What is claimed is:
1. A method for treating a patient suffering from a cancerous disease comprising:
administering to said patient anti-cancer antibodies or fragments thereof produced in accordance with a method for the production of individually customized anti-cancer antibodies which are useful in treating a cancerous disease, said antibodies including a subset of antibodies or fragments thereof characterized as being cytotoxic against cells of a cancerous tissue, said subset being essentially benign to non-cancerous cells;
wherein one or more antibodies or fragments thereof selected from said subset are placed in admixture with a pharmaceutically acceptable adjuvant and are administered in an amount effective to mediate treatment of said cancerous disease.
2. The method for treating a patient suffering from a cancerous disease in accordance with claim 1, wherein said one or more antibodies or fragments thereof selected from said subset are humanized.
3. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 comprising:
conjugating said subset of antibodies or fragments thereof with a member selected from the group consisting of toxins, enzymes, radioactive compounds, and hematogenous cells; and
administering conjugated antibodies or fragments thereof to said patient;
wherein said conjugated antibodies are placed in admixture with a pharmaceutically acceptable adjuvant and are administered in an amount effective to mediate treatment of said cancerous disease.
4. The method of claim 3, wherein said one or more antibodies or fragments thereof selected from said subset are humanized.
5. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the cytotoxicity of said antibodies or fragments thereof is mediated through antibody dependent cellular toxicity.
6. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the cytotoxicity of said antibodies or fragments thereof is mediated through complement dependent cellular toxicity.
7. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the cytotoxicity of said antibodies or fragments thereof is mediated through catalyzing of the hydrolysis of cellular chemical bonds.
8. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the cytotoxicity of said antibodies or fragments thereof is mediated through producing an immune response against putative cancer antigens residing on tumor cells.
9. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the cytotoxicity of said antibodies or fragments thereof is mediated through targeting of cell membrane proteins to interfere with their function.
10. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the cytotoxicity of said antibodies or fragments thereof is mediated through production of a conformational change in a cellular protein effective to produce a signal to initiate cell-killing.
11. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
said method of production utilizes a tissue sample containing cancerous and non-cancerous cells obtained from a particular individual.
12. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the antibodies or fragments thereof are selected from the group consisting of a 3BD-3, a 3BD-6, a 3BD-8, a 3BD-9, a 3BD-15, a 3BD-25, a 3BD-26 and a 3BD-27 monoclonal antibody or combinations thereof.
13. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the antibodies or fragment thereof are produced by one or more hybridoma cell lines having an ATCC Accession Number selected from the group consisting of (______).
14. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the antibodies or fragments thereof are selected from the group consisting of a 1LN-1, a 1LN-12, a 1LN-14, a 2LN-21, a 2LN-28, a 2LN-29, a 2LN-31, a 2LN-33, a 2LN-34 and a 2LN-35 monoclonal antibody or combinations thereof.
15. The method for treating a patient suffering from a cancerous disease in accordance with claim 1 wherein:
the antibodies or fragments thereof are produced by one or more hybridoma cell lines having an ATCC Accession Number selected from the group consisting of (______).
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A database correlating apparatus that is configured to merge distinct databases such that the databases appear to an accessor as a single database comprising:
a database pair generator that creates an initial database pair from a first non-merged database;
a probe set generator that creates a database probe set from a second non-merged database;
a comparator in communication with said database pair generator and said probe set generator, said comparator determining if said database probe set correlates to said database pair; and
an identifier in communication with said comparator to identify a correlation between said database pair and said database probe set so that correlating data from said first database and said second database can be accessed if there is a correlation such that data from the first and second non-merged databases are accessibly simultaneously.
2. The apparatus as recited in claim 1 wherein said database pair comprises a table and field combination from said first database.
3. The apparatus as recited in claim 1 wherein said database pair comprises table and field combinations from a section of said first database.
4. The apparatus as recited in claim 1 wherein said database pair comprises table and field combinations from said first database in its entirety.
5. The database merging apparatus as recited in claim 1 wherein said database pair comprises field and empty table combinations from said first database.
6. The apparatus as recited in claim 1 wherein said database probe set is derived from a section of said second database.
7. The apparatus as recited in claim 1 wherein said database probe set is derived from said second database in its entirety.
8. The apparatus as recited in claim 1 wherein said database probe set is derived from one or more fields of said second database.
9. The apparatus as recited in claim 1 further comprising:
an input in communication with said first and second database, said input receiving commands;
a splitter in communication with said input, said splitter splitting said commands into multiple commands; and
a collector in communication with said splitter, said collector using said commands to access said databases based on the correlation’s identified by said identifier.
10. The apparatus as recited in claim 9 wherein said collector reads data from said databases based on the correlation’s identified by said identifier.
11. The apparatus as recited in claim 9 wherein said collector writes data to said databases based on the correlation’s identified by said identifier.
12. The apparatus as recited in claim 11 further comprising a retriever in communication with said databases wherein if there is a write failure to a database said retriever rolls back all write operations made to other databases.
13. The apparatus as in claim 1, wherein successive database probe sets are generated until the correlation data between the first and second non-merged databases is identified.
14. A computer readable medium containing executable code for correlating two or more databases comprising:
generating a database pair from a first non-merged database;
generating an initial database probe set from a second non-merged database;
determining if said database pairs correlate to said database probe set;
identifying a correlation between said database pairs and said database probe set;
granting access simultaneously to the first and second non-merged databases upon identifying the correlation; and
in response to no correlation from the initial database probe set, generating successive database probe sets until the correlation is determined.
15. The computer readable medium as recited in claim 14 wherein said step of generating one or more database pairs comprises the step of generating a table and field combination from said first database to form said database pair.
16. The computer readable medium as recited in claim 14 wherein said step of generating one or more database pairs further comprises the step of generating table and field combinations from a section of said first database to form said database pairs.
17. The computer readable medium as recited in claim 14 wherein said step of generating a database pair further comprises the step of generating table and field combinations from said first database in its entirety to form said database pairs.
18. The computer readable medium as recited in claim 14 wherein said step of generating a database pair further comprises the step of generating field and empty table combinations from said second database to form said database pairs.
19. The computer readable medium as recited in claim 14 wherein said step of generating said database probe set further comprises the step of generating said database probe set from a section of said second database.
20. The computer readable medium as recited in claim 14 wherein said step of generating said database probe set further comprises the step of generating said database probe set from said second database in its entirety.
21. The computer readable medium as recited in claim 14 wherein said step of generating said database probe set further comprises the step of generating said database probe set from one or more fields of said second database.
22. The computer readable medium as recited in claim 14 further comprising:
receiving commands;
splitting said commands into multiple commands; and
using said commands to access said databases based on the correlations identified by said identifier.
23. The computer readable medium as recited in claim 22 wherein data is read from said databases based on identified correlations.
24. The computer readable medium as recited in claim 22 wherein data is written to said databases based on identified correlations.
25. The computer readable medium as recited in claim 24 wherein if there is a write failure to a database all write operations made to other databases are rolled back.
26. A system for correlating two or more databases comprising:
a means for generating a pair from a first database;
a means for generating an initial database probe set from a second database;
a means for determining if said database pairs correlate to said database probe set;
a means for identifying a correlation between said database pairs and said database probe set so that correlating data from said first database and said second database can be accessed if there is a correlation; and
a means for generating successive database probe sets until the correlation is determined.
27. The system as recited in claim 26 wherein said means for generating one or more database pairs further comprises a means for generating a table and field combination from said first database to form said database pair.
28. The system as recited in claim 26 wherein said means for generating one or more database pairs further comprises a means for generating table and field combinations from a section of said first database to form said database pairs.
29. The system as recited in claim 26 wherein said means for generating a database pair further comprises a means for generating table and field combinations from said first database in its entirety to form said database pair.
30. The system as recited in claim 26 wherein said means for generating a database pair further comprises a means for generating field and empty table combinations from said second database to form said database pair.
31. The system as recited in claim 26 wherein said means for generating said database probe set further comprises means for generating said database probe set from a section of said second database.
32. The system as recited in claim 26 wherein said means for generating said database probe set further comprises a means for generating said database probe set from said second database in its entirety.
33. The system as recited in claim 26 wherein said means for generating said database probe set further comprises a means for generating said database probe set from one or more fields of said second database.
34. The system as recited in claim 26 further comprising the steps of:
means for receiving commands;
means for splitting said commands into multiple commands; and means for using said commands to access said databases based on identified correlations.
35. The system as recited in claim 34 further comprising a means for reading data from said databases based on identified correlation’s.
36. The system as recited in claim 34 further comprising a means for writing data to said databases based on identified correlation’s.
37. The system as recited in claim 36 further comprising a means for rolling back all write operations if there is a write failure to a database.