1. A method for generating an advertising unit in a single environment, the method comprising:
executing an ad unit component module program adapted to operate in a single environment;
simultaneously executing an authoring tool program to facilitate the single environment, wherein the authoring tool program is adapted by the ad unit component module program to provide functionality associated with authoring tool program; and
utilizing at least one tool associated with the ad unit component module program, wherein the at least one tool is adapted to generate an advertising unit in the single environment.
2. The method of claim 1, wherein the single environment comprises an Adobe Flash environment, or a Microsoft Silverlight environment.
3. The method of claim 1, wherein the authoring tool program comprises at least one of the following: Adobe Flash 8, Adobe Flash 9, or another Flash-type product utilizing ActionScript or another scripting language.
4. The method of claim 1, wherein the at least one tool comprises a creative application program tool.
5. The method of claim 1, further comprising:
within the single environment, receiving edited content for the advertising unit from another user, wherein the edited content is adapted to modify the original advertising unit.
6. The method of claim 1, further comprising:
utilizing at least one tracking tool associated with the ad unit component module program, wherein the at least one tracking tool is adapted to collect information associated with at least one event or interaction associated with the advertising unit.
7. The method of claim 1, further comprising:
within the single environment, transferring one or more files associated with the advertising unit to another user.
8. A method for manipulating an advertising unit in a single environment, the method comprising:
simultaneously executing an ad unit component module program and an authoring tool program, wherein the authoring tool program is adapted to facilitate execution of the ad unit component module program in a single environment, and wherein the authoring tool program is adapted by the ad unit component module program to provide functionality associated with authoring tool program;
within the single environment, generating an advertising unit with at least one tool associated with the ad unit component module program;
within the single environment, receiving edited content for the advertising unit from at least one user; and
within the single environment, modifying the advertising unit based at least in part on the received edited content.
9. The method of claim 8, further comprising:
storing the advertising unit.
10. The method of claim 8, further comprising:
utilizing at least one tracking tool associated with the ad unit component module program, wherein the at least one tracking tool is adapted to collect information associated with at least one event or interaction associated with the advertising unit.
11. The method of claim 8, further comprising:
within the single environment, transferring one or more files associated with the advertising unit to the at least one user.
12. The method of claim 8, wherein the single environment comprises an Adobe Flash environment, or a Microsoft Silverlight environment.
13. The method of claim 8, wherein the authoring tool program comprises at least one of the following: Adobe Flash 8, Adobe Flash 9, Microsoft Silverlight, or another Flash-type product utilizing ActionScript or another scripting language.
14. The method of claim 8, wherein the at least one tool comprises a creative application program tool.
15. A system for generating an advertising unit in a single environment, the system comprising:
an ad generation component module program adapted to operate in a single environment; and
an authoring tool program adapted to facilitate the single environment, and further adapted to simultaneously execute with the ad generation component module, wherein the authoring tool program is adapted by the ad unit component module program to provide functionality associated with authoring tool program; and
wherein the ad generation component module program comprises at least one tool adapted to generate an advertising unit in the single environment.
16. The system of claim 15, wherein the ad generation component module program further comprises at least one tracking tool adapted to collect information associated with at least one event or interaction associated with the advertising unit.
17. The system of claim 15, wherein the single environment comprises an Adobe Flash environment, or a Microsoft Silverlight environment.
18. The system of claim 15, wherein the authoring tool program comprises at least one of the following: Adobe Flash 8, Adobe Flash 9, Microsoft Silverlight, or another Flash-type product utilizing ActionScript or another scripting language.
19. The system of claim 15, wherein the at least one tool comprises a creative application program tool.
20. The system of claim 15, wherein the ad generation component module program is further adapted to receive edited content for modification of the advertising unit.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of Formula (I) or a salt thereof:
wherein
L1 is a bond or -lower alkylene-,
L2 is an optionally substituted lower alkylene,
R1 is H or lower alkyl optionally substituted with at least one substituent selected from the group consisting of an optionally substituted aryl, an optionally substituted aromatic heterocyclic group, and \u2014CO2H, or R1 with the nitrogen atom bonded thereto and the HO2C-L2 group on the nitrogen atom form a cyclic amino optionally substituted with \u2014CO2H, and
Ring B is naphthalenediyl, 1,2,3,4-tetrahydronaphthalenediyl, 2,3-dihydroindenediyl, benzothiophenediyl, benzofurandiyl, or 2,3-dihydrobenzofurandiyl.
2. The compound or a salt thereof according to claim 1, wherein
L1 is a bond or C1-3 alkylene,
L2 is lower alkylene optionally substituted with a substituent D1, and
R1 is H or lower alkyl optionally substituted with at least one substituent selected from the group consisting of (i) aryl optionally substituted with a substituent D2, (ii) an aromatic heterocyclic group optionally substituted with a substituent D2, and (iii) \u2014CO2H, or R1 with the nitrogen atom bonded thereto and the HO2C-L2 group on the nitrogen atom form 1,2,3,4-tetrahydroisoquinolin-2-yl substituted with at least one \u2014CO2H group,
the substituent D1 is
halogen,
\u2014OH,
\u2014O-lower alkyl,
\u2014SH,
\u2014S-lower alkyl,
\u2014S(O)-lower alkyl,
\u2014S(O)2-lower alkyl,
\u2014CN,
\u2014NO2,
\u2014NH2,
\u2014NH-(lower alkyl),
\u2014N(lower alkyl)2,
\u2014C(O)-lower alkyl,
aryl substituted with at least one substituent selected from the group consisting of \u2014O-(lower alkyl optionally substituted with at least one \u2014CO2H group), halogen, \u2014CO2H, and lower alkyl which is optionally substituted with at least one substituent selected from the group consisting of halogen and \u2014CO2H,
\u2014C(O)\u2014O-lower alkyl,
\u2014CO2H, or
a biological equivalent thereof,
and
each substituent D2 is independently
halogen,
\u2014OH,
\u2014O-lower alkyl,
\u2014SH,
\u2014S-lower alkyl,
\u2014S(O)-lower alkyl,
\u2014S(O)2-lower alkyl,
\u2014CN,
\u2014NO2,
\u2014NH2,
\u2014NH-(lower alkyl),
\u2014N(lower alkyl)2,
\u2014C(O)-lower alkyl,
\u2014C(O)\u2014NH2,
\u2014C(O)\u2014NH-(lower alkyl),
\u2014C(O)\u2014N(lower alkyl)2,
\u2014C(O)\u2014O-lower alkyl,
\u2014CO2H, or
a biological equivalent thereof,
lower alkyl optionally substituted with halogen, \u2014OH, \u2014O-lower alkyl, \u2014SH, \u2014S-lower alkyl, \u2014S(O)-lower alkyl, \u2014S(O)2-lower alkyl, \u2014CN, \u2014NO2, \u2014NH, \u2014NH-(lower alkyl), \u2014N(lower alkyl)2, \u2014C(O)-lower alkyl, \u2014C(O)\u2014NH2, \u2014C(O)\u2014NH-(lower alkyl), \u2014C(O)\u2014N(lower alkyl)2, \u2014C(O)\u2014O-lower alkyl, \u2014CO2H, or a biological equivalent thereof, or
\u2014O-lower alkyl optionally substituted with halogen, \u2014OH, \u2014O-lower alkyl, \u2014SH, \u2014S-lower alkyl, \u2014S(O)-lower alkyl, \u2014S(O)2-lower alkyl, \u2014CN, \u2014NO2, \u2014NH2, \u2014NH-(lower alkyl), \u2014N(lower alkyl), \u2014C(O)-lower alkyl, \u2014C(O)\u2014NH2, \u2014C(O)\u2014NH-(lower alkyl), \u2014C(O)\u2014N(lower alkyl)2, \u2014C(O)\u2014O-lower alkyl, \u2014CO2H, or a biological equivalent thereof.
3. The compound or a salt thereof according to claim 2,
wherein L1 is a bond or methylene,
L2 is lower alkylene optionally substituted with a substituent D1,
R1 is H or lower alkyl optionally substituted with at least one substituent selected from the group consisting of (i) aryl optionally substituted with a substituent D2, (ii) an aromatic heterocyclic group optionally substituted with a substituent D2, and (iii) \u2014CO2H,
Ring B is naphthalenediyl, 1,2,3,4-tetrahydronaphthalenediyl, 2,3-dihydroindenediyl, or benzothiophenediyl.
4. The compound or a salt thereof according to claim 3, wherein L2 is methylene, ethylene, or ethylene substituted with (phenyl substituted with \u2014CO2H).
5. The compound or a salt thereof according to claim 3, wherein L2 is methylene, methylmethylene, ethylene, or methylmethylene substituted with (phenyl substituted with \u2014CO2H).
6. The compound or a salt thereof according to claim 4, wherein R1 is H or lower alkyl optionally substituted with at least one substituent selected from the group consisting of
(i) phenyl substituted with at least one substituent selected from the group consisting of \u2014CO2H and lower alkyl substituted with \u2014CO2H,
(ii) thienyl substituted with at least one substituent selected from the group consisting of \u2014CO2H and lower alkyl substituted with \u2014CO2H, and
(iii) \u2014CO2H.
7. The compound or a salt thereof according to claim 6, wherein Ring B is naphthalene-1,6-diyl, naphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-1,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl, 2,3-dihydroindene-1,5-diyl, or benzothiophene-3,6-diyl.
8. The compound or a salt thereof according to claim 7, wherein either
L2 is methylene or methylmethylene, and R1 is lower alkyl substituted with at least one substituent selected from the group consisting of
(i) phenyl substituted with at least one substituent selected from the group consisting of \u2014CO2H and lower alkyl substituted with \u2014CO2H, and
(ii) thienyl substituted with at least one substituent selected from the group consisting of \u2014CO2H and lower alkyl substituted with \u2014CO2H,
or
L2 is methylmethylene substituted with (phenyl substituted with \u2014CO2H), and R1 is H.
9. The compound or a salt thereof according to claim 8, wherein L2 is methylene or methylmethylene, and R1 is (phenyl substituted with \u2014CO2H)\u2014CH2\u2014, (phenyl substituted with \u2014CH2\u2014CO2H)\u2014CH2\u2014, or (thienyl substituted with \u2014CO2H)\u2014CH2\u2014.
10. The compound or a salt thereof according to claim 2, wherein
L1 is a bond or methylene, Ring B is naphthalene-1,6-diyl, naphthalene-2,6-diyl, 1,2,3,4-tetrahydronaphthalene-1,6-diyl, 1,2,3,4-tetrahydronaphthalene-2,6-diyl, 2,3-dihydroindene-1,5-diyl, benzothiophene-3,6-diyl, benzofuran-3,6-diyl, or 2,3-dihydrobenzofuran-3,6-diyl, and
(a) L2 is C1-3 alkylene, and R1 is lower alkyl which is substituted with at least one substituent selected from the group consisting of (i) phenyl optionally substituted with at least one substituent selected from the group consisting of \u2014CO2H and lower alkyl substituted with \u2014CO2H, and (ii) thienyl or benzothienyl, either of which is substituted with at least one substituent selected from the group consisting of \u2014CO2H and lower alkyl substituted with \u2014CO2H, the lower alkyl of R1 optionally substituted with at least one \u2014CO2H group,
(b) L2 is C1-3 alkylene substituted with (phenyl substituted with \u2014CO2H), and R1 is H,
or
(c) R1 with the nitrogen atom bonded thereto and the HO2C-L2 group on the nitrogen atom form 1,2,3,4-tetrahydroisoquinolin-2-yl substituted with two \u2014CO2H groups.
11. The compound or a salt thereof according to claim 1, which is
4-{{6-(4-carbamimidamidobenzoyl)oxy-2-naphthoyl}(carboxymethyl)aminomethyl}thiophene-2-carboxylic acid,
3-{({6-(4-carbamimidamidobenzoyl)oxy-1,2,3,4-tetrahydronaphthalen-1-yl}acetyl)(carboxymethyl)aminomethyl}benzoic acid,
3-{({(1R)-6-(4-carbamimidamidobenzoyl)oxy-1,2,3,4-tetrahydronaphthalen-1-yl}acetyl)(carboxymethyl)aminomethyl}benzoic acid,
3-{({(1S)-6-(4-carbamimidamidobenzoyl)oxy-1,2,3,4-tetrahydronaphthalen-1-yl}acetyl)(carboxymethyl)aminomethyl}benzoic acid,
N-{6-(4-carbamimidamidobenzoyl)oxy-1-naphthoyl}-4-carboxy-L-phenylalanine,
4-{({6-(4-carbamimidamidobenzoyl)oxy-1,2,3,4-tetrahydronaphthalen-2-yl}carbonyl)(carboxymethyl)aminomethyl}thiophene-2-carboxylic acid,
3-{({5-(4-carbamimidamidobenzoyl)oxy-2,3-dihydro-1H-inden-1-yl}acetyl)(carboxymethyl)aminomethyl}benzoic acid,
4-{({6-(4-carbamimidamidobenzoyl)oxy-1-benzothiophen-3-yl}carbonyl)(carboxymethyl)aminomethyl}thiophene-2-carboxylic acid,
3-{{6-(4-carbamimidamidobenzoyl)oxy-1-naphthoyl}(carboxymethyl)aminomethyl}benzoic acid,
N-{6-(4-carbamimidamidobenzoyl)oxy-1-naphthoyl}-N-4-(carboxymethyl)benzylglycine,
4-({({6-(4-carbamimidamidobenzoyl)oxy-1,2,3,4-tetrahydronaphthalen-1-yl}acetyl) (1R)-1-carboxyethylamino}methyl)thiophene-2-carboxylic acid,
4-({({6-(4-carbamimidamidobenzoyl)oxy-1,2,3,4-tetrahydronaphthalen-2-yl}carbonyl)(1R)-1-carboxyethylamino}methyl)thiophene-2-carboxylic acid, or
N-({6-(4-carbamimidamidobenzoyl)oxy-1-benzothiophen-3-yl}carbonyl)-N-4-(carboxymethyl)benzylglycine.
12. A pharmaceutical composition comprising the compound or a salt thereof according to claim 11, and a pharmaceutically acceptable excipient.
13. The pharmaceutical composition according to claim 12, which is suitable for preventing or treating a kidney disease.
14. A method of manufacturing a pharmaceutical composition, the method comprising:
manufacturing the pharmaceutical composition with the compound or a salt thereof according to claim 11,
wherein the pharmaceutical composition is suitable for treating a kidney disease.
15-16. (canceled)
17. A method for preventing or treating kidney diseases, the method comprising:
administering an effective amount of the compound or a salt thereof according to claim 11 to a subject in need thereof.
18. The compound or a salt thereof according to claim 11 wherein the compound is 3-{({(1R)-6-(4-carbamimidamidobenzoyl)oxy-1,2,3,4-tetrahydronaphthalen-1-yl}acetyl)(carboxymethyl)aminomethyl}benzoic acid.
19. The compound or a salt thereof according to claim 11 wherein the compound is 4-{({6-(4-carbamimidamidobenzoyl)oxy-1,2,3,4-tetrahydronaphthalen-2-yl}carbonyl)(carboxymethyl)aminomethyl}thiophene-2-carboxylic acid.
20. The compound or a salt thereof according to claim 11 wherein the compound is 3-{({5-(4-carbamimidamidobenzoyl)oxy-2,3-dihydro-1H-inden-1-yl}acetyl)(carboxymethyl)aminomethyl}benzoic acid.