1. A blood examination apparatus for examining cancer cells mixed in an examination object which is flowing blood, comprising:
a flow cell through which the examination object is made to flow;
an imaging optical system which light output from the examination object in an examination region in the flow cell enters, the imaging optical system forming an image of the light on a first image plane;
a first Fourier transformation optical system which optically two-dimensionally Fourier-transforms the image formed on the first image plane by the imaging optical system to form the Fourier-transformed image on a second image plane;
a spatial light filter which selectively allows a portion in a certain range around an optical axis of the first Fourier transformation optical system of the image formed on the second image plane by the first Fourier transformation optical system to pass through; and
a second Fourier transformation optical system which optically two-dimensionally Fourier-transforms the portion which has passed through the spatial light filter of the image formed on the second image plane by the first Fourier transformation optical system to form the Fourier-transformed image on a third image plane;
a photodetection section which detects a light amount of the image formed on the third image plane by the second Fourier transformation optical system;
a flow channel switch section which is provided on the downstream of the examination region of the flow cell, and makes the examination object flowing through the flow cell selectively flow to either a first branched flow channel or a second branched flow channel; and
a controller which controls the flow channel switch section to make the examination object flow to the first branched flow channel when the light amount detected by the photodetection section is larger than a threshold, and controls the flow channel switch section to make the examination object flow to the second branched flow channel when the light amount detected by the photodetection section is not more than the threshold.
2. The blood examination apparatus according to claim 1, further comprising: a laser beam irradiation section which convergently irradiates a laser beam onto a position within the examination region corresponding to a bright spot position in the image formed on the third image plane by the second Fourier transformation optical system.
3. The blood examination apparatus according to claim 1, wherein the spatial light filter selectively allows a ring region with a certain distance from the optical axis in a light beam section to pass through.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An infusion pump device, comprising:
a housing which is divided into at least three operating layers positioned one above the other, wherein
a first operating layer includes an epicyclic gear means comprising a rotatable central gear, a stationary outer ring gear surrounding the central gear, and movable planet gears which are arranged between the central gear and the ring gear and in movable engagement with both the central gear and the ring gear,
a second operating layer includes a roller bearing means comprising a stationary outer ring and a movable inner roller arrangement which is in movable arrangement with the outer ring and coupled with the epicyclic gear means so as to provide a rotational bearing for the central and planet gears, and
a third operating layer includes a rotary peristaltic pump means comprising a stationary flexible, preferably resilient, tubing which includes a bent portion having an essentially part-cycle form, and a rotor which is provided with engagement elements for locally engaging the bent portion of the flexible tubing so as to squeeze it during rotation for a pump action, wherein the rotor is coupled with the central gear of the epicyclic gear means so that a torque is transferred from the central gear to the rotor.
2. The device according to claim 1, wherein the rotor is non-rotatably coupled in coaxial arrangement with the central gear of the epicyclic gear means.
3. The device according to claim 1, wherein the inner roller arrangement of the roller bearing means is non-rotatably coupled with at least the central gear of the epicyclic gear means.
4. The device according to claim 1, wherein the inner roller arrangement of the roller bearing means comprises a rotatable central roller and movable planet rollers which are arranged between the central roller and the outer ring and in movable frictional engagement with both the central roller and the outer ring.
5. The device according to claim 4, wherein the central gear of the epicyclic gear means is non-rotatably coupled in coaxial arrangement with the central roller of the roller bearing means.
6. The device according to claim 4, wherein at least one of the planet gears of the epicyclic gear means is non-rotatably coupled in coaxial arrangement with one of the planet rollers of the roller bearing means.
7. The device according to claim 4, wherein the roller bearing means comprises two planet rollers which are arranged essentially diametrically opposite to the rotary axis of the central roller.
8. The device according to claim 1, wherein the epicyclic gear means comprises two planet gears which are arranged essentially diametrically opposite to the rotary axis of the central gear.
9. The device according to claim 1, wherein the engagement elements of the rotor of the rotary peristaltic pump means are provided as engagement rollers at least one of which is non-rotatably coupled in coaxial arrangement with one of the planet gears of the epicyclic gear means.
10. The device according to claim 9, wherein the rotor of the rotary peristaltic pump means comprises a central roller which is in frictional engagement with the engagement rollers and is non-rotatably coupled in coaxial arrangement with the central gear of the epicyclic gear means.
11. The device according to claim 10, wherein the gear ratio between the planet gears and the central gear of the epicyclic gear means corresponds to the ratio between the diameter of the engagement rollers and the diameter of the central roller of the rotor of the rotary peristaltic pump means.
12. The device according to claim 9, wherein the rotor of the rotary peristaltic pump means comprises two engagement rollers which are arranged essentially diametrically opposite to the rotary axis of the rotor.
13. The device according to claim 4, wherein the central gear of the epicyclic gear means, the central roller of the roller bearing means and the central roller of the rotor of the rotary peristaltic pump means are integrally formed as one piece, andor wherein a planet gear of the epicyclic gear means, a planet roller of the roller bearing means and an engagement roller of the rotor of the rotary peristaltic pump means are integrally formed as one piece.
14. The device according to claim 1, further comprising fixing means for fixing the tubing to the housing so as to prevent radial and peripheral sliding of the tubing relative to the housing.
15. The device according to claim 1, further comprising relaxing means adapted to relax the tubing and to restore its nominal operational diameter, in particular with one engaging element positioned against it andor in case the rotary peristaltic pump means is not in an operational mode.
16. The device according to claim 1, wherein the rotary peristaltic pump means comprises an inlet and an outlet, the tubing extends from the inlet to the outlet, and at the inlet provided is a 3-way valve including an infusionsterilization passage adapted to connect an external bag to the inlet, a blocking portion adapted to close the inlet, and a filling passage adapted to connect the inlet to an external filling port coupled to an external reservoir.
17. The device according to claim 15, further comprising a controller, which includes a first pin, a second pin, a cobbler and at least a pressure sensor element, wherein the first pin is adapted to open the valve for infusion so as to connect an external bag to the inlet of the tubing by said infusionsterilization passage when the controller is arranged at a cartridge, the second pin is adapted to control the relaxing means so that the tubing cannot be relaxed when the controller is arranged at the cartridge, the cobbler is adapted to engage a motor so as to drive the central gear of the epicyclic gear means when the controller is arranged at the cartridge, and the at least one pressure sensor element is adapted to engage with at least a pressure sensor for detecting the pressure in the tubing when the controller is arranged at the cartridge.
18. The device according to claim 1, further comprising a port for connecting to an external bag, and a tag, preferably a wireless tag like an RFID tag, in particular for identification of the content of the external bag and of the therapy.
19. The device according to claim 1, further comprising a filter, preferably an air eliminating filter, as a substrate for supporting the housing.
20. The device according to claim 19, further comprising an inlet spike.
21. The device according to claim 18, further comprising an inlet adapted for a direct connection to a bag or reservoir.
22. The device according to claim 1, wherein the tubing comprises means for coupling with an air-in-line detection means.
23. The device according claim 1, further comprising a cassette for accommodation of a liquid reservoir.
24. The device according to claim 23, wherein the cassette has essentially the shape of a half cylinder.
25. The device according to claim 23, wherein the cassette comprises a wall which is adapted to mount the housing and preferably extends essentially vertically.
26. The device according to claim 1, further comprising a narthex which is adapted to provide a rotational bearing for the central gear of the epicyclic gear means.