1. A method comprising:
displaying by a computing system of a radial configuration of time based information in a graphical user interface of said computing system; and
displaying by said computing system of a graphical object representative of an event together with said radial configuration of time based information in said graphical user interface;
wherein a position of said graphical object relative to said radial configuration of time based information is configured to indicate a relationship between said event and said time based information.
2. The method of claim 1, wherein said radial configuration of time based information comprises a visual representation of an analog clock face, and said graphical object comprises a tab positioned along a perimeter of said analog clock face.
3. The method of claim 2, further comprising displaying by said computing system of a radial color band configured to indicate past time, present time, and future time along said perimeter of said analog clock face, wherein said color band is configured to update based on a passage of time.
4. The method of claim 1, wherein said radial configuration of time based information comprises a timeline spirally disposed about at least one axis point, said graphical object positioned along a section of said timeline.
5. The method of claim 1, wherein said graphical object is one of a plurality of graphical objects representative of a plurality of events of distinct types, and wherein said method further comprises:
displaying by said computing system of said plurality of graphical objects in said graphical user interface, said plurality of graphical objects including a plurality of visual indicators indicating said distinct types.
6. The method of claim 5, wherein said plurality of events of distinct types includes at least two of a communication event, a calendar event, a past event, a present event, and a future event.
7. The method of claim 1, further comprising updating by said computing system of said display of said radial configuration of time based information and said graphical object in said graphical user interface based on a passage of time.
8. The method of claim 7, wherein said passage of time comprises an artificial passage of time controlled by user input.
9. The method of claim 1, further comprising:
detecting by said computing system of a user selection of said graphical object; and
displaying by said computing system of information descriptive of said event in said graphical user interface in response to said user selection of said graphical object.
10. The method of claim 1, further comprising displaying by said computing system of a pop-up window in said graphical user interface, said pop-up window including at least one of information descriptive of said event and a plurality of selectable options associated with said event.
11. The method of claim 1, further comprising displaying by said computing system of an extension object extending from said graphical object, said extension object displaying at least one of information descriptive of said event and at least one actionable option associated with said event.
12. The method of claim 11, wherein said displaying by said computing system of said extension object is performed based on a proximity of said graphical object to a position representative of present time in said radial configured of time based information.
13. The method of claim 1, further comprising visually modifying by said computing system of said graphical object based on a proximity of said graphical object to a position representative of present time in said radial configured of time based information.
14. The method of claim 1, wherein said radial configuration of time based information comprises a timeline having a first section spirally disposed about a first axis point and a second section spirally disposed about a second axis point.
15. The method of claim 14, wherein said first section of said timeline represents future time based information and said second section of said timeline represents past time based information, and wherein said first section and said second section of said timeline are connected together at a location representing present time based information.
16. The method of claim 15, further comprising displaying by said computing system of graphics representative of a horizon between said first section and said second section of said timeline, said location positioned along said horizon, wherein said horizon comprises a linear timeline representative of a same time period as represented by said timeline.
17. The method of claim 16, further comprising displaying by said computing system of a selectable object at said location, said selectable object being moveable along said horizon.
18. The method of claim 17, further comprising:
detecting by said computing system of movement of said selectable object along said horizon; and
graphically scrolling by said computing system of said timeline in accordance with said movement.
19. The method of claim 18, wherein when said movement is in a first direction along said horizon said scrolling includes graphically unwinding said timeline from about said first axis point and correspondingly graphically winding said timeline about said second axis point, and wherein when said movement is in a second direction along said horizon said scrolling includes graphically winding said timeline about said first axis point and correspondingly graphically unwinding said timeline from about said second axis point.
20. The method of claim 18, wherein said scrolling of said timeline is representative of an artificial passage of time and is performed in response to user input causing said movement of said selectable object along said horizon, the method further comprising displaying by said computing system of a second timeline representative of actual time together with said timeline representative of said artificial passage of time in said graphical user interface.
21. The method of claim 1, tangibly embodied as computer-executable instructions on at least one computer-readable medium.
22. A method comprising:
displaying by a computing system of a radial configuration of time based information in a graphical user interface of said computing system, said radial configuration of time based information including a timeline having a first section spirally coiled about a first axis point and a second section spirally coiled about a second axis point; and
displaying by said computing system of a plurality of graphical objects representative of a plurality of events at various positions along said timeline;
wherein said positions of said graphical objects along said timeline indicate relationships between said events and said time based information.
23. The method of claim 22, wherein said first section of said timeline represents future time based information and said second section of said timeline represents past time based information.
24 The method of claim 22, wherein said plurality of graphical objects representative of said plurality of events includes a first subset of said graphical objects representative of a first subset of said events and a second subset of said graphical objects representative of a second subset of said events, said first subset of said events being future events and said second subset of said events being past events.
25. The method of claim 24, wherein said first subset of said graphical objects are visually associated with said first section of said timeline and said second subset of said graphical objects are visually associated with said second section of said timeline in said graphical user interface.
26. A system comprising:
a user interface facility configured to provide a graphical user interface for display; and
a radial time facility configured to
provide data representing a radial configuration of time based information to said user interface facility for inclusion in said graphical user interface, and
provide data representing a graphical object representative of an event to said user interface facility for inclusion together with said radial configuration of time based information in said graphical user interface;
wherein a position of said graphical object relative to said radial configuration of time based information in said graphical user interface is configured to indicate a relationship between said event and said time based information.
27. The system of claim 26, wherein said radial configuration of time based information comprises one of
a visual representation of an analog clock face, and
a visual representation of a timeline spirally disposed about at least one axis point.
28. The system of claim 26 implemented on a mobile phone device.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound represented by the formula (I)
wherein
X is a fluorine atom;
R is a hydrogen atom or alkyl;
R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms;
R2 is alkyl optionally substituted by 1 or 2 substituents selected from the group consisting of a halogen atom and hydroxyl; alkoxy; haloalkoxy; a chlorine atom; cyano; cyclopropyl; nitro; amino; formyl; alkenyl or alkynyl; or
R1 and R2 are bonded to form a 5- or 6-membered ring optionally substituted by alkyl;
R3 is
(1) a fused heterocyclic group of the formula
wherein
represents a single bond or a double bond,
X1 is C(R5) or N,
R4 is a hydrogen atom or alkyl, and
R5 is (a) a hydrogen atom,
(b) a halogen atom,
(c) cyano,
(d) nitro,
(e) hydroxy,
(f) alkyl optionally substituted by 1 to 3 halogen atoms,
(g) alkenyl or alkynyl,
(h) aryl, or
(i) alkoxy optionally substituted by 1 to 3 halogen atoms,
when X1 is C(R5), R4 and R5 are optionally bonded to form a 5- or 6-membered ring optionally substituted by oxo, said fused heterocyclic group is optionally substituted by 1 or 2 substituents selected from the group consisting of a halogen atom, cyano, nitro, hydroxy and alkyl,
(2) a group of the formula
wherein
X2 is C(R8) or N, and
R8, R7 and R8 are each independently,
(a) a hydrogen atom,
(b) a halogen atom,
(c) cyano,
(d) nitro,
(e) amino,
(f) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, alkoxy and amino,
(g) alkenyl,
(h) alkynyl,
(i) aryl,
(j) formyl or CH\u2550N\u2014OH,
(k) carboxy,
(l) carbamoyl,
(m) a 5- to 10-membered aromatic heterocyclic group optionally substituted by alkyl, or
(n) alkenyloxy,
(3) a group of the formula
wherein
X3 and X4 are N, or
X3 is N and X4 is CR\u2033, wherein R\u2033 is hydrogen atom, amino, hydroxy, alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of alkoxy and dimethylamino or mercapto, or
X3 is CH and X4 is N,
R\u2032 is a hydrogen atom or alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of substituted hydroxyl and amino, and
R6 is as defined above,
(4) a group of the formula
wherein
represents a single bond or a double bond and R6 is as defined above,
(5) 3-pyridyl optionally substituted by 1 or 2 substituents selected from the group consisting of
(a) a halogen atom,
(b) cyano,
(c) nitro,
(d) hydroxy,
(e) amino,
(f) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, alkylamino, dialkylamino and hydroxy,
(g) alkenyl, alkynyl
(h) aryl,
(i) cycloalkyl,
(j) alkoxy,
(k) alkylamino,
(l) dialkylamino,
(m) phenylamino optionally substituted by 1 to 3 halogen atoms,
(n) a cyclic amino group optionally substituted by alkoxycarbonyl,
(o) formyl,
(p) carbamoyl optionally substituted by alkyl optionally substituted by hydroxy, and
(q) a 5- to 10-membered aromatic heterocyclic group optionally substituted by alkyl,
(6) 4-pyridyl optionally substituted by a halogen atom,
(7) 5-pyrimidinyl optionally substituted by 1 or 2 substituents selected from the group consisting of amino, alkylamino, dialkylamino and carboxy,
(8) 2-indolyl, 3-indolyl, 5-indolyl, 6-indolyl, benzofuranyl, benzothiophenyl, benzoxazolyl or benzothiazolyl, each optionally substituted by 1 or 2 substituents selected from the group consisting of
(a) a halogen atom,
(b) cyano,
(c) nitro,
(d) hydroxy,
(e) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of amino, alkoxycarbonylamino, alkylamino and dialkylamino,
(f) alkoxy,
(g) formyl,
(h) carboxy, and
(j) amino optionally substituted by 1 or 2 substituents selected from the group consisting of
(i) alkoxycarbonyl,
(ii) alkylcarbonyl optionally substituted by a substituent selected from the group consisting of
(A) cycloalkyloxy optionally substituted by 1 to 3 alkyl,
(B) alkylamino,
(C) dialkylamino,
(D) a cyclic amino group optionally substituted by alkoxycarbonyl, and
(E) a halogen atom,
(iii) phenylcarbonyl optionally substituted by 1 to 3 substituents selected from the group consisting of alkyl and alkoxy,
(iv) cycloalkylcarbonyl,
(v) a 5- to 10-membered aromatic heterocyclylcarbonyl group optionally substituted by alkyl optionally substituted by 1 to 3 halogen atoms,
(vi) benzylcarbonyl optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom and alkoxy,
(vii) arylsulfonyl optionally substituted by alkoxy,
(viii) cycloalkylalkylsulfonyl optionally substituted by 1 to 3 substituents selected from the group consisting of alkyl and oxo,
(ix) a 5- to 10-membered aromatic heterocyclylsulfonyl group optionally substituted by 1 to 3 alkyl, and
(x) \u2014C(\u2550N\u2014CN)\u2014SR9 wherein R9 is alkyl,
(9) a group of the formula
wherein
one of Y1, Y2, Y3 and Y4 is N or N+(\u2014O\u2212), and the remaining three are each C(R25), C(R26) and C(R27),
W is O, S, NH or N(R23)
R23 is a hydrogen atom or alkyl, and
R24, R25, R26 and R27 are each independently,
(a) a hydrogen atom,
(b) cyano, or
(c) nitro,
(10) a group of the formula
wherein
R28 is a hydrogen atom or hydroxy, and
R29 is a hydrogen atom or alkyl,
(11) a group of the formula
wherein
X5 is C(R11) or N,
X6 is CH2, C(\u2550O), O, S, SO2 or N(R12),
X7 is CH(R13), C(\u2550O) or N(R14),
X8 is CH(R15) or C(\u2550O),
R10, R12 and R14 are each independently,
(a) a hydrogen atom or
(b) alkyl, and
R11, R13 and R15 are independently,
(a) a hydrogen atom,
(b) a halogen atom,
(c) cyano,
(d) nitro,
(e) amino,
(f) alkylamino,
(g) dialkylamino,
(h) alkyl optionally substituted by hydroxy, or
(i) alkenyl,
when X5 is C(R11), R10 and R11 are optionally bonded to form a 5- or 6-membered ring optionally substituted by alkyl or oxo, and when X6 is N(R12) and X7 is CH(R13), R12 and R13 are optionally bonded to form a 5- or 6-membered ring,
(12) a group of the formula
wherein R16 is
(a) a hydrogen atom,
(b) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of cyano, alkylamino and dialkylamino,
(c) alkenyl optionally substituted by carboxy,
(d) formyl,
(e) carboxy,
(f) carbamoyl,
(g) \u2014C(R17)\u2550N\u2014OH wherein R17 is a hydrogen atom, cyano or hydroxy,
(h) a 5- to 10-membered aromatic heterocyclic group optionally substituted by alkyl, alkoxycarbonyl, carboxy or phenyl, or cyano,
(13) a group of the formula
wherein
R18 is a hydrogen atom or alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom and phenyl,
n is 0 or 1,
R19, R20 and R33 are each independently,
(a) a hydrogen atom,
(b) a halogen atom,
(c) cyano,
(d) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of
(i) a halogen atom
(ii) cyano,
(iii) hydroxy,
(iv) amino,
(v) alkylamino,
(vi) dialkylamino, and
(vii) a cyclic amino group optionally substituted by alkyl,
(e) alkoxy,
(f) amino optionally substituted by 1 or 2 substituents selected from the group consisting of
(i) alkylcarbonyl optionally substituted by a cyclic amino group,
(ii) alkylsulfonyl,
(iii) carbamoyl,
(iv) alkyl, cycloalkyl or cycloalkylalkyl, and
(v) 5- to 10-membered saturated heterocyclic group,
(g) carboxy,
(h) alkoxycarbonyl,
(i) carbamoyl optionally substituted by alkyl optionally substituted by amino, alkylamino, dialkylamino or alkoxycarbonylamino,
(j) formyl,
(k) a 5- to 10-membered aromatic heterocyclic group optionally substituted by alkyl,
(l) \u2014CH\u2550N\u2014OR21 wherein R21 is a hydrogen atom or alkyl optionally substituted by alkylamino or dialkylamino,
(m) nitro,
(n) a 5- to 10-membered saturated heterocyclic group optionally substituted by amino,
(o) phenyl, or
(p) \u2014NHC(SMe)=CHCN,
(14) a group of the formula
wherein
R30 is (a) a hydrogen atom,
(b) a halogen atom,
(c) cyano,
(d) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom and hydroxy,
(e) alkenyl,
(f) alkynyl,
(g) alkoxy,
(h) formyl,
(i) \u2014CH\u2550N\u2014OH, or
(j) carbamoyl,
(15) naphthyl or isochromenyl,
(16) quinolyl or isoquinolyl, or their oxide derivatives,
(17) a group of the formula
(18) a group of the formula
wherein
U is O or S, and
R31 is (a) a hydrogen atom,
(b) a halogen atom,
(c) alkyl optionally substituted by 1 to 3 halogen atoms,
(d) carboxy,
(e) nitro,
(f) cyano, or
(g) amino,
(19) a group of the formula
wherein
R32 is (a) a halogen atom,
(b) phenyl, or
(c) a group of the formula
(20) a group of the formula
wherein
R34 and R35 are each independently,
(a) a hydrogen atom, or
(b) aminoalkyl,
or
R34 and R35 are bonded to form a 6-membered ring optionally substituted by amino or oxo,
(21) a group of the formula
wherein R36 is
(a) a hydrogen atom,
(b) a halogen atom,
(c) nitro, or
(d) thienyl, or
(22) a group of the formula
or a salt thereof,
providing that, when R1 and R2 are bonded to form a 6-membered ring substituted by alkyl, R3 is not 4-pyridyl, quinolyl or isoquinolyl.
2. The compound of claim 1, wherein R3 is a fused heterocyclic group of the formula
wherein , X1 and R4 are as defined in claim 1, and said fused heterocyclic group is optionally substituted by 1 or 2 substituents selected from the group consisting of a halogen atom, cyano, nitro, hydroxy and alkyl, or a salt thereof.
3. The compound of claim 1, wherein R3 is a group of the formula
wherein X2, R6 and R7 are as defined in claim 1, or a salt thereof.
4. The compound of claim 1, wherein R3 is a group of the formula
wherein X3, X4, R6 and R\u2032 are as defined in claim 1, or a salt thereof.
5. The compound of claim 1, wherein R3 is a group of the formula
wherein and R6 are as defined in claim 1, or a salt thereof.
6. The compound of claim 1, wherein R3 is a group of the formula
wherein R22 is
(a) a halogen atom,
(b) cyano,
(c) nitro,
(d) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, alkylamino, dialkylamino and hydroxy,
(e) alkenyl, alkynyl,
(f) aryl,
(g) cycloalkyl,
(h) alkoxy,
(i) formyl, or
(j) carbamoyl optionally substituted by alkyl optionally substituted by hydroxyl, or a salt thereof.
7. The compound of claim 1, wherein R3 is 5-pyrimidinyl substituted by 1 or 2 substituents selected from the group consisting of amino, alkylamino, dialkylamino and carboxy, or a salt thereof.
8. The compound of claim 1, wherein R3 is 2-indolyl optionally substituted by 1 or 2 substituents selected from the group consisting of
(a) a halogen atom,
(b) cyano,
(c) nitro,
(d) hydroxy,
(e) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of amino, alkoxycarbonylamino, alkylamino and dialkylamino,
(f) alkoxy,
(g) formyl,
(h) carboxy, or
(j) amino optionally substituted by 1 or 2 substituents selected from the group consisting of
(i) alkoxycarbonyl,
(ii) alkylcarbonyl optionally substituted by a substituent selected from the group consisting of
(A) cycloalkyloxy optionally substituted by 1 to 3 alkyl,
(B) alkylamino,
(C) dialkylamino,
(D) a cyclic amino group optionally substituted by alkoxycarbonyl, and
(E) a halogen atom,
(iii) phenylcarbonyl optionally substituted by 1 to 3 substituents selected from the group consisting of alkyl and alkoxy,
(iv) cycloalkylcarbonyl,
(v) a 5- to 10-membered aromatic heterocyclylcarbonyl group optionally substituted by alkyl optionally substituted by 1 to 3 halogen atoms,
(vi) benzylcarbonyl optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom and alkoxy,
(vii) arylsulfonyl optionally substituted by alkoxy,
(viii) cycloalkylalkylsulfonyl optionally substituted by 1 to 3 substituents selected from the group consisting of alkyl and oxo,
(ix) a 5- to 10-membered aromatic heterocyclylsulfonyl group optionally substituted by 1 to 3 alkyl, and
(x) \u2014C(\u2550N\u2014CN)\u2014SR9 wherein R9 is alkyl,
or a salt thereof.
9. The compound of claim 1, wherein R3 is a group formula of the
wherein Y1, Y2, Y3, Y4, W and R24 are as defined in claim 1, or a salt thereof.
10. The compound of claim 1, wherein R3 is a group of the formula
wherein R28 and R29 are as defined in claim 1, or a salt thereof.
11. The compound of claim 1, wherein R3 is a group of the formula
wherein X5, X6, X7, X8 and R10 are as defined in claim 1, or a salt thereof.
12. The compound of claim 1, wherein R3 is a group of the formula
wherein R16a is
(a) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of cyano, alkylamino and dialkylamino,
(b) alkenyl optionally substituted by carboxy,
(c) formyl,
(d) carboxy,
(e) carbamoyl,
(f) \u2014C(R17)\u2550N\u2014OH wherein R17 is a hydrogen atom, cyano or hydroxy,
(g) a 5- to 10-membered aromatic heterocyclic group optionally substituted by alkyl, alkoxycarbonyl, carboxy or phenyl, or
(h) cyano,
or a salt thereof.
13. The compound of claim 1, wherein R3 is a group of the formula
wherein
R18a is alkyl, and
R19a is (a) a halogen atom,
(b) cyano,
(c) alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of
(i) a halogen atom,
(ii) cyano,
(iii) hydroxy,
(iv) amino,
(v) alkylamino,
(vi) dialkylamino, and
(vii) a cyclic amino group optionally substituted by alkyl,
(d) alkoxy,
(e) amino optionally substituted by 1 or 2 substituents selected from the group consisting of
(i) alkylcarbonyl optionally substituted by a cyclic amino group,
(ii) alkylsulfonyl,
(iii) carbamoyl, and
(iv) alkyl or cycloalkyl,
(f) carboxy,
(g) alkoxycarbonyl,
(h) carbamoyl optionally substituted by alkyl optionally substituted by amino, alkylamino, dialkylamino or alkoxycarbonylamino,
(i) formyl,
(j) a 5- to 10-membered aromatic heterocyclic group optionally substituted by alkyl,
(k) \u2014CH\u2550N\u2014OR21 wherein R21 is a hydrogen atom or alkyl optionally substituted by alkylamino or dialkylamino, or
(l) nitro,
or a salt thereof.
14. The compound of claim 1, wherein R3 is a group of the formula
wherein R30 is as defined in claim 1, or a salt thereof.
15. The compound of claim 1, wherein R3 is naphthyl or isochromenyl, or a salt thereof.
16. The compound of claim 1, wherein R3 is quinolyl or isoquinolyl, or their oxide derivatives, or a salt thereof.
17. The compound of claim 1, wherein R is a hydrogen atom, or a salt thereof.
18. The compound of claim 1, wherein R1 is cyclopropyl, 2-fluorocyclopropyl or 2,4-difluorophenyl, or a salt thereof.
19. The compound of claim 1, wherein R2 is methyl, methoxy or a chlorine atom, or a salt thereof.
20. A pharmaceutical composition comprising a compound of claim 1 or a salt thereof and a pharmaceutically acceptable carrier.
21. An antimicrobial agent comprising a compound of claim 1 or a salt thereof.
22. A method for treating a bacterial infection which comprises administering an effective amount of a compound of claim 1 or a salt thereof to a human or an animal.