1. The compound dipterinyl calcium pentahydrate (DCP) or an analog or polymorph thereof.
2. A method of synthesizing dipterinyl calcium pentahydrate (DCP) comprising:
dissolving pterin in an aqueous solution of NaOH,
adding CaCl2.2H2O to the solution with stirring at a pH of about 11,
continuing stirring for about 1 day, and
collecting the precipitate as DCP.
3. A compound of formula (I):
M(pterin)x(H2O)y
wherein:
M is a bivalent metal ion selected from the group consisting of Ca2+, Cu2+, Mg2+, V2+, Cr2+, Mn2+, Fe2+, Mo2+, Zn2+, Sr2+, Ba2+, Ra2+, Ru2+, Rh2+, Pd2+, Cd2+, Sn2+, W2+, Re2+, Os2+, Ir2+, Pt2+, Si2+, and Sm2+;
X is an integr from 1 to 8; and
y is an integer of from 1 to 8.
4. A method of treating disease in a subject comprising the administration of a therapeutically effective amount of a compound of formula (I):
M(pterin)x(H2O)y
wherein:
M is a bivalent metal ion selected from the group consisting of Ca2+, Cu2+, Mg2+, V2+, Cr2+, Mn2+, Fe2+, Mo2+, Zn2+, Sr2+, Ba2+, Ra2+, Ru2+, Rh2+, Pd2+, Cd2+, Sn2+, W2+, Re2+, Os2+, Ir2+, Pt2+, Si2+, and Sm2+;
X is an integr from 1 to 8; and
y is an integer of from 1 to 8.
5. The method of claim 4 wherein the compound of formula (I) is dipterinyl calcium pentahydrate (DCP).
6. The method of claim 5 wherein the disease is a neoplastic disease.
7. The method of claim 5 wherein the disease is an infectious disease.
8. The method of claim 6 comprising modulating tryptophan degradation.
9. The method of claim 6 comprising modulating neopterin production.
10. The method of claim 6 comprising modulating IFN-\u03b3 production.
11. The method of claim 6 comprising modulating the activity of the enzyme IDO.
12. The method of claim 6 comprising modulating immune resistance in human solid tumors.
13. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of formula (I):
M(pterin)x(H2O)y
wherein:
M is a bivalent metal ion selected from the group consisting of Ca2+, Cu2+, Mg2+, V2+, Cr2+, Mn2+, Fe2+, Mo2+, Zn2+, Sr2+, Ba2+, Ra2+, Ru2+, Rh2+, Pd2+, Cd2+, Sn2+, W2+, Re2+, Os2+, Ir2+, Pt2+, Si2+, and Sm2+;
X is an integr from 1 to 8; and
y is an integer of from 1 to 8.
14. A pharmaceutical composition of claim 13 wherein the compound of formula (I) is dipterinyl calcium pentahydrate (DCP).
15. The method of claim 6 wherein the neoplastic disease is selected from breast cancer, ovarian cancer, endometrial cancer, prostate cancer, gastric cancer, salivary gland cancer, pancreatic cancer, colorectal cancer, non-small cell lung cancers, oral cancers, and cutaneous squamous cell carcinoma.
16. The method of claim 15 wherein the neoplastic disease is breast cancer.
17. The method of claim 6 further comprising administering to the subject one or more therapies in addition to an effective amount of DCP.
18. The method of claim 17 wherein the one or more therapies comprise one or more of surgery, radiation therapy, chemotherapy, high dose chemotherapy with stem cell transplant, hormone therapy, and monoclonal antibody therapy.
19. The method of claim 6 comprising administering to the patient DCP at a dose ranging from about 600 mgday to about 4200 mgday.
20. The method of claim 6 comprising administering to the patient DCP at a dose ranging from about 1200 mgday to about 3600 mgday.
21. The method of claim 6 comprising administering to the patient DCP at a dose ranging from about 1800 mgday to about 3000 mgday.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A computer based multi-channel radio system, comprising:
a computer coupled to a display and having a graphical user interface; and
a digital audio radio receiver coupled to the computer for selectively receiving a plurality of channels and data associated with the plurality of channels,
said data including one or more of channel number, artist name, song title, channel name, category or genre, and use percentage of a channel,
wherein the computer selectively displays on the graphic user interface at least a portion of the data associated with the plurality of channels; and
wherein the data associated with the plurality of channels is simultaneously updated.
2. The system of claim 1, wherein the system further comprises at least one among a volume control, a tone control, and an output port on the radio receiver, wherein the output port can selectively stream data or audio or video from a selected channel among the plurality of channels.
3. The system of claim 1, wherein the graphic user interface further comprises a program to selectively tag a desired type of content among the plurality of channels, analyze the data associated with the plurality of channels for an indication of content of the desired type among the plurality of channels, and alert a user of a desired channel containing the indication.
4. The system of claim 3, wherein the user is alerted by a pop-up window of the desired content on the desired channel.
5. The system of claim 1, wherein updates for the data associated with the plurality of channels recur in rapid succession.
6. The system of claim 1, wherein the graphical user interface enables the simultaneous viewing of at least two among a plurality of channel numbers, a plurality of artist names, a plurality of song titles, a plurality of channel names, a plurality of categories, and a plurality of use percentages.
7. The system of claim 1, wherein the graphical user interface enables the viewing of signal strength of a signal received from at least one among a satellite signal and a terrestrial signal.
8. The system of claim 1, wherein the data associated with the plurality of channels is extracted from a broadcast information channel received at the radio receiver as one of the plurality of channels.
9. The system of claim 1, wherein the data associated with the plurality of channels is extracted from a plurality of tuners performing background scanning among the plurality of channels to create a broadcast information channel.
10. The system of claim 1, wherein the radio receiver is selected among a satellite digital audio receiver, a multi-channel digital FM receiver, and a multi-channel digital AM receiver.
11. The system of claim 1, wherein the system further comprises a global network connection.
12. The system of claim 1, wherein the computer controls the radio receiver.
13. A computer based multi-channel radio, comprising:
a digital audio radio receiver for receiving a plurality of channels and data associated with the plurality of channels over-the-air, said data including one or more of channel number, artist name, song title, channel name, category or genre, and use percentage of a channel;
a channel decoder coupled to the radio receiver; and
a port for transmitting data associated with the plurality of channels, transmitting an output signal representative of a selected channel among the plurality of channels, and for receiving control signals from a computer having a graphical user interface,
wherein the computer selectively displays on the graphic user interface at least a portion of the data associated with the plurality of channels and a user selectively controls the channel decoder by selecting the selected channel on the graphical user display.
14. The radio of claim 13, wherein the data associated with the plurality of channels is extracted from a broadcast information channel received at the radio receiver as one of the plurality of channels.
15. The radio of claim 13, wherein the data associated with the plurality of channels is extracted from a plurality of tuners in the radio performing background scanning among the plurality of channels.
16. A method of representing a plurality of channels on a display, comprising:
extracting data associated with each channel in the plurality of channels from a data stream using a digital audio receiver, said data including one or more of channel number, artist name, song title, channel name, category or genre, and use percentage of a channel;
enabling the selective display of the data associated with each of the plurality of channels on a graphical user interface;
simultaneously updating and displaying said data associated with said selected plurality of channels; and
selectively controlling a remotely coupled channel decoder on a radio receiver via the graphical user interface.
17. The method of claim 16, wherein said enabling the selective display of the data comprises simultaneously displaying at least two among a plurality of channel numbers, a plurality of artist names, a plurality of song titles, a plurality of channel names, a plurality of categories, and a plurality of use percentages.
18. The method of claim 16, wherein the graphical user interface includes a plurality of selectable tabs to enable the viewing of a plurality of channels belonging to predetermined categories selected from the group of categories including all, music, news, talk, last 10, favorites, traffic, weather, video, rock, classical, jazz, kids, comedy, and user customizable.
19. The method of claim 16, wherein the method further comprises extracting a signal strength measurement from the radio receiver and displaying the measurement on a screen of the graphical user interface.
20. A method of displaying a group of selected channels among a plurality channels, comprising:
controlling a remote source for receiving a digitally encoded bit stream on at least a portion of the plurality of channels and decoding a selected channel among the plurality of channels using a digital audio receiver;
selectively displaying data associated with each of the plurality of channels on a graphical user interface, said data including one or more of channel number, artist name, song title, channel name, category or genre, and use percentage of a channel; and
updating and displaying the data associated with the plurality of channels in rapid recurring succession.
21. The method of claim 20, wherein the method further comprises selectively tagging a desired type of content on the selected channel by analyzing a broadcast information channel andor an Electronic Program Guide for an indication of content of the desired type among the plurality of channels.
22. The method of claim 21, further comprising alerting a user of a desired channel containing the indication.
23. The method of claim 22, wherein said tagging further comprises storing descriptors representative of the content on the selected channel in a memory.
24. The method of claim 20, wherein said selectively displaying data associated with each of the plurality of channels comprises simultaneously displaying data associated with at least two of the plurality of channels.
25. A machine-readable non-transitory storage, having stored thereon a computer program having a plurality of code sections executable by a machine for causing the machine to perform a method comprising:
extracting data associated with each channel in a plurality of channels from a data stream obtained using a digital audio receiver, said data including one or more of channel number, artist name, song title, channel name, category or genre, and use percentage of a channel;
enabling the selective display of the data associated with each of the plurality of channels on a graphical user interface;
simultaneously updating and displaying said data associated with said selected plurality of channels; and
selectively controlling a remotely coupled channel decoder on a radio receiver via the graphical user interface.
26. A machine-readable non-transitory storage, having stored thereon a computer program having a plurality of code sections executable by a machine for causing the machine to perform a method comprising:
controlling a remote source for receiving a digitally encoded bit stream on at least a portion of the plurality of channels and decoding a selected channel among the plurality of channels using a digital audio receiver;
selectively displaying data associated with each of the plurality of channels on a graphical user interface said data including one or more of channel number, artist name, song title, channel name, category or genre, and use percentage of a channel;
updating and displaying the data associated with the plurality of channels in a rapid recurring succession; and
enabling the output of the selected channel as represented by the graphical user interface.