1. A device for supporting an installed toilet bowl, said device comprising:
a non-porcelain-adhering thin film;
a means for supporting the toilet bowl, wherein said means for supporting is carried substantially beneath the toilet bowl, and wherein said means for supporting comprises a foldable leg, and wherein said means for supporting further comprises a support bar, and wherein said leg is connected to said support bar via an attachment means, and wherein folding of said leg permits removal of said support bar from contact with the toilet bowl, and wherein said means for supporting further comprises a resilient bumper, and wherein said non-porcelain-adhering thin film has a surface that adheres to said resilient bumper and a second surface that is non-adherent to porcelain, said film being disposed between said resilient bumper and the toilet bowl.
2. The device of claim 1, wherein said attachment means comprises a hinge.
3. The device of claim 1, wherein said resilient bumper is carried by said support bar.
4. The device of claim 3, wherein said resilient bumper contacts a bottom portion of the toilet bowl.
5. The device of claim 1, wherein said leg comprises height adjustment.
6. The device of claim 5, further comprising a foot, wherein said leg comprises a single leg that is foldable, and wherein said leg comprises a threaded receptacle and said foot comprises a threaded rod, and wherein said threaded receptacle receives said threaded rod therewithin.
7. The device of claim 6, wherein said threaded rod and said threaded receptacle are adapted to provide adjustable compression of said resilient bumper against a bottom portion of the toilet bowl.
8. The device of claim 1, wherein said support bar comprises a generally-elongated \u2018S\u2019 shape.
9. A toilet bowl support comprising:
a means for supporting a toilet bowl when the toilet bowl is an installed position, wherein said means for supporting is carried substantially beneath the toilet bowl, and wherein said means for supporting further comprises a resilient bumper, and wherein said means for supporting comprises a generally-elongated \u2018S\u2019 shape, wherein said means for supporting comprises a support bar, and wherein said resilient bumper is carried by said support bar, and wherein said resilient bumper comprises a thin film of non-porcelain-adhering material having a first surface that adheres to said resilient bumper and a second surface that is non-adherent to porcelain, said film being disposed between said resilient bumper and the toilet bowl.
10. The toilet bowl support of claim 9, further comprising a single foldable leg in contact with a floor surface beneath the toilet bowl, wherein said leg comprises height adjustment.
11. The toilet bowl support of claim 10, wherein said height adjustment comprises screw adjustment.
12. The toilet bowl support of claim 10, wherein said leg comprises a threaded receptacle.
13. The toilet bowl support of claim 12, further comprising a foot having a threaded rod, wherein said threaded rod cooperatively engages said threaded receptacle.
14. A toilet bowl support for an installed toilet, said support comprising:
an \u2018S\u2019-shaped means for supporting a bowl portion of the toilet, wherein said means for supporting is carried substantially beneath the toilet bowl; a single foldable leg, wherein said single foldable leg comprises an adjustable base, and wherein said base enables height adjustment of said single foldable leg, further comprising a resilient bumper, wherein said resilient bumper compressively engages a bottom portion of the toilet bowl, further comprising a thin film of non-porcelain-adhering material, having a first surface that adheres to said resilient bumper and a second surface that is non-adherent to porcelain, said film being disposed between said resilient bumper and the toilet bowl.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I)
wherein
n represents 0, 1, 2, 3, 4 or 5,
R represents independent from each other hydroxyl, cyano, nitro, halogen, alkyl, alkoxy alkylcarbonyl, alkoxycarbonyl, alkylamine, dialkylamine, alkylcarbonylamine, alkylcarbamate
Y represents one of the following groups:
in free base or acid addition salt form.
2. The compound of formula (I) according to claim 1 wherein n represents zero.
3. The compound according to claim 1, wherein the compound is (4SR,5RS)-(1-Aza-bicyclo3.3.1non-4-yl)-5-(1H-indo-5-yl)-pyridin-2-yl-amine.
4. The compound according to claim 1, wherein the compound is (4SR,5RS)-(1-Aza-bicyclo3.3.1non-4-yl)-5-(1H-indo-5-yl)-pyrimidin-2-yl-amine.
5. The compound according to claim 1, wherein the compound is (4SR,5RS)-(1-Aza-bicyclo3.3.1non-4-yl)-6-(1H-indol-5-yl)-pyridin-3-ylamine.
6. The compound according to claim 1, wherein the compound is (4SR,5RS)-(1-Aza-bicyclo3.3.1non-4-yl)-5-(1H-indol-4-yl)-pyridin-2-yl-amine.
7. The compound according to claim 1, wherein the compound is (4SR,5RS)-(1-Aza-bicyclo3.3.1non-4-yl)-5-(1H-indol-4-yl)-pyrimidin-2-yl-amine.
8. The compound according to claim 1, wherein the compound is (4SR,5RS)-(1-Aza-bicyclo3.3.1non-4-yl)-6-(1H-indol-5-yl)-pyridazin-yl-amine.
9. The compound according to claim 1, wherein the compound is (4SR,5RS)-(1-aza-bicyclo3.3.1non-4-yl)-S(1H-indol-6-yl)-pyridin-2-yl-amine.
10. A process for the preparation of a compound of formula (I) according to claim 1, or a salt thereof, comprising the step of
i) reacting a compound of formula (VIII)
R\u2014Y-Z\u2003\u2003(VIII)
wherein R represents
Y represents one of the following moieties
and Z represents a leaving group, such as Cl, Br, I or Toslylate with a compound of formula (IX)
XB(OR)2\u2003\u2003(IX)
wherein X represents an indolyl-moiety suitably substituted by Rn and R represents H or C1-C4 alkyl or both groups RO together with the Boron atom to which they are attached form a heterocyclic ring;
ii) recovering the so obtained compound of formula (I) in free base or acid addition salt form
iii) optionally separating the stereoisomers by known methods.
11. A process for the preparation of a compound of formula (I) according to claim 1, or a salt thereof, comprising the step of
i) reacting a compound of formula (X)
with a compound of formula (XI)
wherein R and n are as defined in claim 1, and
ii) recovering the so obtained compound of formula (I) in free base or acid addition salt form
iii) optionally separating the stereoisomers by known methods.
12-13. (canceled)
14. A pharmaceutical composition, comprising:
the compound of claim 1 in free base or pharmaceutically acceptable acid addition salt form, in association with a pharmaceutical carrier or diluent.
15-16. (canceled)
17. A method for the treatment of psychotic and neurodegenerative disorders, in a subject in need of such treatment, comprising:
administering to such subject a therapeutically effective amount of the compound of claim 1 in free base or pharmaceutically acceptable acid addition salt form.
18-19. (canceled)
20. A method for treatment of a disease or condition in which nAChR \u03b17 activation plays a role or is implicated, in a subject in need of such treatment, comprising:
administering to such subject a therapeutically effective amount of the compound of claim 1 in free base or pharmaceutically acceptable acid addition salt form.