1. A method of preparing a hair care composition comprising steps of measuring solid Shea butter into a pan; melting the solid Shea butter to a liquid; adding Jojoba and Extra Virgin Olive oils to the melted Shea butter; mixing these oils by hand mixer; adding Clary Sage and Rosemary essential oils into the mixture and mixing; adding Peppermint and Lavender oils into the mixture and mixing; adding Tee Tree essential oil and mixing; adding Vanilla fragrance oil to the mixture and mixing; placing the mixture in a freezer for about 7-10 minutes; removing the mixture from the freezer and mixing again; and repeating the last steps for three more times.
2. The method of preparing a hair care product of claim 1, wherein the amount of the Shea butter is about 8 ounces; the amount of the Jojoba oil is about 4 ounces; the amount of Extra Virgin Olive oil is about 6 ounces; the amount of Clary Sage essential oil is about 0.25 ounces; the amount of Rosemary essential oil is about 0.25 ounces; the amount of Peppermint essential oil is about 0.5 ounces; the amount of Lavender essential oil is about 0.5 ounces; the amount of Tea Tree essential oil is about 0.5 ounces; and the amount of Vanilla fragrance oil is about 1 ounce.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:
wherein:
A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2-fluoroalkyl, halogen, NR6R7, Het, or phenyl;
wherein said phenyl is optionally substituted by one, two or three substituents independently being fluorine, chlorine, C1-3alkyl, OH, methoxy or deuterium;
wherein Het is:
i) a 6-membered heteroaromatic monocyclic ring containing one, two or three ring-nitrogen atoms, or
ii) a 5-membered heteroaromatic monocyclic ring containing one, two or three ring heteroatoms independently being N, O or S, wherein no more than one of the 5-membered ring heteroatoms is O or S; or
iii) a 9 or 10-membered heteroaromatic bicyclic ring containing one, two or three ring nitrogen atoms;
and wherein Het is optionally substituted with one or two substituents independently being C1-3 alkyl, fluorine, chlorine, OH, methoxy or deuterium;
and wherein:
R1 is hydrogen, chlorine, fluorine, bromine, C1fluoroalkyl, cyano or C1-3alkyl;
R2 is hydrogen, fluorine, chlorine, bromine, C1fluoroalkyl, cyano or C1-3alkyl,
R3 is hydrogen, fluorine, chlorine or C1-3alkyl,
R4 is hydrogen;
R5 is hydrogen, fluorine, chlorine or methyl; and
R6 and R7 independently are hydrogen or C1-3alkyl;
or R6 and R7 are taken together and are \u2014(CH2)2\u2014O\u2014(CH2)2\u2014, \u2014(CH2)2\u2014O\u2014(CH2)3\u2014, or \u2014(CH2)n1\u2014 wherein n1 is 3, 4, 5 or 6;
wherein, when A is hydrogen, C1-4 alkyl, C3-6 cycloalkyl, C1-3 alkoxy, C1-3 alkoxy C1-4alkyl, C1-2-fluoroalkyl, halogen or NR6R7, then R1 is chlorine, fluorine, bromine, C1fluoroalkyl, cyano or C1-3alkyl, and at least one of R2 and R3 is other than hydrogen;
and when A is Het or optionally substituted phenyl, then R1 is hydrogen, chlorine, fluorine, bromine, C1fluoroalkyl, cyano or C1-3alkyl, and at least one of R1, R2 and R3 is other than hydrogen;
and wherein, when R5 is fluorine, chlorine or methyl, then R1 is chlorine, fluorine, C1fluoroalkyl or methyl and R2 is hydrogen.
2. The compound or salt as claimed in claim 1 wherein:
A is hydrogen, C1-4alkyl, C1-3alkoxy, C1-2-fluoroalkyl, halogen, NR6R7, Het, or phenyl wherein said phenyl is optionally substituted by one, two or three substituents independently being fluorine, chlorine, C1-3alkyl or methoxy;
wherein Het is:
i) a 6-membered heteroaromatic monocyclic ring containing one, two or three ring-nitrogen atoms, or
ii) a 5-membered heteroaromatic monocyclic ring containing one, two or three ring heteroatoms independently being N, O or S, wherein no more than one of the 5-membered ring heteroatoms is O or S;
and wherein Het is optionally substituted with one or two substituents independently being C1-3 alkyl, fluorine, chlorine, OH, or methoxy;
and wherein:
R1 is hydrogen, chlorine, fluorine, bromine, C1fluoroalkyl, cyano or C1-3alkyl;
R2 is hydrogen, fluorine, chlorine, bromine, C1fluoroalkyl, cyano or C1-3alkyl;
R3 is hydrogen, fluorine or chlorine;
R4 is hydrogen;
R5 is hydrogen, fluorine, chlorine or methyl; and
R6 and R7 independently are hydrogen or C1-3alkyl;
or R6 and R7 are taken together and are \u2014(CH2)2\u2014O\u2014(CH2)2\u2014, \u2014(CH2)2\u2014O\u2014(CH2)3\u2014, or \u2014(CH2)n1\u2014 wherein n1 is 3, 4, 5 or 6;
wherein, when A is hydrogen, C1-4alkyl, C1-3 alkoxy, C1-2-fluoroalkyl, halogen or NR6R7, then R1 is chlorine, fluorine, bromine, C1fluoroalkyl, cyano or C1-3alkyl, and at least one of R2 and R3 is other than hydrogen;
and when A is Het or optionally substituted phenyl, then R1 is hydrogen, chlorine, fluorine, bromine, C1fluoroalkyl, cyano or C1-3alkyl, and at least one of R1, R2 and R3 is other than hydrogen;
and wherein, when R5 is fluorine, chlorine or methyl, then R1 is chlorine, fluorine, C1-fluoroalkyl or methyl and R2 is hydrogen.
3. The compound or salt as claimed in claim 1, wherein A is Het.
4. The compound or salt as claimed in claim 1, wherein Het is:
i) a 6-membered heteroaromatic monocyclic ring containing one or two ring-nitrogen atoms, or
ii) a 5-membered heteroaromatic monocyclic ring containing one, two or three ring heteroatoms independently being N, O or S, wherein no more than one of the 5-membered ring heteroatoms is O or S;
and wherein Het is optionally substituted with one or two substituents independently being methyl or fluorine.
5. (canceled)
6. The compound or salt as claimed in claim 1, wherein:
when Het is an optionally substituted 6-membered heteroaromatic monocyclic ring containing one, two or three ring-nitrogen atoms, then Het is of sub-formula (a):
wherein none, one or two of X8, X9, X10, and X11 are a nitrogen atom, and the remainder of X8, X9, X10, and X11 are C\u2014R8, C\u2014R9, C\u2014R10, and C\u2014R11 respectively in which R8, R9, R10, and R11 are independently hydrogen, deuterium, C1-3 alkyl, fluorine, chlorine, OH or methoxy;
and when Het is an optionally substituted 5-membered heteroaromatic monocyclic ring containing one, two or three ring heteroatoms independently being N, O or S, wherein no more than one of the 5-membered ring heteroatoms is O or S; then Het is of sub-formula (b1), (b2), (b3), (b4) or (b5):
wherein:
X1 is O, S or NR12;
X2, X3, X4, and X5 independently are N or CR13, provided that there are only one, two or three ring heteroatoms present in the 5-membered heteroaromatic monocyclic ring of Het; and
X6 is O or S; and wherein
R12 is hydrogen or C1-3 alkyl; and
each R13 independently is hydrogen, C1-3 alkyl, fluorine, chlorine, OH or methoxy;
provided that R12 and each R13 are such that the 5-membered heteroaromatic monocyclic ring Het is optionally substituted with one or two substituents.
7. The compound or salt as claimed in claim 1, wherein:
A is 4-fluorophenyl, or A is Het,
wherein Het is a 6-membered heteroaromatic monocyclic ring of sub-formula (a1) to (a25):
or Het is a 5-membered heteroaromatic monocyclic ring which is
8. The compound or salt as claimed in claim 1, wherein R1 is chlorine, fluorine or methyl.
9. The compound or salt as claimed in claim 1, wherein R1 is chlorine.
10. The compound or salt as claimed in claim 1, wherein R2 is hydrogen, fluorine, chlorine, \u2014CF3 or methyl.
11. The compound or salt as claimed in claim 1, wherein R5 is hydrogen.
12. The compound or salt as claimed in claim 1, wherein:
R1 is chlorine, fluorine or methyl;
R2 is hydrogen, fluorine, chlorine, \u2014CF3 or methyl;
R3 is hydrogen, fluorine or chlorine; and
R5 is hydrogen, fluorine or chlorine;
wherein at least one of R2 and R3 is other than hydrogen; and
wherein, when R5 is fluorine or chlorine, then R2 is hydrogen and R3 is fluorine or chlorine.
13. The compound or salt as claimed in claim 1, wherein:
R1 is chlorine;
R2 is hydrogen, fluorine, chlorine, \u2014CF3 or methyl;
R3 is hydrogen, fluorine or chlorine; and
R5 is hydrogen;
wherein at least one of R2 and R3 is other than hydrogen.
14. The compound or salt as claimed in claim 1, wherein:
R1 is chlorine;
R2 is hydrogen, fluorine, chlorine or \u2014CF3;
R3 is hydrogen, fluorine or chlorine; and
R5 is hydrogen;
wherein at least one of R2 and R3 is other than hydrogen,
and wherein, when R3 is chlorine then R2 is hydrogen or fluorine.
15. The compound or salt as claimed in claim 1, wherein:
R1 is chlorine, R2 is \u2014CF3, and R3, R4 and R5 are hydrogen; or
R1 is chlorine, R2 is chlorine, and R3, R4 and R5 are hydrogen; or
R1 is chlorine, R2, R4 and R5 are hydrogen, and R3 is chlorine; or
R1 is chlorine, R2, R4 and R5 are hydrogen, and R3 is fluorine.
16. A compound which is:
3-bromo-7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(trifluoromethyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-ethyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-ethyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
3-bromo-7-(2,3-dichlorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
3-bromo-7-(2,4-dichlorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
3-bromo-7-(2,4,6-trichlorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
3-bromo-7-{2-fluoro-3-(trifluoromethyl)phenylcarbonyl}-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(4-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(4-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-phenyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(4-fluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-methyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(3-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(methyloxy)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(4-morpholinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1-pyrrolidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-N,N-dimethyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-amine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-N-methyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-amine,
3-(1-azetidinyl)-7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1-piperidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2,4-difluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1, 1-dimethylethyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(6-methyl-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1-methyl-1H-pyrazol-3-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(3-methyl-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1-methyl-1H-pyrrol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-phenyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(3-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(3-methyl-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(4-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(5-methyl-3-isoxazolyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1H-pyrrol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(3-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(6-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(3-pyridazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(2-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(1-methyl-1H-pyrrol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(5-methyl-3-isoxazolyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(5-methyl-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(3-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(6-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(6-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(4-methyl-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(3-pyridazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(2-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(3-pyridazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(5-methyl-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(3-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(4-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(1-methyl-1H-pyrazol-3-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(1H-pyrrol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-methyl-3-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(3-methyl-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1-methyl-1H-pyrazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(6-methyl-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-phenyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(5-methyl-3-isoxazolyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(1-methyl-1H-pyrazol-3-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(2-methyl-3-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(2-methyl-3-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chlorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichlorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
3-bromo-7-(2-chloro-4-fluorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-furanyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-(methyloxy)phenylcarbonyl}-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-difluorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-6-fluorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(3-chlorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(1-methyl-1H-pyrazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(1-methyl-1H-pyrrol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(3,5-difluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(3,5-difluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
3-(2-pyridinyl)-7-{3-(trifluoromethyl)phenylcarbonyl}-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
2-{3-(2-pyridinyl)-5,6-dihydro1,2,4triazolo4,3-apyrazin-7(8H)-ylcarbonyl}benzonitrile,
7-(2,3-difluorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,6-dichlorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chloro-4-fluorophenyl)carbonyl-3-(1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{2-fluoro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichlorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichlorophenyl)carbonyl-3-(3-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{4-fluoro-2-(trifluoromethyl)phenylcarbonyl}-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichlorophenyl)carbonyl-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(4-chloro-2-fluorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichlorophenyl)carbonyl-3-(1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(2,4-difluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichlorophenyl)carbonyl-3-(4-fluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichlorophenyl)carbonyl-3-(4-fluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichlorophenyl)carbonyl-3-(2,4-difluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichlorophenyl)carbonyl-3-(4-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2-chlorophenyl)carbonyl-3-(1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{4-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(3-chloro-4-fluorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(4-chloro-2-fluorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(4-fluoro-2-methylphenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-{4-fluoro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
3-bromo-7-(2-chloro-4-fluorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(4-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichloro-4-fluorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine,
7-(2,3-dichloro-4-fluorophenyl)carbonyl-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chlorophenyl)carbonyl-3-(4-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chlorophenyl)carbonyl-3-(2-furanyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chlorophenyl)carbonyl-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chlorophenyl)carbonyl-3-(4-fluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chlorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chlorophenyl)carbonyl-3-(3-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
3-(2-pyridinyl)-7-{2-(trifluoromethyl)phenylcarbonyl}-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(3-fluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(3,4-difluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-3-(methyloxy)phenyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(3-chlorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-2-(methyloxy)phenyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
2-{7-(2-chloro-4-fluorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-yl}phenol;
8-{7-(2-chloro-4-fluorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-yl}quinoline;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(2,3-dichlorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine; 7-(2-chloro-4-fluorophenyl)carbonyl-3-(2,3-difluorophenyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(1H-indol-7-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-cyclopropyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-propyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-cyclohexyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(2-methyl-1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-2-(methyloxy)ethyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
2-(7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-yl)phenol;
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-cyclopentyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(1-methyl-1H-imidazol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(5-chloro-2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-{4-chloro-2-(trifluoromethyl)phenylcarbonyl}-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dimethylphenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(4-chloro-2-methylphenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(3-chloro-4-fluoro-2-methylphenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-bromo-4-fluorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-{4-methyl-2-(trifluoromethyl)phenylcarbonyl}-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
2-{7-(2,4-dichloro-3-fluorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-yl}-5-fluorophenol;
7-(3,4-difluoro-2-methylphenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,3-dichloro-4-methylphenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluoro-3-methylphenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-methylphenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(3,4-difluoro-2-methylphenyl)carbonyl-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(3-chloro-4-fluoro-2-methylphenyl)carbonyl-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichlorophenyl)carbonyl-3-(5-isoxazolyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichlorophenyl)carbonyl-3-(5-isothiazolyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(5-methyl-2-furanyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichlorophenyl)carbonyl-3-(1,2,5-thiadiazol-3-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichlorophenyl)carbonyl-3-(3-isoxazolyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
3-(7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-yl)-2-pyridinol;
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2-chloro-4-fluorophenyl)carbonyl-3-(5-fluoro-2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
2-(7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-yl)-3-pyridinol;
7-(2,3-dichloro-4-fluorophenyl)carbonyl-3-(5-methyl-2-furanyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,3-dichloro-4-fluorophenyl)carbonyl-3-(3-pyridazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,3-dichloro-4-fluorophenyl)carbonyl-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(3-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
3-{7-(2,4-dichloro-3-fluorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-yl}-2-pyridinol;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(4-methyl-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-4-(methyloxy)-2-pyridinyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
2-{7-(2,4-dichloro-3-fluorophenyl)carbonyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazin-3-yl}-3-pyridinol;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-6-(methyloxy)-2-pyridinyl-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(4-methyl-2-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(5-isothiazolyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(4-methyl-1,2,3-thiadiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine-d1;
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine-d1;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine-d1;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine-d1;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(1H-pyrazol-1-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(1,3-thiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(5-methyl-1,3-thiazol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(1,2,3-thiadiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(1,2,5-thiadiazol-3-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(4-methyl-1,3-thiazol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,3-dichlorophenyl)carbonyl-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(3-chloro-4-fluoro-2-methylphenyl)carbonyl-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(3-chloro-2-methylphenyl)carbonyl-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(5-methyl-1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichlorophenyl)carbonyl-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(3-chloro-2-methylphenyl)carbonyl-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(3-chloro-4-fluoro-2-methylphenyl)carbonyl-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(3,4-difluoro-2-methylphenyl)carbonyl-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
7-(2,4-dichloro-3-fluorophenyl)carbonyl-3-(4-methyl-3-isothiazolyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
2-chloro-6-{3-(2-pyridinyl)-5,6-dihydro1,2,4triazolo4,3-apyrazin-7(8H)-ylcarbonyl}benzonitrile;
7-(2,4-dichlorophenyl)carbonyl-3-(1,2,4-thiadiazol-5-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine; or
7-(3-chloro-2-methylphenyl)carbonyl-3-(5-methyl-1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine;
or a pharmaceutically acceptable salt thereof.
17. A compound which is:
7-(2-chloro-4-fluorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(5-fluoro-2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-(2,4-dichlorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(4-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-(2,4-dichlorophenyl)carbonyl-3-(1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(2-furanyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-(2,3-dichlorophenyl)carbonyl-3-(1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-(2,3-dichlorophenyl)carbonyl-3-(2-pyridinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-{2-chloro-3-(trifluoromethyl)phenylcarbonyl}-3-(1,3-thiazol-4-yl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-(2,3-dichlorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-(3,4-dichlorophenyl)carbonyl-3-(2-pyrazinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
7-(2,4-Dichloro-3-fluorophenyl)carbonyl-3-(4-pyrimidinyl)-5,6,7,8-tetrahydro1,2,4triazolo4,3-apyrazine, of the structure:
or a pharmaceutically acceptable salt of any of these compounds.
18. A pharmaceutical composition which comprises the compound or salt as defined claim 1, and a pharmaceutically acceptable carrier or excipient.
19. The pharmaceutical composition according to claim 18, which further comprises an additional therapeutic agent.
20. (canceled)
21. A method of treatment of pain, inflammation, a neurodegenerative disease, epilepsy or seizures, which method comprises administering to a human in need thereof an effective amount of the compound or salt as defined in of claim 1.
22-24. (canceled)
25. A method of treatment of degenerative dementia, Alzheimer’s disease, Parkinson’s disease, dementia in Parkinson’s disease, vascular dementia, multi-infarct dementia, dementia with Lewy bodies, Huntingdon’s chorea, mild cognitive impairment, or mild cognitive impairment associated with ageing, which method comprises administering to a human in need thereof an effective amount of the compound or salt as defined in claim 1.