1-45. (canceled)
46. A method for protecting readable script formed on at least one face of an object, referred to as a scripted face, in which readable script on at least one scripted face of the object is covered with a transparent protective film, which adheres to this scripted face, and the object is associated with at least one microcircuit having at least one antenna for contactless remote reading of authenticating information, which can be delivered by this microcircuit and is designed to permit authentication of at least some of the readable script, wherein:
the object is associated with at least one antenna referred to as a matching antenna, formed by printing on a support, this matching antenna having at least one zone for electromagnetic coupling with an individual antenna whose dimensions are smaller than those of the matching antenna,
at least one transparent protective film referred to as a security film is used, which does not carry a matching antenna but carries at least one microcircuit with an integrated individual antenna, referred to as a microtransponder, at a predetermined position so that after the security film has been placed on a scripted face of the object, and for at least one position or state of the object:
it permits electromagnetic coupling of the individual antenna with an electromagnetic coupling zone of a matching antenna associated with the object,
it does not mask any essential part of the readable script,
a security film is applied and adhered to a corresponding scripted face in order to cover readable script and so as to permit electromagnetic coupling of the individual antenna of each microtransponder with a coupling zone and a matching antenna, for at least one position or state of the object, the matching antenna having dimensions designed to permit the remote transmission of information between the individual antenna and a power antenna of a reading device when the object is placed in the field of this power antenna.
47. The method as claimed in claim 46, wherein at least one matching antenna is printed on a printing support which is not a security film carrying at least one microtransponder.
48. The method as claimed in claim 46, wherein at least one matching antenna is printed on a face of the object.
49. The method as claimed in claim 48 wherein the matching antenna is subsequently covered with a protective film.
50. The method as claimed in claim 46, wherein at least one matching antenna is printed on a scripted face before applying a security film to this scripted face.
51. The method as claimed in claim 46, wherein at least one matching antenna is printed on a face of the object which is not a scripted face.
52. The method as claimed in claim 46, wherein at least one matching antenna carried by a film of synthetic material referred to as an antenna film is used, and this antenna film is adhered to a face of the object.
53. The method as claimed in claim 52, wherein the antenna film is applied and adhered to a face of the object which is not a scripted face.
54. The method as claimed in claim 53, wherein the antenna film is applied and adhered to a face of the object which is the verso of a sheet of the object whose recto is a scripted face.
55. The method as claimed in claim 46, wherein at least one matching antenna is used that is printed with an ink which is transparent to visible light and electrically conductive after drying.
56. The method as claimed in claim 52, wherein at least one transfer referred to as an antenna transfer is used, comprising a support sheet carrying an adhesive antenna film, this antenna transfer being designed to make it possible to apply and adhere the antenna film to a face of the object by separating the antenna film from the support sheet.
57. The method as claimed in claim 46, wherein at least one matching antenna comprising an electrical capacitor of adjustable value is used.
58. The method as claimed in claim 46, wherein at least one matching antenna is used which forms a resonant electrical circuit comprising an electrical capacitor incorporated in a graphic pattern of the antenna film andor of the object, or superimposed with such a pattern.
59. The method as claimed in claim 46, wherein at least one matching antenna printed by silkscreen printing is used.
60. The method as claimed in claim 46, wherein at least one given matching antenna is used comprising a plurality of electromagnetic coupling zones for coupling it with a plurality of individual antennas of a plurality of microtransponders.
61. The method as claimed in claim 46, wherein a plurality of security films each comprising at least one microtransponder are used for the protection of readable script on a plurality of scripted faces of the object.
62. The method as claimed in claim 46, wherein at least one security film comprising at least one microtransponder incorporated in its thickness is used.
63. The method as claimed in claim 46, wherein at least one multilayered security film is used.
64. The method as claimed in claim 46, wherein at least one security film formed by printing is used, incorporating at least one microtransponder in the thickness of the security film when the security film is being formed by printing, between two printed layers.
65. The method as claimed in claim 46, wherein at least one security film formed by silkscreen printing is used.
66. The method as claimed in claim 46, wherein at least one transfer referred to as a protection transfer is used, comprising a support sheet carrying an adhesive security film, this protection transfer being designed to make it possible to apply and adhere the security film to a scripted face of the object by separating the security film from the support sheet.
67. The method as claimed in claim 46, wherein information for authenticating at least some of the readable script is recorded in at least one memory of at least one microtransponder carried by at least one security film covering this readable script.
68. The method as claimed in claim 46, wherein authenticating information which represents a key andor an algorithm for authentication andor a certificate resulting from an algorithm is recorded in at least one memory of at least one microtransponder carried by at least one security film covering readable script.
69. The method as claimed in claim 46, wherein at least one microtransponder forming a logic circuit is used.
70. A device for protecting readable script formed on at least one face of an object, referred to as a scripted face, comprising:
at least one transparent protective film, which is intended to adhere to a scripted face while covering readable script, and
at least one microcircuit intended to be associated with the object, having at least one antenna for contactless remote reading of authenticating information, which can be delivered by the microcircuit and is designed to permit authentication of at least some of the readable script, wherein it comprises:
at least one antenna intended to be associated with the object, referred to as a matching antenna, formed by printing on a support and having at least one zone for electromagnetic coupling with an individual antenna whose dimensions are smaller than those of the matching antenna,
at least one transparent protective film referred to as a security film, which does not carry a matching antenna but carries at least one microcircuit and with an integrated individual antenna, referred to as a microtransponder, at a predetermined position so that after the security film has been placed on a scripted face of the object, and for at least one position or state of the object:
it permits electromagnetic coupling of the individual antenna with an electromagnetic coupling zone of a matching antenna associated with the object,
it does not mask any essential part of the readable script,
and wherein the matching antenna has dimensions designed to permit the remote transmission of information between the individual antenna and a power antenna of a reading device when the object is placed in the field of this power antenna.
71. The device as claimed in claim 70, wherein at least one matching antenna is printed on a printing support which is not a security film carrying at least one microtransponder.
72. The device as claimed in claim 70, wherein at least one matching antenna is printed on a face of the object.
73. The device as claimed in claim 72, wherein it comprises at least one protective film designed to cover at least one printed matching antenna.
74. The device as claimed in claim 70, wherein at least one matching antenna is printed on a scripted face.
75. The device as claimed in claim 70, wherein at least one matching antenna is printed on a face of the object which is not a scripted face.
76. The device as claimed in claim 70, wherein it comprises at least one film of synthetic material referred to as an antenna film, which carries at least one printed matching antenna.
77. The device as claimed in claim 70, wherein at least one matching antenna is printed with an ink which is transparent to visible light and electrically conductive after drying.
78. The device as claimed in claim 76, wherein it comprises at least one transfer referred to as an antenna transfer, comprising a support sheet carrying an adhesive antenna film, this antenna transfer being designed to make it possible to apply and adhere the antenna film to a face of the object by separating the antenna film from the support sheet.
79. The device as claimed in claim 70, wherein at least one matching antenna comprises an electrical capacitor of adjustable value.
80. The device as claimed in claim 70, wherein at least one matching antenna forms a resonant electrical circuit comprising an electrical capacitor incorporated in a graphic pattern of the antenna film andor of the object, or superimposed with such a pattern.
81. The device as claimed in claim 70, wherein it comprises at least one given matching antenna comprising a plurality of electromagnetic coupling zones for coupling it with a plurality of individual antennas of a plurality of microtransponders.
82. The device as claimed in claim 70, wherein it comprises a plurality of security films each comprising at least one microtransponder for the protection of readable script on a plurality of scripted faces of the object.
83. The device as claimed in claim 70, wherein at least one security film comprises at least one microtransponder incorporated in its thickness.
84. The device as claimed in claim 70, wherein at least one security film is multilayered.
85. The device as claimed in claim 70, wherein at least one security film is formed by printing and incorporates at least one microtransponder in its thickness, between two printed layers.
86. The device as claimed in claim 70, wherein each microtransponder incorporated in a security film has a thickness of less than 0.2 mm and an area of less than 10 mm2 in the plane of the security film.
87. The device as claimed in claim 70, wherein each microtransponder incorporated in a security film has a thickness of between 50\u03bc and 180\u03bc.
88. The device as claimed in claim 70, wherein it comprises at least one transfer referred to as a protection transfer, comprising a support sheet carrying an adhesive security film, this protection transfer being designed to make it possible to apply and adhere the security film to a scripted face of the object by separating the security film from the support sheet.
89. An object comprising at least one face referred to as a scripted face on which readable script is formed, wherein it comprises:
at least one matching antenna formed by printing on a support and associated with the object, this matching antenna having at least one zone for electromagnetic coupling with an individual antenna whose dimensions are smaller than those of the matching antenna,
at least one security film which does not carry a matching antenna but carries at least one microcircuit and with an integrated individual antenna, referred to as a microtransponder, the security film being applied and adhering to a scripted face in order to cover readable script, the position of each microtransponder being designed so as to permit electromagnetic coupling of the individual antenna of each microtransponder with a coupling zone of a matching antenna, for at least one position or state of the object, the matching antenna having dimensions designed to permit the remote transmission of information between the individual antenna and a power antenna of a reading device when the object is placed in the field of this power antenna, and wherein at least one microtransponder of a security film covering readable script is designed to be able to deliver information for authenticating at least some of the readable script.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-28. (canceled)
29. Crystalline N-{2-4-((R)-2-hydroxy-2-phenylethylamino)phenyl-ethyl}-(R)-2-hydroxy-2-(3-formamido-4-hydroxyphenyl)ethylamine monohydrochloride, wherein the crystalline monohydrochloride salt is characterized by an x-ray powder diffraction pattern having two or more diffraction peaks at 2\u03b8 values selected from 6.00\xb10.2, 7.99\xb10.2, 9.98\xb10.2, 15.98\xb10.2, 24.05\xb10.2, 24.53\xb10.2, 25.35\xb10.2, 26.08\xb10.2 26.77\xb10.2, 28.13\xb10.2, 34.31\xb10.2, and 38.49\xb10.2.
30. The crystalline monohydrochloride salt of claim 29 wherein the crystalline monohydrochloride salt is characterized by an x-ray powder diffraction pattern having two or more diffraction peaks at 2\u03b8 values selected from 15.98\xb10.2, 24.05\xb10, 26.08\xb10.2, and 28.13\xb10.2.
31. The crystalline monohydrochloride salt of claim 29 wherein the crystalline monohydrochloride salt is characterized by an x-ray powder diffraction pattern in which the peak positions are substantially in accordance with the peak positions of the pattern shown in FIG. 1.
32. The crystalline monohydrochloride salt of claim 29, wherein the crystalline monohydrochloride salt has an infrared absorption spectrum with significant absorption bands at about 699, 788, 810, 827, 875, 970, 1026, 1056, 1080, 1101, 1213, 1296, 1374, 1441, 1546, 1596, 1660, 3371, and 3553 cm\u22121.
33. The crystalline monohydrochloride salt of claim 29, wherein the crystalline monohydrochloride salt is characterized by a differential scanning calorimetry trace which shows an onset of endothermic heat flow at about 200\xb0 C.
34. The crystalline monohydrochloride salt of claim 29 wherein the crystalline monohydrochloride salt is characterized by a differential scanning calorimetry trace which is substantially in accordance with that shown in FIG. 2.
35. A pharmaceutical composition comprising a therapeutically effective amount of the crystalline monohydrochloride salt of claim 29 and a pharmaceutically acceptable carrier.
36. The pharmaceutical composition of claim 35, wherein the composition further comprises a therapeutically effective amount of one or more other therapeutic agents selected from corticosteroids, antichlolinergic agents, and PDE4 inhibitors.
37. The pharmaceutical composition of claim 35, wherein the composition is formulated for administration by inhalation.
38. A combination comprising the crystalline monohydrochloride salt of claim 29 and 6\u03b1,9\u03b1-difluoro-17\u03b1-(2-furanylcarbonyl)oxy-11\u03b2-hydroxy-16\u03b1-methyl-3-oxo-androsta-1,4-diene-17\u03b2-carbothioic acid S-fluoromethyl ester.
39. A process for preparing the crystalline monohydrochloride salt of claim 29, the process comprising the steps of:
(a) dissolving N-{2-4-((R)-2-hydroxy-2-phenylethylamino)phenylethyl}-(R)-2-hydroxy-2-(3-formamido-4-hydroxyphenyl)ethylamine in a polar solvent to form a first solution; and (b) adding between about 0.9 and about 1 molar equivalent of hydrochloric acid to form a second solution from which the crystalline monohydrochloride salt of claim 29 is formed.
40. The process of claim 39 wherein the second solution comprises isopropanol and water in a ratio of isopropanol:water of from about 4:1 to about 10:1.
41. The process of claim 39 further comprising in step (a): heating the first solution to a temperature of between about 40\xb0 C. and about 60\xb0 C. and then cooling the first solution to about room temperature.
42. A process for preparing the crystalline monohydrochloride salt of claim 29, the process comprising the steps of:
(a) dissolving N-{2-4-((R)-2-hydroxy-2-phenylethylamino)phenylethyl}-(R)-2-hydroxy-2-(3-formamido-4-hydroxyphenyl)ethylamine in a polar solvent to form a first solution; and
(b) adding a molar excess of an aqueous solution of an inorganic chloride at a pH of between about 5 and about 6 to form a second solution from which the crystalline monohydrochloride salt of claim 29 is formed.
43. A method of treating a mammal having a disease or condition associated with \u03b22 adrenergic receptor activity, the method comprising administering to the mammal, a therapeutically effective amount of the crystalline monohydrochloride salt of claim 29.
44. The method of claim 43 wherein the disease or condition is asthma or chronic obstructive pulmonary disease.
45. A method of treating asthma or chronic obstructive pulmonary disease in a mammal, the method comprising administering to the mammal, a therapeutically effective amount of the crystalline monohydrochloride salt of claim 29 and a pharmaceutically acceptable carrier.
46. The method of claim 45 wherein the method further comprises administering to the mammal a therapeutically effective amount of one or more other therapeutic agents selected from corticosteroids, antichlolinergic agents, and PDE4 inhibitors.
47. The method of claim 45 wherein the method further comprises administering to the mammal a therapeutically effective amount of 6\u03b1,9\u03b1-difluoro-17\u03b1-(2-furanylcarbonyl)oxy-11\u03b2-hydroxy-16\u03b1-methyl-3-oxo-androsta-1,4-diene-17\u03b2-carbothioic acid S-fluoromethyl ester.