1-15. (canceled)
16. A method for treating a p38 mediated disorder comprising. administering to a patient in need of such treatment, an effective amount of a compound of Formula I
or a pharmaceutically acceptable salt thereof,
wherein:
Z is CH,
X1 is O, NR4 (where R4 is hydrogen or alkyl), S or C\u2550O;
R1 is alkyl, cycloalkyl, cycloalkylalkyl or \u2014CH2-alkenyl;
R2 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, alkylene-C(O)\u2014R21 (where R21 is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino), amino, monoalkylamino, dialkylamino, acyl, or NR22\u2014Y\u2014R23 (where Y is \u2014C(O), \u2014C(O)O\u2014, \u2014C(O)NR24 , S(O)2 or S(O)2NR25; R22, R24 and R25 are independently hydrogen or alkyl; and R23 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl or optionally-substituted phenyl); and
R3 is alkyl, haloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkyl, cyanoalkyl, heterocyclyl, heterocyclylalkyl, or -heterocycloamino-SO2\u2014R12 (where R12 is haloalkyl, aryl, aryalkyl, heteroaryl or heteroaralkyl).
17. The method of claim 16, wherein said p38 mediated disorder is rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohns disease, irritable bowel syndrome, inflammatory bowel disease, psoriasis, adult respiratory distress syndrome, asthma, or chronic obstructive pulmonary disease.
18. The method of claim 16, wherein said p38 mediated disorder is Alzheimer’s disease.
19. The method of claim 16, wherein X1 is \u2014O\u2014.
20. The method of claim 19, wherein R1 is alkyl or cycloalkyl.
21. The method of claim 20, wherein R3 is cycloalkyl, cycloalkylalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkyl, heterocyclyl or heterocyclylalkyl.
22. The method of claim 20, wherein R3 is cycloalkyl, heteroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl, heteroalkyl or heterocyclyl.
23. The method of claim 20, wherein R3is optionally-substituted heterocyclyl.
24. The method of claim 20, wherein R3 is hydroxyalkyl or alkoxyalkyl.
25. The method of claim 16, wherein R2 is hydrogen, alkyl, aryl, cycloalkyl or heteroalkyl.
26. The method of claim 16, wherein R2 is alkyl or hydroxyalkyl.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A fitting for a vehicle seat, comprising:
a first fitting part and a second fitting part which are in geared connection via a toothed wheel and a toothed ring, which mesh with each other,
a circumferential eccentric, driven by a driver, for driving a relative rolling movement of the toothed wheel and the toothed ring, wherein the first fitting part receives the eccentric which is supported on the second fitting part, wherein two wedge segments upon which a spring acts, define the eccentric,
a retaining element which retains the eccentric in the non-driven state of the fitting by cooperating with at least one retaining lug of the retaining element via a toothing which is configured on the first fitting part, and which releases the eccentric, when it is driven by the driver, wherein the retaining element has at least one opening which is penetrated by the spring,
wherein the spring penetrates the retaining element at exactly one opening,
wherein the retaining element has an annular basic body and the exactly one opening is provided through a surface of the annular basic body.
2. The fitting according to claim 1, wherein the difference between the dimension of the exactly one opening in the circumferential direction and the dimension of the spring in the circumferential direction within the exactly one opening amounts to a maximum of 3 mm.
3. The fitting according to claim 1, wherein the opening is configured to be oblong-hole shaped, extending in the radial direction in the retaining element.
4. The fitting according to claim 3, wherein the retaining element has at least one spring arm which is supported on the spring and causes engagement of, on the one hand, the latter with one end of the oblong-hole-shaped opening and, on the other hand, the at least one retaining lug with the toothing.
5. The fitting according to claim 1, wherein the annular basic body has a tab which is provided with at least one of the opening and at least one guide section for bearing on the first fitting part.
6. The fitting according to claim 1, wherein the driver has at least one control cam which, when the driver is driven, cooperates with one support finger of the retaining element and releases the retaining element from the toothing.
7. The fitting according to claim 6, wherein when the driver is driven, the support finger moves in the radial direction and releases the at least one retaining lug, which protrudes radially in the opposed direction, from the toothing.
8. The fitting according to claim 1, wherein the toothed ring is configured on the first fitting part having the toothing, and the toothed wheel is configured on the second fitting part, wherein the toothing is configured on the side of the first fitting part which is faced away from the toothed ring.
9. The fitting according to claim 8, wherein the first fitting part receives the eccentric via a slide bearing bush which is concentric to the toothed ring, such slide bearing bush protruding axially with a projection over the receptacle of the first fitting part which is coated by it, wherein the retaining element is supported via at least one of a basic body and at least one guide section and at least one spring arm on the projection of the slide bearing bush.
10. The fitting according to claim 1, wherein an enclosing ring axially holds together the first fitting part and the second fitting part, forming a disc-shaped unit.
11. A vehicle seat, having at least one fitting according to claim 1, a seat part which is connected with one of the two fitting parts, and a backrest which is connected with the other one of the two fitting parts.
12. The fitting according to claim 1, wherein the difference between the dimension of the exactly one opening in the circumferential direction and the dimension of the spring in the circumferential direction within the exactly one opening amounts to a maximum of 0.5 mm.
13. The fitting according to claim 1, wherein the difference between the dimension of the exactly one opening in the circumferential direction and the dimension of the spring in the circumferential direction within the exactly one opening amounts to a maximum of 0.2 mm.
14. The fitting according to claim 5, wherein the annular basic body is composed of spring steel.
15. The fitting according to claim 7, wherein the support finger is provided with a bevel.