1. A compound of the formula (I)
wherein
R1 denotes C1-4alkyl;
R2 denotes hydrogen or C1-4alkyl;
R3 denotes hydrogen or C1-4alkyl;
n denotes 0 or 1;
ring A is phenyl or 5-6 membered heteroaryl;
each R4 is independently of one another selected from among halogen, C1-4alkoxy, C1-4alkyl and \u2014CN;
p denotes 0, 1 or 2;
ring B is a 5-membered heteroaryl;
each R5 independently is Rb1 or a group, optionally substituted by one or more, identical or different Rb1 andor Rc1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rb1 is independently selected from among \u2014ORc1, \u2014NRc1Rc1, halogen, \u2014CN, \u2014C(O)Rc1, \u2014C(O)ORc1, \u2014C(O)NRc1 Rc1, \u2014S(O)2Rc1, \u2014S(O)2NRc1Rc1, \u2014NHC(O)Rc1 and \u2014N(C1-4alkyl)C(O)Rc1;
each Rc1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd1 andor Re1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd1 is independently selected from among \u2014ORe1, \u2014NRe1Re1, halogen, \u2014CN, \u2014C(O)Re1, \u2014C(O)ORe1, \u2014C(O)NRe1Re1, \u2014S(O)2Re1, \u2014S(O)2NRe1Re1, \u2014NHC(O)Re1 and \u2014N(C1-4alkyl)C(O)Re1;
each Re1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf1 andor Rg1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rf1 is independently selected from among \u2014ORg1, \u2014NRg1Rg1, halogen, \u2014CN, \u2014C(O)Rg1, \u2014C(O)ORg1, \u2014C(O)NRg1Rg1, \u2014S(O)2Rg1, \u2014S(O)2NRg1Rg1, \u2014NHC(O)Rg1 and \u2014N(C1-4alkyl)C(O)Rg1;
each Rg1 independently of one another denotes hydrogen or C1-6alkyl;
q denotes 0, 1 or 2;
ring C is phenyl or 5-6 membered heteroaryl;
each R6 independently is Rb2 or a group, optionally substituted by one or more, identical or different Rb2 andor Rc2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rb2 is independently selected from among \u2014ORc2, \u2014NRc2Rc2, halogen, \u2014CN, \u2014C(O)Rc2, \u2014C(O)ORc2, \u2014C(O)NRc2Rc2, \u2014S(O)2Rc2, \u2014S(O)2NRc2Rc2, \u2014NHC(O)Rc2 and \u2014N(C1-4alkyl)C(O)Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2, \u2014NRe2Re2, halogen, \u2014CN, \u2014C(O)Re2, \u2014C(O)ORe2, \u2014C(O)NRe2Re2, \u2014S(O)2Re2, \u2014S(O)2NRe2Re2, \u2014NHC(O)Re2 and \u2014N(C1-4alkyl)C(O)Re2;
each Re2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf2 andor Rg2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rf2 is independently selected from among \u2014ORg2, \u2014NRg2Rg2, halogen, \u2014CN, \u2014C(O)Rg2, \u2014C(O)ORg2, \u2014C(O)NRg2Rg2, \u2014S(O)2Rg2, \u2014S(O)2NRg2Rg2, \u2014NHC(O)Rg2 and \u2014N(C1-4alkyl)C(O)Rg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl;
r denotes 0, 1 or 2;
or a tautomer or salt thereof.
2. A compound according to claim 1, wherein
ring C is phenyl;
each R6 independently is Rb2 or a group, optionally substituted by one or more, identical or different Rb2 andor Rc2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rb2 is independently selected from among \u2014ORc2, \u2014NRc2Rc2, halogen, \u2014CN, \u2014C(O)Rc2, \u2014C(O)ORc2, \u2014C(O)NRc2Rc2, \u2014S(O)2Rc2, \u2014S(O)2NRc2Rc2, \u2014NHC(O)Rc2 and \u2014N(C1-4alkyl)C(O)Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2, \u2014NRe2Re2, halogen, \u2014CN, \u2014C(O)Re2, \u2014C(O)ORe2, \u2014C(O)NRe2Re2, \u2014S(O)2Re2, \u2014S(O)2NRe2Re2, \u2014NHC(O)Re2 and \u2014N(C1-4alkyl)C(O)Re2;
each Re2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf2 andor Rg2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rf2 is independently selected from among \u2014ORg2, \u2014NRg2Rg2, halogen, \u2014CN, \u2014C(O)Rg2, \u2014C(O)ORg2, \u2014C(O)NRg2Rg2, \u2014S(O)2Rg2, \u2014S(O)2NRg2Rg2, \u2014NHC(O)Rg2 and \u2014N(C1-4alkyl)C(O)Rg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl;
r denotes 0, 1 or 2.
3. A compound according to claim 1, wherein
ring C is phenyl;
each R6 independently is Rb2 or a group, optionally substituted by one or more, identical or different Rb2 andor Rc2, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rb2 is independently selected from among \u2014ORc2, \u2014NRc2Rc2, halogen, \u2014CN, \u2014C(O)Rc2, \u2014C(O)ORc2, \u2014C(O)NRc2Rc2, \u2014S(O)2Rc2, \u2014S(O)2NRc2Rc2, \u2014NHC(O)Rc2 and \u2014N(C1-4alkyl)C(O)Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2, \u2014NRe2Re2, halogen, \u2014CN, \u2014C(O)Re2, \u2014C(O)ORe2, \u2014C(O)NRe2Re2, \u2014S(O)2Re2, \u2014S(O)2NRe2Re2, \u2014NHC(O)Re2 and \u2014N(C1-4alkyl)C(O)Re2;
each Re2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf2 andor Rg2, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rf2 is independently selected from among \u2014ORg2, \u2014NRg2Rg2, halogen, \u2014CN, \u2014C(O)Rg2, \u2014C(O)ORg2, \u2014C(O)NRg2Rg2, \u2014S(O)2Rg2, \u2014S(O)2NRg2Rg2, \u2014NHC(O)Rg2 and \u2014N(C1-4alkyl)C(O)Rg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl;
r denotes 0, 1 or 2.
4. A compound according to claim 1, wherein
ring C is phenyl;
each R6 independently is Rb2 or 3-7 membered heterocyclyl, the heterocyclyl optionally substituted by one or more, identical or different Rb2 andor Rc2;
each Rb2 is independently selected from among \u2014ORc2, \u2014C(O)Rc2, \u2014C(O)ORc2, \u2014C(O)NRc2Rc2 and \u2014S(O)2NRc2Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2 and \u2014NRe2Re2;
each Re2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf2 andor Rg2, selected from among C1-6alkyl and 3-7 membered heterocyclyl;
each Rf2 is \u2014ORg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl;
r denotes 0, 1 or 2.
5. A compound according to claim 1, wherein
ring C is phenyl;
each R6 independently is \u2014C(O)NRc2Rc2, \u2014C(O)Rc2 or \u2014ORc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2 and \u2014NRe2Re2;
each Re2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf2 andor Rg2, selected from among C1-6alkyl and 3-7 membered heterocyclyl;
each Rf2 is \u2014ORg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl;
r denotes 0, 1 or 2.
6. A compound according to claim 1, wherein
r is 2.
7. A compound according to claim 1, wherein
ring C is 5-6 membered heteroaryl;
each R6 independently is Rb2 or a group, optionally substituted by one or more, identical or different Rb2 andor Rc2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rb2 is independently selected from among \u2014ORc2, \u2014NRc2Rc2, halogen, \u2014CN, \u2014C(O)Rc2, \u2014C(O)ORc2, \u2014C(O)NRc2Rc2, \u2014S(O)2Rc2, \u2014S(O)2NRc2Rc2, \u2014NHC(O)Rc2 and \u2014N(C1-4alkyl)C(O)Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2, \u2014NRe2Re2, halogen, \u2014CN, \u2014C(O)Re2, \u2014C(O)ORe2, \u2014C(O)NRe2Re2, \u2014S(O)2Re2, \u2014S(O)2NRe2Re2, \u2014NHC(O)Re2 and \u2014N(C1-4alkyl)C(O)Re2;
each Re2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf2 andor Rg2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rf2 is independently selected from among \u2014ORg2, \u2014NRg2Rg2, halogen, \u2014CN, \u2014C(O)Rg2, \u2014C(O)ORg2, \u2014C(O)NRg2Rg2, \u2014S(O)2Rg2, \u2014S(O)2NRg2Rg2, \u2014NHC(O)Rg2 and \u2014N(C1-4alkyl)C(O)Rg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl;
r denotes 0, 1 or 2.
8. A compound according to claim 7, wherein ring C is 5-6 membered heteroaryl;
each R6 independently is Rb2 or a group, optionally substituted by one or more, identical or different Rb2 andor Rc2, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rb2 is independently selected from among \u2014ORc2, \u2014NRc2Rc2, halogen, \u2014CN, \u2014C(O)Rc2, \u2014C(O)ORc2, \u2014C(O)NRc2Rc2, \u2014S(O)2Rc2, \u2014S(O)2NRc2Rc2, \u2014NHC(O)Rc2 and \u2014N(C1-4alkyl)C(O)Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2, \u2014NRe2Re2, halogen, \u2014CN, \u2014C(O)Re2, \u2014C(O)ORe2, \u2014C(O)NRe2Re2, \u2014S(O)2Re2, \u2014S(O)2NRe2Re2, \u2014NHC(O)Re2 and \u2014N(C1-4alkyl)C(O)Re2;
each Re2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf2 andor Rg2, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rf2 is independently selected from among \u2014ORg2, \u2014NRg2Rg2, halogen, \u2014CN, \u2014C(O)Rg2, \u2014C(O)ORg2, \u2014C(O)NRg2Rg2, \u2014S(O)2Rg2, \u2014S(O)2NRg2Rg2, \u2014NHC(O)Rg2 and \u2014N(C1-4alkyl)C(O)Rg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl;
r denotes 0, 1 or 2.
9. A compound according to claim 8, wherein
ring C is pyrazolyl;
each R6 independently is Rb2 or a group, optionally substituted by one or more, identical or different Rb2 andor Rc2, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rb2 is independently selected from among \u2014ORc2, \u2014NRc2Rc2, halogen, \u2014CN, \u2014C(O)Rc2, \u2014C(O)ORc2, \u2014C(O)NRc2Rc2, \u2014S(O)2Rc2, \u2014S(O)2NRc2Rc2, \u2014NHC(O)Rc2 and \u2014N(C1-4alkyl)C(O)Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2, \u2014NRe2 Re2, halogen, \u2014CN, \u2014C(O)Re2, \u2014C(O)ORe2, \u2014C(O)NRe2Re2, \u2014S(O)2Re2, \u2014S(O)2NRe2Re2, \u2014NHC(O)Re2 and \u2014N(C1-4alkyl)C(O)Re2;
each Re2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf2 andor Rg2, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rf2 is independently selected from among \u2014ORg2, \u2014NRg2Rg2, halogen, \u2014CN, \u2014C(O)Rg2, \u2014C(O)ORg2, \u2014C(O)NRg2Rg2, \u2014S(O)2Rg2, \u2014S(O)2NRg2Rg2, \u2014NHC(O)Rg2 and \u2014N(C1-4alkyl)C(O)Rg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl;
r denotes 0, 1 or 2.
10. A compound according to claim 9, wherein
ring C is pyrazolyl;
each R6 independently is a group, optionally substituted by one or more, identical or different Rb2 andor Rc2, selected from among C1-6alkyl and 3-7 membered heterocyclyl;
each Rb2 is independently selected from among \u2014ORc2, \u2014NRc2Rc2, \u2014C(O)Rc2, \u2014C(O)ORc2, \u2014C(O)NRc2Rc2, \u2014S(O)2Rc2 and \u2014S(O)2NRc2Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2 and \u2014NRe2Re2;
each Re2 independently of one another denotes hydrogen or C1-6alkyl optionally substituted by one or more, identical or different Rf2 andor Rg2;
each Rf2 is \u2014ORg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl;
r denotes 0, 1 or 2.
11. A compound according to claim 10, wherein
r is 1.
12. A compound according to claim 10, wherein
r is 1 and ring C and R6 altogether is
R6 independently is a group, optionally substituted by one or more, identical or different Rb2 andor Rc2, selected from among C1-6alkyl and 3-7 membered heterocyclyl;
each Rb2 is independently selected from among \u2014ORc2, \u2014NRc2Rc2, \u2014C(O)Rc2, \u2014C(O)ORc2, \u2014C(O)NRc2Rc2, \u2014S(O)2Rc2 and \u2014S(O)2NRc2Rc2;
each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 andor Re2, selected from among C1-6alkyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd2 is independently selected from among \u2014ORe2 and \u2014NRe2Re2;
each Re2 independently of one another denotes hydrogen or C1-6alkyl optionally substituted by one or more, identical or different Rf2 andor Rg2;
each Rf2 is \u2014ORg2;
each Rg2 independently of one another denotes hydrogen or C1-6alkyl.
13. A compound according to claim 12, wherein
r is 1 and ring C and R6 altogether is
R6 independently is selected from among C1-4alkyl, hydroxy-C2-4alkyl, C1-4alkoxy-C2-4alkyl and (C1-4alkyl)2N\u2014C2-4alkyl.
14. A compound according to claim 12, wherein
r is 1 and ring C and R6 altogether is selected from among
15. A compound according to claim 1, wherein
ring B is a 5-membered heteroaryl;
each R5 independently is Rb1 or a group, optionally substituted by one or more, identical or different Rb1 andor Rc1, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rb1 is independently selected from among \u2014ORc1, \u2014NRc1Rc1, halogen, \u2014CN, \u2014C(O)Rc1, \u2014C(O)ORc1, \u2014C(O)NRc1Rc1, \u2014S(O)2Rc1, \u2014S(O)2NRc1Rc1, \u2014NHC(O)Rc1 and \u2014N(C1-4alkyl)C(O)Rc1;
each Rc1 independently of one another denotes hydrogen or a group, optionally to substituted by one or more, identical or different Rd1 andor Re1, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd1 is independently selected from among \u2014ORe1, \u2014NRe1Re1, halogen, \u2014CN, \u2014C(O)Re1, \u2014C(O)ORe1, \u2014C(O)NRe1Re1, \u2014S(O)2Re1S(O)2NRe1Re1, \u2014NHC(O)Re1 and \u2014N(C1-4alkyl)C(O)Rel;
each Re1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf1 andor Rg1, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rf1 is independently selected from among \u2014ORg1, \u2014NRg1Rg1, halogen, \u2014CN, \u2014C(O)Rg1, \u2014C(O)ORg1, \u2014C(O)NRg1Rg1, \u2014S(O)2Rg1, \u2014S(O)2NRg1Rg1, \u2014NHC(O)Rg1 and \u2014N(C1-4alkyl)C(O)Rg1;
each Rg1 independently of one another denotes hydrogen or C1-6alkyl;
q denotes 0, 1 or 2.
16. A compound according to claim 15, wherein
ring B is pyrazolyl;
each R5 independently is Rb1 or a group, optionally substituted by one or more, identical or different Rb1 andor Rc1, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rb1 is independently selected from among \u2014ORc1, \u2014NRc1 Rc1, halogen, \u2014CN, \u2014C(O)Rc1, \u2014C(O)ORc1, \u2014C(O)NRc1Rc1, \u2014S(O)2Rc1, \u2014S(O)2NRc1Rc1, \u2014NHC(O)Rc1 and \u2014N(C1-4alkyl)C(O)Rc1;
each Rd1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd1 andor Re1, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rd1 is independently selected from among \u2014ORe1, \u2014NRe1Re1, halogen, \u2014CN, \u2014C(O)Re1, \u2014C(O)ORe1, \u2014C(O)NRe1Re1, \u2014S(O)2Re1, \u2014S(O)2NRe1Re1, \u2014NHC(O)Re1 and \u2014N(C1-4alkyl)C(O)Re1;
each Re1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf1 andor Rg1, selected from among C1-6alkyl, C3-6cycloalkyl, phenyl, 5-6 membered heteroaryl and 3-7 membered heterocyclyl;
each Rf1 is independently selected from among \u2014ORg1, \u2014NRg1Rg1, halogen, \u2014CN, \u2014C(O)Rg1, \u2014C(O)ORg1, \u2014C(O)NRg1Rg1, \u2014S(O)2Rg1, \u2014S(O)2NRg1Rg1, \u2014NHC(O)Rg1 and \u2014N(C1-4alkyl)C(O)Rg1;
each Rg1 independently of one another denotes hydrogen or C1-6alkyl;
q denotes 0, 1 or 2.
17. A compound according to claim 16, wherein
ring B is pyrazolyl;
each R5 independently is a group, optionally substituted by one or more, identical or different Rb1 andor Rc1, selected from among C1-6alkyl and 3-7 membered heterocyclyl;
each Rb1 is independently selected from among \u2014ORc1, \u2014NRc1Rc1, halogen, \u2014C(O)ORc1 and \u2014C(O)NRc1Rc1;
each Rd1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd1 andor Re1, selected from among C1-6alkyl, phenyl and 3-7 membered heterocyclyl;
each Rd1 is independently selected from among \u2014ORe1 and \u2014NRe1Re1;
each Re1 independently of one another denotes hydrogen or C1-6alkyl optionally substituted by one or more, identical or different Rf1 andor Rg1;
each Rf1 is \u2014ORg1;
each Rg1 independently of one another denotes hydrogen or C1-6alkyl;
q denotes 0, 1 or 2.
18. A compound according to claim 17, wherein gist.
19. A compound according to claim 17, wherein
q is 1 and ring B and R5 altogether is
R5 is a group, optionally substituted by one or more, identical or different Rb1 andor Rc1, selected from among C1-6alkyl and 3-7 membered heterocyclyl;
each Rb1 is independently selected from among \u2014ORc1, \u2014NRc1 Rc1, halogen, \u2014C(O)ORc1 and \u2014C(O)NRc1Rc1;
each Rc1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd1 andor Re1, selected from among C1-6alkyl, phenyl and 3-7 membered heterocyclyl;
each Rd1 is independently selected from among \u2014ORe1 and \u2014NRe1Re1;
each Re1 independently of one another denotes hydrogen or C1-6alkyl optionally substituted by one or more, identical or different Rf1 andor Rg1;
each Rf1 is \u2014ORg1;
each Rg1 independently of one another denotes hydrogen or C1-6alkyl.
20. A compound according to claim 19, wherein
q is 1 and ring B and R5 altogether is
R5 independently is selected from among C1-4alkyl, hydroxy-C2-4alkyl, C1-4alkoxy-C2-4alkyl and (C1-4alkyl)2N\u2014C2-4alkyl.
21. A compound according to claim 19, wherein
q is 1 and ring B and R5 altogether is selected from among
22. A compound according to claim 1, wherein
R1 is methyl.
23. A compound according to claim 1, wherein
R2 and R3 both denote hydrogen.
24. A compound according to claim 1, wherein
R2 is hydrogen and R3 is C1-4alkyl.
25. A compound according to claim 1, wherein
R2 is hydrogen and R3 is methyl.
26. A compound according to claim 1, wherein
ring A is phenyl or pyridyl;
each R4 is independently of one another selected from among halogen, C1-4alkoxy, C1-4alkyl and \u2014CN;
p denotes 0, 1 or 2.
27. A compound according claim 26, wherein
ring A is phenyl or pyridyl;
p is 0.
28. A compound according to claim 1 selected from the group consisting of
or a tautomer or salt thereof.
29. A pharmaceutically acceptable salt of a compound according to one of claims 1 to 28.
30. A method for the treatment of hepatocellular carcinoma (HCC), non-small cell lung cancer (NSCLC), breast cancer or prostate cancer which comprises administering to a host suffering from one of said conditions a therapeutically effective amount of a compound according to claim 1.
31. A pharmaceutical preparation containing as active substance a compound of formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient or carrier.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A device for tensioning and loosening of an endless conveyor belt which is guided over deflection means, which is additionally supported between the deflection means by a support construction, wherein the device has displacement means for displacing of displaceable deflection means parallel to the direction of travel of the conveyor belt, the device comprising: support means, which are co-displaceable with the displacing of the displaceable deflection means parallel to the direction of travel of the conveyor belt, wherein the support means support the conveyor belt between the support construction and the displaceable deflection means wherein the support means are designed so that they support the conveyor belt throughout the entire region between the support construction and the displaceable deflection means, in which the conveyor belt is not supported by the support construction or the displaceable deflection means regardless of the displacement position of the displaceable deflection means.
2. The device according to claim 1, wherein the support means comprise at least two sliding bar pieces which are spaced apart from each other.
3. The device according to claim 1, wherein the displaceable deflection means are fixedly connected with the support means.
4. A device for tensioning and loosening of an endless conveyor belt which is guided over deflection means, which is additionally supported between the deflection means by a support construction, wherein the device has displacement means for displacing of displaceable deflection means parallel to the direction of travel of the conveyor belt, the device comprising: support means, which are co-displaceable with the displacing of the displaceable deflection means parallel to the direction of travel of the conveyor belt, wherein the support means support the conveyor belt between the support construction and the displaceable deflection means, the displacement means comprise two crank levers, which are connected via a crank axle such that they are not rotatable in relation to each other, and are each rotatably connected with a lever rod via a link, the lever rods for their part being connected with the displaceable deflection means.
5. The device according to claim 4, wherein the displaceable deflection means have a deflection axle and the displacement means are arranged such that the links in the tensioned conveyor belt lie in a plane between the deflection axle and the crank axle.
6. The device according to claim 4, wherein the displacement means have an operating lever connected with the crank axle, with which the crank axle is rotatable.
7. The device according to claim 4, wherein the crank levers or the lever rods are sprung designed, in particular as coil springs or pneumatic springs.
8. The device according to claim 4, wherein the lever rods have several connection gaps, via which they are adjustably connected with the crank levers or with the displaceable deflection means.
9. The device according to claim 4, wherein it has means for automated rotating of the crank levers, in particular a pneumatic drive.