1. A system for detecting cancer margins, comprising:
a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, the probe being selected from the group consisting of GB119 and BMV084;
means for topically administering the imaging probe to the cancer cell; and
an imaging device to detect activation of the imaging probe administered to the cancer cell.
2. The system of claim 1, wherein the protease-specific, fluorescence imaging probe is activated by one of Cathepsin B, and Cathepsin L.
3. The system of claim 1, the system further including an imaging logic to detect a tumor margin, based, at least in part, on the activation of the fluorescent imaging probe.
4. The system of claim 3, the cancer cell being at least one of a breast cancer cell, glioma cell, skin cancer cell, prostate cancer cell, or glioma and the imaging logic detection the breast cancer cell, glioma cell, skin cancer cell, prostate cancer cell, or glioma, based, at least in part, on the activation of the fluorescent imaging probe.
5. The system of claim 1, the system further including a radiologic plan logic to plan a surgical or radiologic treatment based, at least in part, on a detection of a tumor margin, and a detection of an infiltrating cell.
6. The system of claim 1, the system further including an ablative laser plan logic to plan an ablative laser treatment based, at least in part, on a detection of a tumor margin, and a detection of an infiltrating cancer cell.
7. The system of claim 6, the ablative laser plan logic being configured to control, at least in part, an ablative laser.
8. A method, comprising:
topically applying a protease-specific, fluorescence imaging probe to an area in which a cancer cell may be located, the probe being selected from the group consisting of GB119 and BMV084 and being activatable by enzymatic activation to produce a visually differentiated signal upon topical application to the cancer cell, the cancer cell expressing an enzyme that activates the protease-specific, fluorescence imaging probe; and detecting, with an imaging device, imaging probe activation induced by an interaction between the imaging probe and the enzyme expressed by the cancer cell.
9. The method of claim 8, the enzyme being one of, Cathepsin B, and Cathepsin L.
10. The method of claim 8, the cancer cell being at least one of a breast cancer cell, glioma cell, skin cancer cell, prostate cancer cell, or glioma.
11. The method of claim 8, the topical application being conducted in a liquid.
12. The method of claim 8, including:
acquiring an image data associated with the probe activation.
13. The method of claim 8, including determining a radiological or surgical treatment based, at least in part, on the image data.
14. The method of claim 8, including controlling a computer-controllable surgical device based, at least in part, on the image data.
15. The method of claim 8, the surgical device being one of, a laser, a scalpel, a gamma knife, and a micro-electronic machine.
16. A method for performing a medical procedure, comprising:
topically applying a protease-specific, fluorescence imaging probe to an area in which a targeted cancer cell may be located, the imaging probe being selected from the group consisting of GB119 and BMV084 and being activatable by enzymatic activation to produce a visually differentiated signal upon topical application to the cell, the cancer cell expressing an enzyme that activates the protease-specific, fluorescence imaging probe; and imaging the cell to which the probe is topically applied.
17. The method of claim 16, the enzyme being one of Cathepsin B, and Cathepsin L.
18. The method of claim 16, where topically applying includes spraying the imaging probe onto a tissue sample containing the cell.
19. The method of claim 18, the tissue sample being biopsy that is obtained from an animal.
20. The method of claim 16, the cancer cell being at least one of a breast cancer cell, glioma cell, skin cancer cell, prostate cancer cell, or glioma.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A rotor of a motor, comprising:
a rotation shaft serving as a center of rotation of the rotor;
a core installed at the rotation shaft and comprising a plurality of teeth radially protruding with respect to the rotation shaft;
a coil wound around the plurality of teeth to generate a magnetic field via an external power source; and
at least one permanent magnet installed around a respective tooth of the plurality of the teeth.
2. The rotor of claim 1, wherein:
the respective teeth include an extended portion circumferentially extending from ends of the respective tooth so as to be matched with an inner diameter surface of a stator of the motor.
3. The rotor of claim 2, wherein:
the at least one permanent magnet is installed between the extended portion and the coil.
4. The rotor of claim 2, wherein:
the extended portion forms a groove on both sides of the respective tooth, and the at least one permanent magnet is inserted in groove.
5. The rotor of claim 1, wherein:
the permanent magnet is a ferrite magnet.
6. A synchronous motor, comprising:
a cylindrical stator configured to form a magnetic field via an external power source; and
a rotor rotating inside the stator, the rotor including,
a rotation shaft serving as a center of rotation of the rotor;
a core installed at the rotation shaft and comprising a plurality of teeth radially protruding with respect to the rotation shaft;
a coil wound around the plurality of teeth to generate a magnetic field via an external power source; and
at least one permanent magnet installed around a respective tooth of the plurality of the teeth.
7. The synchronous motor of claim 6, wherein the stator comprises:
a stator core formed along the outer perimeter of the stator;
a plurality of stator teeth protruding toward an inside of the stator core in a radial direction at uniform intervals; and
a stator coil wound around the plurality of stator teeth to generate a magnetic field.
8. A wound rotor synchronous motor (WRSM) having a coil wound around a rotor according to claim 1.