It is claimed:
1. A method for treating neuropathic pain of a patient comprising the steps of:
administering an anesthetic to the affected area; and then
transdermally administering a therapeutically effective amount of a composition containing one or more compounds having capsaicin-like properties, the compounds having capsaicin-like properties being present in a total concentration from greater than about 5% by weight to about 10% by weight.
2. The method as in claim 1 wherein the transdermally administered composition includes capsaicin.
3. The method as in claim 1 wherein the compound is a capsaicin analog.
4. The method as in claim 1 wherein the transdermally administered composition contains both capsaicin and one or more capsaicin analogs.
5. The method as in claim 1 wherein the transdermally administered composition also includes an agent having skin absorbing and skin penetrating properties.
6. The method as in claim 1 wherein the anesthetic is administered via a transdermal patch.
7. The method as in claim 1 further comprising the step of
administering a narcotic analgesic to further inhibit the irritant effects of the transdermally administered composition.
8. The method as in claim 1 wherein the total concentration of the compound or compounds having capsaicin-like properties in the transdermally administered composition is about 7.5% by weight.
9. A device for treatment of neuropathic pain in a patient, comprising:
a skin-adherent patch, the patch including a reservoir, the reservoir being of a sufficient construction to contain a formulation and to continuously provide the formulation to the surface of skin for a predetermined period of time; and
one or more compounds having capsaicin-like properties being disposed in the reservoir, the compounds having capsaicin-like properties being present in a total concentration from greater than about 5% to 10% by weight of the formulation.
10. The device as in claim 9 further comprising a second patch, the second patch capable of delivering an anesthetic in an amount effective to desensitize C fibers to the side effects of the capsaicin-like concentration.
11. The composition as in claim 9 wherein the capsaicin-like compound is capsaicin.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for preventing the refill of a cartridge having a central reservoir defined therein, said method comprising the steps of:
providing a drill resistant cage disposed within the central reservoir of the cartridge,
wherein said drill resistant cage prevents a refiller from drilling into the central reservoir with a drill having a bit and introducing a refill ink;
providing a drill bit grabbing mesh disposed within said drill resistant cage, wherein said bit grabbing mesh would impede attempts to drill into the central reservoir;
providing a series of pressure valves within the central reservoir, wherein said pressure valves would close to prevent the introduction of refill ink into the central reservoir by means of a pressure differential;
providing an ink altering material contained within one or more ink altering packets disposed in the central reservoir, wherein said ink altering packets would open during attempted refill and release said ink altering material thus fouling the ink and preventing use of the cartridge.
2. The method for preventing the refill of a cartridge of claim 1 wherein said central reservoir has a top, a bottom, a front wall, a back wall, a right side wall and a left side wall, and wherein said method includes the step of providing said drill resistant cage with a cage top disposed against said central reservoir top to prevent the refiller from drilling through the central reservoir top to access said central reservoir.
3. The method for preventing the refill of a cartridge of claim 2 including the further step of placing said bit grabbing mesh against said cage top.
4. The method for preventing the refill of a cartridge of claim 1 wherein said central reservoir has a top, a bottom, a front wall, a back wall, a right side wall and a left side wall, and wherein said method includes the step of providing said drill resistant cage with a cage top disposed against said reservoir top, a cage bottom disposed against said reservoir bottom, a cage front wall disposed against said reservoir front wall, a cage back wall disposed against said reservoir back wall, a cage right side wall disposed against said reservoir right side wall, and a cage left side wall disposed against said reservoir left side wall, wherein said drill resistant cage prevents a refiller from drilling into and accessing said central reservoir from any point on the cartridge.
5. The method for preventing the refill of a cartridge of claim 4 including the further step of placing said bit grabbing mesh against said cage top, said cage bottom, said cage front wall, said cage back wall, said cage right side wall and said cage left side wall.
6. The method for preventing the refill of a cartridge of claim 4 comprising the further step of incorporating a top pressure valve within said cage top and a bottom pressure valve within said cage bottom, wherein said pressure valves would close if the refiller attempts to introduce ink into said central reservoir by means of a pressure differential.
7. The method for preventing the refill of a cartridge of claim 4 wherein comprising the further step of attaching said ink altering packets to said cage top, cage bottom, cage front wall, cage side wall, cage right side wall and cage left side wall.
8. The method for preventing the refill of a cartridge of claim 7 comprising the further step of providing said ink altering packets with a pressure sensitive covering material that would burst when the pressure within the central reservoir is altered, releasing said ink altering material into the central reservoir.
9. The method for preventing the refill of a cartridge of claim 1 wherein said drill resistant cage is made from heat treatable 400 series stainless steel that is stamped, formed and heat treated to about rc 50-55.
10. The method for preventing the refill of a cartridge of claim 1 wherein said central reservoir has a top, a bottom, a front wall, a back wall, a right side wall and a left side wall and wherein said method includes the further step of providing a bit grabbing mesh is disposed against said reservoir top.
11. The method for preventing the refill of a cartridge of claim 1 wherein said bit grabbing mesh is made from a fibrous metal material, whereby said bit grabbing mesh would grab a bit that would penetrate said drill resistant cage thereby impeding the removal of said bit.
12. The method for preventing the refill of a cartridge of claim 1 wherein said central reservoir has a top, a bottom, a front wall, a back wall, a right side wall and a left side wall, and wherein said method comprises the further step of inserting a top pressure valve disposed against said reservoir top and a bottom pressure valve disposed against said reservoir bottom; whereby said pressure valves would close if the refiller attempts to introduce a refill ink into said central reservoir by means of a pressure differential to either force said refill ink into said central reservoir or create a vacuum to draw said refill ink into said central reservoir.
13. The method for preventing the refill of a cartridge of claim 1 wherein said central reservoir has a top, a bottom, a front wall, a back wall, a right side wall and a left side wall, and wherein said method comprises the further step of attaching a multiplicity of ink altering packets to reservoir top; whereby said ink altering packets would be opened if an object pierces said drill resistant cage top and said ink altering packets, whereby said ink altering material would alter the properties of a refill ink introduced into said reservoir rendering said ink unusable.
14. A device for the prevention of refilling a cartridge having a central reservoir defined therein, said device comprising a hardened drill resistant cage disposed within the central reservoir of said cartridge, wherein said drill resistant cage prevents drilling into said central reservoir and the introduction of a refill material.
15. The device for the prevention of refilling a cartridge of claim 14, wherein said refill material is either ink or toner.
16. The device for the prevention of refilling a cartridge of claim 14, wherein said hardened drill resistant cage is made from heat treatable 400 series stainless steel that is stamped, formed and heat treated to about rc 50-55.
17. The device for the prevention of refilling a cartridge of claim 14 having a central reservoir defined therein, said central reservoir further defined by a top, a bottom, a front wall, a back wall, a right side wall and a left side wall, and said drill resistant cage further defined by a cage top disposed against said reservoir top, a cage bottom disposed against said reservoir bottom, a cage front wall disposed against said reservoir front wall, a cage back wall disposed against said reservoir back wall, a cage right side wall disposed against said reservoir right side wall, and a cage left side wall disposed against said reservoir left side wall, wherein said drill resistant cage prevents a refiller from drilling into and accessing said central reservoir with a drill having a bit and introducing a refill material.
18. A device for the prevention of refilling a cartridge having a central reservoir defined therein, said device comprising a bit grabbing mesh disposed within said central reservoir, wherein said bit grabbing mesh would grab a drill bit of an attempted refiller, thus impeding the refillers ability to drill into said central reservoir.
19. The device for the prevention of refilling a cartridge of claim 18, wherein said bit grabbing mesh is made of a thin fibrous metal mesh material.
20. The device for the prevention of refilling a cartridge of claim 18, wherein said bit grabbing mesh is approximately one eighth inch (\u215b\u2033) thick and is disposed against the walls of said central reservoir.
21. The device for the prevention of refilling of a cartridge of claim 18 wherein said central reservoir is defined by a top, a bottom, a front wall, a back wall, a right wall and a left wall, and wherein said bit grabbing mesh is disposed against said top.
22. The device for the prevention of refilling of a cartridge of claim 18 wherein said central reservoir is defined by a top, a bottom, a front wall, a back wall, a right wall and a left wall, and wherein said bit grabbing mesh is disposed against said top, said bottom, said front wall, said back wall, said right wall and said left wall.
23. A device for the prevention of refilling a cartridge having a central reservoir defined therein, said central reservoir further defined by a top, a bottom, a front wall, a back wall, a right wall and a left wall, wherein said device comprising an anti-pressure chamber created by a bottom plate having a bottom two way check valve therein, said bottom plate disposed near said central reservoir bottom such that a tight seal is created in said central reservoir when said bottom check valve is closed, and wherein said anti-pressure chamber is further created by a top plate having a top two way check valve therein, said top plate disposed near said central reservoir top such that a tight seal is created in said central reservoir when said top two way check valve is closed; whereby said top check valve and said bottom check valve would close in the event that a refiller attempts to introduce a refill material into said central reservoir by means of a pressure differential.
24. The device for the prevention of refilling a cartridge of claim 23, wherein a drill resistant cage is disposed therein, said drill resistant cage having a cage top disposed against said reservoir top, a cage bottom disposed against said reservoir bottom, a cage front wall disposed against said reservoir front wall, a cage back wall disposed against said reservoir back wall, a cage right wall disposed against said reservoir right wall, and a cage left wall disposed against said reservoir left wall, and wherein a top check valve is incorporated into said cage top, and a bottom check valve is incorporated into said cage bottom.
25. A device for the prevention of refilling a cartridge having a central reservoir defined therein, said device comprising an ink altering material contained within a multiplicity of ink altering packets, wherein said ink altering packets are opened during attempted refill thus releasing said ink altering material into a refill ink thereby preventing use of the refill ink.
26. The device for the prevention of refilling a cartridge of claim 25, wherein said ink altering material is dried wall paper paste powder.
27. The device for the prevention of refilling a cartridge of claim 25, wherein said central reservoir is further defined by a top, a bottom, a front wall, a back wall, a right side wall and a left side wall, and wherein said ink altering packets are disposed against said top, and are opened by a refiller using a drill with a bit to penetrate said top to introduce a refill ink; whereby said bit penetrates said ink altering packet and releases said ink altering material and said ink altering material mixes with said refill ink thus altering the properties of said ink to render said ink unusable.
28. The device for the prevention of refilling a cartridge of claim 25, wherein said central reservoir is further defined by a top, a bottom, a front wall, a back wall, a right side wall and a left side wall, and wherein said ink altering packets are disposed against said top, said bottom, said front wall, said back wall, said right wall, and said left wall, and are opened by a refiller using a drill with a bit to penetrate one of the walls of said reservoir, whereby said ink altering material is released thus preventing the use of said cartridge.
29. The device for the prevention of refilling a cartridge of claim 25, wherein said central reservoir is further defined by a top, a bottom, a front wall, a back wall, a right side wall and a left side wall, and wherein said ink altering packets are disposed against said top, said bottom, said front wall, said back wall, said right wall, and said left wall, wherein said ink altering packets contain a thin covering material and said ink altering material contained therein under pressure, wherein said thin covering material bursts if a refiller attempts to introduce ink into the central reservoir by means of a pressure differential.