1. Spintronic circuit comprising:
a) a conductive non-magnetic channel,
b) means for generating spin polarized electrons in the non-magnetic channel, and
c) at least two ferromagnetic contacts arranged on the non-magnetic channel, wherein the ferromagnetic contacts each have an adjustable magnetization direction and a variable contact resistance, and
d) means for adjusting the magnetization direction of the ferromagnetic contacts,
e) wherein the ferromagnetic contacts are arranged on the non-magnetic channel along the non-magnetic channel one after another, and
f) the means for generating the spin polarized electrons operate by spin extraction upon a net electron flow from the non-magnetic channel to one of the ferromagnetic contacts, and
g) the spintronic circuit comprises a means for propagating the spin polarized electrons by way of drift along the non-magnetic channel caused by an applied electric field, and
h) the spintronic circuit comprises means for measuring the contact resistances of the individual ferromagnetic contacts, wherein the contact resistances depend on the relative alignment of the spin polarization direction of the spin polarized electrons in the non-magnetic channel at the ferromagnetic contact on the one hand and the magnetization direction of the ferromagnetic contact on the other hand.
2. Spintronic circuit according to claim 1, wherein the means for generating the spin polarized electrons in the non-magnetic channel comprise:
a) a non-magnetic contact arranged on the non-magnetic channel, and
b) a first current source connected to the non-magnetic contact on the non-magnetic channel for injecting electrons into the non-magnetic channel, and
c) spin extraction upon electron flow into a ferromagnetic contact.
3. Spintronic circuit according to claim 1, wherein the spin polarization direction of the spin polarized electrons in the non-magnetic channel arriving at each ferromagnetic contact is determined by the spin extraction at the preceding ferromagnetic contacts along the channel.
4. Spintronic circuit according to claim 2, wherein
a) the ferromagnetic contacts are connected to the first current source, so that the electron current generated by the first current source flows through the non-magnetic contact into the non-magnetic channel and splits into partial electron currents flowing through the ferromagnetic contacts back to the first current source, wherein the partial currents depend on the contact resistances of the individual ferromagnetic contacts, and
b) an electric output is measured by a measuring unit at one or more of the ferromagnetic contacts.
5. Spintronic circuit according to claim 4, wherein the measuring unit measures the partial current flowing through one of the ferromagnetic contacts.
6. Spintronic circuit according to claim 4, wherein
a) the measuring unity measures a voltage drop between two of the ferromagnetic contacts, and
b) there is a second current source connected in parallel to the measuring unit between the ferromagnetic contacts thereby improving the signal-to-noise ratio of the measurement.
7. Spintronic circuit according to claim 4, wherein
a) the magnetization directions of the ferromagnetic contacts together represent a magnetization configuration of the spintronic circuit, and
b) the electric output measured by the measuring unit is a multi-level output comprising several possible output levels, and
c) each magnetization configuration of the spintronic circuit is associated with one of the output levels of the multi-level output, so that a single measurement by the measuring unit represents the complete magnetization configuration of the spintronic circuit.
8. Spintronic circuit according to claim 1, wherein the means for adjusting the magnetization direction of the ferromagnetic contacts comprises a current carrying conductor generating a stray field.
9. Spintronic circuit according to claim 2, wherein
a) the non-magnetic channel has a characteristic spin diffusion length, so that the spin polarization of the spin polarized electrons substantially decays after diffusion over the spin diffusion length, and
b) there is a specific separation between the adjacent ferromagnetic contacts on the non-magnetic channel, wherein said separation is smaller than the spin diffusion length, so that the electron spin polarization does not substantially decay during propagation from one of the ferromagnetic contacts to the next one of the ferromagnetic contacts.
10. Spintronic circuit according to claim 1, wherein the magnetization direction of one of the ferromagnetic contacts is fixed in order to achieve a unique electric output for each of the magnetization configurations.
11. Spintronic circuit according to claim 10, wherein
the ferromagnetic contact with the fixed magnetization direction has a higher coercivity than the other ferromagnetic contacts.
12. Spintronic circuit according to claim 1, wherein
a) the spintronic circuit is a memory circuit comprising several 1-Bit memory cells each associated with one of the ferromagnetic contacts, wherein in each of the memory cells the magnetization direction of the ferromagnetic contact represents the binary state of the memory cell, and
b) the electric output measured by the measuring unit is a multi-level output, so that a single measurement by the measuring unit represents the binary states of all memory cells of the memory circuit.
13. Spintronic circuit according to claim 1, wherein
a) the spintronic circuit is a logic circuit performing a logic operation, wherein the logic circuit comprises several inputs and one output, and
b) the output of the logic circuit is associated with the electric multi-level output measured by the measuring unit, and
c) the inputs are each associated with the magnetization direction of one of the ferromagnetic contacts.
14. Spintronic circuit according to claim 13, wherein
a) the inputs and the output of the logic circuit are binary, and
b) one or more of the values of the multi-level output are associated to one binary value, while the other values of the multi-level output are associated to the other binary value.
15. Spintronic circuit according to claim 13, wherein at least one of the ferromagnetic contacts is a programming input, so that the magnetization direction of said programming input defines the type of the logic operation performed by the logic circuit.
16. Method of operation of a spintronic circuit comprising a non-magnetic channel and at least two ferromagnetic contacts arranged on the non-magnetic channel, wherein the method comprises the following steps:
a) Adjusting the magnetization direction of the ferromagnetic contacts,
b) generating spin polarized electrons in the non-magnetic channel by spin extraction upon a net electron flow from the non-magnetic channel to the ferromagnetic contacts,
c) propagation of the spin polarized electrons along the non-magnetic channel by an electric field, and
d) measuring a contact resistance of at least one of the ferromagnetic contacts, wherein the contact resistance depends on the relative alignment of the spin polarization direction of the spin polarized electrons in the non-magnetic channel at the ferromagnetic contact on the one hand and the magnetization direction of the ferromagnetic contact on the other hand.
17. Spintronic circuit according to claim 1, wherein the means for adjusting the magnetization direction of the ferromagnetic contacts comprise a spin-transfer torque mechanism.
18. Spintronic circuit according to claim 10, wherein the ferromagnetic contact with the fixed magnetization direction is exchange-biased using an adjacent anti-ferromagnetic layer.
19. Spintronic circuit according to claim 1, wherein the spintronic circuit is a memory circuit.
20. Spintronic circuit according to claim 1, wherein the spintronic circuit is a logic circuit.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-14. (canceled)
15. A plurality of the peptide-linked glucans of claim 11, wherein the average molecular weight is 0.8 kDa.
16. The peptide linked glucan of claim 11, wherein the molecular weight is 0.7 kDa.
17. A plurality of the peptide-linked glucans of claim 11, wherein the average molecular weight is 2.6 kDa.
18. A plurality of the peptide-linked glucans of claim 11, wherein the average molecular weight is 6.2 kDa.
19. A plurality of the peptide-linked glucans of claim 11, wherein the average molecular weight is less than 3.0 kDa.
20. The peptide-linked glucan of claim 11, wherein the peptide-linked glucan is capable of intestinal absorption as determined by the Caco-2 cell monolayer Transwell method.
21-22. (canceled)
23. The peptide-linked glucan of claim 11, prepared by treating Coriolus versicolor with alkali, and separating a supernatant;
subjecting the supernatant to cationic exchange;
subjecting eluate from the cationic exchange to anionic exchange;
subjecting eluate from the anionic exchange to a size fractionation technique, and collecting a fraction comprising the one peptide-linked glucan.
24. The peptide-linked glucan of claim 23, wherein the size fractionation technique is molecular exclusion chromatography or an ethanol-step gradient.
25. The peptide-linked glucan of claim 23, wherein the cationic exchange is performed on CM cellulose column.
26. A pharmaceutical composition comprising the extract or isolated peptide-linked glucan of any one of the preceding claims.
27. A method of purifying a peptide-linked glucan from treating Coriolus versicolor with alkali, and separating a supernatant;
subjecting the supernatant to cationic exchange;
subjecting eluate from the cationic exchange to anionic exchange;
subjecting eluate from the anionic exchange to a size fractionation technique, and collecting a fraction comprising peptide-linked glucan having a molecular weight of 0.7 to 5 kDa.
28. The method of claim 27, wherein the treating step comprises macerating fruiting bodies of the Coriolus versicolor;
extracting with alkali the macerated Coriolus versicolor fruiting bodies to obtain an extract;
removing the insoluble materials from the extract;
clarifying supernatant from the first extract; and,
concentrating the supernatant to obtain a third extract, wherein the third crude extract is subjected to cationic exchange.
29. The method of claim 28, wherein the alkali extraction step comprises boiling the macerated Coriolus versicolor fruiting bodies in an aqueous alkaline solution.
30. The method of claim 29, wherein the aqueous alkaline solution is selected from the group consisting of sodium hydroxide and potassium hydroxide.
31. The method of claim 29, wherein the aqueous alkaline solution has a normality of less than or equal to 0.1N.
32. The method of claim 29, wherein the aqueous alkaline solution has a normality of 0.01N.
33. The method of claim 27, wherein the insoluble materials are removed from the first extract by filtration.
34. The method of claim 29, wherein the fraction comprising peptide-linked glucan having a molecular weight of 0.7 to 5 kDa is clarified by centrifugation.
35. The method of claim 29, wherein the fraction comprising peptide-linked glucan having a molecular weight of 0.7 to 5 kDa is concentrated by rotary evaporation, freezing, or lyophilization.
36. The method of claim 27, wherein the fraction comprising peptide-linked glucan has a molecular weight of 0.7 kDa to about 3.0 kDa.
37-57. (canceled)
58. The peptide-linked glucan of claim 11 is further characterized in that the amino acid sequence is SEQ ID NO:1.