1. A compound of formula III,
wherein:
Y represents \u2014C(O)\u2014Z;
X represents n-butyl; and
Z represents phenyl substituted in the para-position by \u2014OH, \u2014OCH3, \u2014O-benzyl or \u2014ORa where Ra is \u2014(CH2)3\u2014N(Rb2)Rb3, and Rb2 and Rb3 are butyl.
2. The compound of claim 1 wherein Z represents phenyl substituted in the para-position by \u2014OH, \u2014OCH3 or \u2014O-benzyl.
3. A process for the preparation of a compound of a compound of formula III,
wherein X represents hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms, and Y represents \u2014C(O)Z, which process comprises a reaction according to one of (i), (ii), (iii), (iv), (v), (vi) or (vii):
(i) reaction of a compound of formula VII,
Z\u2014C(O)\u2014CH3\u2003\u2003VII
wherein Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12;
with a compound of formula VIII,
X\u2014C(O)-L1\u2003\u2003VIII
wherein L1 represents a suitable leaving group;
(ii) reaction of a compound of formula IX,
X\u2014C(O)\u2014CH3\u2003\u2003IX
wherein X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms;
with a compound of formula X,
Z\u2014C(O)-L1\u2003\u2003X
wherein Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12; and L1 is a suitable leaving group;
(iii) for compounds of formula III, in which Z represents aryl or heteroaryl substituted by \u2014OH, reaction of a corresponding compound of formula XI,
H3C\u2014C(O)\u2014Za\u2003\u2003XI
wherein Za represents aryl or heteroaryl substituted with \u2014O\u2014C(O)\u2014X (in which X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms), with base;
(iv) decarboxylation of a compound of formula XII,
or a protected derivative thereof, wherein X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms, and Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12;
(v) hydrolysis of a compound of formula XIII,
wherein Rs1 and Rs2 independently represent hydrogen, a C1-6 alkyl optionally substituted by one or more halo atoms, or Rs1 and Rs2 are linked together to form, together with the nitrogen atom to which they are necessarily attached, a 4- to 8-membered heterocycloalkyl group, and X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms, and Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12;
(vi) reaction of a compound of formula XIV,
Z\u2014H\u2003\u2003XIV
wherein Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12;
with either:
(A) a compound of formula XV,
X\u2014C(O)\u2014CH2\u2014C(O)-L1\u2003\u2003XV
or a protected derivative thereof, wherein X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms, and L1 is a suitable leaving group; or
(B) a compound of formula XVI,
X\u2014C(O)\u2014CH2\u2014CN\u2003\u2003XVI
or a protected derivative thereof, wherein X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms; or
(vii) reduction of a compound of formula XVIA,
or reduction a compound of formula XVIB,
wherein in both formula XVIA and formula XVIB, X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms and Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014R(Ra10)S(O)2Ra11 and Ra12, in the presence of aqueous acid
and wherein Ra represents an oxy-protecting group, hydrogen or a C1-6 alkyl optionally substituted by one or more substituents selected from the group consisting of halo, \u2014C(O)2Rb1 and \u2014N(Rb2)Rb3; where Ra1, Ra3, Ra6, Ra7, Ra8, Ra9, Ra10, Rb1, Rb2 and Rb3 independently represent hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms; and where Ra4, Ra5, Ra11; and Ra12 independently represent a C1-6 alkyl optionally substituted by one or more halo atoms.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of determining the concentration of an analyte in a biological sample, comprising:
inserting an analyte sensor in a sensor port of an analyte monitoring device, the sensor port comprising:
a first set of contacts positioned along a top portion and a bottom portion of the sensor port for contacting a first analyte sensor having an opposing electrode contact configuration;
a second set of contacts positioned on the top portion or the bottom portion of the sensor port for contacting a second analyte sensor having a co-planar electrode contact configuration;
wherein the analyte monitoring device comprises a processor programmed to:
receive a signal indicative of the concentration of the analyte from the first set of contacts, and
receive a signal indicative of the concentration of the analyte from the second set of contacts; and
depositing the biological sample on the analyte sensor;
receiving, by the processor, the signal from either the first set of contacts or the second set of contacts; and
determining the concentration of the analyte in the biological sample based on the signal.
2. The method of claim 1, wherein the first analyte sensor is a glucose sensor and the second analyte sensor is a ketone sensor.
3. The method of claim 1, wherein both the first and second analyte sensors are glucose sensors.
4. The method of claim 1, further comprising a communication unit.
5. The method of claim 4, wherein the communication unit is configured to provide two-way communication between the sensor port and a device andor network external to the sensor port.
6. The method of claim 4, wherein the communication unit is configured to provide two-way communication between the sensor port and a network external to the sensor port.
7. The method of claim 6, wherein the network is a computer network.
8. The method of claim 4, wherein the communication unit is configured to provide wireless communication between the sensor port and an external device.
9. The method of claim 8, wherein the external device is a medication delivery device or an implanted or partially implanted analyte sensor.
10. The method of claim 8, wherein the external device is an insulin pump.
11. The method of claim 4, wherein the communication unit comprises a Universal Serial Bus (USB) connector.
12. The method of claim 4, wherein the communication unit is configured to provide wireless communication between the sensor port and an external device andor network.
13. The method of claim 12, wherein the communication unit utilizes a wireless communication protocol selected from a radio frequency (RF) protocol and an infrared (IR) protocol.
14. The method of claim 12, wherein the communication unit is configured to provide wireless communication between the sensor port and an external device, the external device comprises a Radio-Frequency Identification (RFID) tag, and the communication unit utilizes an RF wireless communication protocol to communicate with the Radio-Frequency Identification (RFID) tag.
15. The method of claim 12, wherein the communication unit utilizes a wireless communication protocol selected from code division multiple access (CDMA) and Global System for Mobile communications (GSM).
16. The method of claim 1, wherein the sensor port is configured to receive analyte sensors having different widths.
17. The method of claim 16, wherein the sensor port comprises a side wall and a biasing mechanism configured to position the analyte sensors against the sidewall during insertion of the analyte sensors.
18. The method of claim 16, wherein the first analyte sensor has a width which is greater than that of the second analyte sensor.
19. The method of claim 16, wherein the first analyte sensor has a width which is less than that of the second analyte sensor.
20. The method of claim 1, wherein the sensor port comprises an analyte sensor ejector slidably engaged therewith.
21. The method of claim 1, wherein the sensor port comprises at least four sensor port contacts configured to contact the first analyte sensor upon insertion of the first analyte sensor into the sensor port, and at least three sensor port contacts configured to contact the second analyte sensor upon insertion of the second analyte sensor into the sensor port.
22. The method of claim 21, wherein the sensor port comprises at least seven different sensor port contacts.
23. The method of claim 22, wherein the sensor port comprises at least nine different sensor port contacts.
24. The method of claim 21, wherein one of the at least four sensor port contacts is attached to the top portion of the sensor port and three of the at least four sensor port contacts are attached to the bottom portion of the sensor port.
25. The method of claim 21, wherein the at least three sensor port contacts are attached to the top portion of the sensor port.
26. The method of claim 21, wherein the sensor port comprises a protective protrusion extending from the top portion of the sensor port into the interior of the sensor port.