We claim:
1. A compound of formula (I) wherein R1 represents a hydrogen atom or a 3-halogen atom, and R2 represents a straight-chain alkyl group containing up to 6 carbon atoms, a straight-chain alkyl group containing up to 3 carbon atoms with unsubstituted or substituted aromatic ring, or alkoxycarbonyl substituent at the end position, or aryloxyalkoxyalkyl group.
2. A compound according to claim 1 wherein R1 is hydrogen and R2 is n-hexyl, 3-phenylpropyl or 3-methoxycarbonylpropyl. The compounds of claim 2, which are 2,4-diamino-6-(n-hexyl)-5-phenylpyrimidine 2,4-diamino-5-phenyl-6-(3-phenylpropyl)pyrimidine 2,4-diamino-6-(3-methoxycarbonylpropyl)-5-phenylpyrimidine
3. A compound according to claim 1 wherein R1 is 3-chloro and R2 is 3-phenylpropyl, 3-(4-methoxyphenyl)propyl, 3-methoxycarbonylpropyl or 2-(3-phenoxypropyloxy)ethyl. The compounds of claim 3, which are 2,4-diamino-5-(3-chlorophenyl)-6-(3-phenylpropyl)pyrimidine 2,4-diamino-5-(3-chlorophenyl)-6-3-(4-methoxyphenyl)propylpyrimidine 2,4-diamino-5-(3-chlorophenyl)-6-(3-methoxycarbonylpropyl)pyrimidine 2,4-diamino-5-(3-chlorophenyl)-6-2-(3-phenoxypropyloxy)ethylpyrimidine
4. Pharmaceutically acceptable salts of a compound of formula (I) wherein R1 represents a hydrogen atom or a 3-halogen atom, and R2 represents a straight-chain alkyl group containing up to 6 carbon atoms, a straight-chain alkyl group containing up to 3 carbon atoms with unsubstituted or substituted aromatic ring, or alkoxycarbonyl substituent at the end position, or aryloxyalkoxyalkyl group.
5. A process for the production of a compound of formula (I) as in claims 1 and 2, comprising: a) acylation of arylacetonitrile (II) with acid chloride (Ill) employing lithium diisopropylamide in tetrahydrofuran at 78 C. affords the desired keto nitrile (IV); b) reaction of keto nitrile (IV) with diazomethane in dioxane at room temperature affords the corresponding methoxyacrylonitrile (V); c) condensation reaction of the methoxyacrylonitrile (V) with guanidine in dimethyl sulfoxide at 80 C. provides the desired pyrimethamine derivative compound (I).
6. A pharmaceutical composition which comprises a compound of formula (I) wherein R1 represents a hydrogen atom or a 3-halogen atom, and R2 represents a straight-chain alkyl group containing up to 6 carbon atoms, a straight-chain alkyl group containing up to 3 carbon atoms with unsubstituted or substituted aromatic ring, or alkoxycarbonyl substituent at the end position, or aryloxyalkoxyalkyl group. This compound can be used by itself or in synergistic combination with sulfonamides andor other agents.
7. Use of a compound as defined in claim 6 for the treatment or prophylaxis of malaria.
8. Use of a compound as defined in claim 6 for the treatment or prophylaxis of drug-resistant malaria.
9. Use of a compound as defined in claim 6 for the treatment or prophylaxis of malaria resistant to antifolate compounds in use, including pyrimethamine.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A wireless sensor that comprises a wireless sensor location controller that determines a location of the wireless sensor.
2. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller determines a location of the wireless sensor in response to a request from a wireless sensor base station.
3. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller associates identity information of the wireless sensor with location information of the wireless sensor.
4. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller determines a location of the wireless sensor whenever the wireless sensor changes its location.
5. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller provides location information of the wireless sensor to an external wireless device.
6. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller determines a location of the wireless sensor using one of: global positioning system (GPS) technology, time difference of arrival (TDOA) signal measurement technology, angle of arrival (AOA) signal measurement technology, and signal strength measurements of one of: a signal that is transmitted by the wireless sensor and a signal that is received by the wireless sensor.
7. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller generates a beacon signal that uniquely identifies the wireless sensor.
8. The wireless sensor as set forth in claim 1 wherein the wireless sensor location controller generates an alert signal that signifies that an event of interest has occurred with respect to the wireless sensor.
9. A wireless sensor network comprising:
at least one wireless sensor that comprises a wireless sensor location controller that determines a location of the wireless sensor; and
a wireless sensor base station that communicates with the at least one wireless sensor.
10. The wireless sensor network as set forth in claim 9 wherein the wireless sensor location controller of the wireless sensor determines a location of the wireless sensor in response to a request from the wireless sensor base station.
11. The wireless sensor network as set forth in claim 9 wherein the wireless sensor location controller of the wireless sensor determines a location of the wireless sensor whenever the wireless sensor changes its location.
12. The wireless sensor network as set forth in claim 9 wherein the wireless sensor location controller of the wireless sensor determines a location of the wireless sensor using one of: global positioning system (GPS) technology, time difference of arrival (TDOA) signal measurement technology, angle of arrival (AOA) signal measurement technology, and signal strength measurements of one of: a signal that is transmitted by the wireless sensor and a signal that is received by the wireless sensor.
13. The wireless sensor network as set forth in claim 9 wherein the wireless sensor base station comprises a wireless sensor location controller of the base station that comprises a database that contains location information for each wireless sensor in the wireless sensor network.
14. The wireless sensor network as set forth in claim 9 wherein the wireless sensor base station comprises a wireless sensor location controller of the base station that provides for display on a display unit of the base station location information for each wireless sensor in the wireless sensor network.
15. A wireless sensor network that comprises:
at least one wireless sensor; and
a wireless sensor location controller that determines a location of the wireless sensor.
16. The wireless sensor network as set forth in claim 15 wherein the wireless sensor location controller determines a location of the wireless sensor using one of: global positioning system (GPS) technology, time difference of arrival (TDOA) signal measurement technology, angle of arrival (AOA) signal measurement technology, and signal strength measurements of one of: a signal that is transmitted by the wireless sensor and a signal that is received by the wireless sensor.
17. The wireless sensor network as set forth in claim 16 wherein the wireless sensor network is a multi tier wireless sensor network that comprises a plurality of multi tier wireless network elements.
18. A method for operating a wireless sensor network comprising the steps of:
providing at least one wireless sensor that comprises a wireless sensor location controller that determines a location of the wireless sensor; and
providing a wireless sensor base station that communicates with the at least one wireless sensor.
19. The method as set forth in claim 18 further comprising the steps of:
sending a request from the wireless sensor base station to the at least one wireless sensor to obtain location information of the wireless sensor;
in response to the request from the wireless sensor base station, determining a location of the at least one wireless sensor; and
sending the wireless sensor location information of the at least one wireless sensor to the wireless sensor base station.
20. The method as set forth in claim 18 wherein the step of determining a location of the at least one wireless sensor comprises determining the location of the at least one wireless sensor using one of: global positioning system (GPS) technology, time difference of arrival (TDOA) signal measurement technology, angle of arrival (AOA) signal measurement technology, and signal strength measurements of one of: a signal that is transmitted by the wireless sensor and a signal that is received by the wireless sensor.
21. The method as set forth in claim 18 further comprising the steps of:
in response to a change of location of the at least one wireless sensor, determining new location information of the at least one wireless sensor; and
sending the new location information of the at least one wireless sensor to the wireless sensor base station.
22. The method as set forth in claim 18 further comprising the steps of:
in response to an occurrence of an event of interest with respect to the at least one wireless sensor, generating an alert signal in the wireless sensor location controller of the at least one wireless sensor; and
sending the alert signal to the wireless sensor base station.
23. The method as set forth in claim 18 further comprising the steps of:
sending location information for the at least one wireless sensor to the wireless sensor base station;
recording the location information of the at least one wireless sensor in a database in the wireless sensor base station; and
displaying the location information of the at least one wireless sensor on a display unit of the wireless sensor base station.