1. A SSEA-3 (+) pluripotent stem cell, which can be isolated from body tissue.
2. The pluripotent stem cell according to claim 1, which is positive for CD105.
3. The pluripotent stem cell according to claim 1, which is negative for CD117 and negative for CD146.
4. The pluripotent stem cell according to claim 1, which is negative for CD117, negative for CD146, negative for NG2, negative for CD34, negative for vWF, and negative for CD271.
5. The pluripotent stem cell according to claim 1, which is negative for CD34, negative for CD117, negative for CD146, negative for CD271, negative for NG2, negative for vWF, negative for Sox10, negative for Snail, negative for Slug, negative for Tyrp1, and negative for Dct.
6. The pluripotent stem cell according to claim 1, which has low or no telomerase activity.
7. The pluripotent stem cell according to claim 1, which is capable of differentiating into the three germ layers.
8. The pluripotent stem cell according to claim 1, which does not exhibit tumorigenic proliferation.
9. The pluripotent stem cell according to claim 1, which has self-renewal capability.
10. The pluripotent stem cell according to claim 1, which is resistant to stress.
11. The pluripotent stem cell according to claim 1, which has high phagocytic ability.
12. The pluripotent stem cell according to claim 1 which is positive for at least one of the 22 following odorant receptors:
olfactory receptor, family 8, subfamily G, member 2 (OR8G2);
olfactory receptor, family 7, subfamily G, member 3 (OR7G3);
olfactory receptor, family 4, subfamily D, member 5 (OR4D5);
olfactory receptor, family 5, subfamily AP, member 2 (OR5AP2);
olfactory receptor, family 10, subfamily H, member 4 (OR10H4);
olfactory receptor, family 10, subfamily T, member 2 (OR10T2);
olfactory receptor, family 2, subfamily M, member 2 (OR2M2);
olfactory receptor, family 2, subfamily T, member 5 (OR2T5);
olfactory receptor, family 7, subfamily D, member 4 (OR7D4);
olfactory receptor, family 1, subfamily L, member 3 (OR1L3);
olfactory receptor, family 4, subfamily N, member 4 (OR4N4);
olfactory receptor, family 2, subfamily A, member 7 (OR2A7);
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (GNAL);
olfactory receptor, family 6, subfamily A, member 2 (OR6A2);
olfactory receptor, family 2, subfamily B, member 6 (OR2B6);
olfactory receptor, family 2, subfamily C, member 1 (OR2C1);
olfactory receptor, family 52, subfamily A, member 1 (OR52A1);
olfactory receptor, family 10, subfamily H, member 3 (OR10H3);
olfactory receptor, family 10, subfamily H, member 2 (OR10H2);
olfactory receptor, family 51, subfamily E, member 2 (OR51E2);
olfactory receptor, family 5, subfamily P, member 2 (OR5P2); and
olfactory receptor, family 10, subfamily P, member 1 (OR10P1).
13. The pluripotent stem cell according to claim 1, which is positive for at least one of the 5 following chemokine receptors:
chemokine (C-C motif) receptor 5 (CCR5);
chemokine (C-X-C motif) receptor 4 (CXCR4);
chemokine (C-C motif) receptor 1 (CCR1);
Duffy blood group, chemokine receptor (DARC); and
chemokine (C-X-C motif) receptor 7 (CXCR7).
14. The pluripotent stem cell according to claim 1, which is derived from mesodermal tissue or mesenchymal tissue.
15. A cell cluster or a cell fraction, which contains the pluripotent stem cell according to claim 1.
16. A method for isolating a pluripotent stem cell or a pluripotent cell fraction from body tissue, which uses at least one of the following properties (i) to (vi) as an index:
(i) being positive for SSEA-3;
(ii) being positive for CD105;
(iii) being negative for CD117 and negative for CD146;
(iv) being negative for CD117, negative for CD146, negative for NG2, negative for CD34, negative for vWF, and negative for CD271;
(v) being negative for CD34, negative for CD117, negative for CD146, negative for CD271, negative for NG2, negative for vWF, negative for Sox10, negative for Snail, negative for Slug, negative for Tyrp1, and negative for Dct; and
(vi) having low or no telomerase activity.
17. A method for enrichment of a pluripotent stem cell or a pluripotent cell fraction, which comprises exposing body tissue-derived cells to cellular stress and then collecting surviving cells.
18. The method for enrichment of a pluripotent stem cell or a pluripotent cell fraction according to claim 17, wherein cellular stress is selected from among protease treatment, culture under low-oxygen conditions, culture under low phosphate conditions, culture under serum starvation conditions, culture in a sugar starvation state, culture under exposure to radiation, culture under exposure to heat shock, culture in the presence of a toxic substance, culture in the presence of active oxygen, culture under mechanical stimulation, and culture under pressure treatment.
19. The method for enrichment of a pluripotent stem cell or a pluripotent cell fraction according to claim 18, wherein the cellular stress is trypsin incubation.
20. A pluripotent stem cell, which is a cell derived or induced from the pluripotent stem cell according to claim 1.
21. A differentiated cell, which is a cell derived or induced from the pluripotent stem cell according to claim 1.
22. A pharmaceutical composition, which comprises the pluripotent stem cell according to claim 1.
23. A pharmaceutical composition, which comprises the pluripotent stem cell according to claim 20.
24. A pharmaceutical composition, which comprises the differentiated cell according to claim 21.
25. The pluripotent stem cell according to claim 1, which is derived from umbilical cord or fat issue of a living body.
26. A cell therapy composition for allotransplantation comprising the pluripotent stem cell according to claim 1, in which the pulipotent stem cell does not express HLA class II antigen.
27. A method for regenerate a tissue in a subject, which comprises administering the pluripotent stem cell according to claim 1, in which the pulipotent stem cell does not express HLA class II antigen.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A computer-implemented method for generating a transform performed on a computing device using a color engine, the computer-implemented method comprising:
identifying a first device model plug-in to a first device model, the first device model plug-in comprising executable code provided as an extension to the color engine by a third party independent of a provider of the color engine;
identifying a first device model profile plug-in to a first device model profile, the first device model profile plug-in comprising data referenced to the first device model;
executing the first in device model plug-in over the data contained in the first device model profile plug-in via the computing device;
executing a first color appearance model over data in a first color appearance model profile via the computing device;
generating a first gamut boundary shell from execution of the first device model plug-in and the first color appearance model; and
generating a transform based on the first gamut boundary shell via the computing device.
2. The computer-implemented method of claim 1, wherein the first gamut boundary shell is a source gamut boundary shell.
3. The computer-implemented method of claim 1, wherein the first color appearance model alters the first gamut boundary shell based on data contained in the first color appearance model profile.
4. The computer-implemented method of claim 1, further comprising:
identifying a second device model plug-in to a second device model, the second device model plug-in comprising executable code provided as an extension to the color engine by a third party independent of the provider of the color engine;
identifying a second device model profile plug-in to a second device model profile, the second device model profile plug-in comprising data referenced to the second device model;
executing the second device model plug-in on the data from the second device model profile plug-in to generate a second gamut boundary shell via the computing device,
wherein the transform is generated based on the first gamut boundary shell and the second gamut boundary shell.
5. The computer-implemented method of claim 4, wherein the second gamut boundary shell is a destination gamut boundary shell.
6. The computer-implemented method of claim 4, wherein a second color appearance model alters the second gamut boundary shell based on data contained in a second color appearance model profile.
7. The computer-implemented method of claim 4, wherein the first device model plug-in and the second device model plug-in are in direct communication.
8. The computer-implemented method of claim 1, wherein generating a transform comprises:
providing a gamut map model plug-in; and
using the gamut map model plug-in to generate a transform.
9. The computer-implemented method of claim 1, wherein generating a transform comprises:
providing a gamut map model profile plug-in; and;
generating the transform based on data stored in the gamut map model profile plug-in.
10. One or more computer-readable media storing instructions thereon, the instructions being executable to cause a computer to perform a method of generating a transform using a color engine, the method comprising:
providing a first device model profile for a first device;
identifying a reference to a first plug-in of a first device model in the first device model profile, wherein the first plug-in of the first device model comprises a third-party provided extension to the color engine;
using the first-plug-in of the first device model to generate a first gamut boundary shell via the computer, wherein the first-plug-in of the first device model operates on data from a first plug-in of the first device model profile to generate the first gamut boundary shell;
providing a second device model profile for a second device;
identifying a reference to a second plug-in of a second device model in the second device model profile, wherein the second plug-in of the second device model comprises a third-party-provided extension to the color engine;
using the second plug-in of the second device model to generate a second gamut boundary shell via the computer, wherein the second plug-in of the second device model operates on data from a plug-in of the second device model profile to generate the second gamut boundary shell; and
generating a transform based on the first gamut boundary shell and the second gamut boundary shell via the computer.
11. The computer-readable media of claim 10, wherein the first gamut boundary shell is a source gamut boundary shell.
12. The computer-readable media of claim 10, wherein a first color appearance model alters the first gamut boundary shell based on data contained in a first color appearance model profile.
13. The computer-readable media of claim 10, wherein the second gamut boundary shell is a destination gamut boundary shell.
14. The computer-readable media of claim 10, wherein a second color appearance model alters the second gamut boundary shell based on data contained in a second color appearance model profile.
15. The computer-readable media of claim 10, wherein the first plug-in of the first device model and the second plug-in of the second device model are in direct communication.
16. The computer-readable media of claim 10, wherein generating a transform comprises:
providing a gamut map model plug-in; and
using the gamut map model plug-in to generate a transform.
17. The computer-readable media of claim 10, wherein generating a transform comprises:
providing a gamut map model profile plug-in; and
generating the transform based on data stored in the gamut map model profile plug-in.
18. One or more computer-readable media storing instructions thereon, the instructions being executable to cause a computer to perform a method for transforming image data using a color engine, the method comprising:
providing a source device model profile for a source device, the source device model profile describing physical characteristics of the source device;
determining via the computer whether the source device model profile references a first plug-in of a first device model provided as an extension to the color engine by a third party that is independent of a provider of the color engine;
if the source device model profile references the first plug-in of the first device model, using the first plug-in of the first device model to generate a source gamut boundary shell based on data contained within the source device model profile, wherein the first plug-in of the first device model comprises executable code that operates over the data contained within the source device model profile to generate the source gamut boundary shell;
if the source device model profile does not reference the first plug-in of the first device model, using a base-line device model provided as part of the color engine to generate the source gamut boundary shell based on the data contained within the source device model profile, wherein the base-line device model comprises executable code that operates over the data contained within the source device model profile to generate the source gamut boundary shell;
providing a destination device model profile for a destination device, the destination device model profile describing physical characteristics of the destination device;
determining via the computer whether the destination device model profile references a second plug-in of a second device model provided as an extension to the color engine by a third party that is independent of the provider of the color engine;
if the destination device model profile references the second plug-in of the second device model, using the second plug-in of the second device model to generate a destination gamut boundary shell based on data contained within the destination device model profile, wherein the second plug-in of the second device model comprises executable code that operates over the data contained within the destination device model profile to generate the destination gamut boundary shell;
if the destination device model profile does not reference the second plug-in of the second device model, using the base-line device model provided as part of the color engine to generate the destination gamut boundary shell based on the data contained within the destination device model profile, wherein the base-line device model comprises executable code that operates over the data contained within the destination device model profile to generate the destination gamut boundary shell;
using a gamut map model plug-in of a gamut map model to generate a transform via the computer based on the source gamut boundary shell, the destination gamut boundary shell, and data stored in a gamut map model profile plug-in of a gamut map model profile, wherein the plug-in of the gamut map model comprises executable code that operates over the source gamut boundary shell, the destination gamut boundary shell, and the data stored in the plug-in of the gamut map model profile to generate the transform; and
using the transform to convert the image data of an image file via the computer.
19. The computer-readable media of claim 18, wherein the gamut map model profile contains a number of gamut maps, and the gamut map model selects a gamut map based on the source gamut boundary shell and the destination gamut boundary shell.