1. A resin composition comprising:
an ethylene-vinyl alcohol copolymer (A) and a polyamide resin (B), wherein 70 mol % or more of all terminal ends of the polyamide resin (B) are blocked with units containing an imide structure.
2. The resin composition according to claim 1, wherein at least a portion of the units containing an imide structure is units containing a cyclic imide structure.
3. The resin composition according to claim 2, wherein at least a portion of the units containing a cyclic imide structure is units containing a phthalimide structure or a succinimide structure.
4. The resin composition according to claim 1, wherein the amount of terminal amino groups of the polyamide resin (B) is 10 \u03bceqg or less.
5. The resin composition according to claim 1, wherein 75 mol % or more of the units that constitute the polyamide resin (B) are caproamide units.
6. The resin composition according to claim 1, wherein the ethylene-vinyl alcohol copolymer (A) has an ethylene content of 10 to 65 mol % and a saponification degree of 90 mol % or more.
7. The resin composition according to claim 1, wherein the weight ratio of the ethylene-vinyl alcohol copolymer (A) with respect to the polyamide resin (B) is from 955 to 5050.
8. A film comprising a resin composition, wherein the resin composition is as claimed in claim 1.
9. A structure comprising a resin composition, wherein the resin composition is as claimed in claim 1.
10. A method for producing a resin composition, comprising:
mixing an ethylene-vinyl alcohol copolymer (A) and a polyamide resin (B), wherein 70 mol % or more of all terminal ends of the polyamide resin (B) are blocked with units containing an imide structure.
11. The method for producing a resin composition according to claim 10, wherein the relative viscosity of the polyamide resin (B) is 2.0 to 7.0.
12. The method for producing a resin composition according to claim 10, further comprising reacting a polyamide resin (C), 75 mol % or more of all terminal ends of which are amino groups, with a terminal-blocking agent (D) capable of forming an imide structure with the amino groups, to obtain the polyamide resin (B).
13. The method for producing a resin composition according to claim 12, wherein 75 mol % or more of the units that constitute the polyamide resin (C) are caproamide units.
14. The method for producing a resin composition according to claim 12, wherein the relative viscosity of the polyamide resin (C) is 2.0 to 7.0.
15. The method for producing a resin composition according to claim 12, wherein the terminal-blocking agent (D) is a cyclic acid anhydride.
16. The method for producing a resin composition according to claim 15, wherein at least a portion of the cyclic acid anhydride is a phthalic anhydride or a succinic anhydride.
17. The method for producing a resin composition according to claim 10, wherein
the ethylene-vinyl alcohol copolymer (A) has an ethylene content of 10 to 65 mol % and a saponification degree of 90 mol % or more.
18. The method for producing a resin composition according to claim 10, wherein the ethylene-vinyl alcohol copolymer (A) and the polyamide resin (B) are mixed so that the weight ratio of the ethylene-vinyl alcohol copolymer (A) with respect to the polyamide resin (B) results in 955 to 5050.
19. A polyamide resin comprising terminal ends, 70 mol % or more of all of which are blocked with units containing an imide structure.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An oligothiophene derivate according to formula (I)
wherein
R3 is chosen from
and wherein
n is selected from the group consisting of 0, 1, 2, and 3,
Y\u2014 is an anionic counter ion,
X is CH2 when n=0, and X is selected from the group consisting of O and CH2 when n is 1, 2, or 3, and
each R1 and R2 are independently selected from the group consisting of 5-chlorothiophene-2-yl (1), 5-bromothiophene-2-yl (2), 5-iodothiophene-2-yl (3), 5-methylthiophene-2-yl (4), thiophene-2-yl (5), 5-thiophenecarboxylic acid-2-yl (6), 5-formylthiophene-2-yl (7), 5-acetylthiophene-2-yl (8) and methyl 2-yl-thiophene-5-carboxylate (9), 5-fluorothiophene-2-yl with enriched isotopes of 18F or 19F (10), 5-thiophene-2-yl with tritium (11) and 5-methylthiophene-2-yl with isotopically enriched carbon 11C (12) according to the formulas
2. An oligothiophene derivate according to formula I,
wherein R1 is
R3 is chosen from
and wherein,
n is selected from the group consisting of 0, 1, 2, and 3,
Y\u2014 is an anionic counter ion,
X is CH2 when n=0, and X is selected from the group consisting of O and CH2 when n is 1, 2, or 3, and
R2 is selected from the group consisting of 5-chlorothiophene-2-yl (1), 5-bromothiophene-2-yl (2), 5-iodothiophene-2-yl (3), 5-methylthiophene-2-yl (4), thiophene-2-yl (5), 5-thiophenecarboxylic acid-2-yl (6), 5-formylthiophene-2-yl (7), 5-acetylthiophene-2-yl (8) and methyl 2-yl-thiophene-5-carboxylate (9), 5-fluorothiophene-2-yl with enriched isotopes of 18F or 19F (10), 5-thiophene-2-yl with tritium (11) and 5-methylthiophene-2-yl with isotopically enriched 11C (12) according to the formulas
and wherein
R4 is selected from the group consisting of bromine, chlorine, hydrogen, iodine, methyl, 5-methylthiophene-2-yl (4), thiophene-2-yl (5), 5-thiophenecarboxylic acid-2-yl (6), 5-formylthiophene-2-yl (7), 5-acetylthiophene-2-yl (8) and methyl 2-yl-thiophene-5-carboxylate (9), 5-fluorothiophene-2-yl with enriched isotopes of 18F or 19F (10), 5-thiophene-2-yl with tritium (11) and 5-methylthiophene-2-yl with isotopically enriched carbon 11C (12) according to the formulas:
3. An oligothiophene derivate according to formula (I),
wherein R1 is
R3 is chosen from
and wherein
n is selected from the group consisting of 0, 1, 2, and 3,
Y\u2014 is an anionic counter ion,
X is CH2 when n=0, and X is selected from the group consisting of O and CH2 when n is 1, 2, or 3, and
wherein R2 and R4 are independently selected from the group consisting of bromine, chlorine, hydrogen, iodine, methyl, 5-methylthiophene-2-yl (4), thiophene-2-yl (5), 5-thiophenecarboxylic acid-2-yl (6), 5-formylthiophene-2-yl (7), 5-acetylthiophene-2-yl (8) and methyl 2-yl-thiophene-5-carboxylate (9), 5-fluorothiophene-2-yl with enriched isotopes of 18F or 19F (10), 5-thiophene-2-yl with tritium (11) and 5-methylthiophene-2-yl with isotopically enriched carbon 11C (12) according to the formulas:
4. The oligothiophene derivate according to claim 1,
wherein
R3 is according to formula (I),
and wherein
n is 1,
X is CH2,
Y\u2014 is 4-methylbenzenesulfonate, and
R1 and R2 are according to formula 5 in claim 1
which will give formula
P1 (p-HTML).
5. An oligothiophene derivate according to formula (I),
wherein R1 is
wherein R3 is
and wherein
n is 1,
X is CH2,
Y\u2014 is 4-methylbenzenesulfonate,
R4 is H
and
R2 is hydrogen,
which will give the formula
6. An oligothiophene derivate conjugated to a detectable moiety, the oligothiophene derivate according to formula (I)
wherein
R3 is chosen from
and wherein
n is selected from the group consisting of 0, 1, 2, and 3,
Y\u2014 is an anionic counter ion,
X is CH2 when n=0, and X is selected from the group consisting of O and CH2 when n is 1, 2, or 3, and
each R1 and R2 are independently selected from the group consisting of 5-chlorothiophene-2-yl (1), 5-bromothiophene-2-yl (2), 5-iodothiophene-2-yl (3), 5-methylthiophene-2-yl (4), thiophene-2-yl (5), 5-thiophenecarboxylic acid-2-yl (6), 5-formylthiophene-2-yl (7), 5-acetylthiophene-2-yl (8) and methyl 2-yl-thiophene-carboxylate (9), 5-fluorothiophene-2-yl with enriched isotopes of 18F or 19F (10), 5-thiophene-2-yl with tritium (11) and 5-methylthiophene-2-yl with isotopically enriched carbon 11C (12) according to the formulas
7. The oligothiophene derivate according to claim 6, wherein the detectable moiety is selected from the group consisting of a radioisotope, a radionuclide, a fluorescent label, an enzymatic label, a chemiluminescent label, a biotinyl group, a predetermined polypeptide epitope recognized by a secondary binding entity; a binding site for secondary antibody, a metal binding domain, an epitope, a protein tag, and a carbohydrate.
8. The oligothiophene derivate according to claim 7, wherein the radioisotope or radionuclide is selected from the group consisting of 3H, 14C, 35S, 123I, 125I, 131I, \u2033Tc, 111In, 90Y, 188Re, 11C, 3H, 18F, and 64Cu.
9. A method for detecting neural stem cells or neural cancer stem cells in a biological sample in vitro, in situ or in vivo, the method comprising the steps of
a. contacting said sample with a composition comprising at least one oligothiophene derivate according to claim 1 to form at least one neural stern cell-oligothiophene derivate complex or to form at least one neural cancer stem cell-oligothiophene derivate complex, and
b. detecting said neural stem cell-oligothiophene derivate complexes or neural cancer stem cell-oligothiophene derivate complexes.
10. The method according to claim 9, further comprising comparing the neural stem cell-oligothiophene derivate complexes or neural cancer stem cell-oligothiophene derivate complexes to a positive control, wherein the positive control comprises neural stem cells or neural cancer stem cells.
11. The method according to claim 9, further comprising comparing the neural stem cell-oligothiophene derivate complexes or neural cancer stem cell-oligothiophene derivate complexes to a negative control, wherein the negative control does not comprise neural stem cells or neural cancer stem cells.
12. The method according to claim 9, further comprising a step of scoring the amount of neural stem cells-oligothiophene derivate complexes or neural cancer stem celloligothiophene derivate complexes.
13. The method according to claim 9, which is performed on an automated staining device.
14. The method according to claim 9, wherein the detection is made manually.
15. The method according to claim 9, wherein the detection is made by image analysis.
16. A method for separating neural stem cells or neural cancer stem cells from other biological material in a biological sample, the method comprising the steps of
a. contacting said sample with a composition comprising at least one oligothiophene derivate according to claim 1 to form at least one neural stem cell-oligothiophene derivate complex or at least one neural cancer stem cell-oligothiophene derivate complex,
b. detecting said neural stem cell-oligothiophene derivate complexes or neural cancer stem cell-oligothiophene derivate complex, and
c. separating said detected neural stem cell-oligothiophene derivate complexes or neural cancer stem cell-oligothiophene derivate complexes, thereby separating neural stem cells or neural cancer stem cells.
17. The method of claim 16, further comprising the step of isolating said neural stem cells or neural cancer stem cells.
18. The method of claim 17, wherein the isolation is done by mechanical means.
19. The method of claim 17, wherein the isolation is done by flow cytometric means.