1. A biaromatic compound having the following general formula (I):
in which:
R1 is an alkyl radical having from 1 to 10 carbon atoms, an aralkyl radical or an aryl radical;
R2 is a hydrogen atom, a linear or branched alkyl radical having from 1 to 7 carbon atoms, a substituted or unsubstituted aryl radical, a substituted or unsubstituted phenylsulfonyl radical, a substituted or unsubstituted heteroaryl radical, an aralkyl radical or a heterocyclic radical;
R\u20322 is a hydrogen atom;
with the proviso that R2 and R\u20322 can together form a heterocycle,
R3 is a hydrogen atom, an alkyl radical having from 1 to 3 carbon atoms, a polyether radical, an aryl radical, an aralkyl radical, a heteroaryl radical, a monohydroxyalkyl radical or a polyhydroxyalkyl radical;
X is S, CH2, N or O;
Y is an oxygen or sulfur atom;
n is 1 or 2;
and the geometrical isomers and also the salts thereof.
2. The biaromatic compound as defined by claim 1, wherein the double bond bonding the nitrogen to the ring present in the compounds of general formula (I) is in the syn or anti configuration.
3. The biaromatic compound as defined by claim 1, being a salt of an alkali metal or alkaline-earth metal, a zinc salt or a salt of an organic amine.
4. The biaromatic compound as defined by claim 1, having at least one methyl, ethyl, n-propyl, n-butyl, tert-butyl, n-pentyl, n-hexyl or n-heptyl radical substituent.
5. The biaromatic compound as defined by claim 1, having at least one phenyl radical substituent, which may be mono- or disubstituted with one or more atoms or radicals selected from the group consisting of a halogen atom, a CF3 radical and a methyl radical.
6. The biaromatic compound as defined by claim 1, wherein formula (I), R2 is a phenylsulfonyl radical substituted with a methyl group.
7. The biaromatic compound as defined by claim 1, having at least one benzyl radical andor phenethyl radical substituent.
8. The biaromatic compound as defined by claim 1, having at least one heteroaryl radical substituent selected from the group consisting of an aryl radical interrupted with one or more hetero atoms, optionally substituted with at least one halogen atom, an alkyl radical having from 1 to 12 carbon atoms, an alkoxy radical having from 1 to 7 carbon atoms, an aryl radical, a nitro function, a polyether radical, a heteroaryl radical, a benzoyl radical, an alkyl ester group, a carboxylic acid, a hydroxyl group optionally protected with an acetyl or benzoyl group or an amino function optionally protected with an acetyl or benzoyl group or optionally substituted with at least one alkyl radical having from 1 to 12 carbon atoms.
9. The biaromatic compound as defined by claim 1, having at least one morpholino radical substituent.
10. The biaromatic compound as defined by claim 1, wherein formula (I), R3 is a methoxymethoxy, ethoxymethoxy or methoxyethoxymethoxy radical.
11. The biaromatic compound as defined by claim 1, wherein foruma (I), R3 is a 2-hydroxyethyl, 2-hydroxypropyl or 3-hydroxypropyl radical.
12. The biaromatic compound as defined by claim 1, wherein formula (I), R3 is a 2,3-dihydroxypropyl, 2,3,4-trihydroxybutyl and 2,3,4,5-tetrahydroxypentyl radical.
13. The biaromatic compound as defined by claim 1, having at least one halogen atom substituent.
14. The biaromatic compound as defined by claim 1, selected form the group consisting of:
1. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
2. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
3. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-methyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
4. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
5. 4-((3Z)-3-{(benzylamino)carbonothioylhydrazono}-2-oxo-1-methyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
6. 4-{2-3-(benzylaminocarbonothioylhydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
7. 4-{2-3-(benzylaminocarbonothioylhydrazono)-2-oxo-1-benzyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
8. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-benzyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
9. 4-{2-3-(anilinocarbonothioylhydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
10. 4-{2-3-(ethylaminocarbonothioylhydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
11. methyl 4-{2-3-((4-fluoroanilino)carbonylhydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
12. methyl 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-butyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
13. methyl 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
14. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-butyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
15. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
16. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
17. methyl 4-{2-3-((3-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
18. 4-{2-3-((3-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-butyl-2,3-dihydro-1H-indol-5-yl-sulfanylethyl}benzoic acid;
19. methyl 4-{2-3-((3-trifluoromethylanilinocarbonyl)hydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
20. 4-{2-3-((3-trifluoromethylanilinocarbonyl)hydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
21. methyl 4-{2-3((2-chloroanilinocarbonyl)hydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate.
22. 4-{2-3((2-chloroanilinocarbonyl)hydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-yl-sulfanylethyl}benzoic acid;
23. 4-{2-3((2-chloroanilinocarbonyl)hydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
24. 4-{2-3((4-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-yl-sulfanylethyl}benzoic acid;
25. 4-{2-3((4-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
26. 4-{2-3((4-methylbenzenesulfonamido)carbonylhydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
27. methyl 4-{2-3((3,4-dichloroanilinocarbonyl)hydrazono)-2-oxo-1-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
28. methyl 4-(2-{1-butyl-3-(morpholine-4-carbonyl)hydrazono-2-oxo-2,3-dihydro-1H-indol-5-ylsulfanyl}ethyl)benzoate;
29. methyl 4-(2-{1-heptyl-3-(morpholine4-carbonyl)hydrazono-2-oxo-2,3-dihydro-1H-indol-5-ylsulfanyl}ethyl)benzoate;
30. methyl 4-(2-{3-(morpholine4-carbonyl)hydrazono-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanyl}ethyl)benzoate;
31. 4-(2-{1-butyl-3-(morpholine4-carbonyl)hydrazono-2-oxo-2,3-dihydro-1H-indol-5-yl-sulfanyl}ethyl)benzoic acid;
32. 4-(2-{1-heptyl-3-(morpholine-4-carbonyl)hydrazono-2-oxo-2,3-dihydro-1H-indol-5-ylsulfanyl}ethyl)benzoic acid;
33. 4-(2-{3-(morpholine4-carbonyl)hydrazono-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanyl}ethyl)benzoic acid;
34. methyl 4-{2-3-((2-chloro-4-trifluoromethylanilinocarbonyl)hydrazono)-2-oxo-1-phen-ethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
35. 4-{2-3((2-chloro-4-trifluoromethylanilinocarbonyl)hydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
36. methyl 4-{2-3((tert-butylamino)carbonylhydrazono)-2-oxo-1-phenethyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
37. ethyl 4-{2-3(((anilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
38. 4-{2-3-((3-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
39. 4-{2-3((aminocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
40. 4-3-(3-((3-trifluoromethylanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
41. 4-3-(3-((3-chloroanilinocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
42. 4-3-(3-((2-chloroanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
43. 4-3-(3-((4-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
44. 4-{2-3-((3-trifluoromethylanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
45. 4-{2-3-((2-chloro-3-trifluoromethylanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
46. 4-3-(3-((3-chloroanilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
47. 4-{2-3((aminocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
48. 4-{3-3((aminocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanylpropyl}benzoic acid;
49. 4-3-(3-((2-chloro-4-trifluoroanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
50. 4-{3-3((aminocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanylpropyl}benzoic acid;
51. 4-{2-3((thiophen-2-ylamine)carbonylhydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
52. 4-{2-3-((2-chloroanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
53. 4-3-(3-((3-chloroanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
54. 4-{2-3-((3-chlororanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
55. 4-{2-3-((3,4-dichloroanilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
56. 4-{2-3-((3,4-dichloroanilinocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
57. 4-{3-3((aminocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylpropyl}benzoic acid;
58. 4-(2-{3-(morpholine-4-carbonyl)hydrazono-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanyl}ethyl)benzoic acid;
59. 4-3-(3-((2-chloro-4-trifluoroanilinocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
60. 4-3-(3-((3-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
61. 4-3-(3-((3-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
62. 4-3-(3-((anilinocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
63. 4-3-(3-((3-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanyl)ethylbenzoic acid;
64. 4-(3-{1-hexyl-3-(morpholine-4-carbonyl)hydrazono-2-oxo-2,3-dihydro-1H-indol-5-ylsulfanyl}propyl)benzoic acid;
65. 4-3-(3-((anilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
66. 4-(3-{3-(morpholine-4-carbonyl)hydrazono-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanyl}propyl)benzoic acid;
67. 4-(3-{3-(morpholine-4-carbonyl)hydrazono-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanyl}propyl)benzoic acid;
68. 4-{2-3-((4-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
69. 4-3-(3-((3-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
70. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
71. 4-3-(3-((4-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
72. 4-(2-{3-(morpholine-4-carbonyl)hydrazono-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanyl}ethyl)benzoic acid;
73. 4-(2-{1-hexyl-3-(morpholine-4-carbonyl)hydrazono-2-oxo-2,3-dihydro-1H-indol-5-ylsulfanyl}ethyl)benzoic acid;
74. 4-3-(3-((4-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
75. 4-3-(3-((3-trifluoromethylanilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
76. 4-3-(3-((3-trifluoromethylanilinocarbonyl)hydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanyl)propylbenzoic acid;
77. 4-{2-3-((3-fluoroanilinocarbonyl)hydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
78. 4-{2-3-((3,4-dichloroanilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
79. 4-{2-3-((anilinocarbonyl)hydrazono)-2-oxo-1-propyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
80. 4-{2-3((1,3-thiazol-2-amine)carbonylhydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
81. 4-{2-3-((3-trifluoromethylanilino)carbonylhydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
82. 4-{2-3-((4-fluoroanilino)carbonylhydrazono)-2-oxo-1-hexyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
83. 4-{2-3-((2-chloroanilino)carbonylhydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
84. ethyl 4-{2-3-((2-chloroanilinocarbonyl)hydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoate;
85. 4-{2-3((1H-imidazol-2-amine)carbonylhydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
86. 4-{2-3((thiophen-2-ylamine)carbonylhydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
87. 4-{2-3((1,3-thiazol-2-amine)carbonylhydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
88. 4-{2-3((1H-imidazol-2-amine)carbonylhydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylethyl}benzoic acid;
89. 4-{3-3((thiophen-2-ylamine)carbonylhydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylpropyl}benzoic acid;
90. 4-{3-3((1,3-thiazol-2-amine)carbonylhydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylpropyl}benzoic acid;
91. 4-{3-3((1H-imidazol-2-amine)carbonylhydrazono)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-5-ylsulfanylpropyl}benzoic acid;
92. 4-{3-3((thiophen-2-ylamine)carbonylhydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylpropyl}benzoic acid;
93. 4-{3-3((1,3-thiazol-2-amine)carbonylhydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylpropyl}benzoic acid;
94. 4-{3-3((1H-imidazol-2-amine)carbonylhydrazono)-2-oxo-1-heptyl-2,3-dihydro-1H-indol-5-ylsulfanylpropyl}benzoic acid; and mixtures thereof.
15. The biaromatic compound as defined by claim 1, wherein formula (I) at least one of the following conditions is satisfied:
R1 is a methyl, propyl, butyl, pentyl, hexyl or heptyl radical, a benzyl radical or a phenethyl radical;
R2 is a hydrogen atom, an ethyl or tert-butyl radical, an unsubstituted phenyl radical, a phenyl radical mono- or disubstituted with a fluorine or chlorine atom or a CF3 radical, a benzyl radical, a phenylsulfonyl radical substituted with a methyl radical, or an unsubstituted thiophenyl, thiazolyl or imidazolyl radical;
R\u20322 is a hydrogen atom;
with the proviso that R2 and R\u20322 can together form a morpholino radical,
R3 is a hydrogen atom or a methyl or ethyl radical.
16. A cosmetic composition comprising a cosmetically effective amount of at least one biaromatic compound as defined by claim 1, formulated into a cosmetically and physiologically acceptable support therefor.
17. The cosmetic composition as defined by claim 16, comprising from 0.001% to 3% by weight of said at least one biaromatic compound.
18. The cosmetic composition as defined by claim 16, formulated for body or hair hygiene.
19. A pharmaceutical composition comprising a pharmaceutically effective amount of at least one biaromatic compound as defined by claim 1, formulated into a pharmaceutically and physiologically acceptable support therefor.
20. The pharmaceutical composition as defined by claim 19, comprising from 0.001% to 10% by weight of said at least one biaromatic compound.
21. A regime or regimen for regulating andor restoring the metabolism of skin lipids, comprising administering to an individual in need of such treatment, a thus effective amount of the pharmaceutical composition as defined by claim 19.
22. A regime or regimen:
1) for treating dermatological conditions or afflictions linked to a disorder of keratinization involving differentiation and proliferation, for treating acne vulgaris, comedonic or polymorphic acne, acne rosacea, nodulocystic acne, acne conglobata, senile acne or secondary acnes, solar, drug or occupational acne,
2) for treating other types of disorders of keratinization, ichthyoses, ichthyosiform conditions, Darier’s disease, palmoplantar keratoderma, leucoplakia and leucoplakiform conditions, or cutaneous or mucosal (oral) lichen,
3) for treating other dermatological conditions, disorders or afflictions having an inflammatory immunoallergic component, with or without cell proliferation disorder, and all forms of psoriasis, whether cutaneous, mucosal or ungual, and psoriatic rheumatism, or, alternatively, cutaneous atopy, eczema, or respiratory atopy or, alternatively, gingival hypertrophy,
4) for treating all dermal or epidermal proliferations, whether benign or malignant and whether or not of viral origin, common warts, flat warts and epidermodysplasia verruciformis, florid or oral papillomatoses, T lymphoma, and the proliferations which can be induced by ultraviolet radiation, basal cell and prickle cell epithelioma, and also all precancerous skin lesions, keratoacanthomas,
5) for treating other dermatological disorders, conditions or afflictions, immune dermatoses, lupus erythematosus, immune bullous diseases and collagen diseases, scleroderma,
6) for the treatment of dermatological or general conditions having an immunological component,
7) for the treatment of skin disorders due to exposure to UV radiation, and for repairing or combating skin aging, whether photoinduced or chronologic, or for reducing actinic keratoses and pigmentations, or any pathology associated with chronologic or actinic aging, xerosis,
8) for combating disorders of the sebaceous function, hyperseborrhoea of acne or simple seborrhoea,
9) for preventing or treating disorders of cicatrization or for preventing or repairing stretch marks,
10) for the treatment of disorders of pigmentation, hyperpigmentation, melasma, hypopigmentation or vitiligo,
11) for the treatment of conditions of the metabolism of lipids, obesity, hyperlipidaemia or non-insulin-dependent diabetes,
12) for the treatment of inflammatory conditions, arthritis,
13) for the treatment or prevention of cancerous or precancerous conditions,
14) for the prevention or treatment of alopecia of various origins, alopecia due to chemotherapy or to radiation,
15) for the treatment of disorders of the immune system, asthma, type I diabetes mellitus, multiple sclerosis or other selective dysfunctions of the immune system,
16) for the treatment of conditions of the cardiovascular system, arteriosclerosis or hypertension, comprising administering to an individual in need of such treatment, a thus effective amount of the pharmaceutical composition as defined by claim 19.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An image heating apparatus comprising:
a flexible sleeve;
a heater contacted to an inner circumferential surface of said sleeve;
a pressing roller for forming a nip, between itself and said sleeve contacted by said heater, in which a recording material is to be heated; and
a supporting member for supporting said heater, said supporting member being disposed inside said heater and having an area in which said sleeve is sandwiched between said supporting member and said pressing roller at least on an upstream side and a downstream side of a heater supporting position of said supporting member with respect to a rotational direction of said sleeve,
wherein said supporting member is provided, at its surface in the area, with a plurality of recessed portions for permitting passage of a lubricant, and
wherein the recessed portions are provided only in an area in which a predetermined maximum width sheet available in said image heating apparatus is passable.
2. An apparatus according to claim 1, wherein a depth of the recessed portions is smaller at a position closer to an end of said supporting member with respect to a longitudinal direction of said supporting member.