What is claimed:
1. A compound of the formula (I): (I)
17
wherein:
Y is a moiety selected from NR or (CH2)n;
wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1;
18
represents (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, CONH2, CONH(C1-C6) lower alkyl, CON(C1-C6) lower alkyl2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy;
19
represents (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, CONH2, CONH(C1-C6) lower alkyl, CON(C1-C6) lower alkyl2; (2) a 5-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, (C1-C6) lower alkoxy, or halogen; or (3) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen, or (C1-C6) lower alkoxy;
or a pharmaceutically acceptable salt, or pro-drug form thereof.
2. A compound of formula (II)
20
wherein:
21
represents a 5-membered aromatic (unsaturated) heterocyclic ring having one sulfur atom, optionally substituted by (C1-C6) lower alkyl, halogen, or (C1-C6) lower alkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof.
3. A compound according to claim 1 which is 10-(4-cyclohexyl-benzoyl)-10,11-dihydro-5H-pyrrolo 2,1-c1,4benzodiazepine.
4. A compound according to claim 1 which is (4-cyclohexyl-phenyl)-(5,11-dihydro-pyrido2,3-b1,5benzodiazepin-6-yl)-methanone, or a pharmaceutically acceptable salt form thereof.
5. A compound according to claim 1 which is (4-cyclohexyl-phenyl)-(5,11-dihydro-11-methyl-5H-pyrido 2,3-b1,5benzodiazepin-6-yl)-methanone, or a pharmaceutically acceptable salt form thereof.
6. A compound according to claim 1 which is (4-cyclohexyl-phenyl)-(5,11-dihydro-11-ethyl-5H-pyrido2,3-b1,5benzodiazepin-6-yl)-methanone, or a pharmaceutically acceptable salt thereof.
7. A compound according to claim 1 which is (4-cyclohexyl-phenyl)-(5,11-dihydro-10H-dibenzob,e1,4diazepin-10-yl)methanone.
8. A compound according to claim 1 which is (4-cyclohexyl-phenyl)-(5,11-dihydro-5-methyl-10H-dibenzo b,e1,4diazepin-10-yl)-methanone.
9. A compound according to claim 1 which is (4-cyclohexyl-phenyl)-(4H,10H-3a,5,9-triaza-benzofazulen-9-yl)-methanone, or a pharmaceutically acceptable salt thereof.
10. A compound of claim 2 which is (4-cyclohexyl-phenyl)-(5,6,7,8-tetrahydro-thieno3,2-bazepin-4-yl)-methanone.
11. A method of treating disorders which are remedied or alleviated by vasopressin agonist activity in a mammal, the method comprising administering to the mammal in need thereof a pharmaceutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt, or prodrug form thereof.
12. The method of claim 11 wherein the disorder which is remedied or alleviated by vasopressin agonist activity is selected from the group of diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, or bleeding and coagulation disorders.
13. A method of inducing temporary delay of urination in a mammal, the method comprising administering to a mammal in need thereof a pharmaceutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt, or prodrug form thereof.
14. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A fastener member (1) for fastening a dispenser member (4) on a fluid reservoir, said fastener member (1) comprising a fastener ring (2) and a covering hoop (3), the fastener ring (2) including reception means (24) for receiving the dispenser member (4), and fastener means (211) for fastening on the reservoir, the covering hoop (3) being mounted by axial engagement around the ring (2) in such a manner as to mask it at least in part, the hoop (3) including hook means (35) co-operating with retention means (225) formed by the ring (2), said hook means (35) include means (351, 352) for preventing the hoop (3) from rotating around the ring (2) and means (352) for preventing the hoop (3) from moving in axial translation, and thereby becoming axially disengaged from the ring (2), the retention means formed by the ring (2) including at least one retention housing (225) that is accessible by axial engagement, said means for preventing both turning and movement in translation co-operating with the retention housing (225), the means for preventing movement in translation including at least one barb profile (352) adapted to bite into the housing, wherein the retention housing (225) is defined by two opposite, vertical, longitudinal walls (224), the hook means (35) being engaged with said walls (224).
2. A fastener member according to claim 1, in which the means for preventing turning include at least one fastener element (35) that is axially engaged in the retention housing (225).
3. A fastener member according to claim 2, in which the barb profile (352) is formed by the fastener element (35).
4. A fastener member according to claim 1, in which the ring (2) includes a bushing (22) defining a free end (221), the bushing forming said at least one retention housing (225), the hoop (3) including a free bottom end (32), and a top end (33) forming an inwardly-directed rim (34), the hook means (35) being connected to said rim and pointing substantially towards the bottom end (32) of the hoop in such a manner that the hook means (35) penetrates into the retention housing (225) while the hoop (3) is being mounted, by axial engagement, on the ring (2).
5. A fastener member according to claim 4, in which the hook means (35) reaches a final fastening position in its retention housing (225) when the inwardly-directed rim (34) comes into abutment against the free end (221) of the bushing (22).
6. A fastener member according to claim 1, in which the barb profile (352) is adapted to bite into at least one of said walls (224).
7. A fastener member according to claim 1, in which the ring (2) is made of a plastics material, and the hoop (3) is made of metal or of a plastics material that is harder than the plastics material of the ring.
8. The fastener member according to claim 1, further comprising an attached pump or valve.