1. A system for an engine comprising:
a housing having a filter cavity;
a filter element positioned within said filter cavity;
a cover member removably attached to said housing; and
a diverter member positioned between said filter element and a duct of said engine.
2. The system of claim 1, wherein said diverter member extends downward from said cover member.
3. The system of claim 1, wherein said cover member includes a lip positioned along an edge of said cover member.
4. The system of claim 1, wherein said cover member includes a flow directing portion adapted to direct a flow from said duct downward and toward said filter element.
5. The system of claim 1, further comprising an adapter positioned such that an upstream end of said adapter is coupled to a back end of said filter element; and a mass airflow sensor pad operationally connected to said adapter.
6. The system of claim 5, wherein an inner diameter of said adapter towards said upstream end is greater than an inner diameter of said adapter towards a downstream end.
7. The system of claim 6, wherein said adapter includes at least one angle for reducing said inner diameter.
8. The system of claim 1, wherein an edge of said cover member is designed to follow the profile of said duct.
9. The system of claim 1, wherein said diverter member is attached to said housing.
10. The system of claim 1, wherein a distance between said filter element and said diverter member is between about 0.5 inches and about 2.0 inches.
11. A system for an engine comprising:
a housing;
an inverted-top cone filter positioned within said housing;
an adapter clamped to a back end of said inverted-top cone filter; and
a cover assembly removably attached to said housing.
12. The system of claim 11, wherein said cover assembly comprises a cover member and a diverter member extending downward from said cover member.
13. The system of claim 12, wherein said diverter member is integral to said cover member.
14. The system of claim 12, wherein said diverter member is positioned between said inverted-top cone filter and a duct of said engine.
15. The system of claim 11, wherein said housing includes at least one hole for bolting said housing to said adapter.
16. The system of claim 11, further comprising a mass airflow sensor pad operationally connected to said adapter.
17. The system of claim 16, wherein said mass airflow sensor pad is welded to said adapter.
18. The system of claim 11, wherein said adapter comprises a metal.
19. A system for a vehicle comprising:
a housing bolted to a chassis of said vehicle;
a filter element positioned within a filter cavity of said housing;
an adapter clamped to said filter element;
a cover member in contact with said housing, said cover member having an upwardly bent edge; and
a diverter member extending from said cover member and into said filter cavity.
20. The system of claim 19, wherein said adapter is coupled to a plenum box tube of said vehicle.
21. The system of claim 19, wherein cover member includes a flow directing portion.
22. The system of claim 19, wherein said diverter member and said cover member form a diverter angle between about 5\xb0 and about 90\xb0.
23. An assembly for a filtration system comprising:
a housing;
a cover member removably attached to said housing; and
a diverter member extending downward from said cover member.
24. The assembly of claim 23, wherein said cover member includes a lip extending upward along an edge of said cover member, said lip adapted to direct a supply of external air into said housing.
25. The assembly of claim 23, wherein said cover member includes a flow directing portion.
26. The assembly of claim 25, wherein said flow directing portion is positioned over a filter element of said filtration system, said flow directing portion adapted to direct a supply of duct airflow downward and toward said filter element.
27. A system for a vehicle comprising:
a powder-coated steel housing bolted to a chassis of said vehicle;
an inverted-top cone filter positioned within a filter cavity of said powder-coated steel housing;
an aluminum adapter having an inlet opening at an upstream end and an outlet opening towards a downstream end, said aluminum adapter including a flow path extending from said inlet opening to said outlet opening, said aluminum adapter clamped to said inverted-top cone filter, said aluminum adapter including at least one angle such that an inner diameter towards said upstream end is greater than an inner diameter towards said downstream end;
a mass airflow sensor pad operationally connected to said aluminum adapter;
a cover member removably attached to said powder-coated steel housing, said cover member having an upwarding extending lip and a flow directing portion; and
a diverter member connected to said cover member, said diverter member extending downward into said filter cavity, said diverter member positioned between said inverted-top cone filter and a duct of said vehicle.
28. A method of providing a supply of filtered air to a vehicle engine comprising the steps of:
passing a supply of duct airflow from a duct of said vehicle and into a housing;
directing said duct airflow downward towards a filter element within said housing;
reducing the velocity of said duct airflow; and
passing said duct airflow through said filter element to produce said supply of filtered air.
29. The method of claim 28, wherein said step of directing said duct airflow comprises passing said duct airflow along a flow directing portion of a cover assembly, said cover assembly removably attached to said housing.
30. The method of claim 28, wherein said step of reducing the velocity of said duct airflow comprises passing said duct airflow such that said duct airflow contacts a diverter member of a cover assembly, said cover assembly removably attached to said housing.
31. The method of claim 28, wherein said step of passing a supply of duct airflow from a duct comprises passing said duct airflow such that said duct airflow passes between a cover assembly and said housing.
33. The method of claim 29, further comprising the steps of:
passing a supply of external air into said housing from an area external to a front end of said housing; and
passing said external air through said filter element to produce at least a portion of said supply of filtered air.
34. The method of claim 33, wherein said passing a supply of external air may comprise passing said external air between said housing and a lip of a cover assembly, said cover assembly removably attached to said housing.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An isolated tumor suppressor gene product, comprising SEQ ID N 202 or a functional fragment, variant or fusion protein thereof.
2. A functional fragment of a tumor suppressor gene product according to claim 1, whereby said functional fragment comprises at least SEQ ID N 2 or SEQ ID N 161.
3. A variant of a tumor suppressor gene product according to claim 1, whereby said variant comprises at least a sequence selected from the group consisting of SEQ ID N 167, 169, 171, 173, 175, 177, 179, 181, 183, 185, 187, 189, 191, 193, 195, 197, 198 and 200.
4. A fusion protein of a tumor suppressor gene product according to claim 1, whereby said fusion product comprises SEQ ID N 163 or SEQ ID N 165.
5. An isolated nucleic acid encoding a tumor suppressor gene product or a tumor suppressor gene product fragment, variant, or fusion product according to claim any of the claims 1-4.
6. An isolated nucleic acid according to claim 5, comprising the sequence presented in SEQ ID N 1.
7. An isolated nucleic acid according to claim 5, comprising the sequence presented in SEQ ID N 3.
8. An isolated nucleic acid according to claim 5, comprising the sequence presented in SEQ ID N 4.
9. An isolated nucleic acid according to claim 5, comprising the sequence presented in SEQ ID N 201.
10. An isolated nucleic acid according to claim 5, comprising the sequence presented in SEQ ID N 203.
11. An isolated nucleic acid according to claim 5, comprising the sequence presented in SEQ ID N 160.
12. An isolated nucleic acid according to claim 5, comprising the sequence selected from the group consisting of SEQ ID N 166, 168, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, 196 and 199.
13. An isolated nucleic acid according to claim 5, comprising the sequence presented in SEQ ID N 162 or SEQ ID N 164.
14. The use of a nucleic acid according to any of the claims 5-13, or a nucleic acid with at least 60% identity to said nucleic acid, or a functional fragment thereof in diagnosis of cancer andor prediction of the likelihood of developing cancer.
15. The use of a nucleic acid according to any of the claims 5-12, or a nucleic acid with at least 60% identity to said nucleic acid, or a functional fragment thereof in treatment of cancer.
16. The use of a tumor suppressor gene product, or a functional fragment or a variant thereof according to any of the claims 1 to 4, or a protein with at least 60% identity to said tumor suppressor gene product, for the manufacture of a medicament to treat cancer.
17. The use according to any of the claims 14-16, whereby said cancer is meningioma, colorectal cancer, gastric carcinoma andor breast cancer.
18. The use according to any of the claims 14-16, whereby said cancer is neuroblastoma.
19. The use of a tumor suppressor gene product, or a functional fragment or a variant thereof according to any of the claims 1 to 4, or a protein with at least 60% identity to said tumor suppressor gene product for the generation of micronuclei andor the removal of amplified DNA
20. A method for the production of antibodies against a tumor suppressor gene product, using a tumor suppressor gene product, or a functional fragment, variant or fusion product thereof according to any of the claims 1-4, or a protein with at least 60% identity to said tumor suppressor gene product, or an isolated nucleic acid encoding such polypeptide.
21. An antibody obtainable by the use according to claim 20.
22. The use of an antibody according to claim 21 in diagnosis of cancer andor prediction of the likelihood of developing cancer.
23. The use of an antibody according to claim 22, whereby the cancer is meningioma, colorectal cancer, gastric carcinoma andor breast cancer.
24. The use of an antibody according to claim 22, whereby the cancer is neuroblastoma
25. The use of a tumor suppressor gene product or a functional fragment, variant or fusion product thereof according to any of the claims 1-4, or a protein with at least 60% identity to said tumor suppressor gene product, for the isolation of an interacting compound.