1. A method of inhibiting a bacterial biofilm formation, comprising the step of contacting the biofilm-forming bacteria with a composition comprising a recombinant Lactoferrin (rLF) and a plurality of chemical surfactants comprising at least one zwitterionic surfactant and at least one anionic surfactant.
2. The method of claim 1, wherein the biofilm-forming bacteria is a Pseudomonas aeruginosa.
3. The method of claim 1, wherein the bacterial biofilm formation is agent-induced.
4. The method of claim 3, wherein the agent is an antibiotic, a detergent, or a surfactant.
5. The method of claim 4, wherein the antibiotic is a cephalosporin, an aminoglycoside, or their combination.
6. The method of claim 1, wherein the step of contacting comprises topical irrigation.
7. The method of claim 1, wherein the bacterial biofilm is associated with a chronic rhinosinusitis in a subject.
8. The method of claim 1, further comprising the step of contacting the biofilm-forming bacteria with an antibiotic compound.
9. The method of claim 1, wherein said Lactoferrin is human Lactoferrin (rhLF).
10. The method of claim 7, wherein said method is performed following chronic rhinosinusitis surgery in said subject.
11. A method of treating chronic rhinosinusitis in a subject, the method comprising the step of contacting an affected area in said subject with a composition comprising a recombinant human Lactoferrin (rhLF) and a plurality of chemical surfactants comprising at least one zwitterionic surfactant and at least one anionic surfactant, wherein said contacting prevents biofilm formation in said affected area, thereby treating said chronic rhinosinusitis in said subject.
12. The method of claim 11, wherein the step of contacting comprises topical irrigation.
13. The method of claim 11, wherein the chronic rhinosinusitis, is post-surgical chronic rhinosinusitis.
14. The method of claim 11, wherein the composition further comprises an antibiotic compound.
15. The method of claim 14, wherein the antibiotic compound is a cephalosporin, an aminoglycoside, or their combination.
16. A method of inhibiting biofilm formation by a bacterium on a solid surface, comprising the step of contacting the bacterium with a composition comprising recombinant human Lactoferrin (rhLF) and a plurality of chemical surfactants comprising at least one zwitterionic surfactant and at least one anionic surfactant.
17. The method of claim 16, whereby the solid surface is sutures, a surgical surface or body surface, surgical tools, or an implanted medical device.
18. The method of claim 16, whereby the surface is a component of fresh or saltwater ships or vessels, docks, bridges, pipes cabling, or all structures in contact with water or bodies of water.
19. The method of claim 16, whereby the surface is an agricultural product or component.
20. The method of claim 16, wherein the biofilm-forming bacteria is a Pseudomonas aeruginosa.
21. The method of claim 16, wherein the bacterial biofilm formation is agent-induced.
22. The method of claim 21, wherein the agent is an antibiotic, a detergent, or a surfactant.
23. The method of claim 22, wherein the antibiotic is a cephalosporin, an aminoglycoside, or their combination.
24. The method of claim 1, wherein said plurality of chemical surfactants are from a baby shampoo.
25. The method of claim 1, wherein said zwitterionic chemical surfactant is cocamidopropyl betaine.
26. The method of claim 1, wherein said anionic chemical surfactant is sodium trideceth sulfate.
27. The method of claim 1, wherein the chemical surfactants are used at a 0.2-5% concentration.
28. The method of claim 1, wherein the chemical surfactants are used at a 1% concentration.
29. The method of claim 11, wherein said plurality of chemical surfactants are from a baby shampoo.
30. The method of claim 11, wherein said zwitterionic chemical surfactant is cocamidopropyl betaine.
31. The method of claim 11, wherein said anionic chemical surfactant is sodium trideceth sulfate.
32. The method of claim 11, wherein the chemical surfactants are used at a 0.2-5% concentration.
33. The method of claim 32, wherein the chemical surfactants are at a 1% concentration.
34. The method of claim 16, wherein said plurality of chemical surfactants are from a baby shampoo.
35. The method of claim 16, wherein said zwitterionic chemical surfactant is cocamidopropyl betaine.
36. The method of claim 16, wherein said anionic chemical surfactant is sodium trideceth sulfate.
37. The method of claim 16, wherein the chemical surfactants are used at a 0.2-5% concentration.
38. The method of claim 37, wherein the chemical surfactants are used at a 1% concentration.
39. The method of claim 8, wherein the antibiotic compound is a cephalosporin, an aminoglycoside, or their combination.
40. The method of claim 11, wherein the chronic rhinosinusitis is recalcitrant chronic rhinosinusitis.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A shootingcatching section for a lacrosse stick pocket, comprising:
at least two elongate runners; and
a plurality of V-shaped cross-pieces straddling said at least two elongate runners and attached thereto.
2. The shootingcatching section for a lacrosse stick pocket according to claim 1, wherein said elongate runners and said plurality of V-shaped cross-pieces are formed from the same material.
3. The shootingcatching section for a lacrosse stick pocket according to claim 2, wherein said elongate runners and said plurality of V-shaped cross-pieces are formed from die-cutting a single piece of material.
4. The shootingcatching section for a lacrosse stick pocket according to claim 2, wherein said elongate runners and said plurality of V-shaped cross-pieces are formed from an elastomer material.
5. The shootingcatching section for a lacrosse stick pocket according to claim 2, wherein said elongate runners and said plurality of V-shaped cross-pieces are formed from chlorosulfonated polyethylene synthetic rubber. material.
6. The shootingcatching section for a lacrosse stick pocket according to claim 5, wherein said elongate runners and said plurality of V-shaped cross-pieces are formed from two layers of chlorosulfonated polyethylene synthetic rubber weave material that have been welded together and coated with an elastomer.
7. The shootingcatching section for a lacrosse stick pocket according to claim 1, further comprising a plurality of V-shaped chevrons, wherein each of said plurality of V-shaped chevrons is overmolded onto a corresponding one of said plurality of V-shaped cross-pieces.
8. The shootingcatching section for a lacrosse stick pocket according to claim 7, wherein said plurality of V-shaped chevrons are formed from a polymer.
9. The shootingcatching section for a lacrosse stick pocket according to claim 8, wherein said plurality of V-shaped chevrons are formed from thermoplastic polyurethane.
10. The shootingcatching section for a lacrosse stick pocket according to claim 1, wherein said plurality of V-shaped cross-pieces form an angle of approximately 15 degrees.
11. The shootingcatching section for a lacrosse stick pocket according to claim 7 wherein a thickness of said plurality of V-shaped chevrons increases away from a base of the \u201cV\u201d such that each of said plurality of V-shaped chevrons forms the shape of a shallow \u201cU\u201d when viewed in cross-section.
12. The shootingcatching section for a lacrosse stick pocket according to claim 11 wherein the thickness of distal ends of each of said plurality of V-shaped chevrons is approximately 5 mm, and wherein the thickness of centers portions of each of said plurality of V-shaped chevrons is approximately 2 mm.
13. The shootingcatching section for a lacrosse stick pocket according to claim 1 wherein a length of each of said plurality of V-shaped chevrons increases towards a top end of said shootingcatching section.
14. The shootingcatching section for a lacrosse stick pocket according to claim 7, wherein said plurality of V-shaped chevrons further comprise a main body formed from a first material and a top surface inset formed from a second material, wherein said first and second materials have different durometers.
15. The shootingcatching section for a lacrosse stick pocket according to claim 1, further comprising at least one partial-length runner having a length that is shorter than a length of said at least two elongate runners, wherein said at least one partial-length runner is attached to at least one of said plurality of V-shaped cross-pieces between the points of attachment of said at least one of said plurality of V-shaped cross-pieces with said at least two elongate runners.
16. The shootingcatching section for a lacrosse stick pocket according to claim 15 wherein said at least one partial-length runner is located proximate at top end of said shootingcatching section.
17. The shootingcatching section for a lacrosse stick pocket according to claim 1 wherein said at least two elongate runners run scoop-to-throat across a lacrosse head and said plurality of cross-pieces are inverted V-shaped scoop-to-throat.
18. A method of manufacturing a shootingcatching section for a lacrosse stick pocket, the method comprising:
providing a plurality of V-shaped chevrons formed of thermoplastic polyurethane;
placing said plurality of V-shaped chevrons in a channel-shaped mold, wherein said plurality of V-shaped chevrons are placed perpendicularly to the longitudinal axis of said channel-shaped mold in a ladder pattern;
providing an elastomer material comprising at least two elongate runners and a plurality of V-shaped cross-pieces straddling said at least two elongate runners and affixed thereto;
placing said elastomer material over said plurality of V-shaped chevrons in said mold, wherein each one of said V-shaped cross-pieces overlaps one of said plurality of V-shaped chevrons; and
attaching said plurality of V-shaped chevrons to said elastomer material.
19. The method of manufacturing a shootingcatching section for a lacrosse stick pocket of claim 18, wherein said plurality of V-shaped chevrons are evenly spaced from one another when placed in said mold.
20. The method of manufacturing a shootingcatching section for a lacrosse stick pocket of claim 18, wherein said plurality of V-shaped chevrons are attached to said elastomer material by a process of overmolding.
21. The method of manufacturing a shootingcatching section for a lacrosse stick pocket of claim 18, wherein said plurality of V-shaped chevrons are attached to said elastomer material by a process of welding.
22. The method of manufacturing a shootingcatching section for a lacrosse stick pocket of claim 18, wherein said plurality of V-shaped chevrons are formed from thermoplastic polyurethane.
23. The method of manufacturing a shootingcatching section for a lacrosse stick pocket of claim 18, wherein said elastomer is Hypalon\u2122 material.
24. A method of manufacturing a shootingcatching section for a lacrosse stick pocket, the method comprising:
providing an elastomer material;
die-cutting said elastomer material to form a shape consisting of at least two elongate runners and a plurality of V-shaped cross-pieces straddling said at least two elongate runners and affixed thereto.
25. The method of manufacturing a shootingcatching section for a lacrosse stick pocket of claim 24, wherein said elastomer material is chlorosulfonated polyethylene synthetic rubber.
26. The method of manufacturing a shootingcatching section for a lacrosse stick pocket of claim 25, wherein said elastomer material is formed of two layers of chlorosulfonated polyethylene synthetic rubber weave material welded together to create a single piece of chlorosulfonated polyethylene synthetic rubber.