1-42. (canceled)
43. A compound of formula (Ia):
wherein:
R1 is \u2014C(O)NH2;
(R2)C is C1-3alkylene;
R3 is a group of formula ii:
wherein:
Ring A is phenyl;
d is 0;
e is 1; and
R6 is selected from H, halo, alkyl, \u2014S(O)fR7, and \u2014S(O)2NR7R8;
R5 is H;
n is 1;
Q2 is a group of formula: \u2014(R2)aa\u2014(Y2)bb\u2014(R2)cc\u2014R4, wherein:
aa is 0;
bb is 0;
(R2)CC is C1-3alkylene; and
R4 is a group of formula (II):
wherein:
Ring A is selected from morpholine, and piperizine;
d is 0;
e is 1;
R6 is selected from H, halo, alkyl, \u2014S(O)fR7, and \u2014S(O)2NR7R8;
f is 0, 1 or 2; and
each R7 and each R8 are the same or different and are each independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl;
or a pharmaceutically acceptable salt thereof.
44. The compound according to claim 43, wherein R3 is a group of formula (ii) wherein R6 is alkyl and R4 is a group of formula (II) wherein R6 is alkyl.
45. The compound according to claim 43, wherein R3 is a group of formula (ii) wherein R6 is trifluoromethyl.
46. The compound according to claim 43, wherein R4 is a group of formula (ii) wherein Ring A is piperizine.
47. A pharmaceutical formulation comprising a compound according to claim 43 and a pharmaceutically acceptable carrier, diluent or excipient.
48. A method for treating a susceptible neoplasm in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
49. The method according to claim 48, wherein said susceptible neoplasm is selected from breast cancer, colon cancer, lung cancer, prostate cancer, lymphoma, leukemia, endometrial cancer, melanoma, ovarian cancer, pancreatic cancer, squamous carcinoma, carcinoma of the head and neck, and esophageal carcinoma.
50. A method for treating breast cancer in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
51. A method for treating colon cancer in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
52. A method for treating non-small cell lung cancer in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
53. A method for treating lymphoma in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
54. A method for treating leukemia in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
55. A method for treating melanoma in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
56. A method for treating ovarian cancer in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
57. A method for treating pancreatic cancer in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
58. A method for treating carcinoma of the head and neck in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 43.
59. A method for inhibiting proliferation of a cell, said method comprising contacting the cell with an amount of a compound according to claim 43 sufficient to inhibit proliferation of the cell.
60. A compound of formula (Ib):
wherein:
R1 is \u2014C(O)NH2;
each R9 is the same or different and is selected from H, halo and alkyl;
Ring A is phenyl;
d is 0;
e is 1;
R6 is trifluoromethyl;
R5 is H;
n is 1 and Q2 is at C-6;
Q2 is a group of formula: -(R2)aa-(Y2)bb-(R2)cc-R4, wherein:
aa is 0;
bb is 0;
cc is 1 and (R2)CC is C1-3alkylene; and
R4 is a group of formula (II):
wherein:
Ring A is selected from morpholine and piperizine;
d is 0;
e is 1; and
R6 is alkyl;
or a pharmaceutically acceptable salt thereof.
61. The compound according to claim 60, wherein R4 is a group of formula
(ii) wherein Ring A is piperizine.
62. A pharmaceutical formulation comprising a compound according to claim 60 and a pharmaceutically acceptable carrier, diluent or excipient.
63. A method for treating a susceptible neoplasm in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
64. The method according to claim 63, wherein said susceptible neoplasm is selected from breast cancer, colon cancer, lung cancer, prostate cancer, lymphoma, leukemia, endometrial cancer, melanoma, ovarian cancer, pancreatic cancer, squamous carcinoma, carcinoma of the head and neck, and esophageal carcinoma.
65. A method for treating breast cancer in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
66. A method for treating colon cancer in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
67. A method for treating non-small cell lung cancer in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
68. A method for treating lymphoma in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
69. A method for treating leukemia in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
70. A method for treating melanoma in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
71. A method for treating ovarian cancer in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
72. A method for treating pancreatic cancer in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
73. A method for treating carcinoma of the head and neck in a human, said method comprising administering to the human a therapeutically effective amount of a compound according to claim 60.
74. A method for inhibiting proliferation of a cell, said method comprising contacting the cell with an amount of a compound according to claim 60 sufficient to inhibit proliferation of the cell.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
What is claimed is:
1. A distance measuring system adapted for use on a mobile platform, comprising:
at least two platforms separable by a distance, said at least two platforms including a base platform adapted to be supported by said mobile platform and one of a plurality of target platforms;
said base platform supporting at least one camera having each of a portion of said base platform and said one target platform in a line-of-sight image;
a computer in communication with said at least one platform, said computer having at least a conversion program for converting each one of a plurality of images taken by said camera to one of a plurality of pixel images; and
wherein a base platform pixel image converted by said computer is compared to a target platform pixel image converted by said computer to calculate said distance.
2. The system of claim 1, further comprising:
said base platform including a perimeter envelope having a member extendable from said perimeter envelope; and
said member including a fixed end connected to said perimeter envelope and a distal end.
3. The system of claim 2, wherein said member further comprises two sections including an outer tubular section, and an inner tubular section slidably disposed within said outer tubular section.
4. The system of claim 3, wherein said camera is mounted to said perimeter envelope to form a camera reference point.
5. The system of claim 4, wherein said extended member is mounted to said perimeter envelope at said fixed end to form a member reference point.
6. The system of claim 5, wherein said computer further includes a data table having at least said camera reference point, said member reference point and a member length storable therein.
7. The system of claim 1, wherein each of said plurality of pixel images is identifiable as a plurality of coordinate points.
8. The system of claim 7, wherein said plurality of coordinate points of each said one of said plurality of target platforms is comparable to one of a plurality of wire frame models.
9. The system of claim 8, wherein each said wire frame model matches one of a plurality of receiving aircraft.
10. An aircraft refueling boom distance measuring system comprising:
at least one refueling boom adapted to be supported from a refueling aircraft, at least one camera and a computer installed thereon;
each said refueling boom having a boom nozzle;
said boom nozzle being connectable with a receiving aircraft refueling receptacle;
each said camera forming a plurality of images of both said boom nozzle and said refueling receptacle; and
said computer receiving each said image for analysis to extrapolate therefrom a distance between said boom nozzle and said refueling receptacle.
11. The system of claim 10, further comprising:
said refueling boom having an attachment end for attachment of said refueling boom to said refueling aircraft; and
said attachment end forming a fixed reference point between said attachment end and said refueling aircraft.
12. The system of claim 11, wherein said boom nozzle and said fixed reference point are separated by a predetermined distance.
13. The system of claim 12, wherein said at least one camera is fixedly mounted to said refueling aircraft forming a camera reference point.
14. The system of claim 13, wherein said receiving aircraft refueling receptacle further comprises a coordinate set.
15. The system of claim 14, wherein said fixed reference point, said camera reference point, said predetermined distance and said coordinate set each form a plurality of coordinates retrievable by said computer to analyze said distance between said boom nozzle and said refueling receptacle.
16. The system of claim 15, further comprising:
said computer further including a data table and a conversion program to convert each of said plurality of images to one of a plurality of pixel images;
said data table storing a plurality of refueling receptacle geometries; and
each of said geometries forming one of a plurality of reference refueling receptacles for comparison by said computer to each of said plurality of pixel images usable by said computer to analyze said distance between said boom nozzle and said refueling receptacle.
17. The system of claim 16, wherein each of said geometries is selectable by an operator of said computer.
18. A method to measure a distance between an aircraft refueling boom and a receiving aircraft comprising the steps of:
installing a refueling boom having a boom nozzle, at least one camera and a computer on a refueling aircraft;
steering said boom nozzle towards a connection with a refueling receptacle of one of a plurality of receiving aircraft;
creating a plurality of images of both said boom nozzle and said refueling receptacle with said camera; and
using said computer to calculate a distance between said boom nozzle and said refueling receptacle using said images.
19. The method of claim 18, further comprising the step of using said computer to convert each of said images to one of a plurality of pixel images of both said boom nozzle and said refueling receptacle.
20. The method of claim 19, further comprising the steps of:
fixing a connection location for each of said refueling boom and each digital camera on said refueling aircraft; and
inputting said refueling boom connection location and each said digital camera connection location as a set of reference points in said computer.
21. The method of claim 20, further comprising the steps of:
measuring an extended boom length;
loading a data table in said computer having said boom length stored therein; and
storing a plurality of refueling receptacle geometries for each of said plurality of receiving aircraft in said data table.
22. The method of claim 21, further comprising the step of selecting one of said receiving aircraft refueling receptacle geometries as a reference receptacle from said data table.
23. The method of claim 22, further comprising the steps of:
assigning a plurality of pixel coordinates to each of said pixel images; and
identifying a number of pixels in each pixel image.
24. The method of claim 23, further comprising the step of analyzing said distance between said boom nozzle and said refueling receptacle from said pixel coordinates, said number of pixels in each image, said reference points and said reference receptacle.
25. The method of claim 24, further comprising the step of displaying said distance between said boom nozzle and said refueling receptacle on a display screen.
26. The method of claim 25, further comprising the steps of:
storing each of said plurality of receiving aircraft as one of a plurality of three dimensional wire-models in said database;
loading a plurality of both aspects and ranges of each of said plurality of wire-models in said database;
identifying a location of said receiving aircraft from said pixel images and said plurality of both aspects and possible ranges; and
updating each of said plurality of both aspects and possible ranges in a tracking mode.