1. A method of obtaining a plurality of pulse echo sample sets at a plurality of ultrasonic transducer array elements, each pulse echo sample set being representative of an echo characteristic for use in ultrasound imaging using propagation delay compensation signal processing; the steps comprising:
(i) performing data collection iterations by transmitting an ultrasonic pulse, and at each iteration:
(a) receiving a pulse echo at a plurality of array elements, and
(b) at each of the plurality of array elements, obtaining a pulse echo sample subset at a respective time offset, wherein the time offset is varied between successive iterations; and
(ii) for each of the plurality of array elements, aggregating the pulse echo sample subsets of varied offsets into a single synthesized composite pulse echo sample set that is representative of an echo signal.
2. The method of claim 1 wherein the pulse echo sample subset is a single sample.
3. The method of claim 1 wherein the pulse echo sample subset is a single complex sample.
4. The method of claim 1 wherein the pulse echo sample subset contains a number of samples less than or equal to one half the number of samples in the pulse echo sample set.
5. The method of claim 1 wherein each pulse echo sample set is an integer N samples long, and the number of data collection iterations is j, and wherein the number of samples in each pulse echo sample subset is an integer equal to approximately Nj.
6. The method of claim 1 wherein the step of obtaining the pulse echo sample subset is performed by sampling the pulse echo at a sub-Nyquist sampling rate, and wherein the step of aggregating the pulse echo sample subsets is performed by interleaving the samples from the pulse echo sample subsets.
7. The method of claim 1 wherein the plurality of array elements is substantially all the elements in the array.
8. The method of claim 1 wherein the pulse echo sample subsets are obtained using shared sampling hardware resources, and wherein the plurality of array elements are a fraction of all the elements in the array, wherein the fraction is determined by a hardware reuse factor.
9. The method of claim 1 wherein at least one motion-detection sample is obtained at each iteration.
10. The method of claim 1 wherein the smallest time offset is determined by a desired target depth.
11. The method of claim 1 wherein the step of aggregating the pulse echo sample subsets into a single synthesized composite pulse echo sample set comprises manipulating the sample subsets in response to at least one motion estimation value and the respective time offsets.
12. The method of claim 11 wherein the at least one motion estimation value is obtained from a plurality of individual direct-sampled complex echo samples taken over a plurality of iterations, having the same time offset.
13. The method of claim 1 wherein at each of the plurality of array elements, the pulse echo sample subsets at consecutive iterations overlap in time.
14. The method of claim 13 wherein the pulse echo sample subsets from consecutive iterations are used to generate at least one motion estimation value.
15. The method of claim 1 further comprising the step of determining at least one motion estimation value.
16. The method of claim 15 wherein the at least one motion estimation value comprises a plurality of regional motion estimation values for different regions of the array.
17. The method of claim 16 wherein the regional motion estimation values are used to generate array-element specific motion estimation values.
18. The method of claim 1 wherein the time offsets used for each element are varied in accordance with collecting data for producing an image of a plane that is non-parallel to the transducer array.
19. The method of claim 1 wherein the step of transmitting an ultrasonic pulse comprises transmitting a plane wave using all the transducer elements.
20. The method of claim 1 wherein the step of transmitting an ultrasonic pulse comprises transmitting a plane wave using a subset of the transducer elements.
21. The method of claim 1 wherein the step of transmitting an ultrasonic pulse comprises using at least a subset of elements transmitting to a selected focal zone
22. The method of claim 1 wherein the time interval between successive transmit pulses is varied for at least some iterations.
23. A method collecting ultrasonic echo samples for use in ultrasonic image processing, comprising the steps of:
performing multiple transmit firings of ultrasonic waveforms from an ultrasonic transducer array of transducer elements;
after each transmit firing, obtaining a subset of echo samples of an ultrasonic echo at each of a plurality of transducer array elements, wherein each subset is a portion of a desired echo signal as determined by a time offset;
retrospectively formulating an equivalent full set of echo samples from the subsets for each of the plurality of transducer array elements.
24. The method of claim 23 wherein the subset of echo samples are obtained by sampling the ultrasonic echo at a sub-Nyquist sampling rate.
25. The method claim 23 wherein the step of retrospectively formulating an equivalent full set of echo samples is performed in response to a motion estimation value.
26. The method claim 23 wherein the step of retrospectively formulating an equivalent full set of echo samples from the subsets is performed by concatenating samples from the subsets from the respective elements.
27. The method claim 23 wherein the step of retrospectively formulating an equivalent full set of echo samples from the subsets is performed by interleaving samples from the subsets from the respective elements.
28. The method claim 23 wherein the time offset is adjusted in response to at least one motion estimation value.
29. The method claim 23 wherein a time interval between the multiple transmit firings is not constant.
30. A method collecting ultrasonic echo samples for use in ultrasonic image processing, comprising the steps of:
performing multiple transmit firings of ultrasonic waveforms from an ultrasonic transducer array of transducer elements;
at each of a plurality of transducer array elements, obtaining a plurality of sample subsets of echo samples, wherein each subset is a portion of a desired echo signal;
for each of the plurality of transducer array elements, synthesizing an equivalent full set of echo samples at a desired effective sampling rate from each of the plurality of subsets.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound having formula (I)
wherein
R1a, R1b, and R1c are independently hydrogen, hydroxy, nitro, halogen, cyano, trifluoromethyl, trifluoromethoxy, C1-4-alkyl, \u2014ORa, or \u2014NRbRc;
X is heteroaryl, which is optionally substituted with one or more R5;
n is 0, 1, 2, or 3; provided that when n is 1, 2, or 3, m is 0;
m is 0, 1, 2, or 3; provided that when m is 1, 2, or 3, n is 0;
Y is a bond, \u2014O\u2014, \u2014C(O)\u2014, \u2014C(O)O\u2014, \u2014OC(O)\u2014, \u2014NRe\u2014, \u2014NReC(O)\u2014, \u2014C(O)NRe\u2014, \u2014NReC(O)NRe\u2014, \u2014SO2NRe\u2014, or \u2014NReSO2\u2014;
Z is C3-8-cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein the C3-8-cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, are optionally substituted with one or more R6;
R5 is selected from the group consisting of C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, halogen, cyano, nitro, \u2014ORd, \u2014C(O)Rd, \u2014C(O)ORd, \u2014OC(O)Rd, \u2014NReRf, \u2014NReC(O)Rd, \u2014NHC(O)NHRe, \u2014NHSO2Rd, \u2014C(O)NReRf, \u2014SRd, \u2014S(O)Rd, \u2014SO2Rd, \u2014SO2NReNRf, \u2014B(OH)2, \u2014CF3, \u2014CF2CF3, \u2014OCF3, and \u2014OCF2CF3 wherein (a) the R5 C1-8-alkyl, C2-8-alkenyl, and C2-8-alkynyl, substituents are optionally substituted with one or more substituents selected from the group consisting of aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, nitro, \u2014ORg, \u2014C(O)Rg, \u2014C(O)ORg, \u2014OC(O)Rg, \u2014NRhRi, \u2014NRhC(O)Rg, \u2014NHSO2Rg, \u2014NHC(O)NHRh, and \u2014C(O)NRhRi; and wherein (b) the R5 aryl and heterocyclyl substituents are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, C2-8-alkenyl, C2-8-allynyl, aryl, heterocyclyl, halogen, cyano, nitro, oxo \u2014ORj, \u2014C(O)Rj, \u2014C(O)ORj, \u2014OC(O)Rj, \u2014NRkRl, \u2014NRkC(O)Rj, \u2014NHC(O)NHRk, \u2014NHSO2Rj, \u2014C(O)NRkRl, \u2014SRj, \u2014S(O)Rj, \u2014SO2Rj, \u2014SO2NRkNRl, \u2014CF3, \u2014CF2CF3, \u2014OCF3, and \u2014OCF2CF3;
R6 is selected from the group consisting of C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, halogen, cyano, nitro, \u2014ORd, \u2014C(O)Rd, \u2014C(O)ORd, \u2014OC(O)Rd, \u2014NReRf, \u2014NReC(O)Rd, \u2014NHC(O)NHRe, \u2014NHSO2Rd, \u2014C(O)NReRf, \u2014SRd, \u2014S(O)Rd, \u2014SO2Rd, \u2014SO2NReNRf, \u2014B(OH)2, \u2014CF3, \u2014CF2CF3, \u2014OCF3, and \u2014OCF2CF3 wherein (a) the R6 C1-8-alkyl, C2-8-alkenyl, and C2-8-alkynyl, substituents are optionally substituted with one or more substituents selected from the group consisting of aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, nitro, \u2014ORg, \u2014C(O)Rg, \u2014C(O)ORg, \u2014OC(O)Rg, \u2014NRhRi, \u2014NRhC(O)Rg, \u2014NHSO2Rg, \u2014NHC(O)NHRh, and \u2014C(O)NRhRi; and wherein (b) the R6 aryl and heterocyclyl substituents are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, halogen, cyano, nitro, oxo \u2014ORj, \u2014C(O)Rj, \u2014C(O)ORj, \u2014OC(O)Rj, \u2014NRkRl, \u2014NRkC(O)Rj, \u2014NHC(O)NHRk, \u2014NHSO2Rj, \u2014C(O)NRkRl, \u2014SRj, \u2014S(O)Rj, \u2014SO2Rj, \u2014SO2NRkNRl, \u2014CF3, \u2014CF2CF3, \u2014OCF3, and \u2014OCF2CF3;
Ra, at each occurrence, is selected from the group consisting of hydrogen, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl, wherein the C1-8-alkyl, C2-8-alkenyl, C2-8-allynyl, aryl, heterocyclyl, and C3-8-cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, hydroxy, C1-8-alkoxy, \u2014NH2, \u2014NH(C1-8-alkyl), \u2014O(C1-8-alkyl)NH2, and \u2014N(C1-8-alkyl)2;
Rb and Rc, at each occurrence, are independently selected from the group consisting of hydrogen, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl, and optionally, Rb and Rc can be joined together to form a 4-7 membered heterocycloalkyl ring, wherein the C1-8-alkyl, C2-8-alkenyl, C2-8-allynyl, aryl, heterocyclyl, C3-8-cycloalkyl, and 4-7 membered heterocycloalkyl ring are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, hydroxy, C1-8-alkoxy, \u2014NH2, \u2014NH(C1-8-alkyl), and \u2014N(C1-8-allyl)2;
Rd, at each occurrence, is selected from the group consisting of hydrogen, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl, wherein the C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, aryl, aryl-(C1-8-alkyl)-, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, hydroxy, C1-8-alkoxy, \u2014NH2, \u2014NH(C1-8-alkyl), and \u2014N(C1-8-alkyl)2; wherein the aryl, aryl-(C1-8-alkyl)-, heterocyclyl, and C3-8-cycloalkyl, alone or as part of another group, are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, hydroxy, C1-8-alkoxy, \u2014NH2, \u2014NH(C1-8-alkyl), and \u2014N(C1-8-alkyl)2;
Re and Rf, at each occurrence, are independently selected from the group consisting of hydrogen, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl, and optionally, Re and Rf can be joined together to form a 4-7 membered heterocycloalkyl ring, wherein the C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, C3-8-cycloalkyl, and 4-7 membered heterocycloalkyl ring are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, hydroxy, C1-8-alkoxy, \u2014NH2, \u2014NH(C1-8-alkyl), and \u2014N(C1-8-alkyl)2;
Rg, at each occurrence, is selected from the group consisting of hydrogen, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl, wherein the C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, hydroxy, C1-8-alkoxy, \u2014NH2, \u2014NH(C1-8-alkyl), and \u2014N(C1-8-alkyl)2;
Rh and Ri, at each occurrence, are independently selected from the group consisting of hydrogen, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl, and optionally, Rh and Ri can be joined together to form a 4-7 membered heterocycloalkyl ring, wherein the C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, C3-8-cycloalkyl, and 4-7 membered heterocycloalkyl ring are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, hydroxy, C1-8-alkoxy, \u2014NH2, \u2014NH(C1-8-alkyl), and \u2014N(C1-8-alkyl)2;
Rj, at each occurrence, is selected from the group consisting of hydrogen, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl, wherein the C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, hydroxy, C1-8-alkoxy, \u2014NH2, \u2014NH(C1-8-alkyl), and \u2014N(C1-8-alkyl)2;
Rk and Rl, at each occurrence, are independently selected from the group consisting of hydrogen, C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl, wherein the C1-8-alkyl, C2-8-alkenyl, C2-8-alkynyl, aryl, heterocyclyl, and C3-8-cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of C1-8-alkyl, aryl, heterocyclyl, C3-8-cycloalkyl, halogen, cyano, hydroxy, C1-8-alkoxy, \u2014NH2, \u2014NH(C1-8-alkyl), and \u2014N(C1-8-alkyl)2;
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1, wherein R1a, R1b, and R1c are hydrogen.
3. The compound of claim 1, wherein Y is a bond, n is 1 or 2 and m is 0.
4. The compound of claim 1, wherein Y is \u2014C(O)\u2014, n is 0 and m is 0.
5. The compound of claim 1, wherein Z is aryl.
6. The compound of claim 1, wherein Z is phenyl.
7. The compound of claim 1, wherein X is
and p is 0, 1, or 2.
8. The compound of claim 1, wherein R1a, R1b, and R1c are hydrogen, Y is a bond, and n is 1 and m is 0.
9. The compound of claim 1, wherein R1a, R1b, and R1c are hydrogen, Y is \u2014C(O)\u2014, and n is 0 and m is 0.
10. The compound of claim 1, wherein R1a, R1b, and R1c are hydrogen, Y is a bond, n is 1 and m is 0, Z is aryl which is substituted with one or more R6, and X is
11. The compound of claim 1, wherein R1a, R1b, and R1c are hydrogen, Y is \u2014C(O)\u2014, n is 0 and m is 0, Z is aryl which is substituted with one or more R6, and X is
12. The compound of claim 1 which is
2-fluoro-5-{1-oxo-7-(pyridin-4-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzonitrile;
2-fluoro-5-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzonitrile;
2-fluoro-5-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzoic acid;
ethyl 3-{1-oxo-7-(pyridin-4-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzoate;
3-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzoic acid;
ethyl 3-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzoate;
3-{1-oxo-7-(pyridin-4-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzoic acid;
ethyl 3-{1-oxo-7-(pyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzoate;
ethyl 3-{1-oxo-7-(1H-pyrazol-4-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzoate;
3-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzamide;
3-{1-oxo-7-(5H-pyrrolo2,3-bpyrazin-7-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzoic acid;
ethyl 3-{1-oxo-7-(5H-pyrrolo2,3-bpyrazin-7-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzoate;
3-{1-oxo-7-(1H-pyrazol-4-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzamide;
4-(3-nitrobenzyl)-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
4-(4-nitrobenzyl)-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzonitrile;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)isonicotinamide;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)cyclobutanecarboxamide;
4-{3-cyclobutyl(methyl)aminobenzyl}-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)cyclopropanecarboxamide;
N-(3-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)methanesulfonamide;
4-(3-aminobenzyl)-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
4-(4-aminobenzyl)-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
4-{4-(pyridin-2-ylmethyl)aminobenzyl}-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
4-{4-(cyclobutylamino)methylbenzyl}-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)-2-furamide;
4-3-(dicyclobutylamino)benzyl-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)nicotinamide;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzyl)cyclopropanesulfonamide;
4-{4-(dicyclobutylamino)methylbenzyl}-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzyl)methanesulfonamide;
4-{4-(1-isopropylpiperidin-4-yl)aminobenzyl}-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
N2,N2-dimethyl-N-(3-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)glycinamide;
N2,N2-dimethyl-N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzyl)glycinamide;
4-4-(pentan-3-ylamino)benzyl-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
4-{4-(dimethylamino)methylbenzyl}-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
4-4-(aminomethyl)benzyl-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)methanesulfonamide;
4-{4-(1-cyclopropylethyl)aminobenzyl}-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
1-methyl-N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)piperidine-3-carboxamide;
4-3-(dimethylamino)benzyl-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}phenyl)benzamide;
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylcarbonyl}phenyl)methanesulfonamide;
4-(4-{(4-aminocyclohexyl)aminomethyl}benzyl)-7-(1H-pyrrolo2,3-bpyridin-3-yl)pyrrolo1,2-apyrazin-1(2H)-one; or
N-(4-{1-oxo-7-(1H-pyrrolo2,3-bpyridin-3-yl)-1,2-dihydropyrrolo1,2-apyrazin-4-ylmethyl}benzyl)acetamide.
13. A pharmaceutical composition comprising a compound or pharmaceutically acceptable salt of claim 1 and pharmaceutically acceptable excipient.