1460710555-c8e66703-873d-4350-a750-cfbf28491c8c

1. A transmission comprising:
a gear clutching element;
a shaft having a shaft clutching element detachably engaged to the gear clutching element; and
wherein the shaft clutching element comprises a cone clutch actuated by a ball element that engages a spring element disposed through a passageway in the shaft.
2. The transmission of claim 1 wherein the cone clutch comprises first and second cone halves each half with teeth elements on an interior surface engaging the shaft.
3. The transmission of claim 2 wherein said interior surface of the shaft clutching element has an annulus for receiving the ball element to define a neutral position.
4. The transmission of claim 3 wherein when actuated the ball element moves from the annulus to define a first clutched position such that an exterior surface of the shaft clutching element engages the gear clutching element.
5. The transmission of claim 4 wherein the exterior surface has a centrally located actuating groove.
6. The transmission of claim 3 wherein each cone half has an angled cavity that receive wedges that are adjacent and spaced apart from the gear clutching element when the shaft clutching element is in the neutral position.
7. The transmission of claim 6 wherein a removable stop constrains a wedge axially.
8. The transmission of claim 6 wherein a wire spring clip constrains a wedge radially to resist centrifugal force.
9. The transmission of claim 6 wherein the shaft clutching element has at least one circumferential stop to resist movement of the shaft clutching element.
10. The transmission of claim 6 wherein the wedges have a plurality of segments.
11. The transmission of claim 10 wherein an external surface of the shaft clutching element is adjacent to the wedges and is a tapered sided polyhedron with the same number of sides as there are segments.
12. The transmission of claim 1 wherein the ball element is contained axially by a spline tooth of the shaft.
13. A self actuating clutch assembly comprising:
a shaft having a passageway disposed therein;
a spring element disposed through the shaft passageway with a ball element at a first end;
a shaft clutching element having first and second cone halves each half with teeth elements on an interior surface engaging the shaft;
said interior surface of the shaft clutching element has a centrally located annulus for receiving the ball element to define a neutral position;
wherein when actuated the ball element moves from the annulus to define a first clutched position such that an exterior surface of the shaft clutching element engages a first gear clutching element.
14. The self actuating clutch of claim 13 wherein the interior surface of the shaft clutching element has a first and second transfer cones.
15. The self actuating clutch of claim 13 wherein the exterior surface has a centrally located actuating groove.
16. The self actuating clutch assembly of claim 13 wherein the shaft clutching element is a cone clutch.
17. A hydromechanical transmission comprising:
a hydraulic pump fluidly connected to a hydraulic motor;
a plurality of gears rotatably connected to the hydraulic pump and hydraulic motor; and
a self actuating clutch assembly having a first gear clutching element associated with a first gear of the plurality of gears and an output shaft having a shaft clutching element that when actuated engages the first gear clutching element; and
wherein the shaft clutching element comprises a cone clutch actuated by a ball element that engages a spring element disposed through a passageway in the output shaft.
18. The hydromechanical transmission of claim 17 wherein the shaft clutching element self actuates between a first position in engagement with the first gear clutching element and a second position in engagement with a second gear clutching element.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A compound of Formula Va:
or a pharmaceutically acceptable salt thereof;
wherein
each R1 is, independently at each occurrence, halo, OH, \u2014C1-C6 alkyl, or \u2014O\u2014C1-C6 alkyl, wherein the alkyl groups are optionally substituted 1-3 times with halo or OH;
each R2 is, independently at each occurrence, halo, OH, \u2014C1-C6 alkyl, or \u2014O\u2014C1-C6 alkyl, wherein the alkyl groups are optionally substituted 1-3 times with halo or OH;
x is 2 or 3;
Cy is
and R11 is, independently at each occurrence, \u2014OH, halo, \u2014C1-C6 alkyl, \u2014OC(O)CH3, or \u2014H2PO4, wherein n and m are 1, 2, or 3, and at least one R11 is
2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein each R1 is, independently at each occurrence, halo.
3. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein each R2 is, independently at each occurrence, halo or \u2014C1-C6 alkyl, wherein the alkyl is optionally substituted 1-3 times with halo.
4. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from:
5. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.
6. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is