1. A clinical assay process comprising the steps of:
(1) binding a quantity of agmatine to at least one enzyme-linked immunosorbent assay surface resulting in an agmatine-modified surface;
(2) treating the surface so that no further agmatine may bind thereto; Introducing an agmatine-containing sample to the agmatine-modified surface so as to form a surface-agmatine free-agmatine system;
(3) adding an anti-agmatine antibody to the system so that surface-agmatine and free-agmatine must compete to bind to the antibody;
(4) binding any surface-bound anti-agmatine antibodies to an immunoglobin G, wherein the immunoglobin G is also bound to an enzyme;
(5) treating surface-bound enzyme with a substrate wherein the enzyme’s reaction with the substrate is spectroscopically detectable; and
(6) measuring a spectroscopically detectable result relative to suitable control or calibration curve.
2. The process of claim 1, wherein the spectroscopically detectable result is measured by a method selected from the group consisting of visible emission spectroscopy, UV-Vis absorption spectroscopy, NIR absorption spectroscopy, and IR absorption spectroscopy.
3. A clinical assay process comprising the steps of:
(a) introducing an agmatine-containing sample to at least one enzyme-linked immunoassay surface such that the agmatine binds substantially quantitatively thereto resulting in an agmatine-modified surface;
(b) treating the surface so that no further agmatine may bind thereto;
(c) adding an excess of an anti-agmatine antibody to the surface such that it may bind substantially all of the surface-bound agmatine;
(d) reacting any surface-bound anti-agmatine antibodies with an immunoglobin G, wherein the immunoglobin G is also bound to an enzyme;
(e) treating any surface-bound enzyme with a substrate wherein the enzyme’s reaction with the substrate is spectroscopically detectable; and
(f) measuring a spectroscopically detectable result relative to suitable control or calibration curve.
4. The process of claim 3, wherein the spectroscopically detectable result is measured by a method selected from the group-consisting of visible emission spectroscopy, UV-Vis absorption spectroscopy, NIR absorption spectroscopy, and IR absorption spectroscopy.
5. A clinical assay process comprising the steps of:
(i) binding a quantity of agmatine to at least one enzyme-linked immunosorbent assay surface resulting in an agmatine-modified surface;
(ii) treating the surface so that no further agmatine may bind thereto;
(iii) introducing an agmatine-containing sample to the agmatine-modified surface so as to form a surface-agmatine free-agmatine system;
(iv) adding an anti-agmatine antibody to the system so that surface-agmatine and free-agmatine must compete to bind to the antibody, wherein the anti-agmatine antibody is also bound to an enzyme;
(v) treating any surface-bound enzyme with a substrate wherein the enzyme’s reaction with the substrate is spectroscopically detectable; and
(vi) measuring a spectroscopically detectable result relative to suitable control or calibration curve.
6. The process of claim 5, wherein the spectroscopically detectable result is measured by a method selected from the group consisting of visible emission spectroscopy, UV-Vis absorption spectroscopy, NIR absorption spectroscopy, and IR absorption spectroscopy.
7. A clinical assay process comprising the steps of:
(A) introducing an agmatine-containing sample to at least one enzyme-linked immunoassay surface such that the agmatine binds substantially quantitatively thereto resulting in an agmatine-modified surface;
(B) adding an excess of an anti-agmatine antibody to the surface such that it may bind substantially all of the surface-bound agmatine, wherein the anti-agmatine antibody is also bound to an enzyme;
(C) treating surface-bound enzyme with a substrate wherein the enzyme’s reaction with the substrate is spectroscopically detectable; and
(D) measuring a spectroscopically detectable result relative to suitable control or calibration curve.
8. The process of claim 7, wherein the spectroscopically detectable result is measured by a method selected from the group consisting of visible emission spectroscopy, UV-Vis absorption spectroscopy, NIR absorption spectroscopy, and IR absorption spectroscopy.
9. An agmatine assay kit comprising:
an anti-agmatine antibody solution;
an immunoglobin antibody solution, wherein the immunoglobin is conjugated to an enzyme; and
a substrate solution.
10. The kit of claim 9, further comprising at least one enzyme-linked immunosorbent assay surface.
11. The kit of claim 10, comprising at least one enzyme-linked immunosorbent assay plate.
12. The kit of claim 9, further comprising at least one wash buffer.
13. The kit of claim 12, wherein the at least one wash buffer is selected from the group consisting of phosphate buffered saline, and non-fat dry milk solution.
14. The kit of claim 13, wherein the phosphate buffered saline solution comprises an aliquot of a solution made from the following components 7.650 grams of NaCl, 1.243 grams of Na2HPO4.7H2O, 0.210 grams KH2PO4 in 1 liter of distilled water.
15. The kit of claim 14, wherein the non-fat dry milk solution comprises an aliquot of a solution made from the following ingredients 0.3 grams nonfat dry milk, 0.05 grams of polyoxyethylene sorbitan monolaurate 70% in water, and 100 mL of phosphate-buffered saline having a pH 7.4.
16. The kit of claim 9, further comprising at least one agmatine standard.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method in a scheduling node for selecting a downlink resource allocation scheme in a mobile communication network including a plurality of at least partially overlapping sectors, the selected downlink resource allocation scheme being applicable to downlink transmission in at least a current transmission time interval to user equipments located in a one or more of the plurality of at least partially overlapping sectors, the method comprising:
selecting a set of user equipments connected to the scheduling node;
for each user equipment in the selected set of user equipments, determining sector isolation properties of each sector; and
selecting a downlink resource allocation scheme, wherein at least one sector is disabled for downlink transmission to user equipment in the set of user equipments based on determined sector isolation properties.
2. The method according to claim 1, wherein the downlink transmission is downlink data transmission.
3. The method according to claim 1, wherein the downlink resource allocation scheme is selected for a cell of the mobile communication network.
4. The method according to claim 1, wherein the mobile network includes a macro high power level and at least one low power level, wherein one or more low power sectors on the low power level are located within a macro level sector on the macro high power level and wherein the macro level sector includes the scheduling node and one or more macro high power data transmission nodes and the low power sectors (S1, S3) each include at least one low power data transmission node.
5. The method according to claim 1, wherein the downlink resource allocation scheme is arranged to allocate resources enabling spatial division multiplexing.
6. The method according to claim 1, further including sorting the user equipments into a scheduling candidate list according to a given priority level, and wherein the step of selecting a set of user equipments comprises selecting the set of user equipments from the scheduling candidate list.
7. The method according to claim 6, wherein the priority level is configurable based on quality of service requirements.
8. The method according to claim 6, wherein the scheduling candidate list represents a subset of user equipments connected to the scheduling node.
9. The method according to claim 1, wherein the step of determining sector isolation properties of each sector for the selected user equipments includes estimating signal quality measures of each sector for the selected user equipments and comparing the estimated signal quality measures to one or more given thresholds.
10. The method according to claim 9, wherein the signal quality measures represent signal to interference noise ratio, SINR, values.
11. The method according to claim 10, wherein the SINR values are determined for each sector and for each user equipment represented on the scheduling candidates list.
12. The method according to claim 1, further including the step of estimating the effect of the selected downlink resource allocation scheme in each subsequent transmission time interval whereupon the selected downlink resource allocation scheme is maintained, adjusted or rejected.
13. The method according to claim 1, further including the step of
allocating downlink transmission resources in at least a current transmission time interval according to the selected resource allocation scheme.
14. A scheduling node in a mobile communication network including a plurality of at least partially overlapping sectors, the scheduling node comprising:
a memory for storing a sector isolation determination algorithm, and
a processor configured to:
select user equipments connected to the scheduling node,
determine sector isolation properties of each sector for the selected user equipment, and
select a downlink resource allocation scheme wherein at least one sector is disabled for downlink transmission to user equipment in the set of user equipments based on determined sector isolation properties.
15. The scheduling node according to claim 14, wherein the memory further includes a scheduling candidate list comprising user equipments arranged according to given priority level.
16. Logic embodied in a non-transitory computer readable medium which, when executed in a scheduling node, causes the scheduling node to
select user equipments connected to the scheduling node,
determine sector isolation properties of each sector for the selected user equipment, and
select a downlink resource allocation scheme wherein at least one sector is disabled for downlink transmission to user equipment in the set of user equipments based on determined sector isolation properties.