1. A compound, comprising:
an oxetane of Formula 1,
a pharmaceutically acceptable salt, diastereomer, or mixture thereof wherein:
B is a purin-9-yl or a heterocyclic isostere of a purin-9-yl,
wherein the purin-9-yl or heterocyclic isostere of a purin-9-yl comprises
wherein J, L, and M are each independently
hydrogen;
hydroxy;
halogen;
C1-C12 alkyl;
C1-C6 perhaloalkyl;
azido;
cyano;
\u2014COOR21 wherein R21 is hydrogen or C1-C12 alkyl;
\u2014CONR22R23 wherein R22 and R23 are each independently hydrogen or C1-C12 alkyl;
\u2014OR24 wherein R24 is C1-C6 alkyl, C1-C6 perhaloalkyl, phenyl, benzyl, or heterocyclic;
\u2014SR25 wherein R25 is hydrogen, C1-C6 alkyl, C1-C6 perhaloalkyl, phenyl, benzyl, or heterocyclic;
\u2014NR26R27 wherein R26 and R27 are independently hydrogen or C1-C12 alkyl;
\u2014SO2NR26R27 wherein R26 and R27 are defined above;
\u2014NHC(O)R28 wherein R28 is hydrogen, C1-C12 alkyl, carboxyalkyl, or aminoalkyl;
\u2014NC(\u2550NR29)NR30 wherein R29 and R30 are each independently hydrogen or C1-C12 alkyl;
\u2014N(R31)OR32 wherein R31 and R32 are each independently hydrogen or C1-C12 alkyl;
\u2014N(R33)NR34R35 wherein R33, R34, and R35 are each independently hydrogen or C1-C12 alkyl;
hydroxyamino;
phenyl, \u2014O(phenyl), benzyl, \u2014O(benzyl), heterocyclic or \u2014O(heterocyclic) group which may be unsubstituted, or mono-, di- or trisubstituted with one or more of hydroxy, amino, azido, nitro, cyano, halogen, sulfonamide, carboxyl, C1-C6 perfluoroalkyl, \u2014OR24 wherein R24 is as defined above, \u2014NR26R27 wherein R26 and R27 are as defined above, \u2014N(R33)NR34R35 wherein R33, R34, and R35 are as defined above; or
wherein m is 1-5;
R2, R3, R4, and R5 are each independently
hydrogen;
hydroxy;
amino;
azido;
nitro;
cyano;
halogen;
sulfonamide;
\u2014COOR6 wherein R6 is hydrogen or C1-C12 alkyl;
\u2014CONR7R8 wherein R7 and R8 are each independently hydrogen or C1-C12 alkyl;
straight or branched C1-C12 alkyl wherein the branched alkyl chains may form a 3 to 7 member heteroalkyl ring, alkyl ring, or alkenyl ring, and wherein the straight or branched C1-C12 alkyl is optionally substituted with a hydroxy, halogen, \u2014COOR6 wherein R6 is defined above, \u2014CONR7R8 wherein R7 and R8 are defined above, cyclo(C3-C6 alkyl)methyl, \u2014OR9 wherein R9 is C1-C6 alkyl, C1-C6 perhaloalkyl, phenyl, benzyl, or heterocyclic, \u2014SR9, \u2014OR10OR9 wherein R10 is C1-C6 alkylene, C1-C6 perhaloalkylene, phenyl, or heterocyclic and R9 is as defined above, C1-C6 perhaloalkyl, \u2014NR11R12 wherein R11 and R12 are independently hydrogen or C1-C6 alkyl, \u2014NHC(O)R13 wherein R13 is hydrogen, C1-C6 alkyl, carboxyalkyl, or aminoalkyl, \u2014NC(\u2550NR14)NR15 wherein R14 and R15 are each independently hydrogen or C1-C6 alkyl, \u2014N(R16)OR17 wherein R16 and R17 are each independently hydrogen or C1-C6 alkyl, \u2014N(R18)NR19R20 wherein R18, R19, and R20 are each independently hydrogen or C1-C6 alkyl;
\u2014C1-C12 perhaloalkyl;
\u2014OR9 wherein R9 is as defined above;
\u2014SR9 wherein R9 is as defined above;
\u2014O\u2014R10OR9 wherein R9 and R10 are as defined above;
\u2014NR11R12 wherein R11 and R12 are as defined above;
\u2014N(R18)NR19NR20 wherein R18, R19, and R20 are as defined above; or
phenyl, \u2014O(phenyl), \u2014O(benzyl), heterocyclic, or \u2014O(heterocyclic) group which may be unsubstituted, or mono-, di-, or trisubstituted with one or more of hydroxy, amino, \u2014NHC(O)R13 wherein R13 is defined above, azido, nitro, cyano, halogen, sulfonamide, \u2014COOR6 wherein R6 is defined above, \u2014CONR7R8 wherein R7 and R8 are defined above, C1-C6 alkyl, C1-C6 perfluoroalkyl, \u2014OR9 wherein R9 is as defined above, \u2014SR9, \u2014NR11R12 wherein R11 and R12 are as defined above, or \u2014N(R18)NR19R20 wherein R18, R19, and R20 are as defined above; and
wherein R1 is
hydroxy;
amino;
azido;
nitro;
cyano;
halogen;
sulfonamide;
\u2014COOR6 wherein R6 is hydrogen or C1-C12 alkyl;
\u2014CONR7R8 wherein R7 and R8 are each independently hydrogen or C1-C12 alkyl;
\u2014OR9 wherein R9 is as defined above;
\u2014SR9 wherein R9 is as defined above;
\u2014O\u2014R10OR9 wherein R9 and R10 are as defined above;
\u2014NR11R12 wherein R11 and R12 are as defined above;
\u2014N(R18)NR19R20 wherein R18, R19, and R20 are as defined above; or
phenyl, \u2014O(phenyl), \u2014O(benzyl), heterocyclic, or \u2014O(heterocyclic) group which may be unsubstituted, or mono-, di-, or trisubstituted with one or more of hydroxy, amino, \u2014NHC(O)R13 wherein R13 is defined above, azido, nitro, cyano, halogen, sulfonamide, \u2014COOR6 wherein R6 is defined above, \u2014CONR7R8 wherein R7 and R8 are defined above, C1-C6 alkyl, C1-C6 perfluoroalkyl, \u2014OR9 wherein R9 is as defined above, \u2014SR9, \u2014NR11R12 wherein R11 and R12 are as defined above, or \u2014N(R18)NR19R20 wherein R18, R19 and R20 are as defined above;
wherein any two of R1, R2, R3, R4, and R5 may form a substituted or unsubstituted 5 to 7 member carbocyclic ring or a substituted or unsubstituted 5 to 7 member heterocyclic ring wherein the substitution is hydroxy, amino, nitro, halogen, sulfonamide, \u2014COOR6, \u2014CONR7R8, cyclo(C3-C6 alkyl)methyl, C1-C6 alkyl, C1-C6 perfluoroalkyl, \u2014OR9, \u2014SR9, \u2014OR10OR9, \u2014NR11R12, \u2014NHC(O)R13, \u2014NC(\u2550NR14)NR15, \u2014N(R16)OR17, or \u2014N(R18)NR19R20 wherein R6 to R20 are defined above; and with the proviso that
at least one of R2, R3, R4 and R5 is not hydrogen; and
when R2 and R4 are both hydrogen and either R3 or R5 is C1 alkyl substituted with a hydroxy or \u2014O-benzyl group and the other R3 or R5 is hydrogen, then B is not purin-9-yl-6-amine.
2. The compound of claim 1, wherein B is adenine; purin-9-yl-2,6-diamine; 9H-purin-9-yl-6-amine; 2-amino-1H-purin-9-yl-6(9H)-one; 9H-purin-9-yl-2,6-diamine; 6-chloro-9H-purin-9-yl; N-methyl-9H-purin-9-yl-6-amine or N,N,-dimethyl-9H-purin-9-yl-6-amine.
3. The compound of claim 1, wherein R1 is hydroxy, azido, chloro, bromo, or fluoro.
4. The compound of claim 1, wherein R2 or R4 is hydrogen, azido, chloro, bromo, or fluoro.
5. The compound of claim 1, wherein R3 or R5 is hydroxymethyl, azido, chloro, bromo, or fluoro.
6. The compound of claim 1, wherein
1) when R2 and R4 are both hydrogen and either R3 or R5 is C1 alkyl substituted with a hydroxy or \u2014O\u2014R9 group, and the other R3 or R5 is hydrogen, then B is not purin-9-yl-6-amine; or
2) when either R2 or R4 and either R3 or R5 are C1 alkyl substituted with a hydroxy or \u2014O-benzyl group, and the other R2 R4 and R3 or are hydrogen, then B is not 2-amino-purin-9-yl-6-one; or purin-9-yl-6-amine.
7. The compound of claim 1, wherein the oxetane comprises the Formula 1a:
8. A pharmaceutical composition, comprising a pharmaceutically acceptable amount of the compound of claim 1 and a pharmaceutically acceptable carrier.
9. A compound, comprising: an oxetane of Formula 1,
a pharmaceutically acceptable salt, diastereomer, or mixture thereof wherein:
B is a purin-9-yl or a heterocyclic isostere of a purin-9-yl,
wherein the purin-9-yl or heterocyclic isostere of a purin-9-yl comprises
wherein J, L, and M are each independently
hydrogen;
hydroxy;
halogen;
C1-C12 alkyl;
C1-C6 perhaloalkyl;
azido;
cyano;
\u2014COOR21 wherein R21 is hydrogen or C1-C12 alkyl;
\u2014CONR22R23 wherein R22 and R23 are each independently hydrogen or C1-C12 alkyl;
\u2014OR24 wherein R24 is C1-C6 alkyl, C1-C6 perhaloalkyl, phenyl, benzyl, or heterocyclic;
\u2014SR25 wherein R25 is hydrogen, C1-C6 alkyl, C1-C6 perhaloalkyl, phenyl, benzyl, or heterocyclic;
\u2014NR26R27 wherein R26 and R27 are independently hydrogen or C1-C12 alkyl;
\u2014SO2NR26R27 wherein R26 and R27 are defined above;
\u2014NHC(O)R28 wherein R28 is hydrogen, C1-C12 alkyl, carboxyalkyl, or aminoalkyl;
\u2014NC(\u2550NR29)NR30 wherein R29 and R30 are each independently hydrogen or C1-C12 alkyl;
\u2014N(R31)OR32 wherein R31 and R32 are each independently hydrogen or C1-C12 alkyl;
N(R33)NR34R35 wherein R33, R34, and R35 are each independently hydrogen or C1-C12 alkyl;
hydroxyamino; phenyl, \u2014O(phenyl), benzyl, \u2014O(benzyl), heterocyclic or \u2014O(heterocyclic) group which may be unsubstituted, or mono-, di- or trisubstituted with one or more of hydroxy, amino, azido, nitro, cyano, halogen, sulfonamide, carboxyl, C1-C6 alkyl, C1-C6 perfluoroalkyl, \u2014OR24 wherein R24 is as defined above, \u2014NR26R27 wherein R26 and R27 are as defined above, \u2014N(R33)NR34R35 wherein R33, R34, and R35 are as defined above; or
wherein m is 1-5;
wherein R2, R3, R4, and R5 are each independently hydrogen; or
straight or branched C1-C12 alkyl optionally substituted with a hydroxy or \u2014OR9 wherein R9 is C1-C6 alkyl, C1-C6 perhaloalkyl, phenyl, benzyl, or heterocyclic; and
wherein R1 is hydroxy, azido, or halogen; and
with the proviso that at least one of R2, R3, R4 and R5 is not hydrogen; and
when R2 and R4 are both hydrogen and either R3 or R5 is C1 alkyl substituted with a hydroxy or \u2014O-benzyl group and the other R3 or R5 is hydrogen, then B is not purin-9-yl-6-amine.
10. The compound of claim 9, wherein B is adenine; 1H-purin-9-yl-6(9H)-one; N6-cyclopropyl-9H -purin-9-yl-2,6-diamine; 9H-purin-9-yl-6-amine; 2-amino-1H-purin-9-yl-6(9H)-one; 9H-purin-9-yl-2,6-diamine; 6-chloro-9H-purin-9-yl; N-methyl-9H-purin-9-yl-6-amine; or N,N,-dimethyl-9H-purin-9-yl-6-amine.
11. The compound of claim 9, wherein
1) when R2 and R4 are both hydrogen and either R3 or R5 is C1 alkyl substituted with a hydroxy or \u2014O\u2014R9 group, and the other R3 or R5 is hydrogen, then B is not purin-9-yl-6-amine; or
2) when either R2 or R4 and either R3 or R5 are C1 alkyl substituted with a hydroxy or \u2014O-benzyl group, and the other R2 or R4 and R3 or are hydrogen, then B is not 2-amino-purin-9-yl-6-one; or purin-9-yl-6-amine.
12. The compound of claim 9, wherein the oxetane comprises the Formula:
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An offset amount measuring method for measuring an offset amount between a write head and a read head of a composite magnetic head, comprising the steps of
writing a test data obliquely in a designated track and at least one track adjacent to the designated track of one of a rotating magnetic recording medium of a discrete track system, a rotating magnetic recording medium of a bit patterned system and a rotating magnetic recording medium having an unevenly patterned recording layer by moving the composite magnetic head positioned in the designated track under ON track servo control in which a servo information is read out from the designated track, at a designated moving speed K in a radial direction of according to a write start signal by crossing the designated track,
reading the test data by the read head by positioning the composite magnetic head in the adjacent track under the ON track servo control,
detecting a peak position in a read signal read out by the read head,
obtaining a scan time of the read head from a starting time of the write start signal to the peak position of the read signal,
obtaining a relative moving distance in the radial direction of the read head with respect to the test data written in an area from a write start position to the peak position of the read signal by multiplying the scan time with the designated moving speed K, and
calculating the offset amount between the heads with using a difference between the relative moving distance and a distance between the designated track and the adjacent tracks.
2. An offset amount measuring method as claimed in claim 1, wherein the adjacent track includes a plurality of tracks, the peak position and the relative moving distance up to the peak position are obtained correspondingly to the adjacent tracks, respectively, the offset amount between the write head and the read head are calculated correspondingly to the respective adjacent tacks, an average value of the offset amount between the heads being used as the offset amount between the heads.
3. An offset amount measuring method as claimed in claim 2, wherein a write sensitive width of the write head and a read sensitive width of the read head are calculated on the basis of a waveform of the read voltage signal.
4. An offset amount measuring method as claimed in claim 1, wherein the write start signal is an index signal or a sector signal and the read signal is a read voltage signal and, when the maximum voltage of the read voltage signal has a flat portion, a center position of the flat portion is detected as the peak position.
5. An offset amount measuring method as claimed in claim 4, wherein a write sensitive width of the write head and a read sensitive width of the read head are calculated on the basis of a waveform of the read voltage signal.
6. An offset amount measuring method as claimed in claim 1, wherein the write start signal is an index signal or a sector signal, the read signal is a read voltage signal and the peak position is detected by calculating tangential lines of both side curved portions of a waveform of the read voltage signal or an appropriate linear line.
7. An offset amount measuring method as claimed in claim 6, wherein a write sensitive width of the write head and a read sensitive width of the read head are calculated on the basis of the waveform of the read voltage signal.
8. An offset amount measuring device for measuring an offset between a write head and a read head of a composite magnetic head, comprising
a spindle for rotating a magnetic recording medium of a discrete track system or a magnetic recording medium of a bit patterned system or a magnetic recording medium having a recording layer of an uneven pattern,
a servo control circuit for performing an ON track servo control for ON tracking a servo information by reading the servo information from a designated track of the rotating magnetic recording medium,
a composite magnetic head positioning mechanism for positioning the composite magnetic head in the designated track during the ON track servo control,
a test data write circuit for writing a test data in the designated track and at least one track adjacent to the designated track by the write head obliquely with respect to the tracks by moving the composite magnetic head across the designated track in a radial direction of the magnetic recording medium at a designated moving speed K,
a test data read circuit for reading the test data by the read head by positioning the composite magnetic head in the adjacent track during the ON track servo control,
peak position detection means for detecting a peak position in a read signal read by the read head, and
offset amount calculation means for obtaining a scan time of the read head from the generation of the write start signal to the peak position of the read signal, obtaining a relative moving distance of the read head in the radial direction with respect to the test data written from the write start position of the test data to the peak position of the read signal by multiplying the scan time with the designated moving speed K, and calculating the offset amount between the write head and the read head by a distance difference between the relative moving distance and the distance between a track center of the designated track and a track center of the adjacent track.
9. An offset amount measuring device claimed in claim 8, wherein the adjacent track includes a plurality of tracks, the peak position detection means detects the peak positions corresponding to the respective adjacent tracks, the offset amount calculation means obtains the peak position and the relative moving distance up to the peak position correspondingly to the respective adjacent tracks, calculates an offset amount between the write head and the read head correspondingly to the respective adjacent tracks and calculates an average value of the offset amount between these heads as the offset amount of the write head and the read head.
10. An offset amount measuring device claimed in claim 8, wherein the write start signal is an index signal or a sector signal and the read signal is a read voltage signal and, when the maximum voltage of the read voltage signal has a flat portion, a center position of the flat portion is detected as the peak position.
11. An offset amount measuring method as claimed in claim 8, wherein the write start signal is an index signal or a sector signal, the read signal is a read voltage signal and the peak position is detected by calculating tangential lines of both side curved portions of a waveform of the read voltage signal or an appropriate linear line.