1. An implantable drug delivery device for intraocular delivery comprising:
(a) a non-deformable, non-degradable, substantially linear shaped body member for housing a polymeric matrix comprising one or more pharmaceutically active agents and being implanted within a patient’s eye during use of the device to deliver the one or more pharmaceutically active agents to the patient’s eye;
(b) a delivery mechanism for delivery of the one or more pharmaceutically active agents; and
(c) a cap element that remains external to the eye and mates against the outer surface.
2. The implantable drug delivery device of claim 1, wherein the non-deformable, non-degradable, substantially linear shaped body member comprises a material having a Youngs Modulus of at least about 1 GPa.
3. The implantable drug delivery device of claim 1, wherein the non-deformable, non-degradable, substantially linear shaped body member comprises a material selected from steel, titanium, ceramic, ultra-high molecular weight polyethylene (UHMWPE), polymethylmethacrylate (PMMA) and polyether ether ketone (PEEK).
4. The implantable drug delivery device of claim 1, wherein the non-deformable, non-degradable, substantially linear shaped body member comprises stainless steel.
5. The implantable drug delivery device of claim 1, wherein the non-deformable, non-degradable, substantially linear shaped body member comprises a cobalt-chromium-molybdenum alloy.
6. The implantable drug delivery device of claim 1, wherein the polymeric matrix comprises a biodegradable or a non-biodegradable homo- or co-polymer.
7. The implantable drug delivery device of claim 6, wherein the polymeric matrix comprises a biodegradable homo- or co-polymer selected from the group consisting of poly(lactide)s, poly(glycolide)s, poly(lactide-co-glycolide)s, poly(lactic acid)s, poly(lactic acid-co-glycolic acid)s, polycaprolactones, polycarbonates, poly(ester amide)s, polyanhydrides, poly(amino acid)s, polyorthoesters, polyacetals, polycyanoacrylates, poly(ether ester)s, polydioxanones, poly(alkylene alkylate)s, copolymers of poly(ethylene glycol) and polyorthoesters, biodegradable polyurethanes and blends and copolymers thereof.
8. The implantable drug delivery device of claim 1, wherein the polymeric matrix comprises a poly(lactic acid-co-glycolic acid) copolymer.
9. The implantable drug delivery device of claim 1, wherein the one or more pharmaceutically active agents is selected from the group consisting of an anti-glaucoma agent, anti-cataract agent, anti-diabetic retinopathy agent, thiol cross-linking agent, anti-cancer agent, immune modulator agent, anti-clotting agent, anti-tissue damage agent, anti-inflammatory agent, anti-fibrous agent, non-steroidal anti-inflammatory agent, antibiotic, anti-pathogen agent, piperazine derivative, cycloplegic agent, miotic agent, mydriatic agent and mixtures thereof.
10. The implantable drug delivery device of claim 1, wherein the cap element mates the non-deformable, non-degradable, substantially linear shaped body member at a proximal end of the device.
11. The implantable drug delivery device of claim 1, wherein the non-deformable, non-degradable, substantially linear shaped body member has a conical shape at a distal end of the device.
12. The implantable drug delivery device of claim 1, wherein the delivery mechanism comprises one or more openings along the non-deformable, non-degradable, substantially linear shaped body member.
13. The implantable drug delivery device of claim 12, wherein the size andor number of the one or more openings controls the rate of delivery of the one or more pharmaceutically active agents.
14. The implantable drug delivery device of claim 1, wherein the delivery mechanism comprises a permeable or semi-permeable material forming at least a portion of the non-deformable, non-degradable, substantially linear shaped body member.
15. A method of treating an ophthalmic state, disease, disorder, injury or condition, the method comprising:
(a) providing a drug delivery device comprising (i) a non-deformable, non-degradable, substantially linear shaped body member for housing a polymeric matrix comprising one or more pharmaceutically active agents to be delivered; (ii) a delivery mechanism for delivery of the one or more pharmaceutically active agents; and (iii) a cap element that remains external to the eye and mates against the outer surface of the patient’s eye while the substantially linear shaped body member is inserted into the eye; and
(b) inserting the device into a patient’s eye.
16. The method of claim 15, wherein the step of administering comprises:
creating an incision within an eye; and
inserting the drug delivery device through the incision until the cap element mates against the outer surface of the patient’s eye.
17. The method of claim 15, wherein the non-deformable, non-degradable, substantially linear shaped body member comprises a material having a Youngs Modulus of at least about 1 GPa.
18. The method of claim 15, wherein the non-deformable, non-degradable, substantially linear shaped body member comprises a material selected from steel, titanium, ceramic, ultra-high molecular weight polyethylene (UHMWPE), polymethylmethacrylate (PMMA) and polyether ether ketone (PEEK).
19. The method of claim 15, wherein the polymeric matrix comprises a biodegradable or non-biodegradable homo- or co-polymer.
20. The method of claim 15, wherein the polymeric matrix comprises a biodegradable homo- or co-polymer selected from the group consisting of poly(lactide)s, poly(glycolide)s, poly(lactide-co-glycolide)s, poly(lactic acid)s, poly(lactic acid-co-glycolic acid)s, polycaprolactones, polycarbonates, poly(ester amide)s, polyanhydrides, poly(amino acid)s, polyorthoesters, polyacetals, polycyanoacrylates, poly(ether ester)s, polydioxanones, poly(alkylene alkylate)s, copolymers of poly(ethylene glycol) and polyorthoesters, biodegradable polyurethanes and blends and copolymers thereof.
21. The method of claim 15, wherein the polymeric matrix comprises a poly(lactic acid-co-glycolic acid) copolymer.
22. The method of claim 15, wherein the one or more pharmaceutically active agents is selected from the group consisting of an anti-glaucoma agent, anti-cataract agent, anti-diabetic retinopathy agent, thiol cross-linking agent, anti-cancer agent, immune modulator agent, anti-clotting agent, anti-tissue damage agent, anti-inflammatory agent, anti-fibrous agent, non-steroidal anti-inflammatory agent, antibiotic, anti-pathogen agent, piperazine derivative, cycloplegic agent, miotic agent, mydriatic agent and mixtures thereof.
23. The method of claim 15, wherein the non-deformable, non-degradable, substantially linear shaped body member of the device has a conical shape at a distal end of the device.
24. The method of claim 15, wherein the delivery mechanism comprises one or more openings along the non-deformable, non-degradable, substantially linear shaped body member.
25. The method of claim 15, wherein the size andor number of the one or more openings controls the rate of delivery of the one or more pharmaceutically active agents.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A system, comprising:
a back pressure valve configured to mount in a bore of a mineral extraction system, wherein the back pressure valve comprises:
a body; and
a valve disposed in a valve bore extending through the body, wherein the valve is configured to move along a first path of travel between an open position and a closed position relative to a valve seat;
a lock coupled to the body separate from the valve, wherein the lock is configured to move along a second path of travel between an unlocked position and a locked position relative to the bore to selectively unlock and lock the back pressure valve in the bore of the mineral extraction system, wherein the back pressure valve is configured to seat in the bore and lock in the bore via the lock in response to a first axial force in a single first direction delivered via a single retrievable tool, wherein the single retrievable tool is configured to be retrieved from the bore after seating and locking the back pressure valve in the bore.
2. The system of claim 1, wherein the valve comprises a plunger configured to move along the first path of travel in an axial direction relative to a central axis of the back pressure valve.
3. The system of claim 1, comprising the single retrievable tool configured to couple to the back pressure valve and configured to transmit the first axial force in the single first direction.
4. The system of claim 1, wherein the lock is configured to move along the second path of travel in a radial direction relative to a central axis of the back pressure valve, the unlocked position has the lock disposed out of a locking groove in the bore of the mineral extraction system, and the locked position has the lock disposed in the locking groove in the bore of the mineral extraction system.
5. The system of claim 4, wherein the lock comprises a plurality of lock segments disposed circumferentially about the back pressure valve.
6. The system of claim 4, wherein the back pressure valve comprises a sleeve configured to move in an axial direction from a first position to a second position to cause the lock to move along the second path of travel in the radial direction from the unlocked position to the locked position.
7. The system of claim 6, wherein the sleeve comprises a first tapered portion configured to engage a second tapered portion of the lock.
8. The system of claim 6, wherein the sleeve is configured to axially overlap the lock in the locked position and block movement of the lock along the second path of travel in the radial direction from the locked position to the unlocked position.
9. The system of claim 6, wherein the sleeve is coupled to the body via one or more shear structures configured to shear in response to the first axial force in the single first direction.
10. The system of claim 6, wherein the body comprises a spring loaded pin configured to engage a latch groove in the sleeve in the second position of the sleeve.
11. The system of claim 1, wherein the back pressure valve comprises one or more shear structures configured to couple to the single retrievable tool, and the one or more shear structures are configured to shear in response to the first axial force.
12. A system, comprising:
a back pressure valve running tool configured to couple to a back pressure valve having a valve configured to move along a first path of travel between an open position and a closed position relative to a valve seat, wherein the back pressure valve running tool is configured to drive a lock of the back pressure valve to move along a second path of travel from an unlocked position to a locked position relative to a bore of a mineral extraction system, wherein the back pressure valve running tool is configured to transmit a first axial force in a single first direction to seat the back pressure valve in the bore and lock the back pressure valve in the bore via the lock, wherein the back pressure valve running tool is configured to be retrieved from the bore after seating and locking the back pressure valve in the bore.
13. The system of claim 12, wherein the back pressure valve running tool, comprises:
a tool body;
a tool plunger; and
a spring disposed between the tool body and the tool plunger, wherein the spring biases the tool plunger to an extended position.
14. The system of claim 13, wherein the tool plunger is configured to bias the valve of the back pressure valve toward the open position.
15. The system of claim 14, wherein the tool plunger comprises a recess having a depth that is less than a height of a stem of the valve of the back pressure valve.
16. The system of claim 13, wherein the back pressure valve running tool is configured to slide axially relative to the back pressure valve and the tool plunger.
17. The system of claim 12, wherein the back pressure valve running tool comprises one or more shear structures configured to couple to the back pressure valve, and the one or more shear structures are configured to shear in response to the first axial force.
18. The system of claim 12, wherein the back pressure valve running tool is configured to drive a sleeve to move in an axial direction from a first position to a second position to cause the lock to move along the second path of travel in a radial direction from the unlocked position to the locked position.
19. A system, comprising:
a back pressure valve retrieval tool configured to couple to a back pressure valve having a valve configured to move along a first path of travel between an open position and a closed position relative to a valve seat, wherein the back pressure valve retrieval tool is configured to drive a lock of the back pressure valve to move along a second path of travel from a locked position to an unlocked position relative to a bore of a mineral extraction system, wherein the back pressure valve retrieval tool is configured to transmit an axial retrieval force in a single retrieval direction to unlock the back pressure valve from the bore via the lock and extract the back pressure valve from the bore.
20. The system of claim 19, wherein the single retrieval direction is opposite from a single installation direction, wherein an axial installation force in the single installation direction is configured to seat the back pressure valve in the bore and lock the back pressure valve in the bore via the lock.
21. The system of claim 19, wherein the back pressure valve retrieval tool is configured to unlock and extract the back pressure valve in a single trip.
22. The system of claim 19, wherein the back pressure valve retrieval tool comprises a radial lock configured to engage a recess in the back pressure valve, and the back pressure valve retrieval tool is configured to drive the radial lock to move along a third path of travel from a locked tool position to an unlocked tool position relative to the recess.
23. The system of claim 22, wherein the back pressure valve retrieval tool is configured to transmit an axial locking force in a single locking direction to drive the radial lock to move along the third path of travel from the locked tool position to the unlocked tool position, wherein the single locking direction and the single retrieval direction are opposite from one another.
24. The system of claim 19, wherein the back pressure valve retrieval tool is configured to bias the valve of the back pressure valve toward the open position.