1. A leakage determination method comprising:
comparing a correlation profile including a cross-correlation function obtained from measurement data measured at at least a pair of measurement positions and position information for the measurement positions, and a correlation profile at the time of the leakage determination including the cross-correlation function obtained from the measurement data measured at the pair of measurement positions and the position information for the measurement positions; and
determining leakage.
2. The leakage determination method according to claim 1, wherein
the correlation profile includes environmental information upon measurement.
3. The leakage determination method according to claim 2, wherein
the environmental information includes at least any one of year, month, and day of measurement, measurement time, a day of a week, weather information, sound information, and leakage information.
4. leakage determination method according to claim 1, wherein
the cross-correlation function includes a cross-correlation function obtained from measurement data in which a simulated leakage sound is generated and measured at a predetermined position, and
the environmental information includes information about the simulated leakage sound.
5. The leakage determination method according to claim 4, wherein the determining leakage comprising:
comparing a correlation profile including information about the simulated leakage sound and a correlation profile at the time of the leakage determination not including information about the simulated leakage sound are compared, and
determining a leakage position based on a cross-correlation function of a correlation profile including information about the simulated leakage sound similar to a peak position of the cross-correlation function of the correlation profile at the time of the leakage determination.
6. The leakage determination method according to claim 4, wherein the determining leakage comprising:
comparing a correlation profile including information about the simulated leakage sound and a correlation profile at the time of the leakage determination including information about the simulated leakage sound, and
determining a leakage position based on a cross-correlation function of a correlation profile including information about the simulated leakage sound similar to a peak position of the cross-correlation function of the correlation profile upon the determination of the leakage.
7. The leakage determination method according to claim 4, wherein the determining leakage comprising:
comparing a correlation profile including information about the simulated leakage sound and a correlation profile at the time of the leakage determination not including information about the simulated leakage sound, and
determining a leakage position based on based on a height of a peak of a cross-correlation function of a correlation profile upon the determination of the leakage and a height of a peak of a cross-correlation function of a correlation profile including information about the simulated leakage sound.
8. The leakage determination method according to claim 4, wherein a vibration propagation speed database is prepared in which a configuration of a pipe and a vibration propagation speed in each pipe section based on measurement data in which a simulated leakage sound is generated and measured are recorded, and
wherein the determining leakage comprising determining a leakage position based on the vibration propagation speed database, a correlation profile including information about the simulated leakage sound, and a correlation profile at the time of the leakage determination including information about the simulated leakage sound.
9. A leakage determination system comprising:
a correlation profile database in which a correlation profile including a cross-correlation function obtained from measurement data measured at at least a pair of measurement positions and position information for the measurement positions is stored,
a correlation profile acquisition unit configured to acquire a correlation profile at the time of the leakage determination including the cross-correlation function obtained from the measurement data measured at the pair of measurement positions and the position information for the measurement positions; and
a leakage determinator configured to compare a correlation profile of the correlation profile database and the correlation profile acquired by the correlation profile acquisition unit and determine leakage.
10. The leakage determination system according to claim 9, wherein
the correlation profile includes environmental information upon measurement.
11. The leakage determination system according to claim 10, wherein
the environmental information includes at least any one of year, month, and day of measurement, measurement time, a day of a week, weather information, sound information, and leakage information.
12. The leakage determination system according to claim 10, wherein
the cross-correlation function includes a cross-correlation function obtained from measurement data in which a simulated leakage sound is generated and measured at a predetermined position, and
the environmental information includes information about the simulated leakage sound.
13. The leakage determination system according to claim 12, wherein
the leakage determinator:
compares a correlation profile including information about the simulated leakage sound and a correlation profile at the time of the leakage determination not including information about the simulated leakage sound, and
determines a leakage position by a cross-correlation function of a correlation profile including information about the simulated leakage sound similar to a peak position of the cross-correlation function of the correlation profile upon the determination of the leakage.
14. The leakage determination system according to claim 12, wherein
the leakage determinator:
compares a correlation profile including information about the simulated leakage sound and a correlation profile at the time of the leakage determination including information about the simulated leakage sound, and
determines a leakage position by a cross-correlation function of a correlation profile including information about the simulated leakage sound similar to a peak position of the cross-correlation function of the correlation profile upon the determination of the leakage.
15. The leakage determination system according to claim 12, wherein
the leakage determinator:
compares a correlation profile including information about the simulated leakage sound and a correlation profile at the time of the leakage determination not including information about the simulated leakage sound, and
estimates a leakage amount based on a height of a peak of a cross-correlation function of a correlation profile upon the determination of the leakage and a height of a peak of a cross-correlation function of a correlation profile including information about the simulated leakage sound.
16. The leakage determination system according to claim 12, further comprising a vibration propagation speed database in which a configuration of a pipe and a vibration propagation speed in each pipe section based on measurement data in which a simulated leakage sound is generated and measured are recorded, wherein
the leakage determinator determines leakage based on the vibration propagation speed database, a correlation profile including information about the simulated leakage sound, and a correlation profile at the time of the leakage determination including information about the simulated leakage sound.
17. A non-transitory computer readable storage medium storing a program for causing a computer to perform a procedure comprising:
comparing a correlation profile including a cross-correlation function obtained from measurement data measured at at least a pair of measurement positions and position information for the measurement positions, and
a correlation profile at the time of the leakage determination including a cross-correlation function obtained from the measurement data measured at the pair of measurement positions, and the position information for the measurement positions; and
determining leakage.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A transgenic mouse whose genome comprises a first and second transgenic nucleotide sequence, wherein the first transgenic nucleotide sequence comprises a human \u03b1-synuclein coding sequence or a human non-A\u03b2 (NAC) region; and, the second transgenic nucleotide sequence comprises a human amyloid precursor protein (APP) coding sequence, each operably linked to a neuronal specific promoter and the human APP coding sequence comprises a Swedish or a Indiana mutation, wherein expression of said first and second transgenic nucleotide sequence results in amyloid deposits in the brain of said mouse.
2. An isolated neuronal cell from a transgenic mouse set forth in claim 1, wherein cells of the cell line overexpress a human \u03b1-synuclein coding sequence or a human non-A\u03b2(NAC) region.
3. A method of screening for agents that inhibit amyloidogenesis or \u03b1-synuclein aggregation, comprising:
(a) providing a candidate agent, wherein optionally the candidate agent is a candidate therapeutic agent;
(b) providing a transgenic mouse as set forth in claim 1, or a cell line as set forth in claim 2;
(c) administering the candidate agent to the cell line or transgenic mouse; and
(d) evaluating the effect of said candidate agent on amyloidogenesis or amyloid deposition.
4. The method of claim 3, wherein the effect of the candidate agent on amyloidogenesis or amyloid deposition comprises inhibition of \u03b1-synuclein aggregation in neurons.
5. The transgenic mouse of claim 1, wherein an SV40-derived intron operably links the promoter with the first or second transgenic nucleotide sequence.
6. The transgenic mouse of claim 1, wherein the first or second transgenic nucleotide sequence comprises an intron.
7. The transgenic mouse of claim 1, wherein the intron comprises an SV40-derived intron.