1. A method for administering radio resources in a mobile radio cell which includes a plurality of mobile terminals which can be distinguished by their radio signals, and a base station, the method comprising:
requesting a mobile terminal to send out a signal currently present at a receiver of a mobile terminal, the signal being representative of an interference situation at the location of the mobile terminal, together with information for estimating the channel between the mobile terminal and the base station so that the base station receives raw data at the location of the mobile terminal;
evaluating the signal received from the mobile terminal and the information for estimating the channel between the mobile terminal and the base station for determining the radio sources forming the basis of the signal and the intensities of at least some of the radio sources; and
adapting, in the base station in the mobile radio cell, the distribution of the radio resources for improving the interference situation at the location of the mobile terminal.
2. The method as claimed in claim 1, wherein, in the case where the mobile terminal wishes to establish a communication link with a second mobile terminal, the base station initializes a direct link between the mobile terminal and the second mobile terminal if, as a result, the interference situation is improved at the location of the mobile terminal.
3. The method as claimed in claim 2, wherein a direct link between the mobile terminal and the second mobile terminal is established if the strongest radio source identified in the sequence of samples is the second mobile terminal, taking into account the interference situation in the radio cell overall.
4. The method as claimed in claim 1, wherein all mobile terminals in the mobile radio cell repetitively send out received raw data signals to the base station and wherein, on the basis of these signals, the base station checks the distribution of the radio resources in the mobile radio cell.
5. The method as claimed in claim 2, wherein all mobile terminals in the mobile radio cell repetitively send out received raw data signals to the base station and wherein, on the basis of these signals, the base station checks the distribution of the radio resources in the mobile radio cell.
6. The method as claimed in claim 3, wherein all mobile terminals in the mobile radio cell repetitively send out received raw data signals to the base station and wherein, on the basis of these signals, the base station checks the distribution of the radio resources in the mobile radio cell.
7. A method for administering radio resources in a mobile radio cell which includes a plurality of mobile terminals which can be distinguished by their radio signals, and a base station, the method comprising:
receiving a request from the base station to send out a signal currently present at a receiver of a mobile terminal, the signal being representative of an interference situation at the location of the mobile terminal, together with information for estimating the channel between the mobile terminal and the base station so that the base station receives raw data at the location of the mobile terminal, wherein the signal received from the mobile terminal and the information for estimating the channel between the mobile terminal and the base station for determining the radio sources form the basis of the signal and the intensities of at least some of the radio sources and wherein, in the base station in the mobile radio cell, the distribution of the radio resources are adapted to improve the interference situation at the location of the mobile terminal.
8. The method as claimed in claim 7, wherein, in the case where the mobile terminal wishes to establish a communication link with a second mobile terminal, a direct link between the mobile terminal and the second mobile terminal is initialized by the base station it as a result, the interference situation is improved at the location of the mobile terminal.
9. The method as claimed in claim 8, wherein a direct link between the mobile terminal and the second mobile terminal is established if the strongest radio source identified in the sequence of samples is the second mobile terminal, taking into account the interference situation in the radio cell overall.
10. The method as claimed in claim 7, wherein all mobile terminals in the mobile radio cell repetitively send out received raw data signals to the base station and wherein, on the basis of these signals, the distribution of the radio resources in the mobile radio cell is checked by the base station.
11. The method as claimed in claim 8, wherein all mobile terminals in the mobile radio cell repetitively send out received raw data signals to the base station and wherein, on the basis of these signals, the distribution of the radio resources in the mobile radio cell is checked by the base station.
12. The method as claimed in claim 9, wherein all mobile terminals in the mobile radio cell repetitively send out received raw data signals to the base station and wherein, on the basis of these signals, the distribution of the radio resources in the mobile radio cell is checked by the base station.
13. A system for administering radio resources in a mobile radio cell which includes a plurality of mobile terminals which can be distinguished by their radio signals, and a base station, the system comprising:
means for requesting a mobile terminal to send out a signal currently present at a receiver of the mobile terminal, the signal being representative of an interference situation at the location of the mobile terminal, together with information for estimating the channel between the mobile terminal and the base station so that the base station receives raw data at the location of the mobile terminal;
means for evaluating the signal received from the mobile terminal and the information for estimating the channel between the mobile terminal and the base station for determining the radio sources forming the basis of the signal and the intensities of at least some of the radio sources; and
means for adapting, in the base station in the mobile radio cell, the distribution of the radio resources for improving the interference situation at the location of the mobile terminal.
14. The system as claimed in claim 13, further comprising:
means for initializing a direct link between the mobile terminal and a second mobile terminal by the base station, if, as a result, the interference situation is improved at the location of the mobile terminal in the case where the mobile terminal wishes to establish a communication link with the second mobile terminal.
15. The system as claimed in claim 14, further comprising:
means for establishing the direct link between the mobile terminal and the second mobile terminal if the strongest radio source identified in the sequence of samples is the second mobile terminal, taking into account the interference situation in the radio cell overall.
16. The system as claimed in claim 15, further comprising:
means for repetitively sending out received raw data signals to the base station from all mobile terminals in the mobile radio cell; and
means for checking the distribution of the radio resources in the mobile radio cell by the base station on the basis of these signals.
17. The system as claimed in claim 14, further comprising:
means for repetitively sending out received raw data signals to the base station from all mobile terminals in the mobile radio cell; and
means for checking the distribution of the radio resources in the mobile radio cell by the base station on the basis of these signals.
18. The system as claimed in claim 13, further comprising:
means for repetitively sending out received raw data signals to the base station from all mobile terminals in the mobile radio cell; and
means for checking the distribution of the radio resources in the mobile radio cell by the base station on the basis of these signals.
19. A method for determining allocatable radio resources for a mobile radio cell which includes a plurality of mobile terminals distinguishable by their radio signals and a base station, the method comprising:
requesting a mobile terminal to send out a signal, the signal being representative of an interference situation at the location of the mobile terminal; and
evaluating the signal received from the mobile terminal to determine the radio sources forming the basis of the signal and the intensities of at least some of the radio sources.
20. The method as claimed in claim 19, further comprising:
adapting, in the base station in the mobile radio cell, a distribution of the radio resources to improve the interference situation at the location of the mobile terminal.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. A method of producing a compound that selectively binds to a target protein, said method comprising
(a) providing a candidate compound having a molecular weight of less than 1500 daltons and comprising a first group and a second group, wherein said second group covalently bonds to an amino acid side chain of said target protein and said first group does not covalently bond to any amino acid side chain;
(b) testing said candidate compound for inhibition of the interaction of said target protein and a second protein;
(c) testing said candidate compound for binding to a non-target molecule;
(d) testing said candidate compound for bonding reactivity of said second group with said amino acid side chain of said target protein;
(e) altering said first group and selecting for increased selectivity for said target protein, wherein increased selectivity is indicated by an increase in the inhibition of the interaction of the target protein and said second protein, relative to said binding to said non-target molecule;
(f) altering said second group and selecting for decreased bonding reactivity of said second group with said amino acid side chain of said target protein and with the non-target molecule; and
(g) optionally repeating steps (e) and (f), whereby a compound is obtained that has a selectivity for the target protein, relative to the non-target molecule, that is at least 100 times greater than said candidate compound of step (a).
2. The method of claim 1, wherein said compound selectively binds to said target protein at an amino acid side chain that is not part of an enzyme active site, and wherein said compound binds to said target protein at a site of protein-protein interaction.
3. The method of claim 1, wherein said candidate compound is present in or chosen from a combinatorial chemistry library.
4. The method of claim 1, wherein said first group is a Specificity Group that non-covalently binds to said protein under physiological conditions, and said second group is a Bonding Group that forms a covalent bond with said amino acid side chain on said protein, wherein modification of said Specificity Group does not substantially alter the reactivity of said Bonding Group.
5. The method of claim 1, wherein said candidate compound of step (a) is the compound of claim 1.
6. A method of producing a compound that selectively binds to a target protein, said method comprising
(a) providing a candidate compound having a molecular weight of less than 1500 daltons and comprising a first group and a second group, wherein said second group covalently bonds to an amino acid side chain of said target protein and said first group does not covalently bond to any amino acid side chain;
(b) testing said candidate compound for inhibition of the interaction of said target protein and a second protein;
(c) testing said candidate compound for binding to a non-target molecule;
(d) testing said candidate compound for bonding reactivity of said second group with said amino acid side chain of said target protein;
(e) altering said first group and selecting for increased selectivity for said target protein, wherein increased selectivity is indicated by an increase in the inhibition of the interaction of the target protein and said second protein, relative to said binding to said non-target molecule;
(f) altering said second group and selecting for decreased bonding reactivity of said second group with said amino acid side chain of said target protein and with the non-target molecule; and
(g) optionally repeating steps (e) and (f), whereby a compound is obtained that has a selectivity for the target protein, relative to the non-target molecule, that is at least 100 times greater than said candidate compound of step (a), wherein said compound has a covalent bonding rate with the side chain of the corresponding free amino acid of less than 105Msec at room temperature under physiological conditions.
7. The method of claim 6, wherein said compound selectively binds to said target protein at an amino acid side chain that is not part of an enzyme active site, and wherein said compound binds to said target protein at a site of protein-protein interaction.