1. A process for the preparation of the methanesulfonate trihydrate salt of a compound of formula (I):
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comprising the steps of
(i) dissolving the d-()-tartrate salt of the compound of formula (i) in an aqueous methanesulfonic acid solution; and
(ii) allowing the methanesulfonate trihydrate salt to separate out of solution:
2. A process according to claim 1 wherein the molar ratio of methanesulfonic acid to D-()-tartrate salt of the compound of formula (I) is in the range of 1.3 to 1.0.
3. A process according to claim 1 wherein the molar ratio of methanesulfonic acid to D-()-tartrate salt of the compound of formula (I) is in the range of 1.10 to 1.05.
4. A process according to claim 1 wherein the molar ratio of methanesulfonic acid to D-()-tartrate salt of the compound of formula (I) is in the range of 1.10 to 1.08.
5. A process according to claim 1 wherein the aqueous methanesulfonic acid is created using pyrogen-free water.
6. A process according to claim 1 further comprising the steps of (i) dissolving a racemic mixture comprising compounds of formulae (I) and (II)
10
in aqueous methanol in the presence of D-()-tartaric acid; and
(ii) allowing the D-()-tartrate salt of the compound of formula (I) to separate out of solution.
7. A process according to claim 5 wherein the aqueous methanol has a water content of 5 to 20%.
8. A process according to claim 5 wherein the aqueous methanol has a water content of 7 to 10%.
9. A process for the preparation of the D-()-tartrate salt of a compound of formula (I):
11
comprising the steps of
(i) dissolving a racemic mixture comprising compounds of formulae (I) and (II)
12
in aqueous methanol in the presence of D-()-tartaric acid; and
(ii) allowing the D-()-tartrate salt of the compound of formula (I) to separate out of solution.
10. A process according to claim 9 wherein the aqueous methanol has a water content of 5 to 20%.
11. A process according to claim 9 wherein the aqueous methanol has a water content of 7 to 10%.
12. The D-()-tartrate salt of a compound of formula (I):
13
wherein the ratio of the (1 S,2S)-enantiomer to its (1 R,2R)-antipode is greater than 97%.
13. A salt according to claim 10 wherein the ratio of the (1 S,2S)-enantiomer to its (1 R,2R)-antipode is greater than 98%.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for associating data stored in disparate locations into a single document, comprising:
extracting at least one piece of data that describes content of the document;
transforming the extracted at least one piece of data into search-compatible form;
searching at least one data source using the transformed at least one piece of data;
retrieving information from the at least one data source;
transforming the received information into a processing-compatible form; and
associating the information from the data source with the document.
2. The method according to claim 1, wherein searching at least one data source comprises searching multiple data sources and information retrieve from each of the data sources is associated with the image.
3. The method recited in claim 1, wherein the at least one data source is a database or web accessible data retrieval service.
4. The method recited in claim 1, wherein the at least one piece of data is metadata, further comprising retrieving information from the data source using the metadata.
5. The method recited in claim 1, further comprising:
creating a template; and
applying the template to metadata-rich document or context with appropriate formatting and data transformation.
6. The method recited in claim 1, wherein the document is an image document, further comprising:
Collecting metadata information, such as latitude, longitude, elevation, and acquisition date and time information from the image document, and applyingtransformation as appropriate to associate aforementioned information with to at least one data source to retrieve additional information corresponding to the document or viewing context; and
displaying the retrieved additional information to a user as annotations to the image.
7. A system for associating data stored in disparate locations into a single document, comprising:
a computer;
an image display coupled to the computer for displaying an image to a user; and
a template to be executed by the computer to process the image, wherein the template contains references to one or more local or remote databases to obtain, reformat and transform the additional information and cause it to be displayed as annotations on the image or vector layer.
8. The system recited in claim 7, further comprising a macro processor executing on the computer for processing macros in the template;
9. The system recited in claim 7, wherein the template contains references to one or more local and remote databases.
10. The system recited in claim 7, further comprising a web application server, in conjunction with a web browser over a network to extract, generate, control and display image, vector, metadata and external information in association with data or other geospatial, temporal context.
11. The system recited in claim 9, wherein the template further identifies available databases and provides a list of available fields to the user for selection of fields of interest.
12. The system recited in claim 7, further comprising a computer network through which at least one remote database is accessed.
13. The system recited in claim 7, further comprising a customizable right-click menu.