What is claimed is:
1. A method for inhibiting the cyclooxygenase enzyme COX-2 comprising administering a composition comprising a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids.
2. The method of claim 1 wherein said Free-B-Ring flavonoid is selected from the group of compounds having the following structure:
4
wherein
R1, R2, R3, R4, and R5 are independently selected from the group consisting of H, OH, SH, OR, SR, NH2, NHR, NR2, NR3X, a carbon, oxygen, nitrogen or sulfur, glycoside of a single or a combination of multiple sugars including, aldopentoses, methy-laldopentose, aldohexoses, ketohexose and their chemical derivatives thereof;
wherein
R is an alkyl group having between 1-10 carbon atoms; and
X is selected from the group of pharmaceutically acceptable counter anions including, hydroxyl, chloride, iodide, sulfate, phosphate, acetate, fluoride and carbonate.
3. The method of claim 1 wherein said Free-B-Ring flavonoid is obtained by organic synthesis.
4. The method of claim 1 wherein said Free-B-Ring flavonoid is isolated from a plant part.
5. The method of claim 4 wherein said plant is selected from a family consisting of Annonaceae, Asteraceae, Bignoniaceae, Combretaceae, Compositae, Euphorbiaceae, Labiatae, Lauranceae, Leguminosae, Moraceae, Pinaceae, Pteridaceae, Sinopteridaceae, Ulmaceae and Zingiberacea.
6. The method of claim 4 wherein said plant is selected from a genus consisting of Desmos, Achyrocline, Oroxylum, Buchenavia, Anaphalis, Cotula, Gnaphalium, Helichrysum, Centaurea, Eupatorium, Baccharis, Sapium, Scutellaria, Molsa, Colebrookea, Stachys, Origanum, Ziziphora, Lindera, Actinodaphne, Acacia, Derris, Glycyrrhiza, Millettia, Pongamia, Tephrosia, Artocarpus, Ficus, Pityrogramma, Notholaena, Pinus, Ulmus and Alpinia.
7. The method of claim 4 wherein the Free-B-Ring flavonoid is isolated from a plant part selected from the group consisting of stems, stem barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves and other aerial parts.
8. A method for preventing and treating COX-2 mediated diseases and conditions comprising administering to a host in need thereof an effective amount of a composition comprising a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.
9. The method of claim 8 wherein said Free-B-Ring flavonoid is selected from the group of compounds having the following structure:
5
wherein
R1, R2, R3, R4, and R5 are independently selected from the group consisting of H, OH, SH, OR, SR, NH2, NHR, NR2, NR3X, a carbon, oxygen, nitrogen or sulfur, glycoside of a single or a combination of multiple sugars including, aldopentoses, methyl-aldopentose, aldohexoses, ketohexose and their chemical derivatives thereof;
wherein
R is an alkyl group having between 1-10 carbon atoms; and
X is selected from the group of pharmaceutically acceptable counter anions including, hydroxyl, chloride, iodide, sulfate, phosphate, acetate, fluoride and carbonate.
10. The method of claim 8 wherein said Free-B-Ring flavonoid is obtained by organic synthesis.
11. The method of claim 8 wherein said Free-B-Ring flavonoid is isolated from a plant part.
12. The method of claim 11 wherein said plant is selected from a family consisting of Annonaceae, Asteraceae, Bignoniaceae, Combretaceae, Compositae, Euphorbiaceae, Labiatae, Lauranceae, Leguminosae, Moraceae, Pinaceae, Pteridaceae, Sinopteridaceae, Ulmaceae and Zingiberacea.
13. The method of claim 11 wherein said plant is selected from a genus consisting Desmos, Achyrocline, Oroxylum, Buchenavia, Anaphalis, Cotula, Gnaphalium, Helichrysum, Centaurea, Eupatorium, Baccharis, Sapium, Scutellaria, Molsa, Colebrookea, Stachys, Origanum, Ziziphora, Lindera, Actinodaphne, Acacia, Derris, Glycyrrhiza, Millettia, Pongamia, Tephrosia, Artocarpus, Ficus, Pityrogramma, Notholaena, Pinus, Ulmus and Alpinia.
14. The method of claim 11 wherein the Free-B-Ring flavonoid is isolated from the plant part selected from the group consisting of stems, stem barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers and other reproductive organs, leaves and other aerial parts.
15. The method of claim 8 wherein the COX-2 mediated disease or condition is selected from the group consisting of inflammation associated with osteoarthritis, rheumatoid arthritis, menstrual cramps, Systemic Lupus Erythromatosis, psoriasis, chronic tension headache, migraine headaches, inflammatory bowel disease; topical wound and minor inflammation conditions selected from the group consisting of minor abrasions, sunburn and contact dermatitis; and solid cancers.
16. The method of claim 8 wherein the Free-B-Ring flavonoid composition is comprised of 0.01% to 100% of the Free-B-Ring flavanoid.
17. The method of claim 8 wherein the composition is administered in a dosage selected from 0.01 to 200 mgkg of body weight.
18. The method of claim 8 wherein the routes of the administration are selected from the group consisting of oral, topical, suppository, intravenous, and intradermic, intragaster, intramusclar, intraperitoneal and intravenous administration in an appropriate pharmaceutical formula.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An insulation film of a signal transmission line, comprising:
a substrate layer; and
a bonding layer, arranged on the substrate layer, for directly covering metal conductors of the signal transmission line;
wherein the bonding layer is made of a polyolefin copolymer resin or a polyolefin resin mixture.
2. The insulation film of claim 1, wherein the bonding layer is made of an ethylene copolymer resin.
3. The insulation film of claim 2, wherein the bonding layer is made of an ethylene-maleic anhydride copolymer resin.
4. The insulation film of claim 1, wherein the bonding layer is made of a mixture of an ethylene-maleic anhydride copolymer resin and a low-density polyethylene resin.
5. The insulation film of claim 4, wherein a weight ratio of the ethylene-maleic anhydride copolymer resin to the low-density polyethylene resin is between 0.25 and 4.
6. The insulation film of claim 1, wherein the bonding layer further comprises a flame retardant.
7. The insulation film of claim 6, wherein the flame retardant is a phosphorus-based flame retardant, and a weight ratio of the flame retardant to the polyolefin copolymer resin or the polyolefin resin mixture is between 0.1 and 0.8.
8. A signal transmission line, comprising:
a plurality of metal conductors, arranged at intervals;
a first insulation film, comprising:
a first substrate layer; and
a first bonding layer, arranged on the first substrate layer, for directly covering a first side of each of the metal conductors; and
a second insulation film, comprising:
a second substrate layer; and
a second bonding layer, arranged on the second substrate layer, for directly covering a second side of each of the metal conductors opposite to the first side;
wherein the first bonding layer and the second bonding layer are made of a polyolefin copolymer resin or a polyolefin resin mixture.
9. The signal transmission line of claim 8, wherein the first bonding layer and the second bonding layer are made of an ethylene copolymer resin.
10. The signal transmission line of claim 9, wherein the first bonding layer and the second bonding layer are made of an ethylene-maleic anhydride copolymer resin.
11. The signal transmission line of claim 8, wherein the first bonding layer and the second bonding layer are made of a mixture of an ethylene-maleic anhydride copolymer resin and a low-density polyethylene resin.
12. The signal transmission line of claim 11, wherein a weight ratio of the ethylene-maleic anhydride copolymer resin to the low-density polyethylene resin is between 0.25 and 4.
13. The signal transmission line of claim 8, wherein the first bonding layer and the second bonding layer further comprise a flame retardant.
14. The signal transmission line of claim 13, wherein the flame retardant is a phosphorus-based flame retardant, and a weight ratio of the flame retardant to the polyolefin copolymer resin or the polyolefin resin mixture is between 0.1 and 0.8.
15. The signal transmission line of claim 8 further comprising a shielding layer for covering the first insulation film and the second insulation film.