- and di-substituted alkylamino wherein substituted alkyl is defined in F herein;
qq) mono- and di-arylamino wherein aryl is defined in F21 herein;
rr) mono- and di-heteroarylamino wherein heteroaryl is defined in F22 herein;
ss) mono- and di-heterocyclicamino wherein heterocyclic is defined in F23 herein;
tt) unsymmetric di-substituted amino having different substituents selected from alkyl, substituted alkyl, aryl, heteroaryl and heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;

22) heteroaryl of from 1 to 15 ring carbon atoms and 1 to 4 ring heteroatoms selected from oxygen, nitrogen and sulfur, optionally substituted with from 1 to 5 substituents selected from:
a) alkyl as defined in A herein;
b) substituted alkyl as defined in F herein;
c) alkoxy as defined in F1 herein;
d) substituted alkoxy as defined in F2 herein;
e) aryl as defined in F21 herein;
f) aryloxy having the formula \u2014O-aryl wherein aryl is defined in F21 herein;
g) halo selected from fluoro, chloro, bromo and iodo;
h) nitro;
i) heteroaryl as defined in F22 herein;
j) thiol;
k) thioalkoxy having the formula \u2014S-alkyl, wherein alkyl is defined in A herein;
l) substituted thioalkoxy having the formula \u2014S-substituted alkyl, wherein substituted alkyl is defined in F herein;
m) thioaryloxy having the formula \u2014S-aryl wherein aryl is defined in F21 herein; and
n) trihalomethyl wherein halo is defined in 120 herein;

23) heterocyclic of from 1 to 15 ring carbon atoms and from 1 to 4 ring atoms selected from nitrogen, sulfur and oxygen, optionally substituted with from 1 to 5 substituents selected from:
a) alkyl as defined in A herein;
b) substituted alkyl as defined in F herein;
c) alkoxy as defined in F1 herein;
d) substituted alkoxy as defined in F2 herein;
e) aryl as defined in F21 herein;
f) aryloxy having the formula \u2014O-aryl wherein aryl is defined in F21 herein;
g) halo selected from fluoro, chloro, bromo and iodo;
h) nitro;
i) heteroaryl as defined in F22 herein;
j) thiol;
k) thioalkoxy having the formula \u2014S-alkyl, wherein alkyl is defined in A herein;
l) substituted thioalkoxy having the formula \u2014S-substituted alkyl, wherein substituted alkyl is defined in F herein;
m) thioaryloxy having the formula \u2014S-aryl wherein aryl is defined in F21 herein; and
n) trihalomethyl wherein halo is selected from fluoro, chloro, bromo and iodo;

24) aryloxy of the formula \u2014O-aryl wherein aryl is defined in F21 herein;
25) heteroaryloxy of the formula \u2014O-heteroaryl wherein heteroaryl is defined in F22 herein;
26) hydroxyamino;
27) alkoxyamino wherein alkoxy is defined in F1 herein;
28) nitro;
29) \u2014SO-alkyl wherein alkyl is defined in A herein;
30) \u2014SO-substituted alkyl wherein substituted alkyl is defined in F herein;
31) \u2014SO-aryl wherein aryl is defined in F21 herein;
32) \u2014SO-heteroaryl wherein heteroaryl is defined in F22 herein;
33) \u2014SO2-alkyl wherein alkyl is defined in A herein;
34) \u2014SO2-substituted alkyl wherein substituted alkyl is defined in F herein;
35) \u2014SO2-aryl wherein aryl is defined in F21 herein;
36) \u2014SO2-heteroaryl wherein heteroaryl is defined in F22 herein;
37) mono- and dialkylamino wherein alkyl is defined in A herein;
38) mono- and di-substituted alkylamino wherein substituted alkyl is defined in F herein;
39) mono- and di-arylamino wherein aryl is defined in F21 herein;
40) mono- and di-heteroarylamino wherein heteroaryl is defined in F22 herein;
41) mono- and di-heterocyclicamino wherein heterocyclic is defined in F23 herein;
42) unsymmetric di-substituted amino having different substituents selected from alkyl, substituted alkyl, aryl, heteroaryl and heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;

G) substituted alkenyl having from 1 to 3 substituents selected from the group consisting of:
1) alkoxy as defined in F1 herein;
2) substituted alkoxy as defined in F2 herein;
3) acyl as defined in F7 herein;
4) acylamino as defined in F8 herein;
5) acyloxy as defined in F9 herein;
6) amino;
7) aminoacyl as defined in F11 herein;
8) aminoacyloxy as defined in F12 herein;
9) cyano;
10) halogen selected from fluoro, chloro, bromo and iodo;
11) hydroxyl;
12) carboxyl;
13) carboxylalkyl as defined in F17 herein;
14) thiol;
15) thioalkoxy as defined in F19 herein;
16) substituted thioalkoxy as defined in F20 herein;
17) aryl as defined in F21 herein;
18) heteroaryl as defined in F22 herein;
19) heterocyclic as defined in F23 herein;
20) nitro;
21) \u2014SO-alkyl wherein alkyl is defined in A herein;
22) \u2014SO-substituted alkyl wherein substituted alkyl is defined in F herein;
23) \u2014SO-aryl wherein aryl is defined in F21 herein;
24) \u2014SO-heteroaryl wherein heteroaryl is defined in F22 herein;
25) \u2014SO2-alkyl wherein alkyl is defined in A herein;
26) \u2014SO2-substituted alkyl wherein substituted alkyl is defined in F herein;
27) \u2014SO2-aryl wherein aryl is defined in F21 herein;
28) \u2014SO2-heteroaryl wherein heteroaryl is defined in F22 herein;
29) mono- and dialkylamino wherein alkyl is defined in A herein;
30) mono- and di-substituted alkylamino wherein substituted alkyl is defined in F herein;
31) mono- and di-arylamino wherein aryl is defined in F21 herein;
32) mono- and di-heteroarylamino wherein heteroaryl is defined in F22 herein;
33) mono- and di-heterocyclicamino wherein heterocyclic is defined in F23 herein; and
34) unsymmetric di-substituted amino having different substituents selected from alkyl, substituted alkyl, aryl, heteroaryl and heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;

H) substituted alkynyl of from 1 to 3 substituents selected from:
1) alkoxy as defined in F1 herein;
2) substituted alkoxy as defined in F2 herein;
3) acyl as defined in F7 herein;
4) acylamino as defined in F8 herein;
5) acyloxy as defined in F9 herein;
6) amino;
7) aminoacyl as defined in F11 herein;
8) aminoacyloxy as defined in F12 herein;
9) cyano;
10) halogen selected from fluoro, chloro, bromo and iodo;
11) hydroxyl;
12) carboxyl;
13) carboxylalkyl as defined in F17 herein;
14) thiol;
15) thioalkoxy as defined in F19 herein;
16) substituted thioalkoxy as defined in F20 herein;
17) aryl as defined in F21 herein;
18) heteroaryl as defined in F22 herein;
19) heterocyclic as defined in F23 herein;
20) nitro;
21) \u2014SO-alkyl wherein alkyl is defined in A herein;
22) \u2014SO-substituted alkyl wherein substituted alkyl is defined in F herein;
23) \u2014SO-aryl wherein aryl is defined in F21 herein;
24) \u2014SO-heteroaryl wherein heteroaryl is defined in F22 herein;
25) \u2014SO2-alkyl wherein alkyl is defined in A herein;
26) \u2014SO2-substituted alkyl wherein substituted alkyl is defined in F herein;
27) \u2014SO2-aryl wherein aryl is defined in F21 herein;
28) \u2014SO2-heteroaryl wherein heteroaryl is defined in F22 herein;
29) mono- and dialkylamino wherein alkyl is defined in A herein;
30) mono- and di-substituted alkylamino wherein substituted alkyl is defined in F herein;
31) mono- and di-arylamino wherein aryl is defined in F21 herein;
32) mono- and di-heteroarylamino wherein heteroaryl is defined in F22 herein;
33) mono- and di-heterocyclicamino wherein heterocyclic is defined in F23 herein; and
34) unsymmetric di-substituted amino having different substituents selected from alkyl, substituted alkyl, aryl, heteroaryl and heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;

I) substituted cycloalkyl having 3 to 12 carbon atoms and from 1 to 5 substituents selected from the group consisting of:
1) hydroxy;
2) acyl as defined in F7 herein;
3) acyloxy as defined in F9 herein;
4) alkyl as defined in A herein;
5) substituted alkyl as defined in F herein;
6) alkoxy as defined in F1 herein;
7) substituted alkoxy as defined in F2 herein;
8) alkenyl as defined in B herein;
9) substituted alkenyl as defined in G herein;
10) alkynyl as defined in C herein;
11) substituted alkynyl as defined in H herein;
12) amino;
13) aminoacyl as defined in F11 herein;
14) alkaryl of the formula -alkylene-aryl having 8 carbon atoms in the alkylene moiety and aryl is defined in F21 herein;
15) aryl as defined in F21 herein;
16) aryloxy having the formula \u2014O-aryl wherein aryl is defined in F21 herein;
17) carboxyl;
18) carboxylalkyl having the formula \u201c\u2014C(O)Oalkyl\u201d wherein alkyl is defined in A herein;
19) cyano;
20) halo selected from fluoro, chloro, bromo and iodo;
21) nitro;
22) heteroaryl as defined in F22 herein;
23) thioalkoxy as defined in F19 herein;
24) substituted thioalkoxy as defined in F20 herein; and
25) trihalomethyl wherein halo is selected from fluoro, chloro, bromo and iodo;

J) substituted cycloalkenyl having from 4 to 8 carbon atoms and from 1 to substituents selected from the group consisting of:
1) hydroxy;
2) acyl as defined in F7 herein;
3) acyloxy as defined in F9 herein;
4) alkyl as defined in A herein;
5) substituted alkyl as defined in F herein;
6) alkoxy as defined in F1 herein;
7) substituted alkoxy as defined in F2 herein;
8) alkenyl as defined in B herein;
9) substituted alkenyl as defined in G herein;
10) alkynyl as defined in C herein;
11) substituted alkynyl as defined in H herein;
12) amino;
13) aminoacyl as defined in F11 herein;
14) alkaryl of the formula -alkylene-aryl having 8 carbon atoms in the alkylene moiety and aryl is defined in F21 herein;
15) aryl as defined in F21 herein;
16) aryloxy having the formula \u2014O-aryl wherein aryl is defined in F21 herein;
17) carboxyl;
18) carboxylalkyl having the formula \u201c\u2014C(O)Oalkyl\u201d wherein alkyl is defined in A herein;
19) cyano;
20) halo selected from fluoro, chloro, bromo and iodo;
21) nitro;
22) heteroaryl as defined in F22 herein;
23) thioalkoxy as defined in F19 herein;
24) substituted thioalkoxy as defined in F20 herein; and
25) trihalomethyl wherein halo is selected from fluoro, chloro, bromo and iodo;

K) aryl as defined in F21 herein;
L) heteroaryl as defined in F22 herein; and
M) heterocyclic as defined in F23 herein;
R2 is independently selected from the group consisting of:
N) alkyl as defined in A herein;
O) alkenyl as defined in B herein;
P) alkynyl as defined in C herein;
Q) substituted alkyl as defined in F herein;
R) substituted alkenyl as defined in G herein;
S) substituted alkynyl as defined in H herein;
T) cycloalkyl as defined in D herein;
U) aryl as defined in F21 herein;
V) heteroaryl as defined in F22 herein;
W) heterocyclic as defined in F23 herein;
W1) 2-aminopyrid-6-yl;
W2) 2-methylcyclopentyl;
W3) cyclohex-2-enyl; and
W4)\u2014(CH2)4NHC(O)OC(CH3)3;
wherein Q is selected from the group consisting of:
wherein Ra is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as define din F2 herein, amino, carboxyl, carboxylalkyl as defined in F17 herein, cyano, and halo;
Rb is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkenyl as defined in B herein, substituted alkenyl as defined in G herein, alkynyl as defined in C herein, substituted alkynyl as defined in H herein, acyl as defined in F7 herein, aryl as defined in F21 herein, heteroaryl as defined in F22 herein, and heterocyclic as defined in F23 herein;
each V is independently selected from the group consisting of hydroxy, acyl as defined in F7 herein, acyloxy as defined in F9 herein, alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as defined in F2 herein, alkenyl as defined in B herein, substituted alkenyl as defined in G herein, alkynyl as defined in C herein, substituted alkynyl as defined in H herein, amino, aminoacyl as defined in F11 herein, alkaryl as defined in F21 herein, aryl as defined in F21 herein, aryloxy as defined in F21 herein, carboxyl, carboxyalkyl as defined in F17 herein, cyano, halo, nitro, heteroaryl as defined in F22 herein, thioalkoxy as defined in F22 herein, substituted thioalkoxy as defined in F22 herein, and trihalomethyl as defined in F22 herein;
t is an integer from 0 to 4;
w is an integer from 0 to 3;
or pharmaceutically acceptable salts thereof.
92. The pharmaceutical composition according to claim 91, wherein Q is:
wherein Ra is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as define din F2 herein, amino, carboxyl, carboxylalkyl as defined in F17 herein, cyano, and halo;
Rb is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, acyl, aryl, heteroaryl, and heterocyclic;
each V is independently selected from the group consisting of hydroxy, acyl, acyloxy, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amino, aminoacyl, alkaryl, aryl, aryloxy, carboxyl, carboxyalkyl, cyano, halo, nitro, heteroaryl, thioalkoxy, substituted thioalkoxy, and trihalomethyl;
t is an integer from 0 to 4;
or pharmaceutically acceptable salts thereof.
93. The pharmaceutical composition according to claim 91, wherein Q is:
wherein Ra is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as define din F2 herein, amino, carboxyl, carboxylalkyl as defined in F17 herein, cyano, and halo;
Rb is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, acyl, aryl, heteroaryl, and heterocyclic;
each V is independently selected from the group consisting of hydroxy, acyl, acyloxy, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amino, aminoacyl, alkaryl, aryl, aryloxy, carboxyl, carboxyalkyl, cyano, halo, nitro, heteroaryl, thioalkoxy, substituted thioalkoxy, and trihalomethyl;
t is an integer from 0 to 4;
or pharmaceutically acceptable salts thereof.
94. The pharmaceutical composition according to claim 91, wherein Q is:
wherein Ra is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as define din F2 herein, amino, carboxyl, carboxylalkyl as defined in F17 herein, cyano, and halo;
Rb is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, acyl, aryl, heteroaryl, and heterocyclic;
w is an integer from 0 to 3;
or pharmaceutically acceptable salts thereof.
95. The pharmaceutical composition according to claim 91, wherein R1 is optionally substituted aryl or optionally substituted heteroaryl.
96. The pharmaceutical composition according to claim 91, wherein R1 is selected from the group consisting of:
A) phenyl;
B) a substituted phenyl group of the formula:
wherein Rb\u2033 is selected from the group consisting of acyl, alkyl, alkoxy, alkylalkoxy, azido, cyano, halo, hydrogen, nitro, trihalomethyl, thioalkoxy, and wherein Rb\u2032\u2033 and Rb\u2033 are fused to form an optionally substituted heteroaryl or an optionally substituted heterocyclic ring with the phenyl ring wherein the optionally substituted heteroaryl or optionally substituted heterocyclic ring contains from 3 to 8 atoms of which from 1 to 3 heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur;
Rb\u2032\u2033 and Rb\u2032 are independently selected from the group consisting of hydrogen, halo, nitro, cyano, trihalomethyl, alkoxy, and thioalkoxy with the proviso that when Rb\u2033 is hydrogen, then Rb\u2032\u2033 and Rb\u2032 are either both hydrogen or both substituents other than hydrogen;

C) 2-naphthyl;
D) 2-naphthyl substituted at the 4, 5, 6, 7, andor 8 positions with 1 to 5 substituents selected from the group consisting of alkyl, alkoxy, halo, cyano, nitro, trihalomethyl, thioalkoxy, aryl, and heteroaryl;
E) heteroaryl; and
F) substituted heteroaryl containing 1 to 3 substituents selected from the group consisting of alkyl, alkoxy, aryl, aryloxy, cyano, halo, nitro, heteroaryl, thioalkoxy, and thioaryloxy, provided that said substituents are not ortho to the heteroaryl attachment to the \u2014NH group.
97. The pharmaceutical composition according to claim 91, wherein R1 is selected from the group consisting of mono-, di-, and tri-substituted phenyl groups.
98. The pharmaceutical composition according to claim 97, wherein R1 is a monosubstituted phenyl selected from the group consisting of 4-azidophenyl, 4-bromophenyl, 4-chlorophenyl, 4-cyanophenyl, 4-ethylphenyl, 4-fluorophenyl, 4-iodophenyl, 4-(phenylcarbonyl)-phenyl, and 4-(1-ethoxy)ethylphenyl.
99. The pharmaceutical composition according to claim 97, wherein R1 is a disubstituted phenyl selected from the group consisting of 3,5-dichlorophenyl, 3,5-difluorophenyl, 3,5-di(trifluoromethyl)-phenyl, 3,4-dichlorophenyl, 3,4-difluorophenyl, 3-(trifluoromethyl)-4-chlorophenyl, 3-chloro-4-cyanophenyl, 3-chloro-4-iodophenyl, and 3,4-methylenedioxyphenyl.
100. The pharmaceutical composition according to claim 97, wherein R1 is a trisubstituted phenyl selected from the group consisting of 3,4,5-trifluorophenyl and 3,4,5-tricholorophenyl.
101. The pharmaceutical composition according to claim 91, wherein R1 is selected from 2-naphthyl, quinolin-3-yl, 2-methylquinolin-6-yl, benzothiazol-6-yl, 5-indolyl, and phenyl.
102. The pharmaceutical composition according to claim 91, wherein R2 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted heterocycle.
103. The pharmaceutical composition according to claim 91, wherein R2 is selected from the group consisting of:
methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, tert-butyl, \u2014CH2C H(C H2CH3)2, 2-methyl-n-butyl, 6-fluoro-n-hexyl, phenyl, benzyl, cyclohexyl, cyclopentyl, cycloheptyl, allyl, iso-but-2-enyl, 3-methylpentyl, \u2014CH2-cyclopropyl, \u2014CH2-cyclohexyl, \u2014C H2CH2-cyclopropyl, \u2014CH2CH2-cyclohexyl, \u2014C H2-indol-3-yl, p-(phenyl)phenyl, o-fluorophenyl, m-fluorophenyl, p-fluorophenyl, m-methoxyphenyl, p-methoxyphenyl, phenethyl, benzyl, m-hydroxybenzyl, p-hydroxybenzyl, p-nitrobenzyl, m-trifluoromethylphenyl, p-(C H3)2NCH2CH2CH2O-benzyl, p-(CH3)3COC(O)C H2O-benzyl, p-(HOOCCH2O)-benzyl, 2-aminopyrid-6-yl, p-(N-morpholino-CH2CH2O)-benzyl, \u2014CH2CH2C(O)N H2, \u2014C H2-imidazol-4-yl, \u2014C H2-(3-tetrahydrofuranyl), \u2014CH2-thiophen-2-yl, \u2014CH2(1-methyl)cyclopropyl, \u2014CH2-thiophen-3-yl, thiophen-3-yl, thiophen-2-yl, \u2014CH2\u2014C(O)O-t-butyl, \u2014CH2\u2014C(CH3)3, 2-methylcyclopentyl, cyclohex-2-enyl, \u2014CHCH(CH3)2COOCH3, \u2014CH2CH2N(CH3)2, \u2014CH2C(CH3)\u2550CH2, \u2014CH2CH\u2550CHCH3 (cis and trans), \u2014CH2OH, \u2014CH(OH)CH3, \u2014CH(O-t-butyl)CH3, \u2014CH2OCH3, \u2014(CH2)4N H-tert-butyloxycarbonyl, \u2014(C H2)4N H2, \u2014CH2-pyridyl, pyridyl, \u2014CH2-naphthyl, \u2014CH2\u2014(N-morpholino), p-(N-morpholino-CH2CH2O)-benzyl, benzobthiophen-2-yl, 5-chlorobenzobthiophen-2-yl, 4, 5,6,7-tetrahydrobenzobthiophen-2-yl, benzobthiophen-3-yl, 5-chlorobenzobthiophen-3-yl, benzobthiophen-5-yl, 6-methoxynaphth-2-yl, \u2014CH2CH2SCH3, thien-2-yl, and thien-3-yl.
104. A compound of formula IC:
wherein R1 is selected from the group consisting of:
A) alkyl of from 1 to 10 carbon atoms;
B) alkenyl of from 2 to 10 carbon atoms and 1-2 sites of alkenyl unsaturation;
C) alkynyl of from 2 to 10 carbon atoms and from 1-2 sites of alkynyl unsaturation;
D) cycloalkyl of from 3 to 12 carbon atoms;
E) cycloalkenyl of from 4 to 8 carbon atoms;
F) substituted alkyl of from 1 to 10 carbon atoms, having from 1 to 3 substituents selected from:
1) alkoxy of from 1 to 10 carbon atoms;
2) substituted alkoxy of the formula substituted alkyl-O\u2014 where substituted alkyl is as defined in F herein;
3) cycloalkyl which is as defined in D herein;
4) substituted cycloalkyl is defined in I herein;
5) cycloalkenyl which is defined in E herein;
6) substituted cycloalkenyl which is defined in J herein;
7) acyl selected from alkyl-C(O)\u2014, substituted alkyl-C(O)\u2014, cycloalkyl-C(O)\u2014, substituted cycloalkyl-C(O)\u2014, aryl-C(O)\u2014, heteroaryl-C(O)\u2014 and heterocyclic-C(O)\u2014 wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein cycloalkyl is defined in D herein; wherein substituted cycloalkyl is defined in I herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
8) acylamino having the formula \u2014C(O)NRR where each R is independently hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, or heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
9) acyloxy selected from alkyl-C(O)O\u2014, substituted alkyl-C(O)O\u2014, cycloalkyl-C(O)O\u2014, aryl-C(O)O\u2014, heteroaryl-C(O)O\u2014, and heterocyclic-C(O)O\u2014 wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein cycloalkyl is defined in D herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
10) amino;
11) aminoacyl having the formula \u2014NRC(O)R wherein each R is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, and heterocyclic; wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
12) aminoacyloxy having the formula \u2014NRC(O)OR wherein each R is independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, and heterocyclic; wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
13) cyano;
14) halogen;
15) hydroxyl;
16) carboxyl;
17) carboxylalkyl having the formula \u201c\u2014C(O)Oalkyl\u201d wherein alkyl is defined in A herein;
18) thiol;
19) thioalkoxy having the formula \u2014S-alkyl, wherein alkyl is defined in A herein;
20) substituted thioalkoxy having the formula \u2014S-substituted alkyl, wherein substituted alkyl is defined in F herein;
21) aryl having from 6 to 14 ring carbon atoms, optionally substituted with from 1 to 5 substituents selected from the group consisting of:
a) hydroxy;
b) acyl as defined in F7 herein;
c) acyloxy as defined in F9 herein;
d) alkyl as defined in A herein;
e) substituted alkyl as defined in F herein;
f) alkoxy as defined in F1 herein;
g) substituted alkoxy as defined in F2 herein;
h) alkenyl as defined in B herein;
i) substituted alkenyl as defined in G herein;
j) alkynyl as defined in C herein;
k) substituted alkynyl as defined in H herein;
l) amino;
m) aminoacyl as defined in F11 herein;
n) acylamino as defined in F8 herein;
o) alkaryl of the formula -alkylene-aryl having 8 carbon atoms in the alkylene moiety and aryl is defined in F21 herein;
p) aryl as defined in F21 herein;
q) aryloxy having the formula \u2014O-aryl wherein aryl is defined in F21 herein;
r) azido;
s) carboxyl;
t) carboxylalkyl having the formula \u201c\u2014C(O)Oalkyl\u201d wherein alkyl is defined in A herein;
u) cyano;
v) halo selected from fluoro, chloro, bromo and iodo;
w) nitro;
x) heteroaryl as defined in F22 herein;
y) heterocyclic as defined in F23 herein;
z) aminoacyloxy as defined in F12 herein;
aa) oxyacylamino having the formula \u2014OC(O)NRR where each R is independently hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, or heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;
bb) thioalkoxy having the formula \u2014S-alkyl, wherein alkyl is defined in A herein;
cc) substituted thioalkoxy having the formula \u2014S-substituted alkyl, wherein substituted alkyl is defined in F herein;
dd) thioaryloxy having the formula \u2014S-aryl wherein aryl is defined in F21 herein;
ee) thioheteroaryloxy having the formula \u2014S-heteroaryl wherein heteroaryl is defined F22 herein;
ff) \u2014SO-alkyl wherein alkyl is defined in A herein;
gg) \u2014SO-substituted alkyl wherein substituted alkyl is defined in F herein;
hh) \u2014SO-aryl wherein aryl is defined in F21 herein,
ii) \u2014SO-heteroaryl wherein heteroaryl is defined in F22 herein;
ii) \u2014SO2-alkyl wherein alkyl is defined in A herein;
kk) \u2014SO2-substituted alkyl wherein substituted alkyl is defined in F herein;
II) \u2014SO2-aryl wherein aryl is defined in F21 herein;
mm) \u2014SO2-heteroaryl wherein heteroaryl is defined in F22 herein;
nn) trihalomethyl wherein halo is defined in 120 herein;
oo) mono- and dialkylamino wherein alkyl is defined in A herein;
pp) mono- and di-substituted alkylamino wherein substituted alkyl is defined in F herein;
qq) mono- and di-arylamino wherein aryl is defined in F21 herein;
rr) mono- and di-heteroarylamino wherein heteroaryl is defined in F22 herein;
ss) mono- and di-heterocyclicamino wherein heterocyclic is defined in F23 herein;
tt) unsymmetric di-substituted amino having different substituents selected from alkyl, substituted alkyl, aryl, heteroaryl and heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;

24) aryloxy of the formula \u2014O-aryl wherein aryl is defined in F21 herein;
25) heteroaryloxy of the formula \u2014O-heteroaryl wherein heteroaryl is defined in F22 herein;
26) hydroxyamino;
27) alkoxyamino wherein alkoxy is defined in F1 herein;
28) nitro;
29) \u2014SO-alkyl wherein alkyl is defined in A herein;
30) \u2014SO-substituted alkyl wherein substituted alkyl is defined in F herein;
31) \u2014SO-aryl wherein aryl is defined in F21 herein;
32) \u2014SO-heteroaryl wherein heteroaryl is defined in F22 herein;
33) \u2014SO2-alkyl wherein alkyl is defined in A herein;
34)\u2014SO2-substituted alkyl wherein substituted alkyl is defined in F herein;
35) \u2014SO2-aryl wherein aryl is defined in F21 herein;
36) \u2014SO2-heteroaryl wherein heteroaryl is defined in F22 herein;
37) mono- and dialkylamino wherein alkyl is defined in A herein;
38) mono- and di-substituted alkylamino wherein substituted alkyl is defined in F herein;
39) mono- and di-arylamino wherein aryl is defined in F21 herein;
40) mono- and di-heteroarylamino wherein heteroaryl is defined in F22 herein;
41) mono- and di-heterocyclicamino wherein heterocyclic is defined in F23 herein;
42) unsymmetric di-substituted amino having different substituents selected from alkyl, substituted alkyl, aryl, heteroaryl and heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and
wherein heterocyclic is defined in F23 herein;

H) substituted alkynyl of from 1 to 3 substituents selected from:
1) alkoxy as defined in F1 herein;
2) substituted alkoxy as defined in F2 herein;
3) acyl as defined in F7 herein;
4) acylamino as defined in F8 herein;
5) acyloxy as defined in F9 herein;
6) amino;
7) aminoacyl as defined in F11 herein;
8) aminoacyloxy as defined in F12 herein;
9) cyano;
10) halogen selected from fluoro, chloro, bromo and iodo;
11) hydroxyl;
12) carboxyl;
13) carboxylalkyl as defined in F17 herein;
14) thiol;
15) thioalkoxy as defined in F19 herein;
16) substituted thioalkoxy as defined in F20 herein;
17) aryl as defined in F21 herein;
18) heteroaryl as defined in F22 herein;
19) heterocyclic as defined in F23 herein;
20) nitro;
21) \u2014SO-alkyl wherein alkyl is defined in A herein;
22) \u2014SO-substituted alkyl wherein substituted alkyl is defined in F herein;
23) \u2014SO-aryl wherein aryl is defined in F21 herein;
24) \u2014SO-heteroaryl wherein heteroaryl is defined in F22 herein;
25) \u2014SO2-alkyl wherein alkyl is defined in A herein;
26) \u2014SO2-substituted alkyl wherein substituted alkyl is defined in F herein;
27)\u2014SO2-aryl wherein aryl is defined in F21 herein;
28) \u2014SO2-heteroaryl wherein heteroaryl is defined in F22 herein;
29) mono- and dialkylamino wherein alkyl is defined in A herein;
30) mono- and di-substituted alkylamino wherein substituted alkyl is defined in F herein;
31) mono- and di-arylamino wherein aryl is defined in F21 herein;
32) mono- and di-heteroarylamino wherein heteroaryl is defined in F22 herein;
33) mono- and di-heterocyclicamino wherein heterocyclic is defined in F23 herein; and
34) unsymmetric di-substituted amino having different substituents selected from alkyl, substituted alkyl, aryl, heteroaryl and heterocyclic wherein alkyl is defined in A herein; wherein substituted alkyl is defined in F herein; wherein aryl is defined in F21 herein; wherein heteroaryl is defined in F22 herein; and wherein heterocyclic is defined in F23 herein;

K) aryl as defined in F21 herein;
L) heteroaryl as defined in F22 herein; and
M) heterocyclic as defined in F23 herein;
R2 is independently selected from the group consisting of:

N) alkyl as defined in A herein;
O) alkenyl as defined in B herein;
P) alkynyl as defined in C herein;
Q) substituted alkyl as defined in F herein;
R) substituted alkenyl as defined in G herein;
S) substituted alkynyl as defined in H herein;
T) cycloalkyl as defined in D herein;
U) aryl as defined in F21 herein;
V) heteroaryl as defined in F22 herein;
W) heterocyclic as defined in F23 herein;
W1) 2-aminopyrid-6-yl;
W2) 2-methylcyclopentyl;
W3) cyclohex-2-enyl; and
W4) \u2014(CH2)4NHC(O)OC(CH3)3;
wherein Q is selected from the group consisting of:
wherein Ra is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as define din F2 herein, amino, carboxyl, carboxylalkyl as defined in F17 herein, cyano, and halo;
Rb is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkenyl as defined in B herein, substituted alkenyl as defined in G herein, alkynyl as defined in C herein, substituted alkynyl as defined in H herein, acyl as defined in F7 herein, aryl as defined in F21 herein, heteroaryl as defined in F22 herein, and heterocyclic as defined in F23 herein;
each V is independently selected from the group consisting of hydroxy, acyl as defined in F7 herein, acyloxy as defined in F9 herein, alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as defined in F2 herein, alkenyl as defined in B herein, substituted alkenyl as defined in G herein, alkynyl as defined in C herein, substituted alkynyl as defined in H herein, amino, aminoacyl as defined in F11 herein, alkaryl as defined in F21 herein, aryl as defined in F21 herein, aryloxy as defined in F21 herein, carboxyl, carboxyalkyl as defined in F17 herein, cyano, halo, nitro, heteroaryl as defined in F22 herein, thioalkoxy as defined in F22 herein, substituted thioalkoxy as defined in F22 herein, and trihalomethyl as defined in F22 herein;
t is an integer from 0 to 4;
w is an integer from 0 to 3;
or pharmaceutically acceptable salts thereof.
105. The compound according to claim 104, wherein Q is:
wherein Ra is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as define din F2 herein, amino, carboxyl, carboxylalkyl as defined in F17 herein, cyano, and halo;
Rb is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, acyl, aryl, heteroaryl, and heterocyclic;
each V is independently selected from the group consisting of hydroxy, acyl, acyloxy, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amino, aminoacyl, alkaryl, aryl, aryloxy, carboxyl, carboxyalkyl, cyano, halo, nitro, heteroaryl, thioalkoxy, substituted thioalkoxy, and trihalomethyl;
t is an integer from 0 to 4;
or pharmaceutically acceptable salts thereof.
106. The compound according to claim 104, wherein Q is:
wherein Ra is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as define din F2 herein, amino, carboxyl, carboxylalkyl as defined in F17 herein, cyano, and halo;
Rb is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, acyl, aryl, heteroaryl, and heterocyclic;
each V is independently selected from the group consisting of hydroxy, acyl, acyloxy, alkyl, substituted alkyl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, amino, aminoacyl, alkaryl, aryl, aryloxy, carboxyl, carboxyalkyl, cyano, halo, nitro, heteroaryl, thioalkoxy, substituted thioalkoxy, and trihalomethyl;
t is an integer from 0 to 4;
or pharmaceutically acceptable salts thereof.
107. The compound according to claim 104, wherein Q is:
wherein Ra is selected from the group consisting of alkyl as defined in A herein, substituted alkyl as defined in F herein, alkoxy as defined in F1 herein, substituted alkoxy as define din F2 herein, amino, carboxyl, carboxylalkyl as defined in F17 herein, cyano, and halo;
Rb is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, acyl, aryl, heteroaryl, and heterocyclic;
w is an integer from 0 to 3;
or pharmaceutically acceptable salts thereof.
108. The compound according to claim 104, wherein R1 is optionally substituted aryl or optionally substituted heteroaryl.
109. The compound according to claim 104, wherein R1 is selected from the group consisting of:
A) phenyl;
B) a substituted phenyl group of the formula:
wherein Rb\u2033 is selected from the group consisting of acyl, alkyl, alkoxy, alkylalkoxy, azido, cyano, halo, hydrogen, nitro, trihalomethyl, thioalkoxy, and wherein Rb\u2032\u2033 and Rb\u2033 are fused to form an optionally substituted heteroaryl or an optionally substituted heterocyclic ring with the phenyl ring wherein the optionally substituted heteroaryl or optionally substituted heterocyclic ring contains from 3 to 8 atoms of which from 1 to 3 heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur;
Rb\u2032\u2033 and Rb\u2032 are independently selected from the group consisting of hydrogen, halo, nitro, cyano, trihalomethyl, alkoxy, and thioalkoxy with the proviso that when Rb\u2033 is hydrogen, then Rb\u2032\u2033 and Rb\u2032 are either both hydrogen or both substituents other than hydrogen;