1. A method for treating breast cancer, comprising administering to a warm-blooded species in need thereof, a therapeutically effective amount of a compound of formula I:
its enantiomer, diastereomer, or pharmaceutically acceptable salts thereof, wherein
X and Y are independently O, OCO, S, SO SO2, CO, CO2, NR10, NR11CO, NR12CONR13, NR14CO2, NR15SO2, NR16SO2NR17, SO2NR18, CONR19, halogen, nitro, cyano, or X or Y are absent;
Z is O, S, N, or CR20;
R1 is hydrogen, CH3, OH, OCH3, SH, SCH3, OCOR21, SOR22, SO2R23, SO2NR24R25, CO2R26, CONR27R28, NH2, NR29SO2NR30R31, NR32SO2R33, NR34COR35, NR36CO2R37, NR38CONR39R40, halogen, nitro, or cyano;
R2 and R3 are independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aralkyl, substituted aralkyl, heterocycloalkyl or substituted heterocycloalkyl, or when X is halo, nitro or cyano R2 is absent or when Y is halo, nitro or cyano R3 is absent;
R4 is alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aralkyl, substituted aralkyl;
R5 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aralkyl, or substituted aralkyl;
or R4 and R5 may together form an optionally substituted monocyclic 5-7 membered saturated or unsaturated carbocyclic or heterocyclic ring, or an optionally substituted bicyclic 7-11 membered saturated or unsaturated heterocyclic ring, except that when Z is O or S, R5 is absent;
R6 is hydrogen, alkyl, substituted alkyl, substituted aryl, heterocyclo, substituted heterocyclo, NR7R8, OR9 or halogen;
R7 is selected from the group consisting of hydrogen, C2-C20 alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, and substituted heterocyclo,
R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R21, R24, R25, R26, R27, R28, R29, R30, R31, R32, R34, R35, R36, R38, R39 and R40 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, and substituted heterocyclo,
R22, R23, R33 and R37 are independently selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, and substituted heterocyclo; and
R20 is selected from the group consisting of hydrogen, lower alkyl and substituted alkyl, or R20 is absent if the carbon to which it is attached is part of an unsaturated aryl or heteroaryl ring;
with the provisos that:
a. R2 is not hydrogen if X is SO, SO2, NR14CO2, or NR15SO2,
b. R3 is not hydrogen if Y is SO, SO2, NR14CO2, or NR15SO2 and a pharmaceutically acceptable carrier.
2. A method for treating rheumatoid arthritis, which comprises administering to a warm-blooded species in need thereof a therapeutically effective amount of a compound of formula I:
its enantiomer, diastereomer, or pharmaceutically acceptable salt thereof, wherein
X and Y are independently O, OCO, S, SO SO2, CO, CO2, NR10, NR11CO, NR12CONR13, NR14CO2, NR15SO2, NR16SO2NR17, SO2NR18, CONR19, halogen, nitro, cyano, or X or Y are absent;
Z is O, S, N, or CR20;
R1 is hydrogen, CH3, OH, OCH3, SH, SCH3, OCOR21, SOR22, SO2R23, SO2NR24R25, CO2R26, CONR27R28, NH2, NR29SO2NR30R31, NR32SO2R33, NR34COR35, NR36CO2R37, NR38CONR39R40, halogen, nitro, or cyano;
R2 and R3 are independently hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aralkyl, substituted aralkyl, heterocycloalkyl or substituted heterocycloalkyl, or when X is halo, nitro or cyano R2 is absent or when Y is halo, nitro or cyano R3 is absent;
R4 is alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aralkyl, substituted aralkyl;
R5 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, aralkyl, or substituted aralkyl;
or R4 and R5 may together form an optionally substituted monocyclic 5-7 membered saturated or unsaturated carbocyclic or heterocyclic ring, or an optionally substituted bicyclic 7-11 membered saturated or unsaturated heterocyclic ring, except that when Z is O or S, R5 is absent;
R6 is hydrogen, alkyl, substituted alkyl, substituted aryl, heterocyclo, substituted heterocyclo, NR7R8, OR9 or halogen;
R7 is selected from the group consisting of hydrogen, C2-C20 alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, and substituted heterocyclo,
R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R21, R24, R25, R26, R27, R28, R29, R30, R31, R32, R34, R35, R36, R38, R39 and R40 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, and substituted heterocyclo,
R22, R23, R33 and R37 are independently selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, and substituted heterocyclo; and
R20 is selected from the group consisting of hydrogen, lower alkyl and substituted alkyl, or R20 is absent if the carbon to which it is attached is part of an unsaturated aryl or heteroaryl ring;
with the provisos that:
a. R2 may not be hydrogen if X is SO, SO2, NR14CO2, or NR15SO2,
b. R3 may not be hydrogen if Y is SO, SO2, NR14CO2, or NR15SO2.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An antenna device comprising:
an antenna board, including
a first antenna element operating in a first frequency band,
a first feeding point electrically connected to the first antenna element,
a second antenna element operating in a second frequency band that is lower than the first frequency band, and
a second feeding point electrically connected to the second antenna element,
wherein, the first feeding point is arranged on the side of a first lateral portion of the board, and the second feeding point is arranged on the side of a second lateral portion opposite to the first lateral portion.
2. The antenna device according to claim 1, wherein the first antenna element and the second antenna element are arranged between the first feeding point and the second feeding point.
3. The antenna device according to claim 2, wherein the first antenna element and the second antenna element are arranged in a manner in which an open side of the first antenna element and an open side of the second antenna element are disposed at a distance from each other in a direction where the first feeding point and the second feeding point are arranged.
4. A portable radio apparatus comprising the antenna device described in claim 1.
5. The portable radio apparatus according to claim 4, comprising:
a first matching circuit which is a matching circuit for the first antenna element; and
a second matching circuit which is a matching circuit for the second antenna element,
wherein the first matching circuit is arranged adjacent to the first feeding point of the board mounted in the portable radio apparatus, and the second matching circuit is arranged adjacent to the second feeding point of the board mounted in the portable radio apparatus.
6. The portable radio apparatus of claim 4, comprising:
a first housing including an image display and a first print circuit board;
a second housing including a microphone and a second print circuit board;
a connection board that electrically connects the first print circuit board and the second print circuit board;
a hinge that pivotably connects the first housing and the second housing; and
a first joint member and a second joint member that electrically connects the first feeding point and the second feeding point of the antenna device to the second print circuit board, respectively, with the connection board being arranged to pass in-between the first joint member and the second joint member.
7. The portable radio apparatus according to claim 6, wherein the antenna device is arranged on a side where the hinge is installed, the side being within the second housing.
8. The portable radio apparatus according to claim 6, wherein the antenna device is arranged on a side opposite to a side where the microphone is installed, the side being within the second housing.
9. The portable radio apparatus according to claim 4, comprising:
a first housing including an image display and a first print circuit board;
a second housing including a microphone and a second print circuit board;
a connection board that electrically connects the first print circuit board and the second print circuit board;
a hinge that pivotably connects the first housing and the second housing; and
a first joint member and a second joint member that electrically connects the first feeding point and the second feeding point of the antenna device to the second print circuit board, respectively, with the connection board being arranged to pass in-between the first joint member and the second joint member.
10. The portable radio apparatus according to claim 9, wherein the antenna device is arranged on a side where the hinge is installed, the side being within the first housing.