1. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of highly-compactable filler in combination with a highly water-absorbing material and;
b) adding purified water to the mixture of highly compactable filler and highly water-absorbing material until granules are formed by visual inspection thus creating the cushioning component; and
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and milled cushioning component with or without said extrusion and spheronization to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
2. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of Avicel PH101 and Ac-Di-Sol and;
b) adding purified water to the mixture of Avicel PH101 and Ac-Di-Sol until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and milled cushioning component with or without said extrusion and spheronization to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
3. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of Avicel PH101 and Ac-Di-Sol in a ratio that the mixture will have Ac-Di-Sol ranging from 5 to 90% by weight and;
b) adding of purified water to the mixture of Avicel PH101 and Ac-Di-Sol until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and the milled cushioning component with or without said extrusion and spheronization to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
4. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of a highly-compactable filler in combination with a highly water-absorbing material and;
b) adding of purified water to the mixture of highly-compactable filler and highly water-absorbing material until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including nonactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and the milled cushioning component with or without said extrusion and spheronization until a LOD of 2-15% is achieved to create the Cushioning Beads followed by an optional step of extrusion and spheronization of the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
5. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of Avicel PH 101 and Ac-Di-Sol and;
b) adding purified water to the mixture of Avicel PH101 and Ac-Di-Sol until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and milled cushioning component with or without said extrusion and spheronization until a LOD of 2-15% is achieved to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast tablet for treatment of a patient in need of said treatment.
6. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of Avicel PH101 and Ac-Di-Sol in a ratio that the mixture will have Ac-Di-Sol ranging from 5 to 90% by weight;
b) adding of purified water to the mixture of Avicel PH101 and Ac-Di-Sol until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and milled cushioning component with or without said extrusion and spheronization until a LOD of 2-15% is achieved to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
7. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of a highly-compactable filler in combination with a highly water-absorbing material and;
b) adding purified water to the mixture of highly-compactable filler and highly water-absorbing material until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding more than one type of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and milled cushioning component with or without said extrusion and spheronization to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
8. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of Avicel PH101 and Ac-Di-Sol and;
b) adding purified water to the mixture of Avicel PH101 and Ac-Di-Sol until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of more than one type of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and milled cushioning component with or without said extrusion and spheronization to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
9. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of Avicel PH101 and Ac-Di-Sol in a ratio that the mixture will have Ac-Di-Sol ranging from 5 to 90% by weight and;
b) adding of purified water to the mixture of Avicel PH101 and Ac-Di-Sol until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of more than one type of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and the milled cushioning component with or without said extrusion and spheronization to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
10. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of a highly-compactable filler in combination with a highly water-absorbing material and;
b) adding of purified water to the mixture of highly-compactable filler and highly water-absorbing material until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of more than one type of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and the milled cushioning component with or without said extrusion and spheronization until a LOD of 2-15% is achieved to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
11. A method for the of manufacture of a fast dissolve tablet that includes:
a) blending of Avicel PH101 and Ac-Di-Sol and;
b) adding purified water to the mixture of Avicel PH101 and Ac-Di-Sol until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of more than one type of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and milled cushioning component with or without said extrusion and spheronization until a LOD of 2-15% is achieved to create the Cushioning Beads; and
f) and compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
12. A method for the manufacture of a fast dissolve tablet that includes:
a) blending of Avicel PH101 and Ac-Di-Sol in a ratio that the mixture will have Ac-Di-Sol ranging from 5 to 90% by weight and;
b) adding of purified water to the mixture of Avicel PH101 and Ac-Di-Sol until granules are formed by visual inspection thus creating the cushioning component and;
c) the cushioning component is milled to a particle size of between 10-325 mesh (2000-45 micron); and
d) adding of more than one type of active-loaded beads to the milled cushioning component to create a mixture followed by an optional step of extrusion and spheronization and the option of including inactive ingredients to improve patient compliance, functionality or manufacturability; and
e) freeze-drying of the mixture of active-loaded beads and milled cushioning component with or without said extrusion and spheronization until a LOD of 2-15% is achieved to create the Cushioning Beads; and
f) compressing the Cushioning Beads into a fast dissolve tablet for treatment of a patient in need of said treatment.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-5. (canceled)
6. An ink media set, comprising:
a recording ink, and
a recording medium,
wherein the recording ink comprises at least a solid component, a liquid component, and water; the solid component comprises a colorant and a resin and is a solid at 25\xb0 C.; the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C.; the total content of the liquid component in the recording ink is 20% by mass or less; the recording medium comprises a support, and a coating layer on at least one surface of the support; the transfer amount of purified water to the recording medium for a contact time of 100 ms is 2 mLm2 to 35 mLm2; and the transfer amount of purified water to the recording medium for a contact time of 400 ms is 3 mLm2 to 40 mLm2 measured using a dynamic scanning absorbing liquid meter.
7. An ink media set, comprising:
a recording ink, and
a recording medium,
wherein the recording ink comprises at least a solid component, a liquid component, and water; the solid component comprises a colorant and a resin and is a solid at 25\xb0 C.; the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C.; the total content of the liquid component in the recording ink is 30% by mass or less; the total content of the solid component in the recording ink is 20% by mass or more; the total content of resin components in the solid component is 40% by mass to 95% by mass relative to the total amount of the solid components; the recording medium comprises a support, and a coating layer on at least one surface of the support; the transfer amount of purified water to the recording medium for a contact time of 100 ms is 2 mLm2 to 35 mLm2; and the transfer amount of purified water to the recording medium for a contact time of 400 ms is 3 mLm2 to 40 mLm2 measured using a dynamic scanning absorbing liquid meter.
8. The ink media set according to claim 7, wherein the resin comprises resin fine particles having a glass transition temperature of 25\xb0 C. or less, and the volume average particle diameter of the resin fine particles is 10 nm to 1,000 nm.
9. The ink media set according to claim 7, wherein the colorant is a pigment of a polymer emulsion type containing a color material which is water insoluble or hardly water soluble in polymer fine particles.
10. An ink media set, comprising:
a recording ink, and
a recording medium,
wherein the recording ink comprises at least a solid component, a liquid component, and water; the solid component comprises a colorant and a resin and is a solid at 25\xb0 C.; the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C.; the total content of the liquid component in the recording ink is 30% by mass or less; the total content of the solid component in the recording ink is 20% by mass or more; the total content of resin components in the solid component is 40% by mass to 95% by mass relative to the total amount of the solid components; and the recording medium comprises a non-porous substrate.
11. The ink media set according to claim 10, wherein the non-porous substrate is any one selected from plastic films, plastic laminate papers, plastic coat papers, glasses and metals.
12. The ink media set according to claim 10, wherein the non-porous substrate is a polyester film.
13. The ink media set according to claim 10, wherein the resin comprises resin fine particles having a glass transition temperature of 25\xb0 C. or less, and the volume average particle diameter of the resin fine particles is 10 nm to 1,000 nm.
14. The ink media set according to claim 10, wherein the colorant is a pigment of a polymer emulsion type containing a color material which is water insoluble or hardly water soluble in polymer fine particles.
15. An ink cartridge, housing a recording ink in a container,
wherein the recording ink comprises at least a solid component, a liquid component, and water; the solid component comprises a colorant and a resin and is a solid at 25\xb0 C.; the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C.; the total content of the liquid component in the recording ink is 30% by mass or less; the total content of the solid component in the recording ink is 20% by mass or more; and the total content of resin components in the solid component is 40% by mass to 95% by mass relative to the total amount of the solid components.
16. A moisturizing agent, comprising one selected from (1) a liquid medium composed of water, (2) a liquid medium whose main component is water, (3) a liquid medium whose main components are water and a liquid component which has a higher boiling point than that of water and is a liquid at 25\xb0 C., and (4) a liquid medium containing the same components as a recording ink which comprises at least a solid component, a liquid component, and water, the solid component comprises a colorant and a resin and is a solid at 25\xb0 C., the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C., the total content of the liquid component is 20% by mass or less; and the content of the solid component being a solid at 25\xb0 C. in the liquid medium is less than that of the recording ink.
17. An inkjet recording method, comprising:
flying a recording ink in an ink media set by applying an impulse to the recording ink to form an image on a recording medium in the ink media set,
wherein the recording ink comprises at least a solid component, a liquid component, and water; the solid component comprises a colorant and a resin and is a solid at 25\xb0 C.; the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C.; the total content of the liquid component in the recording ink is 30% by mass or less; the total content of the solid component in the recording ink is 20% by mass or more; the total content of resin components in the solid component is 40% by mass to 95% by mass relative to the total amount of the solid components; the recording medium comprises a support, and a coating layer on at least one surface of the support; the transfer amount of purified water to the recording medium for a contact time of 100 ms is 2 mLm2 to 35 mLm2; and the transfer amount of purified water to the recording medium for a contact time of 400 ms is 3 mLm2 to 40 mLm2 measured using a dynamic scanning absorbing liquid meter.
18. The inkjet recording method according to claim 17, wherein after recording the image on the recording medium, the image is dried by at least either heating or sending air.
19. An inkjet recording method, comprising
flying a recording ink in an ink media set by applying an impulse to the recording ink to form an image on a recording medium in the ink media set,
wherein the recording ink comprises at least a solid component, a liquid component, and water; the solid component comprises a colorant and a resin and is a solid at 25\xb0 C.; the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C.; the total content of the liquid component in the recording ink is 30% by mass or less; the total content of the solid component in the recording ink is 20% by mass or more; the total content of resin components in the solid component is 40% by mass to 95% by mass relative to the total amount of the solid components; and the recording medium comprises a non-porous substrate.
20. The inkjet recording method according to claim 19, wherein after recording the image on the recording medium, the image is dried by at least either heating or sending air.
21. An inkjet recording method, comprising:
replacing a recording ink with a moisturizing agent when inkjet recording is stopped for a long time, and
replacing the moisturizing agent with the recording ink when inkjet recording is restarted,
wherein the recording ink comprises at least a solid component, a liquid component, and water; the solid component comprises a colorant and a resin and is a solid at 25\xb0 C.; the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C.; the total content of the liquid component in the recording ink is 20% by mass or less; the moisturizing agent comprises at least one selected from (1) a liquid medium composed of water, (2) a liquid medium whose main component is water, (3) a liquid medium whose main components are water and a liquid component which has a higher boiling point than that of water and is a liquid at 25\xb0 C., and (4) a liquid medium containing the same components as a recording ink which comprises at least a solid component, a liquid component, and water, the solid component comprises a colorant and a resin and is a solid at 25\xb0 C., the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C., the total content of the liquid component is 20% by mass or less; and the content of the solid component being a solid at 25\xb0 C. in the liquid medium is less than that of the recording ink.
22. An inkjet recording method, comprising:
supplying a moisturizing agent to a capping unit which is
configured to cap the nozzle of a recording head when inkjet recording is stopped for a long time,
wherein the moisturizing agent comprises at least one selected from (1) a liquid medium composed of water, (2) a liquid medium whose main component is water, (3) a liquid medium whose main components are water and a liquid component which has a higher boiling point than that of water and is a liquid at 25\xb0 C., and (4) a liquid medium containing the same components as a recording ink which comprises at least a solid component, a liquid component, and water, the solid component comprises a colorant and a resin and is a solid at 25\xb0 C., the liquid component has a higher boiling point than that of water and is a liquid at 25\xb0 C., the total content of the liquid component is 20% by mass or less; and the content of the solid component being a solid at 25\xb0 C. in the liquid medium is less than that of the recording ink.
23. An ink media set, comprising:
a recording ink, and
a recording medium,
wherein the recording ink comprises at least a pigment of a polymer emulsion type containing a color material which is water insoluble or hardly water soluble in polymer fine particles, water dispersible resin fine particles, and a wetting agent; the total solid content of the pigment of the polymer emulsion type and the water dispersible resin fine particles is 20% by mass or more; the content of the wetting agent is 20% by mass or more; the transfer amount of purified water to the recording medium for a contact time of 100 ms is 2 mLm2 to 35 mLm2, and the transfer amount of purified water to the recording medium for a contact time of 400 ms measured using a dynamic scanning absorbing liquid meter is 3 mLm2 to 40 mLm2.
24. An inkjet recording method, comprising:
flying a recording ink in an ink media set by applying an impulse to the recording ink to form an image on a recording medium in the ink media set, and
drying the image formed on the recording medium,
wherein the ink media set comprises a recording ink, and
a recording medium; the recording ink comprises at least a pigment of a polymer emulsion type containing a color material which is water insoluble or hardly water soluble in polymer fine particles, water dispersible resin fine particles, and a wetting agent; the total solid content of the pigment of the polymer emulsion type and the water dispersible resin fine particles is 20% by mass or more; the content of the wetting agent is 20% by mass or more; the transfer amount of purified water to the recording medium for a contact time of 100 ms is 2 mLm2 to 35 mLm2, and the transfer amount of purified water to the recording medium for a contact time of 400 ms measured using a dynamic scanning absorbing liquid meter is 3 mLm2 to 40 mLm2.
25. An ink media set, comprising:
a recording ink, and
a recording medium,
wherein the recording ink comprises at least a colorant, a water dispersible resin, and a wetting agent; the total solid content of the recording ink is 20% by mass or more; the content of the wetting agent is 20% by mass or more; the wetting agent contains glycerine alone, or the content of the glycerine in the wetting agent is 80% by mass or more; the transfer amount of purified water to the recording medium for a contact time of 100 ms is 2 mLm2 to 35 mLm2, and the transfer amount of purified water to the recording medium for a contact time of 400 ms measured using a dynamic scanning absorbing liquid meter is 3 mLm2 to 40 mLm2.
26. An inkjet recording method, comprising:
flying a recording ink in an ink media set by applying an impulse to the recording ink to form an image on a recording medium in the ink media set, and
drying the image formed on the recording medium,
wherein the ink media set comprises a recording ink, and a recording medium; the recording ink comprises at least a colorant, a water dispersible resin, and a wetting agent; the total solid content of the recording ink is 20% by mass or more; the content of the wetting agent is 20% by mass or more; the wetting agent contains glycerine alone, or the content of the glycerine in the wetting agent is 80% by mass or more; the transfer amount of purified water to the recording medium for a contact time of 100 ms is 2 mLm2 to 35 mLm2, and the transfer amount of purified water to the recording medium for a contact time of 400 ms measured using a dynamic scanning absorbing liquid meter is 3 mLm2 to 40 mLm2.
27-29. (canceled)