1. A ceramic wiring board provided with an insulating layer of a high dielectric constant formed of a ceramic sintered product having a high dielectric constant wherein said ceramic sintered product contains a crystal phase of lanthanum titanate and a glass phase present on the grain boundaries of said crystal phase, and the ceramic sintered product has a coefficient of thermal expansion at 40 to 400 C. of not smaller than 8106 C., a specific inductive capacity at 1 MHz of not smaller than 10, and a porosity of not more than 0.5%.
2. A ceramic wiring board according to claim 1, wherein said lanthanum titanate is expressed by the following formula,
La2O3.xTiO2
wherein x is a mol fraction satisfying 2×5.
3. A ceramic wiring board according to claim 1, wherein said ceramic sintered product contains not leas than 10% by weight of a crystal phase of lanthanum titanate.
4. A ceramic wiring board according to claim 1, wherein said ceramic sintered product contains a crystal phase of a composite oxide that contains Ti and an alkaline earth metal.
5. A ceramic wiring board to claim 4, wherein said ceramic sintered product contains zirconium as a solid solution in said glass phase andor in the crystal phase of the composite oxide containing Ti and the alkaline earth metal.
6. A ceramic wiring board according to claim 1, wherein said ceramic sintered product contains a crystal phase of a composite oxide that contains Si and an alkaline earth metal.
7. A ceramic wiring board according to claim 1, wherein said ceramic sintered product is obtained by firing 35 to 70% by weight of a glass component and 30 to 65% by weight of a filler component that contains at least lanthanum titanate.
8. A ceramic wiring board according to claim 7, wherein said glass component has a coefficient of thermal expansion at 40 to 400 C. of 6 to 18106 C.
9. A ceramic wiring board according to claim 7, wherein said filler component comprises:
(a) lanthanum titanate;
(b) at least one titanium compound selected from the group consisting of calcium titanate, strontium titanate, barium titanate and titania; and
(c) an oxide containing zirconium;
and said ceramic sintered product has a specific inductive capacity at 1 MHz of not smaller than 14.
10. A ceramic wiring board according to claim 9, wherein said filler component (b) is used in an amount of from 20 to 80% by weight per the sum of the filler components (a), and (b).
11. A ceramic wiring board according to claim 9, wherein said filler component (c) is used in an amount of from 5 to 30% by weight per the sum of the filler components (a), (b) and (c).
12. A ceramic wiring board according to claim 9, wherein said filler component further contains (d) magnesium titanate, and said ceramic sintered product has a specific inductive capacity at 1 MHz to 3 GHz of not smaller than 14 and a dielectric loss tangent (tan ) at 1 MHz to 3 GHz of not larger than 25 104.
13. A ceramic wiring board according to claim 12, wherein said filler component (d) is used in an amount of from 20 to 80 % by weight per the sum of the filler components (a) and (d).
14. A ceramic wiring board according to claim 13, wherein said filler component (b) is used in an amount of from 20 to 80% by weight per the sum of the filler components (a), (b) and (d), and said filler component (c) in an amount of from 5 to 30% by weight per the sum of the filler components (a) to (d).
15. A ceramic wiring board according to claim 7, wherein said glass component contains 15 to 40% by weight of an alkaline earth metal oxide, 30 to 60% by weight of SiO2 and 1 to 20% by weight of ZrO2, and said ceramic sintered product has a dielectric loss tangent (tan ) at 1 MHz to 3 GHz of not larger than 30 404.
16. A ceramic wiring board according to claim 15, wherein said ceramic sintered product has a peak intensity ratio II0 of a maximum peak intensity I, as measured an X-ray diffraction measurement, is smaller than 1, wherein I means a maximum peak intensity of detected composite oxides containing alkaline earth metal and Si, and I0 means a maximum peak intensity of detected oxides containing Ti.
17. A ceramic wiring board according to claim 1 wherein the ceramic wiring board comprises a laminate of the insulating layer of a high dielectric constant formed of said ceramic sintered product having a high dielectric constant and an insulating layer of a low dielectric constant formed of a ceramic sintered product having a low specific inductive capacity which is smaller than 10.
18. A ceramic wiring board according to claim 17, wherein said ceramic sintered product of a low dielectric constant has, as a crystal phase, quartz and a composite oxide crystal containing Si and Mg, and has a difference in the thermal expansion at 40 to 400 C. of not larger than 0.5 ppm C. between said insulating layer of a high dielectric constant and said insulating layer of a low dielectric constant.
19. A ceramic wiring board according to claim 18, wherein the composite oxide crystal containing Si and Mg is MgSiO3 or Mg2SiO5.
20. A ceramic wiring board according to claim 1, wherein said insulating layer of a high dielectric constant is arranged between a pair of electrode layers.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (Ia):
or pharmaceutically acceptable salt thereof, wherein the symbols have the following meanings and are, for each occurrence, independently selected:
R1 is n-butyl or (E)-but-2-enyl;
R2 is ethyl, 1-hydroxyethyl, isobutyl or n-butyl;
W is O or S;
n is an integer of 3, 4, 5 or 6;
R5 is H or methyl;
each occurrence of RA and RB is independently hydrogen or (C1-C4)alkyl, optionally substituted by one or more groups RD which may be the same or different, in which each occurrence of RD is independently halogen, hydroxy, O(C1-C4)alkyl, C(\u2550O)(C1-C4)alkyl, C(\u2550O)O(C1-C4)alkyl; or RA and RB, together with the nitrogen atom to which they are attached, form a saturated or unsaturated heterocyclic ring containing from three to seven ring atoms, which ring may optionally contain another heteroatom selected from the group consisting of nitrogen, oxygen and sulfur and may be optionally substituted by from one to four groups which may be the same or different selected from (C1-C4)alkyl, phenyl and benzyl.
2. The compound of claim 1, having the following chemical structure:
wherein W is S or O;
n is 3, 4, 5, or 6;
Ra is H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, CH2CMe3, phenyl, or CH2-phenyl; and
Rb is H, n-propyl, n-butyl, i-butyl, t-butyl, CH2CMe3, phenyl, or CH2-phenyl;
or
\u2003is
\u2003in which Rc is H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, CH2CMe3, phenyl, or CH2-phenyl.
3. The compound of claim 1, having the following chemical structure:
wherein W is S or O;
n is 3, 4, 5, or 6;
Ra is H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, CH2CMe3, phenyl, or CH2-phenyl; and
Rb is H, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, CH2CMe3, phenyl, or CH2-phenyl;
or
\u2003is
\u2003in which Rc is H, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, t-butyl, CH2CMe3, phenyl, or CH2-phenyl.
4. The compound of claim 1, selected from the group consisting of:
(R)-2-(N,N-Diethylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporine;
(R)-3-(N,N-Diethylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporine;
(R)-3-(N-Morpholino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N,N-Diethylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N,N-Diethylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Morpholino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-Pyrrolidinyl)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-1H-Imidazolyl)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-Piperidinyl)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-Morpholino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-Thiomorpholino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(Piperazinyl)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-4-Methylpiperazinyl)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-4-Ethylpiperazinyl)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-4-n-Propylpiperazinyl)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-4-iso-Propylpiperazinyl)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-Pyrrolidinyl)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-1H-Imidazolyl)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-Piperidinyl)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-Morpholino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-Thiomorpholino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(Piperazinyl)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-4-Methylpiperazinyl)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-4-Ethylpiperazinyl)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-4-n-Propylpiperazinyl)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-4-iso-Propylpiperazinyl)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N,N-Di-n-propylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-n-Propylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-n-Propyl-N-methylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-n-Propyl-N-ethylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N,N-Di-iso-propylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Propylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Propyl-N-methylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Propyl-N-ethylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Butylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Butyl-N-methylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Butyl-N-ethylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)ethylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N,N-Diethylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N,N-Di-n-proylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-n-Propylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-n-Propyl-N-methylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-n-Propyl-N-ethylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N,N-Di-iso-propylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Propylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Propyl-N-methylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Propyl-N-ethylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Butylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Butyl-N-methylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-iso-Butyl-N-ethylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)ethoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Azetidinyl)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Pyrrolidinyl)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-1H-Imidazolyl)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Piperidinyl)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Thiomorpholino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(Piperazinyl)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-4-Methylpiperazinyl)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-4-Ethylpiperazinyl)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-4-n-Propylpiperazinyl)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-4-iso-Propylpiperazinyl)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Azetidinyl)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Pyrrolidinyl)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-1H-Imidazolyl)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Piperidinyl)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Morpholino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-Thiomorpholino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(Piperazinyl)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-4-Methylpiperazinyl)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-4-Ethylpiperazinyl)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-4-n-Propylpiperazinyl)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-4-iso-Propylpiperazinyl)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N,N-Dimethylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N,N-Di-n-proylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-n-Propylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-n-Propyl-N-methylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-n-Propyl-N-ethylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N,N-Di-iso-propylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Propylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Propyl-N-methylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Propyl-N-ethylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Butylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Butyl-N-methylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Butyl-N-ethylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)propylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N,N-Dimethylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N,N-Diethylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N,N-Di-n-proylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-n-Propylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-n-Propyl-N-methylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-n-Propyl-N-ethylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N,N-Di-iso-propylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Propylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Propyl-N-methylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Propyl-N-ethylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Butylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Butyl-N-methylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-iso-Butyl-N-ethylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)propoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Azetidinyl)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Pyrrolidinyl)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-1H-Imidazolyl)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Piperidinyl)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Morpholino)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Thiomorpholino)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(Piperazinyl)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-4-Methylpiperazinyl)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-4-Ethylpiperazinyl)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-4-n-Propylpiperazinyl)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-4-iso-Propylpiperazinyl)Butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Azetidinyl)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Pyrrolidinyl)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-1H-Imidazolyl)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Piperidinyl)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Morpholino)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-Thiomorpholino)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(Piperazinyl)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-4-Methylpiperazinyl)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-4-Ethylpiperazinyl)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-4-n-Propylpiperazinyl)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-4-iso-Propylpiperazinyl)Butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N,N-Dimethylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N,N-Diethylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N,N-Di-n-proylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-n-Propylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-n-Propyl-N-methylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-n-Propyl-N-ethylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N,N-Di-iso-propylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Propylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Propyl-N-methylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Propyl-N-ethylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Butylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Butyl-N-methylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Butyl-N-ethylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)butylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N,N-Dimethylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N,N-Diethylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N,N-Di-n-proylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-n-Propylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-n-Propyl-N-methylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-n-Propyl-N-ethylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N,N-Di-iso-propylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Propylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Propyl-N-methylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Propyl-N-ethylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Butylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Butyl-N-methylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-iso-Butyl-N-ethylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)butoxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Azetidinyl)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Pyrrolidinyl)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-1H-Imidazolyl)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Piperidinyl)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Morpholino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Thiomorpholino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(Piperazinyl)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-4-Methylpiperazinyl)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-4-Ethylpiperazinyl)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-4-n-Propylpiperazinyl)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-4-iso-Propylpiperazinyl)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Azetidinyl)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Pyrrolidinyl)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-1H-Imidazolyl)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Piperidinyl)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Morpholino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-Thiomorpholino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(Piperazinyl)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-4-Methylpiperazinyl)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-4-Ethylpiperazinyl)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-4-n-Propylpiperazinyl)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-4-iso-Propylpiperazinyl)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N,N-Dimethylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N,N-Diethylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N,N-Di-n-proylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-n-Propylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-n-Propyl-N-methylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-n-Propyl-N-ethylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N,N-Di-iso-propylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Propylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Propyl-N-methylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Propyl-N-ethylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Butylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Butyl-N-methylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Butyl-N-ethylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)pentylthio-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N,N-Dimethylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N,N-Diethylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N,N-Di-n-proylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-n-Propylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-n-Propyl-N-methylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-n-Propyl-N-ethylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N,N-Di-iso-propylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Propylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Propyl-N-methylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Propyl-N-ethylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Butylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Butyl-N-methylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-iso-Butyl-N-ethylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)pentyloxy-Sar-3-N-methylisoleucine-4-cyclosporin;
(R)-2-(N-Pyrrolidinyl)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-1H-Imidazolyl)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-Piperidinyl)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-Morpholino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-Thiomorpholino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(Piperazinyl)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-4-Methylpiperazinyl)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-4-Ethylpiperazinyl)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-4-n-Propylpiperazinyl)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-4-iso-Propylpiperazinyl)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-Pyrrolidinyl)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-1H-Imidazolyl)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-Piperidinyl)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-Morpholino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-Thiomorpholino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(Piperazinyl)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-4-Methylpiperazinyl)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-4-Ethylpiperazinyl)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-4-n-Propylpiperazinyl)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-4-iso-Propylpiperazinyl)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N,N-Di-n-proylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-n-Propylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-n-Propyl-N-methylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-n-Propyl-N-ethylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N,N-Di-iso-propylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Propylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Propyl-N-methylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Propyl-N-ethylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Butylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Butyl-N-methylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Butyl-N-ethylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)ethylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N,N-Diethylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N,N-Di-n-proylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-n-Propylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-n-Propyl-N-methylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-n-Propyl-N-ethylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N,N-Di-iso-propylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Propylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Propyl-N-methylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Propyl-N-ethylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Butylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Butyl-N-methylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-iso-Butyl-N-ethylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-2-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)ethoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-Azetidinyl)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-Pyrrolidinyl)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-1H-Imidazolyl)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-Piperidinyl)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-Thiomorpholino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(Piperazinyl)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-4-Methylpiperazinyl)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-4-Ethylpiperazinyl)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-4-n-Propylpiperazinyl)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-4-iso-Propylpiperazinyl)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-Azetidinyl)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-Pyrrolidinyl)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-1H-Imidazolyl)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-Piperidinyl)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-Morpholino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-Thiomorpholino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(Piperazinyl)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-4-Methylpiperazinyl)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-4-Ethylpiperazinyl)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-4-n-Propylpiperazinyl)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-4-iso-Propylpiperazinyl)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N,N-Dimethylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N,N-Di-n-proylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-n-Propylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-n-Propyl-N-methylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-n-Propyl-N-ethylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N,N-Di-iso-propylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Propylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Propyl-N-methylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Propyl-N-ethylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Butylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Butyl-N-methylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Butyl-N-ethylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)propylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N,N-Dimethylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N,N-Diethylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N,N-Di-n-proylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-n-Propylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-n-Propyl-N-methylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-n-Propyl-N-ethylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N,N-Di-iso-propylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Propylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Propyl-N-methylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Propyl-N-ethylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Butylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Butyl-N-methylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-iso-Butyl-N-ethylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)propoxy-Sar-3-N-methylvaline-4-yclosporin;
(R)-3-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)propoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Azetidinyl)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Pyrrolidinyl)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-1H-Imidazolyl)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Piperidinyl)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Morpholino)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Thiomorpholino)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(Piperazinyl)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-4-Methylpiperazinyl)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-4-Ethylpiperazinyl)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-4-n-Propylpiperazinyl)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-4-iso-Propylpiperazinyl)Butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Azetidinyl)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Pyrrolidinyl)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-1H-Imidazolyl)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Piperidinyl)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Morpholino)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-Thiomorpholino)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(Piperazinyl)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-4-Methylpiperazinyl)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-4-Ethylpiperazinyl)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-4-n-Propylpiperazinyl)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-4-iso-Propylpiperazinyl)Butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N,N-Dimethylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N,N-Diethylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N,N-Di-n-proylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-n-Propylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-n-Propyl-N-methylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-n-Propyl-N-ethylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N,N-Di-iso-propylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Propylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Propyl-N-methylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Propyl-N-ethylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Butylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Butyl-N-methylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Butyl-N-ethylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)butylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N,N-Dimethylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N,N-Diethylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N,N-Di-n-proylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-n-Propylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-n-Propyl-N-methylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-n-Propyl-N-ethylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N,N-Di-iso-propylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Propylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Propyl-N-methylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Propyl-N-ethylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Butylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Butyl-N-methylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-iso-Butyl-N-ethylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-4-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)butoxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Azetidinyl)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Pyrrolidinyl)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-1H-Imidazolyl)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Piperidinyl)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Morpholino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Thiomorpholino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(Piperazinyl)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-4-Methylpiperazinyl)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-4-Ethylpiperazinyl)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-4-n-Propylpiperazinyl)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-4-iso-Propylpiperazinyl)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Azetidinyl)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Pyrrolidinyl)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-1H-Imidazolyl)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Piperidinyl)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Morpholino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-Thiomorpholino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(Piperazinyl)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-4-Methylpiperazinyl)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-4-Ethylpiperazinyl)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-4-n-Propylpiperazinyl)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-4-iso-Propylpiperazinyl)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N,N-Dimethylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N,N-Diethylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N,N-Di-n-proylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-n-Propylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-n-Propyl-N-methylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-n-Propyl-N-ethylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N,N-Di-iso-propylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Propylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Propyl-N-methylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Propyl-N-ethylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Butylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Butyl-N-methylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Butyl-N-ethylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)pentylthio-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N,N-Dimethylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N,N-Diethylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N,N-Di-n-proylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-n-Propylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-n-Propyl-N-methylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-n-Propyl-N-ethylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N,N-Di-iso-propylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Propylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Propyl-N-methylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Propyl-N-ethylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Butylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Butyl-N-methylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-iso-Butyl-N-ethylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propyl-N-methylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin; and
(R)-5-(N-(2\u2032,2\u2032-dimethyl)propyl-N-ethylamino)pentyloxy-Sar-3-N-methylvaline-4-cyclosporin;
or pharmaceutically acceptable salt thereof.
5. The compound of claim 4 selected from the group consisting of:
(R)-2-(N,N-Diethylamino)ethylthio-Sar-3-N-MeIle-4-cyclosporin;
(R)-3-(N,N-Diethylamino)propylthio-Sar-3-N-MeIle-4-cyclosporin;
(R)-3-(N-Morpholino)propyl-Sar-3-N-MeIle-4-cyclosporin;
(R)-3-(N-Pyrrolidinyl)propylthio-Sar-3-N-MeIle-4-cyclosporin;
(R)-3-(N-Piperidinyl)propylthio-Sar-3-N-MeIle-4-cyclosporin;
(R)-3-(N-4-Methylpiperazinyl)propylthio-Sar-3-N-MeIle-4-cyclosporin;
(R)-3-(N,N-Diethylamino)propylthio-Sar-3-N-MeVal-4-cyclosporin;
(R)-3-(N-Morpholino)propyl-Sar-3-N-MeVal-4-cyclosporin;
(R)-3-(N-Pyrrolidinyl)propylthio-Sar-3-N-MeVal-4-cyclosporin;
(R)-3-(N-Piperidinyl)propylthio-Sar-3-N-MeVal-4-cyclosporin; and
(R)-3-(N-4-Methylpiperazinyl)propylthio-Sar-3-N-MeVal-4-cyclosporin, or pharmaceutically acceptable salt thereof.
6. A pharmaceutical composition comprising at least one compound according to claim 1 and a pharmaceutically-acceptable carrier or diluent.
7. A method for treating HIV infection, hepatitis C virus infection or hepatitis B virus infection in a mammalian species in need thereof, the method comprising administering to the mammalian species a therapeutically effective amount of at least one compound according to claim 1.