1. A method for generating a magnetic resonance image comprising the steps of:
for a PROPELLER scan, acquiring raw magnetic resonance data from a subject for each of a plurality of PROPELLER strips with a plurality of magnetic resonance reception coils using a partial acquisition technique (PAT), each of said magnetic resonance reception coils having a coil sensitivity;
entering said raw data in said plurality of PROPELLER strips into k-space according to said PROPELLER scan;
conducting a PAT reconstruction of the data in k-space dependent on the respective coil sensitivities; and
conducting a PROPELLER reconstruction of said data in k-space after said PAT reconstruction for generating a magnetic resonance image of the subject.
2. A method as claimed in claim 1 wherein PROPELLER strips in a conventional PROPELLER scan each occupy a plurality of lines of data in k-space, and wherein the step of acquiring raw magnetic resonance data from a subject for each of a plurality of PROPELLER strips comprises acquiring magnetic resonance data from a subject for each of a plurality of PROPELLER strips occupying a plurality of lines in k-space that is less than said plurality of lines occupied in k-space by each PROPELLER strip of said conventional PROPELLER scan.
3. A method as claimed in claim 1 wherein a PROPELLER strip of a conventional PROPELLER scan occupies a width in k-space, and wherein the step of acquiring raw magnetic resonance data from a subject for each of a plurality of PROPELLER strips comprises acquiring raw magnetic resonance data from a subject for each of a plurality of PROPELLER strips occupying a width in k-space that is greater than said width in k-space occupied by each PROPELLER strip in said conventional PROPELLER scan.
4. A method as claimed in claim 1 comprising obtaining raw magnetic resonance data from the subject with a conventional PROPELLER scan, without PAT, and using said raw magnetic resonance data from said conventional PROPELLER scan as a reference for designating said coil sensitivities in said PAT reconstruction.
5. A method as claimed in claim 1 wherein k-space had a central region wherein all of said plurality of PROPELLER strips overlap, and comprising applying a gridding algorithm to said central region for obtaining information describing said respective coil sensitivities for use in said PAT reconstruction.
6. A method as claimed in claim 1 comprising employing partial parallel acquisition as said PAT.
7. A magnetic resonance imaging apparatus comprising:
a magnetic resonance scanner having an antenna array including a plurality of reception coils, each of said reception coils having a coil sensitivity;
a sequence controller connected to said magnetic resonance scanner for operating said magnetic resonance scanner for acquiring raw magnetic resonance data from a subject for each of a plurality of PROPELLER strips in a PROPELLER scan with said plurality of reception coils using a partial acquisition technique (PAT); and
an image computer supplied with said raw magnetic resonance data for entering said raw magnetic resonance data in said plurality of PROPELLER strips into k-space according to said PROPELLER scan, conducting a PAT reconstruction of said data in k-space dependent on the respective coil sensitivities and for conducting a PROPELLER reconstruction of said data in k-space after said PAT reconstruction for generating a magnetic resonance image of the subject.
8. An apparatus as claimed in claim 7 wherein PROPELLER strips in a conventional PROPELLER scan each contain a plurality of lines of data in k-space, and wherein said sequence controller operates said magnetic resonance scanner for acquiring raw magnetic resonance data from a subject for each of a plurality of PROPELLER strips occupying a plurality of lines in k-space that is less than said plurality of lines occupied in k-space by each strip of said conventional PROPELLER scan.
9. An apparatus as claimed in claim 7 wherein a PROPELLER strip of a conventional PROPELLER scan occupies a width in k-space, and wherein said sequence controller operates said magnetic resonance scanner for acquiring raw magnetic resonance data from a subject for each of a plurality of PROPELLER strips occupying a width in k-space that is greater than said width in k-space occupied by each PROPELLER strip in said conventional PROPELLER scan.
10. An apparatus as claimed in claim 7 wherein said sequence controller operates said magnetic resonance scanner for obtaining raw magnetic resonance data from the subject with a conventional PROPELLER scan, without PAT, and wherein said image computer uses said raw magnetic resonance data from said conventional PROPELLER scan as a reference for designating said coil sensitivities in said PAT reconstruction.
11. An apparatus as claimed in claim 7 wherein k-space has a central region wherein all of said plurality of PROPELLER strips overlap, and wherein said image computer applies a gridding algorithm to said central region for obtaining information describing said respective coil sensitivities for use in said PAT reconstruction.
12. An apparatus as claimed in claim 7 wherein said sequence controller operates said magnetic resonance scanner for employing partial parallel acquisition as said PAT.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A therapeutically effective amount of an aqueous Aquilaria agallocha woody hull of the fruit of Aquilaria agallocha extract for treating cancer wherein the extract is obtained by methanol extraction of Aquilaria agallocha followed by a partition with ethyl acetate and water, wherein the ethyl acetate layer is further eluted by a hexane-ethyl acetate mixture and methanol with silica column chromatography.
2. The extract of claim 1, wherein the ethyl acetate layer is eluted by mobile phases of (i) hexane-ethyl acetate mixture in a ratio of 1:0, 10:1, 10:2, 10:3, 10:4, 10:5, 10:6, 10:8, 1:1 and 0:1 and (ii) methanol with silica column chromatography so that 13 fractions are obtained.
3. The extract of claim 2, wherein Fractions 10:5 and 10:6 specifically contain cucurbitacin E and cucurbitacin I.
4. The extract of claim 2, wherein Fraction 3 (10:2) contains beta-sitosterol, Fraction 7 (10:5) contains genkwanin, Fraction 8 (10:5) contains cucurbitacin E, Fraction 9 (10:5) contains cucurbitacin I and cucurbitacin E glucoside, Fraction 11 (1:1) contains cucurbitacin I glucoside and Fraction 12 (0:1) contains genkwanin 5-0-glucoside and mangiferin.
5. The extract of claim 1, wherein the ethyl acetate layer is partitioned by centrifugal partition chromatography to obtain 9 fractions.
6. The extract of claim 4, wherein Fraction 2 contains magiferin, Faction 4 contains curcurbitacin I glucoside, Fraction 5 contains curcurbitacin E glucoside, Fraction 6 contains curcurbitacin I, Fraction 7 contains beta-sitosterol and Fraction 8 contains curcurbitacin E.
7. The extract of claim 6, wherein the fractions can be further purified by molecular sieve chromatography.
8. The extract of claim 1, wherein the aqueous Aquilaria agallocha woody hull of the fruit of Aquilaria agallocha extract is from Aquilaria agallocha Roxb.
9. A pharmaceutical formulation, consisting essentially of the extract of claim 1 and a pharmaceutically acceptable carrier.
10. The pharmaceutical formulation of claim 9, which is for oral, rectal, topical, buccal, parenteral or transdermal administration.
11. The pharmaceutical formulation of claim 10, which is in a form selected from the group consisting of cachet, lozenge, tablet, powder, granule, solution, suspension and emulsion.