1. A reversible ratcheting wrench pawl, the pawl comprising a rigid body having a side with a plurality of teeth, said plurality of teeth including a first teeth portion having a first center of curvature and a second teeth portion having a second center of curvature located at a position different from the first center of curvature, wherein the pawl has a first ratcheting position, wherein the first teeth portion is completely engaged with a gear wheel and the second teeth portion is disengaged with the gear wheel, and a second ratcheting position wherein the second teeth portion is completely engaged with the gear wheel and the first teeth portion is disengaged with the gear wheel, wherein the pawl moves between the first ratcheting position and the second ratcheting position by rotating about an axis that does not intersect said rigid body.
2. The pawl as claimed in claim 1, with the first center of curvature having a radius and the second center of curvature having a radius equal to the radius of the first center of curvature, with the gear wheel has a radius equal to the radii of the first and second centers of curvature.
3. The pawl as claimed in claim 2, with each of the first and second teeth portions including at least five teeth.
4. The pawl as claimed in claim 3, wherein the first and second teeth portions combined include at least ten teeth.
5. The pawl as claimed in claim 4, with the first teeth portion and the second teeth portion being arranged in a continuous manner.
6. The pawl as claimed in claim 1, with each of the first and second teeth portions including at least five teeth.
7. The pawl as claimed in claim 6, wherein the first and second teeth portions combined include at least ten teeth.
8. The pawl as claimed in claim 7, with the first teeth portion and the second teeth portion being arranged in a continuous manner.
9. The pawl as claimed in claim 8, with the pawl including a face having a recess adapted to be engaged by a tip for moving the pawl between the first and second ratcheting positions.
10. The pawl as claimed in claim 9, with the pawl including an other side facing away from the plurality of teeth, with the face being a top extending between the side and the other side.
11. The pawl as claimed in claim 10, with the other side being formed to bear against a wall portion of a compartment section formed in a head extending from a handle.
12. The pawl as claimed in claim 11, with the side including first and second faces extending outwardly on opposite sides of the plurality of teeth and interconnected to the other side.
13. The pawl as claimed in claim 1, with the pawl including an other side facing away from the plurality of teeth, with the other side being formed to bear against a wall portion of a compartment section formed in a head extending from a handle, wherein the other side bears against one side of the wall portion in the first ratcheting position and bears against an opposite side of the wall portion in the second ratcheting position.
14. The pawl as claimed in claim 1, wherein the pawl includes an other side facing away from the plurality of teeth and wherein the side includes first and second faces extending outwardly on opposite sides of the plurality of teeth and being interconnected to the other side.
15. The pawl as claimed in claim 1, wherein the pawl is adapted to be installed in a wrench.
16. The pawl as claimed in claim 1, wherein the first teeth portion and the second teeth portion are adjacent.
17. The pawl as claimed in claim 1, wherein the first teeth portion and the second teeth portion are adjoining.
18. The pawl as claimed in claim 1, wherein the plurality of teeth form a substantially concave surface.
19. The pawl of claim 1 wherein the first center of curvature is fixed relative to the second center of curvature.
20. A pawl comprising:
a rigid body having a first side comprising:
a plurality of teeth including a first portion having a first center of curvature and a second portion having a second center of curvature, the first and second centers of curvature being located at different points; wherein said first portion and said second portion are disposed on the first side;
a first face located on the first side and adjoining the first portion;
a second face located on the first side and adjoining the second portion; and
a second side facing substantially opposite the first side, wherein the first and second faces adjoin the second side,
wherein the pawl has a first ratcheting position, wherein the first portion is completely engaged with a gear wheel and the second portion is disengaged with the gear wheel, and a second ratcheting position wherein the second portion is completely engaged with the gear wheel and the first portion is disengaged with the gear wheel, wherein the pawl moves between the first ratcheting position and the second ratcheting position by rotating about an axis that does not intersect said rigid body.
21. The pawl of claim 20, wherein the first portion and the second portion are adjacent.
22. The pawl of claim 20, wherein the first portion and the second portion are adjoining.
23. The pawl of claim 20, wherein the first portion is substantially concave and the second portion is substantially concave.
24. The pawl of claim 20, wherein the pawl is adapted to at least partially mesh with the gear wheel in a wrench.
25. The pawl of claim 20 wherein the first center of curvature is fixed relative to the second center of curvature.
26. A pawl for use in a reversible ratcheting hand tool, comprising:
a rigid body having a first side and a second side;
the first side comprising a plurality of teeth, a first face, and a second face;
the body further comprising a second side facing away from the first side, wherein the first and second faces adjoin the second side; and
wherein the plurality of the teeth comprise a first teeth portion having a first center of curvature and a second teeth portion having a second center of curvature located at a position different from the first center of curvature, wherein the pawl has
a first ratcheting position, wherein the first teeth portion is completely engaged with a gear wheel and the second portion is disengaged with the gear wheel, and
a second ratcheting position wherein the second teeth portion is completely engaged with the gear wheel and the first teeth portion is disengaged with the gear wheel
wherein the pawl moves between the first ratcheting position and the second ratcheting position about an axis that does not intersect said rigid body.
27. The pawl of claim 26, wherein the first face adjoins the first teeth portion and wherein the second face adjoins the second teeth portion.
28. The pawl of claim 26, wherein the first teeth portion is adjacent to the second teeth portion.
29. The pawl of claim 26, wherein the plurality of teeth form a substantially concave surface.
30. The pawl of claim 26, wherein the first teeth portion is concave and wherein the second teeth portion is concave.
31. The pawl of claim 26, wherein the pawl is adapted to engage the gear wheel in a reversible ratcheting wrench.
32. The pawl of claim 26 , wherein the second side includes at least one recess.
33. The pawl of claim 26 wherein the position of the first center of curvature is fixed relative to the position of the second center of curvature.
34. A pawl for use in a reversible ratcheting hand tool, comprising:
a concave first teeth portion having a first center of curvature;
a concave second teeth portion having a second center of curvature, the first center of curvature being located at a different point than the second center of curvature;
wherein said first teeth portion and said second teeth portion are located on one side of a rigid pawl body, wherein the pawl has
a first ratcheting position, wherein the first teeth portion is completely engaged with a with the gear wheel and the second teeth portion is disengaged with the gear wheel, and a second ratcheting position wherein the second teeth portion is completely engaged
wherein the pawl moves between the first ratcheting position and the second ratcheting position by rotating about an axis that does not intersect said rigid body.
35. The pawl of claim 34, wherein the first teeth portion and the second teeth portion are continuous.
36. The pawl of claim 34, wherein the first teeth portion and the second teeth portion pivot about the outer periphery of a gear wheel.
37. The pawl of claim 34, further comprising a first side and a second side, the second side facing substantially opposite the first side, wherein the first teeth portion and the second teeth portion are disposed on the first side.
38. The pawl of claim 37, wherein the first side further includes a first face spaced from a second face by the first teeth portion and by the second teeth portion.
39. The pawl of claim 38, wherein the first face abuts the second side and wherein the second face abuts the second side.
40. The pawl of claim 38, wherein the first face and the second face are each planar.
41. The pawl of claim 38, wherein the first face extends from the first teeth portion to the second side and wherein the second face extends from the second teeth portion to the second side.
42. The pawl of claim 34 wherein the first center of curvature is fixed relative to the second center of curvature.
43. A pawl for use in a reversible ratcheting hand tool, the pawl comprising:
a unitary pawl body sized to fit within a compartment disposed within a reversible ratcheting hand tool;
a first teeth portion disposed on a first side of said unitary pawl body and having a first center of curvature;
a second teeth portion disposed on the first side of said unitary pawl body and having a second center of curvature; wherein the first and second centers of curvature are located at different positions, wherein the pawl has
a first ratcheting position, wherein the first teeth portion is completely engaged with a gear wheel and the second teeth portion is disengaged with the gear wheel, and
a second ratcheting position wherein the second teeth portion is completely engaged with the gear wheel and the first teeth portion is disengaged with the gear wheel,
wherein the pawl moves between the first ratcheting position and the second ratcheting position by rotating about an axis that does not intersect said rigid body.
44. The pawl of claim 43 further comprising a recess disposed within a second side of said unitary pawl body, wherein the first side of said unitary pawl body is adjacent to the second side.
45. The pawl of claim 44 wherein the first side is concave and the second side is convex.
46. The pawl of claim 43 wherein the first and second teeth portions are continuous.
47. The pawl of claim 43 wherein the first center of curvature is fixed relative to the second center of curvature.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-26. (canceled)
27. A method of treating, preventing, modifying or managing pain, which comprises administering to a patient a therapeutically or prophylactically effective amount of a compound of formula:
in which
Y is oxygen or H2,
a first of R1 and R2 is halo, alkyl, alkoxy, alkylamino, dialkylamino, cyano, or carbamoyl, the second of R1 and R2, independently of the first, is hydrogen, halo, alkyl, alkoxy, alkylamino, dialkylamino, cyano, or carbamoyl, and
R3 is hydrogen, alkyl, or benzyl;
or a pharmaceutically acceptable salt, solvate or stereoisomer thereof.
28. A method of treating, preventing, modifying or managing pain, which comprises administering to a patient a therapeutically or prophylactically effective amount of 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline having the formula:
or a pharmaceutically acceptable salt, solvate or stereoisomer thereof.
29. The method of claim 27 or 28, wherein the compound is 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline.
30. The method of claim 27 or 28, wherein the compound is a pharmaceutically acceptable salt.
31. The method of claim 27 or 28, wherein the compound is a pharmaceutically acceptable solvate.
32. The method of claim 27 or 28, wherein the compound is a pharmaceutically acceptable stereoisomer.
33. The method of claim 32, wherein the stereoisomer is an enantiomerically pure R isomer.
34. The method of claim 32, wherein the stereoisomer is an enantiomerically pure S isomer.
35. The method of claim 27 or 28, which further comprises administering a therapeutically or prophylactically effective amount of a second active agent.
36. The method of claim 35, wherein the second active agent is an antidepressant, antihypertensive, anxiolytic, calcium channel blocker, alpha-adrenergic receptor agonist, alpha-adrenergic receptor antagonist, ketamine, anesthetic, muscle relaxant, non-narcotic analgesic, opioid analgesic, anti-inflammatory agent, immunomodulatory agent, immunosuppressive agent, corticosteroid, anticonvulsant, cox-2 inhibitor, hyperbaric oxygen, or a combination thereof.
37. The method of claim 35, wherein the second active agent is salicylic acid acetate, celecoxib, ketamine, gabapentin, carbamazepine, oxcarbazepine, phenyloin, sodium valproate, prednisone, nifedipine, clonidine, oxycodone, meperidine, morphine sulfate, hydromorphone, fentanyl, acetaminophen, ibuprofen, naproxen sodium, griseofulvin, amitriptyline, imipramine or doxepin.
38. The method of claim 27 or 28, wherein the pain is nociceptive pain or neuropathic pain.
39. The method of claim 27 or 28, wherein the pain is associated with chemical or thermal burn, cut of the skin, contusion of the skin, osteoarthritis, rheumatoid arthritis, tendonitis, or myofascial pain.
40. The method of claim 27 or 28, wherein the pain is diabetic neuropathy, post herpetic neuralgia, trigeminal neuralgia, post-stroke pain, complex regional pain syndrome, sympathetic maintained pain syndrome, reflex sympathetic dystrophy, reflex neurovascular dystrophy, reflex dystrophy, spinal cord injury pain, Sudeck atrophy of bone, algoneurodystrophy, shoulder hand syndrome, post-traumatic dystrophy, cancer related pain, phantom limb pain, fibromyalgia, chronic fatigue syndrome, radiculopathy, luetic neuropathy, or painful neuropathic condition induced from a drug.
41. The method of claim 40, wherein the complex regional pain syndrome is type I or type II.
42. The method of claim 40, wherein the painful neuropathic condition is iatrogenically induced by vincristine, velcade or thalidomide.
43. The method of claim 27 or 28, wherein the pain is visceral pain, migraine, tension-type headache, post-operative pain, or mixed pain of nociceptive and neuropathic pain.
44. The method of claim 27 or 28, wherein the compound is administered orally.
45. The method of claim 44, wherein the compound is administered in the form of a capsule or tablet.
46. The method of claim 27 or 28, wherein the compound is administered in an amount of from about 0.1 to about 150 mg per day.
47. The method of claim 28, wherein the compound is administered in an amount of from about 0.1 to about 40 mg per day.
48. The method of claim 47, wherein the compound is administered in an amount of from about 0.5 to about 25 mg per day.
49. The method of claim 47, wherein the compound is administered in an amount of from about 2 to about 10 mg per day.
50. The method of claim 47, wherein the compound is administered in an amount of about 5 mg per day.