1. A door gap guard made of a resilient material,comprising:
an elongated center portion;
a longitudinal strip of mounting portion connected to one side of said elongated center portion and affixed to a doorframe;and
a narrow elongated motion portion connected to an opposite side of said elongated center portion for covering the gap between said doorframe and a door panel being hinged to said doorframe.
2. The door gap guard as claimed in claim 1,wherein said elongated center portion is formed of a torional spring.
3. The door gap guard as claimed in claim 1, further comprising a rod-like free end portion longitudinally connected to one side of said narrow elongated motion portion elongated center portion.
4. The door gap guard as claimes in claim 3,further comprising a curved portion longitudinally connected between said narrow elongated motion portion and said rod-like free end portion.
5. The door gap guard as claimed in claim 3, wherein said narrow elongated motion portion has a transverse width greater than said longitudinal strip of mounting portion.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. A polymer comprising a polymeric backbone and at least one functional group having the formula:
46
wherein X is selected from the group consisting of an amino, a polyamino, a C1-C24 aliphatic, a C6-C30 aryl, a C3-C30 heteroaromatic having 1 to 3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, a C3-C30 nonaromatic cyclic, and an oximyl, and Q is selected from the group consisting of an acridinyl, an anthracenyl, a benzimidazolyl, a benzisoxazolyl, a benzofuryl, a benzothienyl, a benzoxazolyl, a benzopyrazolyl, a benzothiazolyl, a carbazolyl, a chlorophyllyl, a cinnolyl, a furyl, an imidazolyl, an indolyl, an isobenzofuryl, an isoindolyl, an isoxazolyl, an isothiazolyl, an isoquinolyl, a naphthyl, an oxazolyl, a phenanthryl, a phenanthridinyl, a phenothiazinyl, a phenoxazinyl, a phenyl, a phthalimidyl, a phthalazinyl, a phthalocyaninyl, a pteridinyl, a purinyl, which is optionally part of a nucleic acid, a ribosylpurinyl, a pyrazinyl, a pyrazolyl, a pyridazyl, a pyridyl, a pyrimidyl, which is optionally part of a nucleic acid, a ribosylpyrimidyl, a pyrrocolinyl, a pyrryl, a quinolyl, a quinoxalinyl, a quinazolinyl, a sydnonyl, a tetrazolyl, a thiazolyl, a thienyl, a thyroxinyl, a triazinyl, and a triazolyl, wherein a ring atom of Q is bonded to an oxygen atom of the at least one functional group, wherein X is bound to the polymeric backbone, and wherein X and Q are optionally substituted.
2. The polymer of claim 1, wherein the polymeric backbone is selected from the group consisting of a polyolefin, a polyurethane, a peptide, a protein, a polyethyleneimine, a starburst dendrimer, a polyamide, a polyether, a polyester, a nucleic acid, and a polysaccharide.
3. The polymer of claim 2, wherein the polyolefin is selected from the group consisting of a polystyrene, a polyethylene, a polytetrafluoroethylene, a polyvinylchloride, and a polyvinylidene difluoride.
4. The polymer of claim 2, wherein the polyamide is nylon.
5. The polymer of claim 1, wherein Q is part of a vitamin.
6. The polymer of claim 1, wherein Q is part of a hormone.
7. The polymer of claim 1, wherein Q is a pyrimidyl, which, optionally, is part of a nucleic acid.
8. The polymer of claim 7, wherein Q is a ribosylpyrimidyl.
9. The polymer of claim 1, wherein Q is a purinyl, which, optionally, is part of a nucleic acid.
10. The polymer of claim 9, wherein Q is a ribosylpurinyl.
11. The polymer of claim 1, wherein X is linked to the N1 nitrogen through an atom other than a carbon atom.
12. The polymer of claim 1, wherein X is substituted with one or more moieties selected from the group consisting of N(NO)O, a halo, hydroxy, an alkylthio, an alkoxy, an aryloxy, an amino, cyano, a sulfonato, mercapto, nitro, a C1-C12 aliphatic, a C3-C8 cycloalkyl, a C3-C8 heterocyclic, a C2-C12 olefinic, benzyl, phenyl, benzylcarbonyl, phenylcarbonyl, glucosyl, ribosyl, glucosyl, mannosyl, deoxyribosyl, dextranyl, starch, glycogenyl, lactosyl, fucosyl, galactosyl, fructosyl, glucosaminyl, galactosaminyl, heparinyl, maltosyl, sucrosyl, sialyl, cellulose, phosphorylated pentosyl, polyphosphorylated pentosyl, phosphorylated hexosyl, polyphosphorylated hexosyl, phosphono, phosphato, and phosphato in which one or more oxygen atoms are independently replaced with S or NR1, wherein R1 is a C1-C8 aliphatic, a C3-C8 cycloalkyl, a C6-C8 aryl, or a C3-C8 heteroaromatic having 1 to 3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur.
13. The polymer of claim 1, wherein Q is substituted with one or more moieties selected from the group consisting of XN(O)NO, wherein X is as defined in claim 1, halo, hydroxy, alkylthio, arylthio, alkoxy, aryloxy, amino, mono- or di-substituted amino, ammonio, substituted ammonio, nitroso, cyano, sulfonato, mercapto, nitro, oxo, a C1-C24 aliphatic, a C2-C12 olefinic, a C3-C24 cycloalkyl, a C3-C24 heterocyclic, benzyl, phenyl, substituted benzyl, substituted phenyl, benzylcarbonyl, phenylcarbonyl, glucosyl, ribosyl, glucosyl, mannosyl, deoxyribosyl, dextranyl, starch, glycogenyl, lactosyl, fucosyl, galactosyl, fructosyl, glucosaminyl, galactosaminyl, heparinyl, maltosyl, sucrosyl, sialyl, cellulose, phosphorylated pentosyl, polyphosphorylated pentosyl, phosphorylated hexosyl, polyphosphorylated hexosyl, substituted benzylcarbonyl, substituted phenylcarbonyl, phosphono, phosphato, and phosphato in which one or more oxygen atoms are independently replaced with S or NR1, wherein R1 is a C1-C10 aliphatic, a C3-C10 cycloalkyl, a C6-C10 aryl, or a C1-C10 heteroaromatic having 1 to 3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur.
14. The polymer of claim 1, wherein the functional group has the formula:
47
wherein b and d can be the same or different and may be zero or one, R1, R2, R3, R4, and R5 are the same or different and are selected from the group consisting of hydrogen, C3-C8 cycloalkyl, C1-12 straight or branched chain alkyl, benzyl, benzoyl, phthaloyl, acetyl, trifluoroacetyl, p-toluyl, t-butoxycarbonyl, and 2,2,2-trihalo-t-butoxycarbonyl, and i, j, and k are the same or different and are integers from 2 to 12.
15. The polymer of claim 1, wherein the functional group has the formula:
wherein D is
48
and wherein R10 and R11 are the same or different and are selected from the group consisting of hydrogen, C3-8 cycloalkyl, C1-12 straight or branched chain alkyl, benzyl, benzoyl, phthaloyl, acetyl, trifluoroacetyl, p-toluyl, t-butoxycarbonyl, and 2,2,2-trichloro-t-butoxycarbonyl, and f is an integer from 0 to 12.
16. The polymer of claim 1, wherein the functional group has the formula:
49
wherein R6 and R7 can be the same or different and are H, a C1-C12 straight chain alkyl, a C1-C12 alkoxy or acyloxy substituted straight chain alkyl, a C2-C12 hydroxy or halo substituted straight chain alkyl, a C3-C12 branched chain alkyl, a C3-C12 hydroxy, halo, alkoxy, or acyloxy substituted branched chain alkyl, a C2-C12 straight chain olefinic, or a C3-C12 branched chain olefinic, wherein R6 and R7 are optionally substituted with hydroxy, alkoxy, acyloxy, halo or benzyl; or R6 and R7 together with the nitrogen atom to which they are bonded form a heterocyclic ring selected from the group consisting of:
50
wherein A is N, O, or S, w is 1 to 12, y is 1 or 2, z is 1 to 5, R8 is hydrogen, a C1-C8 straight chain alkyl, a C3-C8 branched chain alkyl, a C3-C8 cycloalkyl, a C6-C30 aryl, or a C3-C30 heteroaromatic having 1 to 3 heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur, and R9 is hydrogen, a C1-C6 straight chain alkyl or a C3-C6 branched chain alkyl.
17. The polymer of claim 16, wherein R6 is hydrogen.
18. The polymer of claim 16, wherein R6 and R7 are ethyl and Q is selected from the group consisting of:
51
19. The polymer of claim 1, wherein the ring atom of Q bonded to the oxygen atom is carbon or nitrogen.
20. A composition comprising a polymer of claim 1 and a carrier.
21. A compound having the formula:
52
wherein X is selected from the group consisting of an amino, a polyamino, a C1-C24 aliphatic, a C6-C30 aryl and a C6-C30 non-aromatic cyclic, and R is a saccharide, which is attached to the O2 of the compound by the 2 position of a pyranose ring or a furanose ring, with the proviso that, when X is a saccharide, it is not attached to N1 of the compound by the 2 position of a pyranose or a furanose ring.
22. The compound of claim 21, wherein the saccharide is selected from the group consisting of a monosaccharide, a disaccharide, an oligosaccharide, and a polysaccharide.
23. The compound of claim 22, wherein the disaccharide is sucrose or maltose.
24. The compound of claim 22, wherein the monosaccharide is mannose, fucose or glucose.
25. The compound of claim 21, wherein said saccharide is a recognition sequence for receptor-mediated cellular phenomena.
26. The compound of claim 21, wherein X is an amino group that is linked to the N1-nitrogen through a nitrogen atom.
27. The compound of claim 21, wherein said X is substituted with a moiety selected from the group consisting of N(NO)O, a halo, a hydroxy, an alkylthio, an alkoxy, an aryloxy, an amino, a cyano, a sulfonato, a mercapto, a nitro, a C1-C12 aliphatic, a C3-C8 cycloalkyl, a C3-C8 heterocycloalkyl, a C3-C12 olefinic, a benzyl, a phenyl, a benzylcarbonyl, a phenylcarbonyl, a saccharide, phosphono, phosphato, and phosphato it which one or more oxygen atoms is independently replaced with S or NR1, wherein R1 is a C1-C8 aliphatic, a C3-C8 cycloalkyl, benzyl, phenyl, or R18CN(OH) in which R18 is a C1-C10 aliphatic.
28. The compound of claim 21, having the formula
53
wherein b and d can be the same or different and may be zero or one, R1, R2, R3, R4, and R5 are the same or different and are selected from the group consisting of hydrogen, C3-C8 cycloalkyl, C1-12 straight or branched chain alkyl, benzyl, benzoyl, phthaloyl, acetyl, trifluoroacetyl, p-toluyl, t-butoxycarbonyl, or 2,2,2-tri-halo-t-butoxycarbonyl, and i, j, and k are the same or different and are integers from 2 to 12.
29. The compound of claim 21, wherein X is R19R20N and R19 and R20 are the same or different and are hydrogen, a C1-12 straight chain alkyl, a C3-12 branched chain alkyl, or a C2-12 straight or C3-12 branched chain olefinic, wherein R19 and R20 are optionally substituted with an alkoxy, an acyloxy, an acylthio, a hydroxy, a halo or a benzyl group, or R19 and R20, together with the nitrogen atom to which they are bonded, form a heterocyclic ring selected from the group consisting of:
54
wherein A is N, O, or S, w is 1-12, y is 1 or 2, z is 1-5, R8 is hydrogen, a C1-8 straight chain alkyl, a C3-8 branched chain alkyl, a C3-8 cycloalkyl, an aryl, or carboxylato, and R9 is hydrogen, a C1-6 straight chain alkyl or a C3-6 branched chain alkyl.
30. The compound of claim 29, wherein R19R20N is N(CH2CH2NH2)2 and the saccharide is fucose or mannose.
31. The compound of claim 21, wherein the saccharide is ribose, deoxyribose, lactose, galactose, fructose, glucosamine, glucose, mannose, fucose, galactosamine, and glucuronic acid, or a pentose or hexose, either one of which is phosphorylated, 3,5-cyclophosphorylated, or polyphosphorylated.
32. The compound of claim 31, wherein the glucosamine has the structure:
55
wherein R12 and R13 can be the same or different and are a hydrogen, a C1-6 alkyl, an acyl, a phosphate, a sulfate, a peptide or a protein.
33. The compound of claim 31, wherein the glucuronic acid has the structure:
56
wherein R14 is X1R15R16, wherein X1 is N, O or S and, when X1 is N, R15 and R16 are independently hydrogen or a C1-24 alkyl, C3-24 cycloalkyl, C2-24 olefinic, a C3-C30 aryl or a heterocyclic group selected from the group consisting of:
57
wherein A is N, O, or S, w is 1-12, y is 1 or 2, z is 1-5, R8 is hydrogen, a C1-8 straight chain alkyl, a C3-8 branched chain alkyl, a C3-8 cycloalkyl, an aryl or carboxylato, and R9 is hydrogen, a C1-6 straight chain alkyl or a C3-6 branched chain alkyl, and when X1 is O or S, there is no R16 group.
34. The compound of claim 33, wherein the aryl is selected from the group consisting of an acridine, an anthracene, a benzene, a benzofuran, a benzothiophene, a benzoxazole, a benzopyrazole, a benzothiazole, a carbazole, a chlorophyll, a cinnoline, a furan, an imidazole, an indole, an isobenzofuran, an isoindole, an isoxazole, an isothiazole, an isoquinoline, a naphthalene, an oxazole, a phenanthrene, a phenanthridine, a phenothiazine, a phenoxazine, a phthalimide, a phthalazine, a phthalocyanine, a porphin, a pteridine, a purine, a pyrazine, a pyrazole, a pyridazine, a pyridine, a pyrimidine, a pyrrocoline, a pyrrole, a quinolizinium ion, a quinoline, a quinoxaline, a quinazoline, a sydnone, a tetrazole, a thiazole, a thiophene, a thyroxine, a triazine, and a triazole.
35. A compound having the formula:
58
wherein X is an inorganic moiety and R is a saccharide, which is attached to the O2 atom of the compound by the 2 position of a pyranose ring or a furanose ring.
36. The compound of claim 35, in which X is O3S or O.
37. A compound having the formula:
wherein D is
59
and wherein R21 is a saccharide, which is attached to the O2 atom of the compound by the 2 position of a pyranose ring or a furanose ring, f is an integer from 0 to 12, and R10 and R11, which can be the same or different, can be hydrogen, a C3-C8 cycloalkyl, a C1-C12 straight- or a C3-C12 branched-chain alkyl, benzyl, benzoyl, phthaloyl, acetyl, trifluoroacetyl, p-toluyl, t-butoxycarbonyl or 2,2,2-trihalo-t-butoxycarbonyl.
38. A compound having the formula:
60
wherein R is a C1-12 straight chain alkyl, a C3-12 branched chain alkyl, a C2-12 straight chain or a C3-12 branched chain olefinic, a C1-12 acyl, sulfonyl, carboxamido, a glycosyl group, a C1-C30 aryl group or a group of the formula (CH2)nONN(O)NR28R29, wherein n is an integer of 2-8, and R28 and R29 are independently a C1-12 straight chain alkyl, a C3-12 branched chain alkyl, or a C2-12 straight chain or a C3-12 branched chain olefinic, or R28 and R29, together with the nitrogen atom to which they are bonded, form a heterocyclic group selected from the group consisting of a pyrrolidino, a piperidino, a piperazino and a morpholino group; and R22 is hydrogen, hydroxyl, OM, wherein M is a cation, a halo, X1R23R24, wherein X1 is O, N or S, and R23 and R24 are independently a C1-24 alkyl, a C3-24 cycloalkyl, a C2-24 olefinic, a C3-C30 aryl, or a heterocyclic group, and, when X1 is O or S, there is no R24.
39. The compound of claim 38, wherein R is substituted with a hydroxy, halo, acyloxy, alkoxy, acylthio or benzyl.
40. The compound of claim 38, wherein, when X1 is nitrogen, R23 and R24, together with the nitrogen to which they are bonded, form a heterocyclic ring selected from the group consisting of:
61
wherein A is O, N or S, w is 1-12, y is 1 or 2, z is 1-5, R8, R9, R25, and R26 are hydrogen, a C1-8 straight chain alkyl, a C3-8 branched chain alkyl, a C3-8 cycloalkyl, or a C3-C30 aryl.
41. The compound of claim 38, wherein the aryl is selected from the group consisting of an acridine, an anthracene, a benzene, a benzofuran, a benzothiophene, a benzoxazole, a benzopyrazole, a benzothiazole, a carbazole, a chlorophyll, a cinnoline, a furan, an imidazole, an indole, an isobenzofuran, an isoindole, an isoxazole, an isothiazole, an isoquinoline, a naphthalene, an oxazole, a phenanthrene, a phenanthridine, a phenothiazine, a phenoxazine, a phthalimide, a phthalazine, a phthalocyanine, a porphin, a pteridine, a purine, a pyrazine, a pyrazole, a pyridazine, a pyridine, a pyrimidine, a pyrrocoline, a pyrrole, a quinolizinium ion, a quinoline, a quinoxaline, a quinazoline, a sydnone, a tetrazole, a thiazole, a thiophene, a thyroxine, a triazine, and a triazole.
42. The compound of claim 40, wherein, when X1 is nitrogen and R23 and R24, together with the nitrogen to which they are bonded, form the heterocyclic ring
62
R25 is hydrogen, a C1-C8 straight chain alkyl, a C3-C8 branched chain alkyl, a C3-C8 cycloalkyl or a C3-C30, aryl, R26 is hydrogen, a C1-C8 alkyl, a C3-C30 aryl, or C(O)YR27, wherein Y is sulfur, oxygen or nitrogen and R27 is CH2OCH3, vinyl, a C1-C9 straight chain alkyl, a C3-C6 branched chain alkyl, a C3-C8 cycloalkyl, polyethylene glycol, a polysaccharide, a peptide or a protein.
43. A composition comprising a compound of claim 21 and a carrier.
44. A pharmaceutical composition comprising a compound having the formula:
63
wherein X and R are saccharides which are attached to the O2 atom of the compound by the 2 position of a pyranose ring or a furanose ring.
45. A composition comprising a compound of claim 35 and a carrier.
46. A composition comprising a compound of claim 37 and a carrier.
47. A composition comprising a compound of claim 38 and a carrier.
48. The compound of claim 21, wherein X and Q are imidazoles.
49. The compound of claim 21, wherein X is bound to a polymer.
50. A method of treating or preventing a biological disorder in an animal, wherein said disorder is selected from the group consisting of angina, acute myocardial infarction, congestive heart failure, hypertension and metastasis, which method comprises administering to said animal an amount of a polymer of claim 1 sufficient to treat or prevent the biological disorder in said animal.
51. The method of claim 48, wherein said biological disorder is due to hypertension.
52. The method of claim 48, wherein said biological disorder is due to acute myocardial infarction.
53. The method of claim 48, wherein said biological disorder is due to metastasis.
54. A method of treating or preventing a biological disorder in a mammal, wherein said disorder is selected from the group consisting of angina, acute myocardial infarction, congestive heart failure, hypertension and metastasis, which method comprises administering to the animal a polymer of claim 1 in an amount sufficient to treat or prevent the biological disorder.
55. A method of treating an animal infected with an infectious agent comprising a zinc finger protein that can be inactivated by nitric oxide, the method comprising administering to said animal an amount of a polymer of claim 1 sufficient to inactivate the zinc finger protein in the infectious agent so as to treat the infection in the animal.
56. A method of treating an animal for cancer, wherein the cancer involves a zinc finger protein that can be inactivated by nitric oxide, the method comprising administering to the animal an amount of a polymer of claim 1 sufficient to inactivate the zinc finger protein so as to treat the cancer in said animal.
57. A method of treating an animal for cancer, wherein the cancer is resistant to treatment with a chemotherapeutic agent, the method comprising administering to the animal an amount of a polymer of claim 1 sufficient to render the cancer in the animal treatable with the chemotherapeutic agent.
58. A method of modulating steroid hormone activity in a mammal, wherein the mammal is in need of modulation of steroid hormone and wherein the animal has a steroid hormone receptor comprising a zinc finger protein which can be inactivated by nitric oxide, the method comprising administering to the animal an amount of a polymer of claim 1 sufficient to inactivate the steroid hormone receptor protein so as to modulate steroid hormone activity in the mammal.
59. The method of claim 55, wherein the infectious agent is a virus.
60. The method of claim 59, wherein the virus is HIV.
61. The method of claim 55, wherein said infectious agent is a parasite.
62. The method of claim 61, wherein said parasite is Giardia.
63. The method of claim 57, wherein the chemotherapeutic agent is a DNA-damaging agent.
64. The method of claim 63, wherein the DNA-damaging agent is selected from the group consisting of an alkylating agent and an oxidizing agent.
65. A method of treating a plant, a plant cell or a tissue culture thereof, which is infected with an infectious agent comprising a protein that can be inactivated by a polymer of claim 1 which method comprises contacting said plant, plant cell or tissue culture thereof with an amount of a polymer of claim 1 sufficient to inactivate the protein in said infectious agent so as to treat the infection in said plant, plant cell or tissue culture thereof.
66. The method of claim 65, wherein said infectious agent is a virus.
67. The method of claim 66, wherein said virus is selected from the group consisting of tobacco streak virus and alfalfa mosaic virus.
68. A method of reducing on an inanimate object the presence of an infectious agent comprising a zinc finger protein that can be inactivated by a polymer of claim 1, which method comprises contacting said inanimate object with an amount of a polymer of claim 1 sufficient to inactivate the zinc finger protein so as to reduce the presence of the infectious agent on said inanimate object.
69. The method of claim 68, wherein said infectious agent is selected from the group consisting of a virus, a bacterium, and a parasite.