1. A compound of formula A:
wherein:
R1 is hydrogen, alkyl, or aryl;
Each X is independently C1-10 alkyl;
Y is heteroaryl, saturated heterocyclic, or NR2R3,
R2 and R3 are independently hydrogen, alkyl, or R2 and R3, together with the nitrogen atom to which they are attached, combine to form a saturated heterocyclic or heteroaryl ring;
or pharmaceutically acceptable salts of any of the foregoing.
2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmacologically effective amount of a compound according to claim 1.
3. A pharmaceutical composition of claim 2, wherein the pharmaceutically acceptable carrier is selected from an aqueous solution, an injectable solution, an aeorsolizer, an inhaler or a transdermal delivery vehicle.
4. A pharmaceutical composition of claim 2 contained in a unit dosage form.
5. The pharmaceutical composition of claim 2 wherein the pharmaceutically acceptable carrier comprises a transdermal delivery vehicle, wherein the pharmaceutically acceptable carrier contains a detergent, an emulsifier or liposomes.
6. The pharmaceutical composition of claim 2 in the form of an injectable solution wherein the concentration of the compound in the injectable solution is between about 0.5 milligram per milliliter to about 200 milligram per milliliter.
7. The pharmaceutical composition of claim 2 contained in a unit dosage form wherein the unit dosage form contains about 0.5 milligram to about 1.2 gram of the compound.
8. A method for inducing anesthesia, the method comprising administering to a subject in need thereof an effective amount of at least one compound according to claim 1, wherein the compound according to claim 1 is administered in the form of an intravenous injection of an aqueous composition comprising the compound.
9. A compound selected from:
and pharmaceutically acceptable salts of any of the foregoing.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. A fuel, useful as a diesel fuel comprising a Fischer-Tropsch derived hydrocarbon distillate having 343 C.<T90<538 C. and a cold filter plugging point of less than or equal to 5 C.
2. A fuel according to claim 1 having having 349 C.<T90<338 C.
3. A fuel according to claim 1 having 371 C.<T90<482 C.
4. A fuel according to claim 1 having 371 C.<T90<427 C.
5. A fuel according to claim 1, 2, 3 or 4 wherein the cold filter plugging point is less than or equal to 5 C.
6. A fuel according to claim 1, 2, 3 or 4 wherein the cold filter plugging point is less than or equal to 15 C.
7. A fuel according to claim 1, 2, 3 or 4 wherein the cold filter plugging point is less than or equal to 30 C.
8. A fuel according to claim 1 wherein the hydrocarbon distillate contains:
<10 wppm Sulfur, Nitrogen
<2 wt % aromatics
<0.1 wt % polyaromatics.
9. A fuel according to claim 1 wherein the hydrocarbon distillate contains:
<5 wppm Sulfur, Nitrogen
<1 wt % aromatics
<0.1 wt % polyaromatics.
10. A fuel according to claim 1 wherein the hydrocarbon distillate contains:
<1 wppm Sulfur, Nitrogen
<0.1 wt % aromatics
<0.1 wt % polyaromatics.
11. A fuel according to claim 1 wherein the hydrocarbon distillate has a cetane number greater than 65.
12. A fuel according to claim 1 wherein the hydrocarbon distillate has a cetane number greater than 75.
13. A method of reducing smoke during operation of a diesel engine comprising combusting a Fischer-Tropsch derived hydrocarbon distillate having a 343 C.<T90<538 C. and containing;
<10 wppm Sulfur, Nitrogen
<2% aromatics
<0.1% polyaromatics
wherein the cold filter plugging point of the distillate is less than or equal to 5 C.
14. A method according to claim 13 wherein the hydrocarbon distillate has a 349 C.<T90<338 C.
15. A method according to claim 13 wherein the hydrocarbon distillate has a having 371 C.<T90<482 C.
16. A method according to claim 13 wherein the hydrocarbon distillate has a having 371 C.<T90<427 C.
17. A method according to claim 13, 14, 15 or 16 wherein the hydrocarbon distillate has a cold filter plugging point of less than or equal to 15 C.
18. A method according to claim 13, 14, 15 or 16 wherein the hydrocarbon distillate has a cold filter plugging point of less than or equal to 30 C.
19. A method according to claim 13 wherein the hydrocarbon distillate contains:
<5 wppm Sulfur, Nitrogen
<1 wt % aromatics
<0.1 wt % polyaromatics
and has a cetane number of at least 65.
20. A method according to claim 18 wherein the hydrocarbon distillate contains:
<1 wppm Sulfur, Nitrogen
<0.1 wt % aromatics
<0.1 wt % polyaromatics
and has a cetane number of at least 75.
21. A method of making a fuel, useful as a diesel fuel, comprising a Fischer-Tropsch derived hydrocarbon distillate having 343 C.<T90<538 C. and a cold filter plugging point of less than or equal to 5 C.
22. A method according to claim 21 wherein the hydrocarbon distillate contains:
<1 wppm Sulfur, Nitrogen
<0.1 wt % aromatics
<0.1 wt % polyaromatics
and has a cetane number of at least 75.